Antiepileptic Drug Monitoring

Overview

4.5 out of 5 (57 Reviews)

Credits

1.00

Post-Assessment Questions

5

Start Date

1 Sep 2023

Last Review Date

21 Jan 2025

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


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Activity Description

Antiepileptic drug-level monitoring has been integral to seizure management since the introduction of antiseizure medications. The challenge lies in maintaining drug levels within therapeutic margins despite numerous factors influencing serum concentrations. Pharmacokinetic factors, including absorption, distribution, metabolism, and excretion, significantly affect drug levels. Diet, other drugs, and nutritional status can alter these processes. Drug metabolism through systems like cytochrome P450 and conjugation reactions plays a vital role, especially when multiple drugs are administered concurrently. Clinical evaluation, supported by electroencephalograms and magnetic resonance imaging, forms the basis for diagnosing epilepsy, with drug levels serving as an adjunct for assessing efficacy in specific situations. The International League Against Epilepsy (ILAE) provides guidelines on best practices for therapeutic drug monitoring, highlighting scenarios where this approach is particularly advantageous. This activity emphasizes the importance of understanding these guidelines and recent studies regarding interpreting drug levels, considering individual patient factors and treatment goals. Effective communication about treatment plans and the reasons for drug monitoring are crucial. This activity examines the utility, diversity, and applicability of monitoring antiepileptic drug levels in various clinical contexts.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify common misconceptions associated with the practice of maintaining antiepileptic drug levels within laboratory-defined therapeutic ranges.

  • Assess the efficacy, variability, and utility of monitoring antiepileptic drug levels in various settings.

  • Implement appropriate practices to assess antiepileptic drug efficacy clinically.

  • Implement effective collaboration and communication among interprofessional team members to improve outcomes for patients who might benefit from antiepileptic drug monitoring.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

John L. on 10/1/2021

Claire H. on 10/17/2021

Micheal M. on 11/19/2021

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Michael N. on 2/10/2022

Micheal M. on 2/21/2022

Surabhi C. on 3/24/2022

Sarah H. on 4/18/2022

we should able to communicate with person on phone when we have difficulty rather than go forth & back on email

Manoj v. on 5/8/2022

Dr.Mallikarjun K. on 5/10/2022

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Great presentation!

Olesia G. on 1/7/2025

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Greg S. on 1/26/2025

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Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6773 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 8050 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$49 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$329 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$499 per 1 year per user