McArdle Disease (Glycogen Storage Disease Type 5)

Overview

4.4 out of 5 (13 Reviews)

Credits

1.00

Post-Assessment Questions

11

Start Date

1 Sep 2023

Last Review Date

22 Jan 2025

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


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Activity Description

McArdle disease, also known as glycogen storage disorder (GSD) type 5, is a rare inherited metabolic disorder primarily affecting skeletal muscles. It results from a deficiency of the enzyme muscle glycogen phosphorylase, which is responsible for breaking down glycogen into glucose, the energy source for muscles. This disorder follows an autosomal recessive inheritance pattern and leads to the accumulation of glycogen in muscles. Symptoms vary widely but often include exercise intolerance, muscle cramps, weakness, and fatigue. In some cases, rhabdomyolysis, characterized by muscle breakdown, can occur, leading to serious complications such as acute renal failure.

The disease typically presents in childhood or adolescence, though adult-onset cases exist. Diagnosis is often delayed due to its clinical heterogeneity and difficulty recognizing certain diagnostic phenomena. Diagnostic tests include nonischemic forearm exercise tests, muscle biopsies, and genetic testing. Currently, McArdle disease has no specific treatments, but dietary interventions, including high carbohydrate intake before exercise and moderate-intensity graded aerobic exercise therapy, can help manage symptoms. Despite the lack of a cure, proper management can improve the quality of life and reduce symptoms for many patients. This activity for healthcare professionals is designed to enhance the learner's competence in recognizing this rare metabolic disorder, performing the recommended evaluation, and implementing an appropriate interprofessional management approach to improve patient outcomes.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Determine the genetic basis of myophosphorylase deficiency in the glycogen metabolism in muscle cells.

  • Identify the key clinical manifestations of McArdle disease to facilitate early diagnosis.

  • Implement best practices in the management of McArdle disease to improve patient quality of life.

  •  Apply interprofessional team strategies to improve care coordination and outcomes in patients with McArdle disease.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Gibi G. on 12/3/2021

K.Navanitha R. on 10/6/2022

Manish Kumar S. on 10/7/2022

Christine U. on 8/2/2023

Sweta S. on 8/10/2023

Adithya nikhileshwar B. on 9/9/2023

Akshaya K. on 11/13/2023

Malani K. on 4/15/2024

Likta N. on 5/15/2024

Mamta B. on 5/25/2024

Gautam P. on 9/23/2024

Dr Prashasti k. on 10/16/2024

Inderpreet K. on 1/7/2025

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Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6724 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7991.5 hours of CME.

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6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

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