Overview

4.7 out of 5 (317 Reviews)

Credits

2.00

Post Assessment Questions

9

Start Date

1 Sep 2023

Last Review Date

30 Jan 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

120 Minutes


Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6820 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 8100.5 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$98 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$329 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$499 per 1 year per user
 
Need Help?  If you have a system or content concerns, please contact support@statpearls.com

Activity Description

Addison disease, also known as autoimmune adrenalitis, is an acquired primary adrenal insufficiency. Primary adrenal insufficiency is termed Addison disease when an autoimmune process causes the condition and is a rare but potentially life-threatening emergency condition. Addison disease results from the destruction of the bilateral adrenal cortex, leading to decreased adrenocortical hormones, including cortisol, aldosterone, and androgens. Addison disease's insidious course of action usually presents with glucocorticoid deficiency followed by mineralocorticoid. However, the condition can also present acutely, often triggered by intercurrent illness. The presentation of adrenal insufficiency depends on the rate and extent of adrenal function involvement. The most common cause of primary adrenal insufficiency is Addison disease, associated with increased levels of 21-hydroxylase antibodies.[1][2]

Addison disease usually manifests as an insidious and gradual onset of nonspecific symptoms, often resulting in a delayed diagnosis. The symptoms may worsen over a period, which makes early recognition difficult. A high clinical suspicion should be maintained to avoid misdiagnosis.[22] In many cases, the diagnosis is made only after the patient presents with an acute adrenal crisis manifesting with hypotension, hyponatremia, hyperkalemia, and hypoglycemia. The diagnosis is established by demonstrating low cortisol and aldosterone levels, high renin levels, and a blunt cortisol response with ACTH stimulation. Addison crisis is a severe endocrine emergency; immediate recognition and treatment are required. For stabilized patients diagnosed with Addison disease, life-long treatment with hormonal replacement is needed. Maintenance therapy aims to provide a replacement to maintain a physiologic glucocorticoid and mineralocorticoid level. This activity for healthcare professionals aims to enhance learners' competence in selecting appropriate diagnostic tests, managing Addison disease, and fostering effective interprofessional teamwork to improve outcomes.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify potential causes of Addison disease.

  • Determine when Addison disease should be included in the differential diagnosis.

  • Develop a management plan for patients with Addison disease.

  • Collaborate with the interprofessional team to educate, treat, and manage patients with Addison disease and improve their outcomes.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 2.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Orthopaedic Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment Examination requirements of the American Board of Orthopaedic Surgery’s (ABOS) Maintenance of Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABOS credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 2.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 2.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Deborah Z. on 2/17/2021

Henrik H. on 2/19/2021

This was very well done!

Ira on 9/5/2021

Katherine N. on 9/14/2021

Gibi G. on 10/15/2021

Diane P. on 11/30/2021

Brandon C. on 12/28/2021

Valerie F. on 12/28/2021

Sara E. on 12/29/2021

Dawn L. on 1/3/2022

jaime r. on 1/3/2022

Gwendolyn R. on 1/26/2022

Russell R. on 3/7/2022

devin n. on 3/19/2022

Ira on 3/19/2022

Manish Kumar S. on 4/1/2022

Angjelin S. on 5/3/2022

marina h. on 6/8/2022

MOLY J. on 5/16/2022

K.Navanitha R. on 6/29/2022

saurabh t. on 6/18/2022

Rodabeh M. on 9/5/2022

Louie L. on 7/9/2022

Brian T. on 7/16/2022

Brittany T. on 8/1/2022

Kara C. on 8/9/2022

MANJARI G. on 8/19/2022

Alex N. on 8/30/2022

Holly E. on 9/6/2022

Kellie K. on 10/4/2022

Sweta S. on 10/26/2022

Maylin G. on 11/14/2022

Raymond A. on 11/23/2022

Gary M. on 11/27/2022

Dr.NIRMALA M. on 12/27/2022

Vektra C. on 12/26/2022

syble c. on 1/14/2023

Ehsan Q. on 1/15/2023

Linda H. on 1/25/2023

Lisa B. on 1/28/2023

Ronald L. on 2/3/2023

Przemyslaw L. on 2/1/2023

Arthur L. on 2/4/2023

amy s. on 2/17/2023

Michael W. on 2/17/2023

Katherine C. on 2/28/2023

Lena S. on 3/2/2023

Patricia R. on 3/15/2023

Jeanette S. on 5/2/2023

Stephen H. on 5/16/2023

Amber S. on 6/13/2023

none

Iftikhar A. on 6/25/2023

Ashley W. on 6/30/2023

Natalie M. on 7/3/2023

Lily L. on 7/4/2023

Gary A. on 7/6/2023

Michael B. on 7/26/2023

Mergene T. on 7/31/2023

Brittany W. on 8/31/2023

Whittney H. on 8/11/2023

Susan S. on 8/18/2023

Kelli T. on 8/24/2023

P m. on 8/24/2023

Alice F. on 8/30/2023

Xasan W. on 9/18/2023

Nicole O. on 9/25/2023

Qefli N. on 9/27/2023

Kimberly K. on 9/30/2023

Mary C. on 10/4/2023

Tanveer H. on 10/5/2023

Richard C. on 10/8/2023

John M. on 10/11/2023

Karamo C. on 10/21/2023

Susan H. on 10/28/2023

Shalamar S. on 10/29/2023

Allyson M. on 10/31/2023

Gary J. on 11/1/2023

Lazo K. on 11/1/2023

Shivan K. on 11/2/2023

alexandria g. on 11/3/2023

Juan H. on 11/4/2023

A M. on 11/5/2023

Melissa B. on 11/15/2023

Ali I. on 11/6/2023

Katelyn J. on 11/7/2023

Louis C. on 11/8/2023

Kenneth S. on 11/10/2023

Donna P. on 11/14/2023

NATHAN M. on 11/18/2023

Nizar N. on 11/19/2023

rachel j. on 11/21/2023

Christopher K. on 11/25/2023

Amanda C. on 12/14/2023

Sahar M. on 11/26/2023

Ashley C. on 11/27/2023

kristi f. on 11/30/2023

Kathryn g. on 12/2/2023

Jennifer S. on 12/3/2023

None

Daniel A. on 12/3/2023

unnikrishnan t. on 12/4/2023

Mohamed E. on 12/6/2023

Claudia C. on 12/6/2023

Edward F. on 12/7/2023

Antonio H. on 12/7/2023

Mark M. on 12/14/2023

Dong D. on 12/13/2023

THAN A. on 12/13/2023

Lori M. on 12/14/2023

Nitin S. on 12/14/2023

Jonathan Z. on 12/15/2023

Brian M. on 12/17/2023

Cynthia M. on 12/17/2023

Ranjana S. on 12/17/2023

William S. on 12/18/2023

Amanda w. on 12/19/2023

Keith E. on 12/19/2023

Michael C. on 12/20/2023

Larry M. on 12/21/2023

ROMAN F. on 12/22/2023

Sam B. on 12/23/2023

Antonio D. on 12/24/2023

Shandal E. on 12/25/2023

mohamad a. on 12/25/2023

Susan W. on 12/27/2023

Aurelio T. on 12/27/2023

Charlotte G. on 12/27/2023

priya c. on 12/28/2023

Rashmi M. on 12/28/2023

Cherie T. on 12/28/2023

sandra r. on 12/28/2023

BRANDI B. on 12/29/2023

Antonio V. on 12/30/2023

Jyotsna on 12/30/2023

Dr. J. on 12/31/2023

TRINA S. on 1/1/2024

Genevieve M. on 1/1/2024

Marcelo on 1/2/2024

larry N. on 1/7/2024

Andrea H. on 1/5/2024

Jacqueline M. on 1/6/2024

Ashraf E. on 1/6/2024

Denise on 1/9/2024

Marti E. on 1/12/2024

Zhengyi C. on 1/16/2024

EVAN S. on 1/18/2024

Julia L. on 1/20/2024

paul n. on 1/19/2024

David B. on 1/19/2024

Vivian S. on 1/20/2024

SUSAN L. on 6/15/2024

THAN A. on 1/26/2024

Lisa C. on 1/27/2024

William F. on 1/27/2024

Stephanie E. on 1/28/2024

Todd M. on 1/31/2024

Laura K. on 1/31/2024

Trent p. on 1/31/2024

Charlotte G. on 2/3/2024

Anuradha S. on 2/4/2024

NISHA N. on 2/5/2024

Brittany C. on 2/7/2024

Noelle D. on 2/7/2024

James d. on 2/8/2024

Jackie K. on 2/11/2024

Idrissa i. on 2/13/2024

Michael Z. on 2/13/2024

Luis T. on 2/14/2024

Rebecca M. on 2/15/2024

Joseph S. on 2/17/2024

Yongmei J. on 2/18/2024

Katayun S. on 2/19/2024

Truclinh N. on 2/20/2024

john d. on 2/21/2024

Leila Z. on 2/25/2024

Lisa W. on 2/23/2024

ghizlane a. on 2/25/2024

Lori M. on 2/26/2024

Eric F. on 2/29/2024

Dilyara I. on 3/3/2024

Michael R. on 3/6/2024

Bogdana T. on 3/9/2024

ahdy b. on 3/9/2024

Helean Z. on 3/9/2024

Laura D. on 3/10/2024

Christopher K. on 3/16/2024

julian c. on 3/17/2024

Torrance G. on 3/18/2024

SAJJAD M. on 3/18/2024

Paige B. on 3/19/2024

ISLAM A. on 3/20/2024

Kaman C. on 3/22/2024

Kathryn H. on 3/25/2024

SANjay s. on 3/24/2024

Robin H. on 3/25/2024

Luis R. on 3/29/2024

Laura C. on 3/29/2024

Mohammad I. on 3/31/2024

ken p. on 4/4/2024

Tracie P. on 4/2/2024

Julie C. on 4/2/2024

Shamra B. on 4/4/2024

Hui S. on 4/4/2024

Yashpal m. on 4/5/2024

Jayshree K. on 4/6/2024

larry m. on 4/6/2024

Stacy T. on 4/6/2024

Mohammad G. on 4/6/2024

Dr Prashasti k. on 10/8/2024

Kelly S. on 4/11/2024

Kristine R. on 4/13/2024

Anita m. on 4/15/2024

Thomas K. on 4/17/2024

Mary B. on 4/17/2024

Mark G. on 4/18/2024

Kate J. on 4/21/2024

Brian V. on 4/23/2024

Narin A. on 4/24/2024

Gabriel P. on 4/28/2024

on 4/29/2024

hiba e. on 5/1/2024

Kristine G. on 5/2/2024

Richard M. on 5/3/2024

Katie R. on 5/3/2024

brenda s. on 5/5/2024

Katelyn K. on 5/5/2024

Lauren G. on 5/8/2024

John K. on 5/10/2024

Mark M. on 5/11/2024

daniel p. on 5/11/2024

Marcela D. on 5/11/2024

Tara P. on 5/11/2024

Megan W. on 5/12/2024

XIAOBIN L. on 5/15/2024

Mamta B. on 5/17/2024

ishvar p. on 5/17/2024

William N. on 5/18/2024

Katy A. on 5/23/2024

Rajat V. on 5/24/2024

Rex G. on 5/26/2024

Douglas G. on 5/29/2024

Chris H. on 6/6/2024

Iyad A. on 6/8/2024

Rachel G. on 6/9/2024

Anwar K. on 6/15/2024

Jennifer S. on 6/16/2024

Jessica M. on 6/18/2024

April P. on 6/18/2024

James M. on 6/18/2024

Christine A. on 6/19/2024

Tino C. on 6/19/2024

MATEO B. on 6/22/2024

James R. on 6/25/2024

Shadi S. on 7/1/2024

Steven L. on 7/5/2024

wei z. on 7/7/2024

Angela P. on 7/8/2024

Lesly P. on 7/10/2024

Ikechukwu A. on 7/15/2024

Azzam A. on 7/16/2024

Kelly W. on 7/18/2024

Herbert R. on 7/20/2024

Jana W. on 7/20/2024

Alison G. on 7/24/2024

Dorian M. on 7/29/2024

Zehneel J. on 7/29/2024

Li s. on 7/31/2024

maureen c. on 8/6/2024

CHAULA P. on 8/9/2024

jeffrey m. on 8/13/2024

mohammad s. on 8/15/2024

Jeanne B. on 8/18/2024

Akilah A. on 8/19/2024

Andre M. on 9/4/2024

Paras P. on 9/4/2024

Gautam P. on 9/6/2024

Holly H. on 9/18/2024

Laura F. on 9/23/2024

Gregory L. on 9/25/2024

Jacob W. on 10/9/2024

Trini N. on 10/4/2024

abdallah s. on 10/6/2024

Smita R. on 10/11/2024

Nephtali G. on 10/14/2024

Mariella G. on 10/16/2024

Nancy M. on 10/17/2024

Jeffrey F. on 10/26/2024

Lauren S. on 10/21/2024

JOHN L. on 10/21/2024

Liam M. on 10/29/2024

Nancy R. on 10/27/2024

james m. on 10/28/2024

Sagar P. on 11/9/2024

sean c. on 11/2/2024

Rebecca J. on 11/2/2024

Richard L. on 11/5/2024

leonard o. on 11/5/2024

Excellent review of adrenal insufficiency and Addisons! Thank you.

Louis M. on 11/6/2024

George N. on 11/7/2024

Sahar M. on 11/9/2024

Megan G. on 11/10/2024

Amir R. on 11/11/2024

Ismael C. on 11/12/2024

Jeffrey b. on 11/17/2024

Rodney K. on 11/22/2024

Ashlyn P. on 11/22/2024

Mohamed E. on 11/23/2024

Carl H. on 11/23/2024

Robert O. on 11/26/2024

Eric S. on 11/27/2024

Eric M. on 11/27/2024

Shelby K. on 12/3/2024

Lauren Q. on 12/4/2024

Ashley C. on 12/5/2024

Lawrence P. on 12/11/2024

Ayla G. on 12/15/2024

LASEAN R. on 12/16/2024

Vinay P. on 12/20/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6820 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 8100.5 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$98 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$329 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$499 per 1 year per user