BRCA1 and BRCA2 Mutations

Overview

4.8 out of 5 (601 Reviews)

Credits

1.00

Post Assessment Questions

8

Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Breast cancer genes BRCA1 and BRCA2 are tumor suppressor genes whose mutations significantly increase the likelihood of developing particular types of epithelial malignancies, namely breast and ovarian cancer. The management of patients with a BRCA1 and BRCA2 gene mutations is individualized and can include increased surveillance, chemoprevention using tamoxifen, a bilateral prophylactic oophorectomy, and/or bilateral prophylactic mastectomy. This activity describes the etiology, epidemiology, pathophysiology, screening, evaluation, and management of BRCA 1 and 2 mutations and shows the importance of the interprofessional team in educating patients about the risk of cancer and management strategy for such patients.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the pathophysiology of cancers associated with BRCA 1 and 2 mutations.
  • Outline the clinical presentation of patients with BRCA 1 and 2 mutations.
  • Explain the screening, monitoring, and treatment strategies in patients with BRCA 1 and 2 mutations.
  • Describe how an interprofessional team can collaborate to improve the diagnosis, monitoring, evaluation, and management of this condition and educate patients about the risk of cancer with BRCA 1 and 2 mutations.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

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In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

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Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

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  1. Register for the activity.    
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  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

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Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

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Reviews

Deborah Z. on 7/16/2021

Michael B. on 9/19/2021

Christine Z. on 10/7/2021

Kimberly P. on 12/2/2021

Christopher N. on 3/19/2022

Alexei K. on 5/26/2022

Shannon j. on 6/29/2022

Vincent I. on 7/1/2022

Richard H. on 7/31/2022

thank you for the presentation. it was a good format. I learned more from the teaching points after the questions than the article.

Faith G. on 8/2/2022

Deborah Z. on 8/2/2022

Phu D. on 9/15/2022

Sara M. on 9/21/2022

Tamatha J. on 10/4/2022

Nancy O. on 11/17/2022

Charles W. on 11/20/2022

Larissa k. on 11/28/2022

Thank you for the overview

Brittany S. on 12/19/2022

Clark P. on 2/8/2023

Nikotah C. on 3/2/2023

Mary Y. on 3/10/2023

Malcolm B. on 4/12/2023

Aseeb R. on 4/17/2023

Kelsey H. on 6/30/2023

Amy H. on 7/5/2023

Rebecca L. on 7/10/2023

Tracey O. on 9/11/2023

Celynne A. on 9/18/2023

Essam M. on 9/23/2023

Luba D. on 9/23/2023

Kathern R. on 10/1/2023

Jennifer T. on 10/11/2023

manojkumar b. on 10/24/2023

Sarah R. on 11/6/2023

ISLAM A. on 11/12/2023

louis v. on 11/22/2023

Susan S. on 11/26/2023

edward c. on 11/28/2023

Your questions for the quiz were excellent real world situations. Again, I'd encourage you to refer patients for genetic counseling to do a complete assessment of family history as there are often other hereditary cancer risks identified such as Lynch or polyposis syndromes. Also, genetic testing in the context of breast and ovarian cancer rarely includes only the two BRCA genes anymore as there are so many more breast and ovarian cancer genes identified now that larger gene panels are usually more appropriate.

Cherie R. on 12/13/2023

Waldo F. on 12/27/2023

Julie D. on 12/23/2023

Mary H. on 12/28/2023

MONICA D. on 12/30/2023

Kelly M. on 12/31/2023

Waldo F. on 1/3/2024

William R. on 1/21/2024

Maria D. on 1/27/2024

Great review.

Richard P. on 2/25/2024

Edward W. on 2/28/2024

Lisa R. on 3/2/2024

Mark A. on 3/16/2024

Elizabeth B. on 3/17/2024

DEAN E. on 4/3/2024

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Dr K. on 4/14/2024

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Rosario L. on 4/27/2024

Amber S. on 5/11/2024

Sarah S. on 5/13/2024

Kira W. on 6/19/2024

ishvar p. on 6/30/2024

Lori Z. on 7/7/2024

Fatima H. on 7/14/2024

Jessica B. on 8/10/2024

SUSAN A. on 8/10/2024

Joseph B. on 8/10/2024

Tasha M. on 8/10/2024

Jes R. on 8/11/2024

Excellent

Lindita H. on 8/11/2024

SANJAY P. on 8/11/2024

Nimish S. on 8/11/2024

Thanks!

Patricia J. on 8/11/2024

fahad A. on 8/11/2024

Jennifer G. on 8/11/2024

Sandra G. on 8/11/2024

Rania Dahab Eltaher E. on 8/12/2024

Cedric . on 8/12/2024

Sharyn S. on 8/12/2024

Colleen S. on 8/12/2024

Karen P. on 8/13/2024

Christina A. on 8/12/2024

Hung K. on 8/12/2024

Carlos A. on 8/13/2024

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Sara Y. on 8/14/2024

Sarah T. on 8/13/2024

aliceson k. on 8/13/2024

Jeanmarie C. on 8/14/2024

Jane R. on 8/14/2024

Abdul S. on 8/14/2024

Rebecca N. on 8/14/2024

Diane L. on 8/15/2024

PHUNG T. on 8/15/2024

Lars S. on 8/15/2024

Heather C. on 8/15/2024

It was very informative

Carolina S. on 8/15/2024

Fiona W. on 8/15/2024

Karen F. on 8/16/2024

MYINT MYINT K. on 8/17/2024

Akilah A. on 8/17/2024

Jane G. on 8/17/2024

Jasmine C. on 8/18/2024

Gee G. on 8/18/2024

Statpearls has very easy to understand resourceful information that is required for any physician to ensure proper management of patients

Maxwel D. on 8/22/2024

Ellen p. on 8/18/2024

LaToyia R. on 8/18/2024

Rebecca S. on 8/18/2024

Noraini A. on 8/18/2024

Renae M. on 8/18/2024

Practical article on material to prevent developing of breast cancer.

Dung N. on 8/24/2024

I DON'T HAVE THESE, BUT SO HAVE ATM GENE ISSUES.

Marijane E. on 8/19/2024

Habeeb A. on 8/19/2024

NAWAL TARIQ AHMED A. on 8/19/2024

Terry K. on 8/19/2024

Grace K. on 8/19/2024

Crystal F. on 8/19/2024

Mary Jo H. on 8/19/2024

ashley E. on 8/19/2024

Aleksandra P. on 8/19/2024

Andrea Guadalupe G. on 8/20/2024

Good information.

Gladys Flavy R. on 8/20/2024

Ajinkya R. on 8/20/2024

Rami E. on 8/20/2024

Luz L. on 8/20/2024

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Kimberly C. on 8/22/2024

Samantha A. on 8/22/2024

Leigh Andra W. on 8/23/2024

ashley r. on 8/23/2024

Excellent service!!

Kenneth R. on 8/23/2024

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Meeli G. on 8/25/2024

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Elizabeth M. on 8/26/2024

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Mary M. on 8/27/2024

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Bala santhoshKumar N. on 8/29/2024

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Denise R. on 8/28/2024

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George W. on 8/28/2024

Sandra S. on 8/28/2024

Alexa M. on 8/28/2024

La-Teeka R. on 8/28/2024

Lisa T. on 8/29/2024

Lisa S. on 8/29/2024

Heather J. on 8/29/2024

Kanguei D. on 8/30/2024

Jennifer C. on 8/29/2024

Victoria A. on 8/29/2024

marcela u. on 8/30/2024

Ameer A. on 8/30/2024

Thank you for keeping this format free for all. Continuing education should not be hindered for monetary value.

Kathleen Y. on 8/30/2024

Laura P. on 8/30/2024

Sreeja P. on 8/30/2024

Erin J. on 10/25/2024

Kia C. on 8/30/2024

Self Assessment questions should be representative of the information provided in the module. outcomes/complications of breast reconstruction surgery were not present in the educational material yet there was a question related to this on the self assessment. Similarly no data was presented regarding HRT recommendations in BRCA gene carriers but it was in the assessment.

Deanna D. on 8/31/2024

James F. on 8/31/2024

Michael S. on 8/31/2024

Joseph L. on 8/31/2024

Lawrence M. on 9/1/2024

It was an excellent opportunity provided by statpearls for learning.

Livingstone Z. on 9/1/2024

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Donelle R. on 9/2/2024

Catherine W. on 9/2/2024

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STACIE A. on 9/4/2024

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Jeanette M. on 9/4/2024

Maria S. on 9/4/2024

Terry H. on 9/4/2024

Nancy C. on 9/4/2024

Paige F. on 9/4/2024

None

Jessica A. on 9/4/2024

Kimberly S. on 9/4/2024

Andrea H. on 9/5/2024

Kelly G. on 9/5/2024

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Katherine W. on 9/5/2024

Antoine D. on 9/5/2024

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Thuya N. on 9/6/2024

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steven s. on 9/9/2024

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Abigail B. on 9/10/2024

Scott R. on 9/10/2024

Kaitlin S. on 9/10/2024

Bethany H. on 9/10/2024

Gayla S. on 9/10/2024

Steven L. on 9/10/2024

John K. on 9/10/2024

Davida R. on 9/11/2024

Amber L. on 9/11/2024

Ann W. on 9/11/2024

Lucia N. on 9/11/2024

nigam v. on 9/12/2024

Whitney G. on 9/12/2024

I will share this learning activity with co workers. It is a very basic and clear explanation of these gene mutations as well as their significance statically

elizabeth W. on 9/12/2024

Dina R. on 9/12/2024

Nurse educator recommendation

Lourdes A. on 9/12/2024

Sheri V. on 9/12/2024

angela m. on 9/12/2024

Paul D. on 9/13/2024

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Amy A. on 9/14/2024

Karen B. on 9/14/2024

None

Daniel R. on 9/15/2024

nikeeta w. on 9/15/2024

Excellent presentations.

Dwain F. on 9/15/2024

Delores Maxine H. on 9/15/2024

Excellent review.

Lennard G H. on 9/15/2024

Victoria M. on 9/15/2024

Jennifer R. on 9/15/2024

Melanie L. on 9/15/2024

HELEN V. on 9/16/2024

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kochurani m. on 9/18/2024

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I learn more from this activity I require more this type of activity

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Casey D. on 10/7/2024

excellent site

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Thank you

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none

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excellent

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VERY GOOD CONTENT & CONSIDERING THE CONCISE NATURE MAKES IT USEFUL FOR US WHO HAVE TIME Constraint

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none

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Thanks

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anna s. on 11/13/2024

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None

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none

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none

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