Urea Cycle Disorders

Overview

4.4 out of 5 (25 Reviews)

Credits

1.50

Post Assessment Questions

9

Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


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Activity Description

Urea cycle disorders are inborn errors of metabolism resulting from defects in one of the enzymes or transporter molecules involved in the hepatic removal of ammonia from the bloodstream. Removal of ammonia from the bloodstream normally occurs via its conversion to urea, which is then excreted by the kidneys. Consequently, urea cycle disorders lead to an accumulation of ammonia. Ammonia is extremely toxic, particularly to the central nervous system. Newborns with severe mutations in any one of the first four enzymes of the urea cycle can become catastrophically ill within 36 to 48 hours of birth despite appearing normal at birth. It is therefore possible for a newborn to be discharged from the hospital before signs of urea cycle disorders develop. The newborn may subsequently develop signs that go unrecognized at home. Hyperammonemia is key to the diagnosis of urea cycle disorders and treatment should not be delayed while a definitive diagnosis is sought. This activity reviews the evaluation and management of urea cycle disorders and highlights the role of interprofessional team members in collaborating to provide well-coordinated care and enhance outcomes for affected patients and families.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Explain why the potential for urea cycle disorders poses a risk to early discharge of seemingly healthy newborns.
  • Explain how high serum ammonia level should be managed in a newborn.
  • Explain the management of urea cycle disorders.
  • Explain the importance of improving coordination amongst the interprofessional team to enhance care for patients affected by urea cycle disorders.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurses: StatPearls designates this activity for 1.50 ANCC contact hour(s). Nurses should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Gibi G. on 12/7/2021

Dr.Ayodhyaprasad S. on 7/8/2022

K.Navanitha R. on 10/9/2022

Manish Kumar S. on 8/6/2022

SYED M. on 12/4/2022

Mark K. on 12/24/2022

joanna b. on 1/8/2023

Kurni R. on 1/20/2023

Please it would be more helpful if complete treatment of UCDs with doses available,thank you

Arelly J. on 1/20/2023

Gautam P. on 3/10/2023

Dr Jagveer S. on 4/13/2023

Ajay P. on 5/25/2023

Adithya nikhileshwar B. on 6/4/2023

Sweta S. on 8/7/2023

Nivetha V. on 11/9/2023

Akshaya K. on 11/19/2023

Nida A. on 11/24/2023

Gautam P. on 4/4/2024

Likta N. on 4/13/2024

Dr. Neha K. on 4/17/2024

Malani K. on 5/27/2024

Anuradha S. on 5/28/2024

PRANEET R. on 6/15/2024

Dr Prashasti k. on 10/9/2024

Inderpreet K. on 11/5/2024

Unlimited Nurse CE

Stay up to date on the latest medical knowledge with 6821 CE activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 8103.5 hours of CE.

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6 Month Unlimited Nurse CE

Access to all the Unlimited Nurse CE activities in all specialties.

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