Urinary retention is the inability to void urine voluntarily. It can be acute or chronic. It is a common medical problem across the globe, and acute retention can be a urologic emergency that occurs most commonly in men. Acute urinary retention in men is most commonly secondary to benign prostatic hyperplasia (BPH). Acute urinary retention in women is rare, and this article will focus on urinary retention in men. The discussion will be a review of the epidemiology, pathophysiology, etiology, history and physical evaluation, laboratory and testing to evaluate and diagnosis urinary retention, the treatment, patient instruction for discharge and follow up, and key points to the health team managing acute urinary retention.
Causes of the urinary retention are numerous and categorized as obstructive, infectious, inflammatory, pharmacologic, neurologic, or other.
1. Obstructive causes of urinary retention
The mechanisms of acute urinary retention can include, outflow obstruction which can be mechanical such as from physical narrowing of the urethral channel. The other dynamic is from an increase in the muscle tone within and around the urethra as in with benign prostatic hypertrophy/ hyperplasia.
Other obstructive causes can occur by constipation, cancer of the prostate or bladder, urethral stricture, urolithiasis, phimosis, or paraphimosis.
3. Neurologic causes
Neurologic impairment, another etiology of urinary retention, is because of the interruption of the sensory or motor innervation of the detrusor muscle. The process of voluntary urination involves the integration and coordination of high cortical neurologic functions involving sympathetic, parasympathetic and somatic nerves and the detrusor and sphincter smooth muscle. Discernment of a full bladder is by nerves sensing pressure creating a sensory impulse to the cortical centers, allowing the cortical areas to coordinate voluntary urination, which leads to continence of the bladder storing urine through relaxation of the detrusor muscle through beta-adrenergic stimulation and parasympathetic inhibition. The contraction of the bladder detrusor muscle(voiding) is brought on by cholinergic muscarinic receptors and relaxation of the internal sphincter the bladder neck and the urethral sphincter through alpha-adrenergic inhibition. The dyssynergia occurs by interruption of the neurologic pathways such as from a stroke, spinal cord injury, infarction, demyelination along with other neurologic disorders (e.g., traumatic cord injuries, epidural abscess, epidural metastasis, Guillain-Barre syndrome, diabetic neuropathy, multiple sclerosis). These neurologic impairments may develop acute on chronic urinary retention.
4. Muscle dysfunction
Inefficient detrusor muscle can cause acute urinary retention and can be brought on by the result of the fluid challenge, during general or epidural analgesia without an indwelling catheter. Patients with symptoms of obstructive uropathy at baseline are most at risk for this.
Medications can cause acute urinary retention by their effects on neurotransmitters, neuroreceptors, cholinergic, and muscarinic receptors. The classification of the drugs associated with urinary retention are sympathomimetics alpha-adrenergic (ephedrine sulfate, phenylephrine, phenylpropanolamine, pseudoephedrine), sympathomimetics beta-adrenergic agents (isoproterenol, metaproterenol, terbutaline), antidepressants (imipramine, nortriptyline, amitriptyline, doxepin, amoxapine, maprotiline), antiarrhythmics (quinidine, procainamide, disopyramide), anticholinergics (atropine, scopolamine, glycopyrrolate, mepenzolate, oxybutynin, flavoxate, hyoscyamine, belladonna, propantheline, dicyclomine), antiparkinsonian agents (trihexyphenidyl, benztropine, amantadine, levodopa, bromocriptine), hormonal agents (progesterone, estrogen, testosterone), antipsychotics (haloperidol, thiothixene, thioridazine, chlorpromazine, fluphenazine, prochlorperazine), antihistamines (diphenhydramine, chlorpheniramine, brompheniramine, cyproheptadine, hydroxyzine), antihypertensives (hydralazine, nifedipine), muscle relaxants (diazepam, baclofen, cyclobenzaprine) and multiple other drugs (indomethacin, carbamazepine, amphetamines, dopamine, vincristine, morphine/other opioids, anesthetic agents). These agents act through a variety of mechanism some are apparent such as sympathomimetics and anticholinergic and there effects on smooth muscle tone of the urethra or bladder neck, and the detrusor muscle.
Other etiologies such as trauma and operative procedures can cause urinary retention by altering the anatomy or injury the bladder, sphincter or the urethra.
Chronic Urinary retention:
Causes of chronic urinary retention are mostly neurologic in nature and detrusor muscle dysfunction. The neurologic causes of chronic urinary retention are related to diabetes mellitus and are the result of neuropathy developed from myogenic and neurogenic alterations as of the result of prolonged hyperglycemia and production of oxidative stress products. While this can occur in men, the incidence is limited. The peripheral neuropathy causes bladder dysfunction. Studies have shown an association with detrusor muscle contraction impairment and decreased bladder emptying.There is an associated 8% prevalence of neuropathy as a cause of bladder dysfunction.  Spinal injury caused by infarction and demyelination present as acute urinary retention but as they are often irreversible lead to chronic urinary retention.
Detrusor muscle dysfunction may occur in patients with weakening muscle from chronic overdistention of the bladder muscle. The patient has incomplete bladder emptying during infection or from stricture. The patient presentation for urinary retention gets delayed and when corrected the muscle has lost tonicity; this can occur acutely during spinal anesthesia and postoperatively during general anesthesia without foley catheter. 
Acute urinary retention is most common in men in their 60s to 80s. Research determined that over a five-year period 10% of men over age 70 and close to one-third in their 80s will develop acute urinary retention. The risk for this in men is prostatic enlargement, with risk factors of increasing age, African American race, obesity, diabetes mellitus, high alcohol consumption, and physical inactivity. Neurogenic causes of urinary retention tend to occur in younger males and women. The mortality rate for men with spontaneous urinary retention at 1-year increases from 4.1% in patients age 45 to 54 years to 33% in those 85 years and older.
The history of the patient presenting with symptoms of acute urinary retention should focus on lower urinary tract symptoms using questions such as, Over the past month,
1. How frequently have you had the sensation of not being able to empty your bladder completely after voiding/urinating?
2. How frequently have you had to urinate again less than two hours after finished urinating?
3. How frequently have you found you stopped and started several times when you were voiding?
4. How often have you have found it difficult to postpone urination?
5. Over the past month how often have had a weak stream?
6. How often have had to push or strain to begin urination?
7. How many times did you get up to urinate from the time you go to bed until you get up in the morning?
The American Urological Association developed a scoring system using these question using a rating scale:
Teh clinician should inquire about the history of prostate diseases such as cancer, trauma, surgery, kidney stones, prostate infections, sexually transmitted diseases, radiation treatment or exposure, and back pain. History on the presence of hematuria, dysuria, fever, low back pain, neurologic symptoms of tremors, weakness is vital. Thorough urogenital review of systems is a must. The medication list should undergo thorough review as several medications can cause urinary retention, and inquiry into past surgical procedures and anesthesia may also prove informative.
Physical examinations should focus on the lower quadrants of abdomen, pelvis, and genitals. Palpation can often note the distended bladder; the rectal exam can note an enlarged prostate (showing prostatic hyperplasia) or fecal impaction (showing impingement on the bladder neck or urethra), or poor sphincter tone (showing a spinal cord problem). Neurologic examination for strength, sensation, reflexes and muscle tone is also informative. A thorough patient history and physical exam will often identify the etiology.
The diagnosis of acute urinary retention is aided by bladder ultrasound, but catheterization is reasonable as it is both diagnostic and therapeutic. The bladder ultrasound that suggests a volume greater than or equal to 300 mL in a patient unable to void suggests urinary retention. Bladder ultrasound can be inaccurate because of body habitus, tissue edema, prior surgery, and scarring. The placement of a catheter might be needed. The volume of urine obtained from drainage in the first 10 to 15 minutes should be recorded. If the volume exceeds 400 mL, the catheter will typically remain in place. For volumes of 200 to 400 mL, the decision to leave the catheter in place is guided by the clinical scenario as volumes less than 200 mL likely do not have acute urinary retention and should undergo evaluation for other causes of abdominal or suprapubic discomfort.
The following outlines treatment of lower outlet tract obstruction, prostatic, and urethral causes:
As the patient with acute urinary retention is in discomfort, placement of a urinary catheter or suprapubic catheter (if the urethra is not accessible) should be done to decompress the bladder and relieve the lower tract obstruction. Urethral catheterization is particularly useful in patients where the cause of the urinary retention is temporary such as infection or medication. Urethral catheterization is contraindicated in patients with recent urologic surgery such as radical prostatectomy or urethral reconstruction. These patients should have suprapubic catheterization(SPC).
The urethral catheter should be 16 to 18 French as first-line therapy. If one suspects an enlarged prostate as the cause of the obstruction, then they may need a larger catheter 20 to 22 French gauge with a firm coude tip. If stricture or prostatic scar is a concern, a smaller catheter 10 to 12 French may be an option. If failure to pass the catheter happens, then urologic consultation may be required. The urologist may be able to perform bedside flexible cystoscopy with either dilatation of the stricture or passage of wire over which one may place a urinary catheter.
After initial decompression with a catheter, discussion with the patient to perform a clean intermittent catheterization versus short-term placement of a catheter with a later trial without catheterization. There are fewer complications with clean intermittent catheterization, and it correlates with an increased rate of spontaneous voiding and a reduction in urinary tract infections. Clean intermittent catheterization is often more acceptable to the patient if the nursing staff focuses on good instruction and placement of the catheter. Further outpatient setting with support services may help. Patients are usually receptive to education.
Treatment of those with nontemporary (chronic) etiology of urinary retention: neurogenic, spinal, demyelination, and contraindication to Foley catheter placement
For patients who had to have a suprapubic catheter due to contraindications or failed urethral catheterization; the urologist usually places suprapubic catheters, but in emergent conditions where a urologist is not present, and the patient is in distress, suprapubic aspiration via a needle is an option. This procedure is performable with ultrasound guidance at the bedside. Some studies show patients with suprapubic catheters experience less discomfort. Placement of suprapubic catheters is not without risk, as bowel perforation and wound infection are possible.
The rate of bladder decompression through studies have shown that rapid, complete drainage is best. Clamping and partial drainage do not reduce the complications of hematuria, hypotension, and post-obstructive diuresis. The studies also showed that partial drainage and clamping increased the risk of urinary infection.
Overview of catheterization treatment:
The underlying etiology determines the duration of catheterization. In the patients where the underlying etiology is temporary such as with medications or anesthetic should have a post-voiding trial as soon as possible, within 2 to 3 days. In patients with a spinal injury where urinary retention is not likely to resolve, catheterization may become chronic. These patients are candidates for clean intermittent catheterization or suprapubic catheterization.
The underlying etiology such as infection should receive treatment. Medications causing urinary retention should be stopped. Benign prostatic hyperplasia should receive medical treatment and evaluation for surgical intervention such as transurethral resection.
Indications for admission to the hospital are patients:
-Who have urosepsis, have obstruction due to malignancy, or acute myelopathy.
Most cases of acute urinary retention will be managed safely outpatient with referral for further evaluation of etiology if not identified in the emergent setting. Patients discharged need instruction in catheterization for intermittent catheterization, Foley catheter care, how to empty catheter bag, and monitoring their urine output. Patients should not be placed on antibiotics unless a urinary infection is present. Prophylactic antibiotics have been shown not to prevent infection and may increase resistance.
Benign prostatic hyperplasia (BPH) is the most common etiology in men especially over the age of 60; therefore, a focus of the treatment is medicine and referral to urology for further evaluation of the need for surgical treatment. Medical treatment of BPH includes an alpha-1 adrenergic antagonist (alfuzosin 10mg or tamsulosin 0.1mg). Alpha-1 adrenergic antagonists work by relaxing smooth muscle at the bladder neck and the prostates capsule. Other medications such as 5-alpha reductase inhibitors decrease the incidence of acute urinary retention in men with BPH. Patients need to be treated over one year to prevent acute urinary retention and reduce the need for surgery. Trial without catheter should be tried twice before considering surgical therapy. The studies have shown increase success with patients with following characteristics, age less than 65, detrusor pressure greater than 35cm water, a drained volume of less than one liter at catheterization and the identification of the precipitating event.
The duration of catheterization in men with BPH should not be over 7 days. There has been a large observation study which patients with medical treatment showed greater success with spontaneous voiding with catheterization of 3 days or fewer. For those men who have BPH and fail a second trial without catheter Transurethral resection of the prostate (TURP) reduces the risk of developing acute urinary retention 85 to 90 percent. The timing of surgery is to wait 30 days from the episode of acute urinary retention. Urologists usually perform urodynamic studies to assure the retention is directly related to outlet obstruction.
As discussed under etiologies, the differential diagnosis for an acute urinary retention event is wide with the most common in men over 65 is BPH. Other causes of the event include medications, anesthetics, surgical procedures, nerve injury, spinal cord injury, stroke, demyelinating diseases, infection bacteria and viral (herpes, herpes zoster), stricture, scaring and trauma. History and review of systems are the primary way to identify the cause followed by a physical exam with through neurologic examination. Laboratory evaluation for associated complications of infection, renal dysfunction, and electrolyte imbalance is necessary. Further diagnostic testing should proceed based on the findings of the history and physical to evaluate for infection, stroke, and spinal cord diseases.
Men with BPH who develop acute urinary retention are usually older makes ages greater than 70, with more comorbidities and have a higher risk of complications. These comorbidities include infection and renal dysfunction such as CKD and ESRD. The prognosis is determined by response to therapy. Studies have shown that transurethral resection reduces acute urinary retention by 85 to 90 percent. Patients who undergo immediate surgery following an episode of acute urinary retention are at increased risk of complications, including operative bleeding and sepsis from bacteriuria. Men who underwent prostatectomy for acute urinary retention had increased risk of death at 30 and 90 days compared to men who underwent elective prostatectomy. The older the patient, the higher the risk from complications. Those with other causes of acute urinary retention from neurologic conditions are at increased risk from infection and sequelae of the underlying disease. Acute urinary retention due to temporary causes has a better prognosis than those that are due to long-term or chronic disease because of associated complications with long-term catheterization. The use of modalities of intermittent catheterization and suprapubic catheterization has been shown to result in fewer complications.
As stated in previous sections, complications from acute urinary retention are from the underlying causes and treatments. They include infection, renal dysfunction, electrolyte imbalances, stricture of the urethra, bladder neck dilation, and detrusor muscle dysfunction. The treatment via catheterization for bladder decompression can result in adverse events such as hematuria which occurs in between 2 to 16 percent of the patients but is rarely significant. This complication usually resolves with irrigation. Transient hypotension is a complication that occurs after initial bladder decompensation, but it is transient, and blood pressure normalizes without intervention. Post obstructive diuresis may persist after decompression of the bladder. This primarily occurs with chronic urinary retention and usually represents an appropriate attempt to excrete excess fluid retained during the period of obstruction. This situation is managed by increasing oral fluid intake unless the patient is unable. If intravenous fluid replacement is needed, replacement is guided by a measure of urine output, replacing one half the urine volume with isotonic saline. The replacement fluid can be different depending on the presence of hypernatremia or hyponatremia.
The patient with acute urinary retention needs to be educated about catheter care and monitoring urinary output. If the patient is performing clean intermittent catheterization, they need to be taught proper techniques to prevent complications. Those with suprapubic catheters need to be shown proper care of these catheters and keeping the suprapubic site clean and free of the urinary leak to prevent dermatitis. Patients may need followup home care and education if they have complications. The patient with benign prostatic hyperplasia requires education about the trial without catheterization and follow-up care. The surgical options and the risk and complications of surgical treatment should be shared with the patient. If the etiology of the acute urinary retention is medication-based, the patient should understand the side effects of the medication and the need to find an alternative.
The health outcomes can be enhanced by a thorough history using the questions suggested by the American Urological Association. One needs to obtain a medication review and perform a thorough physical examination to rule out a neurological disorder. Patients should receive counseling about catheter care and the importance of antisepsis. The nursing team needs to know of contraindications of catheter placement and be able to recognize them. Timely, urologic consultation for suprapubic catheterization is thre recommendaiton in patients who have acute retention and inability to pass a urethral catheter. The clinician needs to be knowledgeable of how to do suprapubic needle drainage or temporary catheter drainage if the patient is in extreme discomfort or distress when a urologist is not immediately available.
The patient and patient’s support (family or caregivers) should receive training regaridng clean intermittent catheterization, as well as education on medications used to treat benign prostatic hyperplasia.
Co-ordination between primary care clinicians, nephrologists, urologists and emergency room clinicians is needed.
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