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Hypercalcemia, when present, suggests bony metastasis or a paraneoplastic phenomenon. Bone metastasis is often osteolytic and causes pathologic fractures, spinal cord compression, and hypercalcemia. It can produce a number of substances that lead to hypercalcemia (PTHrP), erythrocytosis (erythropoietin), and Cushing syndrome (ACTH), etc. A third... Renal Cancer

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Familial Hypocalciuric Hypercalcemia

Familial hypocalciuric hypercalcemia (FHH) is a genetic condition characterized by mild hypercalcemia, typically found in otherwise healthy and asymptomatic individuals.


Malignancy-Related Hypercalcemia

More than 90% of hypercalcemia cases are caused by primary hyperparathyroidism (PHPT) or malignancy-induced hypercalcemia, with malignancy being the most common cause of hypercalcemia in hospitalized patients.


Milk-Alkali Syndrome
Milk-alkali syndrome now accounts for more than 10% of the cases of hypercalcemia and is the third most common cause of hypercalcemia in hospitalized patients (after hyperparathyroidism and hypercalcemia of malignancy).

Calcium
Genetic mutations of CaSRs, such as those found in familial hypocalciuric hypercalcemia (FHH), can affect the sensitivity of the receptors to serum calcium levels, resulting in hypo- or hypercalcemia.

Calcitriol

Hypercalcemia is the most common adverse reaction reported in at least one-third of patients taking systemic calcitriol.

Also known as: Decostriol, Calcitriol Oral Solution, Asentar

Physiology, Parathyroid Hormone
If serum PTH is found to be elevated in the context of hypercalcemia, further investigation of the parathyroid gland is warranted and will be initiated with imaging.
Also known as: PTH

Vitamin D Toxicity
Toxicity leads to hypercalcemia and an imbalance in the regulation of bone metabolism with resultant hypercalcemia and its associated signs and symptoms.

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