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StatPearls Answer :

While there has been a slight decrease in prescription opioid fatalities, at the same time, there has been an increase in overdose fatalities from opioid and non-opioid agents.[27][28] According to the CDC, fatalities from benzodiazepines nationwide and in Florida are also significant, with alprazolam being the most common drug. Florida Opioid P... Florida Controlled Substance Prescribing

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Alprazolam

Most of the near-fatal cases with alprazolam are due to polydrug use.

Also known as: Alplax, Alpronax, Alviz, Cassadan, Restyl, Solanax, Tranquinal, Xanor, Staccato alprazolam, Trankimazin, Esparon, Tafil, Ralozam, Alprox, Alprazolan

Benzodiazepines

Exceptions are triazolam, alprazolam and midazolam.

GABA Receptor Positive Allosteric Modulators

Benzodiazepines consist of drugs such as alprazolam, lorazepam, diazepam, etc.

Drug Enforcement Administration Drug Scheduling

Controlled Substance Act

Schedule IV substances include benzodiazepines (eg, alprazolam, diazepam, clonazepam), zolpidem, and tramadol.

Benzodiazepine Toxicity

Some benzodiazepines such as clonazepam, lorazepam, midazolam, and alprazolam will not show up on many urine drug screens as a result.

Lomitapide

Weak CYP3A4 inhibitors: Weak CYP3A4 inhibitors, including alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, pazopanib, ranitidine, ranolazine, ticagrelor, zileuton can increase lomitapide exposure approximately 2-fold.

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