Lung Sounds

Definition/Introduction

The pulmonary exam includes multiple components, including inspection, palpation, percussion, and auscultation. In this article, we will focus on the auscultation of lung sounds, which are useful in predicting chest pathology when considered alongside the clinical context. The lungs produce three categories of sounds that clinicians appreciate during auscultation:  breath sounds, adventitious sounds, and vocal resonance.  

Breath Sounds

For the purpose of this article, we refer to breath sounds as normal lung sounds heard through the chest wall with the use of a stethoscope rather than audible breathing through the mouth. Normal breath sounds are classified as bronchial, vesicular, or bronchovesicular, which have different acoustic properties based on the anatomical characteristics of the location where you are auscultating. Bronchial sounds (also called tubular sounds) normally arise from the tracheobronchial tree, and vesicular sounds normally arise from the finer lung parenchyma. Loud, harsh, and high-pitched bronchial sounds are typically heard over the trachea or at the right apex. They are predominantly heard during expiration. If heard in other areas of the lung, bronchial sounds are abnormal. In contrast, vesicular breath sounds are soft, low-pitched, predominantly inspiratory, and appreciated especially well at the posterior lung bases. Bronchovesicular sounds can be heard during inspiration and expiration and have a mid-range pitch and intensity. They are commonly heard over the upper third of the anterior chest. Note that the terms high and low pitch are defined by the American Thoracic Society Committee as 400hz or greater and 200hz or less, respectively, although the actual frequencies of these sounds may violate that official rule.[1][2]

The intensity and duration of breath sounds are also clinically significant and will be covered in detail below.

Adventitious Sounds

Adventitious sounds refer to sounds that are heard in addition to the expected breath sounds mentioned above. The most commonly heard adventitious sounds include crackles, rhonchi, and wheezes. Stridor and rubs will also be discussed here. There are many other terms that are used to describe adventitious sounds, which are too numerous to cover. These terms are generally redundant with, or sub-categories of, the ones noted below. For instance, crackles and rales refer to the same finding; many terms are used interchangeably and vary by the clinician and geographic location of the practice.

The first trait that assists in the classification of adventitious sounds is whether the sounds are continuous or intermittent. For example, rhonchi and wheezes are continuous sounds, whereas crackles are not. Crackles could be counted by the examiner as discrete acoustic events [<25ms, interrupted, like dropping a marble on the floor], whereas rhonchi and wheezes are somewhat inseparable noise [>250ms, constant, like the whirring of a fan]. The next thing to note is the pitch:  wheezes and fine crackles are high-pitched, whereas rhonchi and coarse crackles are low-pitched 

Crackles are generated by small airways snapping open on inspiration.[2]  Therefore, they are predominantly inspiratory. The difference between the coarse and fine crackles is believed to come from the size of the airway snapping open (larger airways, deeper pitched, coarser crackles). Some have compared it to separating hook-and-loop fasteners (e.g., velcro).

Wheezes and rhonchi, which have the same pathology and are separated only by pitch, are produced by the fluttering of narrowed airways and the air that flows through them.[3]  Wheezes are musical sounds caused by air movement through constricted small airways, such as bronchioles. Rhonchi are coarse, loud sounds caused by constricted larger airways, including the tracheobronchial passages. These sounds occur during expiration, or both inspiration and expiration, but they do not occur in inspiration alone.   Interestingly, physicians often agree on auscultation of wheezing but less so for other findings, such as crackles.[4]

Stridor is a high-pitched sound originating from the upper airway and occurring on inspiration. It is distinguished from other sounds by its intensity in the neck more so than the chest, timing (inspiratory), and pitch (high). Like wheezes, stridor is produced by airway narrowing, but only in the upper airways.

A rub is a grating sound coming from an inflamed pleura rubbing against one another. It is usually louder than other lung sounds due to its generation closer to the chest wall. Rubs usually occur during both inspiration and expiration at a mirrored point in the respiratory cycle.[5]  Rubs are most often confused with crackles but are distinguished by the rub's biphasic, localized quality, often with overlying point pain on the chest wall. 

Vocal Resonance                                          

Normal lung tissue acts as a low-pass filter in that it allows low-frequency sounds to move through easily while filtering high-frequency sounds. Pathological lung tissue can transmit higher frequency sounds more efficiently; this occurs when a normally air-filled lung becomes occupied by another material, such as fluid. Physicians can exploit this phenomenon through the physical exam.[2] Tests used to detect this phenomenon, known as vocal resonance, include bronchophony, egophony, and whispered pectoriloquy. To test for these, the clinician places their stethoscope over symmetric areas of the patient's chest and asks the patient to speak. The clinician usually would hear an unintelligible, distant, and muffled vocal sound. In bronchophony, the voice appears closer and louder. Egophony occurs when pathological lung tissue distorts vowel sounds and makes them more nasal in quality, and therefore makes the sound of a hard E heard as an A, referred to as "E to A changes." [6] Pectoriloquy describes the finding of a clear and intelligible sound when the patient whispers; it usually is unclear and unintelligible. 

Issues of Concern

Issues of Concern

The performance of auscultation and interpretation of lung sounds is most familiar with a traditional stethoscope; however, newer, electronic stethoscopes may increase the detection of abnormal lung sounds. Computerized interpretation of lung sounds is also actively under investigation; this could take the form of digitized analysis of sounds or of a visual display of the acoustic information that a clinician could interpret.  Computerized augmentation may prove to be more accurate in the future.[7]

Clinical Significance

Adventitious sounds reflect the pathology that produces them, so the specific clinical context is critical for accurate interpretation.  For example, crackles and the sound of airways snapping open frequently occur in interstitial lung disease, pulmonary edema from heart failure, and infection.  Later and higher-pitched crackles often represent interstitial lung disease, whereas earlier and lower-pitched crackles tend more toward chronic obstructive lung disease.    Wheezing, the sound of air movement through narrowed airways, occurs in conditions such as asthma, chronic obstructive lung disease, and focal masses. Without a specific clinical context, these sounds are fairly nonspecific. The duration, rather than pitch, of wheezing throughout the respiratory cycle is most predictive of the degree of pathology.[1] 

Breath sound intensity can be graded on a 0-4 scale (zero being none, one being barely appreciated, two being diminished, three being normal, and four being louder than normal), although the clinical utility of grading intensity has been questioned.[4] In the right context, the intensity of vesicular breath sounds can indicate pathology.  Greater intensity of breath sounds correlates with more profound ventilation, in contrast, quieter breath sounds can indicate decreased ventilation, and the worsening of a disease such as asthma.[8] If fluid, air, or other matter lies in the pleural space, it will decrease the intensity (as occurs in a pleural effusion).  An asymmetric intensity of breath sounds is especially helpful, especially after intubation, where asymmetric breath sounds are pathognomonic for an accidental endobronchial placement of the tube.[9]

If bronchial breath sounds are outside their normal geographic territory on the chest, this is a sign of underlying pathology, usually pulmonary consolidation or collapse; this can be a tricky concept because normal breath sounds in one area of the lung could be pathological if heard elsewhere in the lung so the examiner should be conscientious when examining the chest. 

The ease of transmission of certain frequency sounds can change with pathology, so we will discuss two specific examples as an illustration.  In patients with lobar pneumonia, the normal, air-filled lung instead contains fluid.  As fluid transmits sounds better than air, vocal resonance is increased such that bronchophony, egophony, and whispered pectoriloquy might be present. Contrast this with pleural effusions which may transmit lower frequency sounds less, but higher frequencies better.[8][9][10] Note that these findings can be dynamic and inconsistent, with decreases in vocal resonance sometimes occurring if enough fluid builds up between the stethoscope and the lung.  When assessing vocal resonance, the examiner should compare sounds from the opposite side as well as different locations throughout the lungs.  Even healthy lungs will distort transmitted sound, but a unilateral change in an isolated area often indicates pathology.

Media

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Stethoscope bell Image courtesy S Bhimji MD

References

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[1]

Meslier N, Charbonneau G, Racineux JL. Wheezes. The European respiratory journal. 1995 Nov:8(11):1942-8     [PubMed PMID: 8620967]

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[2]

Pramono RXA, Bowyer S, Rodriguez-Villegas E. Automatic adventitious respiratory sound analysis: A systematic review. PloS one. 2017:12(5):e0177926. doi: 10.1371/journal.pone.0177926. Epub 2017 May 26     [PubMed PMID: 28552969]

Level 1 (high-level) evidence

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[3]

Nagasaka Y. Lung sounds in bronchial asthma. Allergology international : official journal of the Japanese Society of Allergology. 2012 Sep:61(3):353-63. doi: 10.2332/allergolint.12-RAI-0449. Epub     [PubMed PMID: 22722817]

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Holleman DR Jr, Simel DL. Does the clinical examination predict airflow limitation? JAMA. 1995 Jan 25:273(4):313-9     [PubMed PMID: 7815660]

Level 1 (high-level) evidence

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[5]

Sarkar M, Madabhavi I, Niranjan N, Dogra M. Auscultation of the respiratory system. Annals of thoracic medicine. 2015 Jul-Sep:10(3):158-68. doi: 10.4103/1817-1737.160831. Epub     [PubMed PMID: 26229557]

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[6]

Shellenberger RA, Balakrishnan B, Avula S, Ebel A, Shaik S. Diagnostic value of the physical examination in patients with dyspnea. Cleveland Clinic journal of medicine. 2017 Dec:84(12):943-950. doi: 10.3949/ccjm.84a.16127. Epub     [PubMed PMID: 29244648]

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[7]

Andrès E, Gass R, Charloux A, Brandt C, Hentzler A. Respiratory sound analysis in the era of evidence-based medicine and the world of medicine 2.0. Journal of medicine and life. 2018 Apr-Jun:11(2):89-106     [PubMed PMID: 30140315]

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[8]

Baughman RP, Loudon RG. Sound spectral analysis of voice-transmitted sound. The American review of respiratory disease. 1986 Jul:134(1):167-9     [PubMed PMID: 3729151]

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[9]

Forgacs P. The functional basis of pulmonary sounds. Chest. 1978 Mar:73(3):399-405     [PubMed PMID: 630938]

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[10]

Thomas DC, K P, Harigovind G, Sen D. Lung Consolidation Detection through Analysis of Vocal Resonance Signals. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2018 Jul:2018():957-960. doi: 10.1109/EMBC.2018.8512319. Epub     [PubMed PMID: 30440549]