Magnetic Resonance Imaging Contraindications

Issues of Concern

Radiologists, referring physicians and MR technologists, need to be able to assess MRI safety, patients' condition, and compatibility of medical devices to keep patients safe. There are different contraindications regarding MRI scanning:

A) Absolute contraindications:

• The cardiac implantable electronic device (CIED) such as pacemakers, implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) devices: Patients with CIED are at risk for inappropriate device therapy, device heating/movement, and arrhythmia during MRI. These patients must be scheduled in a CIED blocked slot or scheduled with electrophysiology nurse or technician support. But nowadays MRI conditional cardiac implantable electronic devices are widely available.[6]
• Metallic intraocular foreign bodies: The patient should be asked if he/she has ever welded without eye protection or had any facial injury with metal; if yes, an orbit x-ray must be taken and reviewed by the radiologist for approval before the MRI. 
• Implantable neurostimulation systems
• Cochlear implants/ear implant: BAHA cochlear implant type can be scanned on a 1.5-tesla scanner only after the patient removes the battery. Cochlear implant wrapping scheduling must take place before the patient's MRI appointment.
• Drug infusion pumps (insulin delivery, analgesic drugs, or chemotherapy pumps): If possible, the patient has to remove the device.
• Catheters with metallic components (Swan-Ganz catheter)
• Metallic fragments such as bullets, shotgun pellets, and metal shrapnel 
• Cerebral artery aneurysm clips
• Magnetic dental implants
• Tissue expander
• Artificial limb
• Hearing aid 
• Piercing

It is important to know that some of these objects are unsafe, some are safe at 1.5 teslas only, and some are safe at 3 teslas MRI scanners. All devices and implants require investigation through a certified MRI safety website or the individual manufacturers' website. Any Referring physician, radiologist, or MR technologist must know how to find information about the compatibility of medical implants or devices in patients. It is for decades that medical materials, devices, and implants were made from non-ferromagnetic materials and are usually marked as MR safe or MR conditional.[4] If there is no evidence or information about MRI safety of a device or implant, it has to be considered MRI unsafe. 

B) Relative contraindications:

 There are several relative contraindications:

• A patient presenting with any of the following objects require an evaluation with caution before MRI: 
• Coronary and peripheral artery stents
• Programmable shunts: patients must understand that they have to reprogram their shunt with their provider after the scan. 
• Airway stents or tracheostomy: If the tracheostomy is plastic, continue with an MRI scan. If it is unknown or unsafe, have to swap out for a plastic trach before the patient entering the MRI scanner. 
• Intrauterine device (IUD): Make and model merit investigation. Unknown IUDs are acceptable with 1.5 teslas only. 
• Ocular prosthesis
• Stapes implants
• Surgical clips or wire sutures
• Penile prosthesis
• Joint replacement or prosthesis
• Inferior vena cava (IVC) filter: If make and model of filter unknown, the patient can be scanned on a 1.5 tesla after six weeks of being implanted. 
• Harrington rods: These patients are scannable on 1.5-tesla scanners. 
• Medication patch: The patches require removal before the procedure. 
• Tattoos: If the tattoo is in the area of interest and is less than six weeks old, reschedule the patient. Ice packs or padding should be used against any tattoo that is in contact with the bore of the scanner or the MRI coil. Patients must be encouraged to squeeze the communication ball if they feel any warmth around their tattoos. 
• Colonoscopy procedure in the last eight weeks: Obtain confirmation whether any endoscopy clips or pill cam were used or placed during the procedure with the patient or through patient's medical records. If existence is confirmed or unknown, there is a need for a consult with the radiology or referring physician. 

Some other devices and implants might be contraindicated. To ensure patients' safety, the radiologist and MRI technologist must evaluate the type of device that patients have. Claustrophobic patients might refuse to complete the MRI scan and need sedation. These patients need to be well informed about the MRI scan procedure. The recommendation is that a physician has a discussion with them about the details in advance. Using Larger and opener MRI systems might be helpful in claustrophobic patients.[7][8]

• Patients who are unable to be still or obey breathing instructions in the scanner need special attention. Some patients in pain might move during the procedure, which degrades the quality of the images, restrict the interpretation, and decrease the accuracy of the report. Some MRI sequences need to obtain while patients hold their breath and lie motionless. 
• Patients with high body mass index (BMI) might have face difficulty to fit into the narrow bore of the MRI machine. MRI scanners with more substantial space can scan these patients. 

Gadolinium portion of the MRI: 

MRI contrast agents are gadolinium chelates with different stability, viscosity, and osmolality. Gadolinium is a relatively very safe contrast; however, it rarely might cause allergic reactions in patients. Following patients need to be evaluated carefully before injection of gadolinium for MRI procedure:

• Patients on dialysis
• Patients with a history of renal disease (renal transplant, single kidney, renal cancer)
• Patients who had received a dose of contrast in the last 24 hours
• Patients who had a previous allergic or anaphylactic reaction to gadolinium
• Patients who have risk factors for nephrogenic systemic fibrosis (NSF)
  • Patients with impaired renal function are at risk of NSF associated with gadolinium chelate. Patients with known or at risk of renal impairment need to require evaluation regarding their renal function before an MRI scan. 
• Patients with diabetes mellitus or hypertension who are receiving treatment with medications; calculate these patients' estimated glomerular filtration rate, and if less than 35 mL/min/1.73 m2, there is a need to consult a radiologist for further instructions. 
• Patients with eGFR below 30 mL/min/1.73 m2.
• Patients who are pregnant: The administration of contrast during pregnancy is predicated on a risk-benefit assessment. 

Pregnancy and breastfeeding:  

During pregnancy, MRI is a helpful imaging technique to evaluate obstetric and nonobstetric disorders during any trimester. To date, there is no known adverse effect or specific consequence for fetuses exposed to non-contrast MRI. However, the FDA determines gadolinium as a class C agent, and there is no established definitive evidence regarding MRI safety during pregnancy. Before MRI, a pregnant patient or who is suspected to be pregnant, the radiology team and physician should be informed. MRI only be taken during pregnancy to rule out suspected abnormalities and on a 1.5-tesla scanner.[9]

The gadolinium contrast is excreted into breast milk in less than 0.04% of the dose injected to a mother. Also, of that tiny amount excreted into the milk, only 0.8% is absorbed by the baby. Thus, there should be no concern about continuing breastfeeding after MRI.[10]

Clinical Significance

In recent years, diagnostic strategies increasingly use magnetic resonance imaging (MRI) to aid therapeutic plans. MRI helps in high-resolution investigations of soft tissues without the use of ionizing radiation. This safe modality currently becomes the imaging technique of choice for diagnosing musculoskeletal, neurologic, and cardiovascular disease. However, there are restrictions and contraindications caused by MRI magnetic fields, machine structure, and gadolinium contrast agents. Healthcare professionals need to be trained in magnetic resonance imaging safety to protect patients as well as other healthcare workers from the potential risks of MRI. It is essential to establish a close collaboration between the radiology team and physicians who provide care for the patient.[11]

Nursing, Allied Health, and Interprofessional Team Interventions

Due to potentially serious problems regarding safety issues with MRI, each patient needs to answer an MRI safety screening form before the scan. This screening is done during a verbal interview with the patient to ensure there is no contraindication for MRI. Patients need to be asked about any foreign substance that might interfere or with MRI acquisition. If a patient has devices or implants, the make and model of the object requires a check against relevant databases and MRI safety websites. Discussion with a radiologist or referring physician might be helpful to determine whether an MRI scan is the most suitable imaging modality or not. It is recommended that patients wear gowns in the MRI environment, To avoid metallic components of clothing. It is also recommended that the patient be informed about the details and the time of the procedure before the scan.

Although gadolinium chelates are generally well tolerated, MRI technologists and physicians need to be aware of adverse reactions to these contrast agents. MRI departments should provide appropriate medications and facilities to deal with possible reactions to contrast in patients. MRI scanner makes loud knocking noise during the procedure, which can cause damage to the hearing system. These noises could be attenuated by the patient using headphones and earplugs during the scan. During the MRI procedure, the personnel on hand must monitor the patient. With the help of an intercommunication system, the patient can speak with the MRI technologist or radiology nurse specialist, squeeze the communication ball, and also get commands.