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Trochlear Nerve Palsy

Editor: Gitanjli Sood Updated: 9/8/2024 8:56:03 AM

Introduction

The fourth cranial nerve, also known as the trochlear nerve, arises from the midbrain at the level of the inferior colliculus (ventral to the Sylvian aqueduct). This nerve supplies only a single muscle - the superior oblique (SO) muscle. It is the only cranial nerve that emerges from the dorsal aspect of the brainstem and decussates to supply the muscle of the contralateral side.

The nerve has a very long course, making it more vulnerable to injury. Palsy of the trochlear nerve is a common presentation in ophthalmology clinics.[1]

Etiology

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Etiology

  • Idiopathic: Most idiopathic cases are believed to be congenital, with presentation occurring in adult life.
  • Trauma: Trauma (moderate frontal head trauma) is a frequent cause of bilateral trochlear nerve palsy.
  • Vascular
  • Others

Dosunmu et al. studied the causes of fourth nerve palsy and found that the most common causes were presumed congenital (49%), hypertension (18%), and trauma (18%). Other causes seen included hypertension with diabetes (5%), post-neurosurgery (3%), intracranial neoplasms (1%), diabetes (1%), and post-Herpes Zoster ophthalmicus (1%).  No cause could be determined for 4% of cases.[2] 

In a study by Bagheri et al.,  presumed congenital was found to be the etiology of fourth nerve palsy in 76.7% of cases, and trauma accounted for 16.4 % of the cases.[3] Similarly, Ellis et al. found the superior oblique muscle paresis to be congenital in 83 out of 108 patients (76.8%).[4] Rare causes of trochlear nerve palsy that have been reported include pseudotumor cerebri, meningioma, Lyme disease, and Guillain-Barre Syndrome.[1]

Epidemiology

The annual incidence of trochlear nerve palsy was found to be 5.73 per 100,000 per year.[2] In several studies, it has been observed that this entity is much more common in the male gender.[5] This may be due to a higher incidence of head trauma in males.[6] It has also been seen that most cases of fourth nerve palsy presented in the fourth decade of life. The likely cause for this delayed presentation is the decompensation of the control of deviation over time. For post-head injury cases, the most common presentation was in the third decade of life.

Pathophysiology

Classically, in most cases of presumed congenital trochlear nerve palsy, the exact pathophysiology is not well understood. Studies using high-definition magnetic resonance imaging (MRI) have been done, and these are suggestive of two different pathogenic mechanisms in patients with congenital palsy of the superior oblique. In a majority of patients, the trochlear nerve was absent, and the superior oblique muscle was atrophied. This entity should be considered as a congenital cranial dysinnervation syndrome. In the second group of patients, the trochlear nerve was found to be normal, but the tendon of the superior oblique was presumed to be abnormal.[7]

Cases of acquired post-traumatic palsy of the trochlear nerve have been seen to be associated with mild to moderate degrees of closed head injury.[8] Only 2 out of 27 patients had a loss of consciousness lasting more than 30 minutes in a study by Khawan.[9] Post mortem examination suggests the site of injury to be at the exit of the nerve from the brainstem in the dorsal midbrain.[10] Another injury that has been reported is parenchymal contusion at the dorsal midbrain.[11] Burger, in his study on 13 patients, found that frontolateral blows were associated with unilateral trochlear nerve palsy while mid-frontal blows had resulted in bilateral palsy of the trochlear nerve.[12]

History and Physical

Patients with trochlear nerve palsy complain of double vision vertically (vertical diplopia) or the images being tilted or rotated (torsional diplopia). The diplopia is binocular and may worsen or improve in different gazes. In the case of a right superior oblique involvement, the vertical diplopia is maximum when the right eye is directed downwards and inwards.[13] The use of red-green colored glasses helps to document the diplopia more accurately.

The main actions of the superior oblique muscle are intorsion, depression, and abduction of the eye. Palsy of the fourth cranial nerve results in the impairment of these actions. The clinical examination may show the following:

  • Abnormal head posture (torticollis): To compensate for the diplopia, the patient may adopt a head tilt and face turn to the opposite side.
  • Facial asymmetry: Midfacial hypoplasia may be seen in congenital cases of paresis.
  • Strabismus: In the affected eye, there is hypertropia, excyclotorsion, and in some cases, esotropia.

Maddox Rod test helps to determine ocular cyclotorsion. When the lines of a Maddox rod are oriented vertically, a horizontal line is seen by normal eyes. In the case of trochlear nerve palsy, the horizontal line will be perceived as tilted downwards nasally because of the excyclotorsion.[13]

  • Parks three-step test: This test allows the identification of the paretic muscle in cases of vertical diplopia.
    • Step 1: Identification of the hypertropic eye in the primary position.
    • Step 2: Identification of the hypertropic eye in the right and left gaze.
    • Step 3: It is also known as the Bielschowsky head tilt test. The head is tilted to each side to determine the side on which the hypertropia worsens.

In a case of trochlear nerve palsy, the hypertropia of the paretic eye increases on the opposite gaze and on tilting the head to the same side. The Parks 3-step test, however, is not infallible and can lead to an erroneous diagnosis of cyclovertical muscle palsy in cases with skew deviation, prior strabismus surgery, blowout fracture of the orbit, bilateral trochlear nerve palsy, and myasthenia gravis.[14]

  • In some long-standing cases, the hypertropia may be equal in different positions of gaze. This is known as the spread of comitance.[15]

In the case of trochlear nerve palsy, this spread of comitance is characterized by:

  1. Contracture of the ipsilateral antagonist (Ipsilateral inferior oblique)
  2. Overaction of the contralateral yoke muscle (contralateral inferior rectus)
  3. Secondary inhibitional palsy of the contralateral antagonist (contralateral superior rectus)
  • Bilateral superior oblique palsy should be suspected in cases with alternating hypertropia in gazes and tilts, objective torsion more than 10 degrees, V- pattern esotropia, bilateral fundus torsion, or a chin-down head posture. A case of bilateral superior oblique paresis may be misdiagnosed as unilateral paresis; a condition referred to as masked bilateral superior oblique paresis.[4]
  • Assessment of torsion:

    Subjective method: Torsion can be subjectively assessed using the double Maddox rod test. Subjective torsion is usually very little or absent in congenital trochlear nerve palsy, while acquired palsy has a measurable degree of torsion. Excyclotorsion of more than 10 degrees is seen in cases of bilateral palsy of the superior oblique.

    Objective method: Objectively, torsion is measured using an indirect ophthalmoscope or fundus photography.

  • Knapp's Classification:[16]
    • Class 1: Maximum hypertropia is in the opposite upfield (Overaction of the antagonist inferior oblique)
    • Class 2: Maximum hypertropia is in the opposite downgaze (Underaction of the paretic superior oblique)
    • Class 3: Maximum hypertropia in the entire field to the opposite side
    • Class 4: Maximum hypertropia in the entire field to the opposite side and across the lower field
    • Class 5: Maximum hypertropia is across the lower field.
    • Class 6: Bilateral superior oblique paresis
    • Class 7: It is caused by direct trauma to the superior oblique resulting in paresis and restriction of relaxation (Brown syndrome). This is also known as ‘Canine tooth syndrome.’

Evaluation

An extensive neurological evaluation is not needed in most patients with isolated fourth nerve palsy. The majority of cases are congenital, and documentation of long-standing head tilt and facial asymmetry helps to rule out an acquired etiology. In cases of acquired palsy, the absence of association with head trauma or the presence of any associated neurological findings mandates neuroimaging (magnetic resonance imaging).

Rarely, conditions like myasthenia gravis may mimic trochlear nerve palsy. Suspected cases should be investigated for anti-acetylcholine receptor antibody, computed tomography of the chest to look for thymic mass, and nerve conduction studies.

Treatment / Management

Non-Surgical: Diplopia can be managed with the use of prism glasses.[17] Injection of Botulinum toxin into the overacting inferior oblique muscle has been tried in cases of acute traumatic trochlear nerve palsy while awaiting spontaneous recovery. Studies have shown that this results in a better binocular status of the patients in the acute setting.[18](B2)

Surgical: Surgical correction is required in many cases, and the choice of the procedure depends on the pattern and severity of deviation. The most commonly performed procedure is inferior oblique weakening with additional vertical and horizontal rectus surgery if needed. The general principles that guide the management are mentioned below:

  1. Intraoperatively, forced duction testing of the obliques is done. This helps in the identification of a lax tendon, often seen in cases with congenital superior oblique palsy. Superior oblique tuck is a procedure performed in such cases.[19]
  2. For cases with hypertropia (less than 15 prism dioptres) and inferior oblique overaction, weakening procedures of the inferior oblique muscle are done. They include myectomy, recession, and anterior transposition.[20]
  3. If there is no overaction of the inferior oblique, the surgical options include the recession of the ipsilateral superior rectus muscle or the contralateral inferior rectus muscle.
  4. For deviations of more than 15 prism dioptres, inferior oblique weakening procedures can be combined with a recession of ipsilateral superior rectus or contralateral inferior rectus, or both.[21]
  5. Large degrees of excyclotorsion seen in bilateral cases cannot be sufficiently corrected with inferior oblique weakening. The Harada-Ito procedure has been described for such cases and involves the splitting of the superior oblique and the advancement of the anterior half of the tendon. The advantage of this procedure is that the vertically acting posterior fibers can be left undisturbed, and only the anterior fibers that are responsible for torsion are operated upon. The Harada-Ito procedure has been classically described for objective torsion more than 10 degrees but being performed for lesser degrees of torsion by some surgeons.[22]
  6. (B2)

Differential Diagnosis

1. Skew Deviation: The perception of the earth-vertical (gravity) is mediated by the vestibulo-ocular pathway. Any lesion along this pathway, or in the cerebellum can lead to an erroneous estimation of gravity, and the body may perceive the head to be tilted, even when it is not. This results in a compensatory head tilt to the opposite side. In patients with skew deviation, the higher eye is elevated and incyclotorted, while the lower eye is depressed and excyclotorted (a consequence of the ocular tilt reaction). The underlying lesion can be due to ischemia, trauma, multiple sclerosis, abscess, or neoplasia. 

Patients can be frequently asymptomatic or complain of vertical diplopia. The vertical diplopia in skew deviation does not alleviate with head tilt (unlike trochlear nerve palsy). Associated neurological features depend on the site of the lesion. The three-step test may fallaciously point towards a fourth nerve palsy. The Supine-Upright test is a very specific test that helps in differentiating between the two clinical entities. The vertical misalignment between the two eyes decreases by more than 50% on changing the patient's position from upright to supine in a skew deviation. This occurs due to a change in the position of the utricle and a reduction of the utriculo-ocular reflex.[23][24]

2. Thyroid-associated ophthalmopathy (TAO): Restriction of the inferior rectus may mimic a fourth nerve palsy in the other eye. Presence of proptosis, lid retraction, lagophthalmos heps in clinical differentiation. Radiologically, enlargement of the muscle belly with sparing of the tendon is seen in TAO.

3. Primary overaction of the Inferior Oblique muscle: These patients do not have primary position vertical deviation, subjective torsion, and the Bielchowsky's head tilt test is negative.

4. Myasthenia gravis: It can mimic cyclovertical muscle palsies, and suspected cases should be investigated accordingly. Clinically, an edrophonium test has been described.

5. Blow-out fracture of the orbit: Orbital blow-out fracture with entrapment of the inferior rectus muscle can result in a misleading three-step test. Infraorbital hypoaesthesia, enophthalmos, and findings on imaging help in arriving at the diagnosis.

6. Congenital torticollis: Patients with congenital palsy may have a head tilt and face turn from early childhood that may lead to a torticollis-like picture. Orthopedician may be the first person whom parents meet thinking it to be a musculoskeletal disorder. Thus both ophthalmologists and orthopedists must be aware of either entity as management is entirely different.

Prognosis

Spontaneous recovery in cases of trochlear nerve palsy, as seen by Park et al., occurs in 82.6% of cases, with as many as 52.2% of patients showing complete recovery.[25] Complete or partial spontaneous recovery has been noted in 45% of the cases of acquired fourth nerve palsy by Phuljhele et al.[26]

For cases that need surgical intervention, the success rate is usually good.[21][22]

Complications

  1. Overcorrection: Surgical intervention in cases of trochlear nerve palsy may occasionally result in an overcorrection, and the hypertropia may be converted into hypotropia. The resulting diplopia may be incapacitating for the patient.
  2. Iatrogenic Brown syndrome: Deficiency of elevation in adduction can occur due to excessive tucking of the superior oblique muscle.
  3. The manifestation of trochlear palsy: In cases of bilateral masked palsy of the fourth nerve, the paresis in the other eye may manifest after surgery of one eye if initially misdiagnosed as a unilateral case.

Deterrence and Patient Education

Acute or insidious onset of double vision with tilting of images or images separated vertically can be a symptom of trochlear nerve palsy. Patients should be encouraged to seek a strabismology opinion when faced with such issues. The symptoms of trochlear nerve palsy, in most, cases can be managed medically/surgically. An extensive neurological workup might be needed in selected cases.

Pearls and Other Issues

The diagnosis of trochlear palsy should not be totally based only on the three-step test as a number of other clinical conditions can mimic the same. Bilateral fourth nerve palsy can be missed and wrongly diagnosed as unilateral palsy, only to manifest postoperatively. Any surgical intervention in acquired cases should be undertaken after a waiting period of 6 to 12 months as many patients show partial or complete recovery within this period.

Enhancing Healthcare Team Outcomes

While cases of isolated trochlear nerve palsy can be managed by ophthalmologists alone, patients with neurological etiology need collaborative effort involving neurologists, radiologists, nursing personnel, and, at times, neurosurgeons and orthopedics. Any neurosurgical intervention, if needed, should be planned before any surgery for strabismus. Optometrists play an important role in non-surgical management by prescribing the required prismatic correction.

References


[1]

Kim SY, Motlagh M, Naqvi IA. Neuroanatomy, Cranial Nerve 4 (Trochlear). StatPearls. 2024 Jan:():     [PubMed PMID: 30725929]


[2]

Dosunmu EO, Hatt SR, Leske DA, Hodge DO, Holmes JM. Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. American journal of ophthalmology. 2018 Jan:185():110-114. doi: 10.1016/j.ajo.2017.10.019. Epub 2017 Nov 2     [PubMed PMID: 29102606]


[3]

Bagheri A, Fallahi MR, Abrishami M, Salour H, Aletaha M. Clinical features and outcomes of treatment for fourth nerve palsy. Journal of ophthalmic & vision research. 2010 Jan:5(1):27-31     [PubMed PMID: 22737323]


[4]

Ellis FJ, Stein LA, Guyton DL. Masked bilateral superior oblique muscle paresis. A simple overcorrection phenomenon? Ophthalmology. 1998 Mar:105(3):544-51     [PubMed PMID: 9499789]

Level 2 (mid-level) evidence

[5]

Ellis FD, Helveston EM. Superior oblique palsy: diagnosis and classification. International ophthalmology clinics. 1976 Fall:16(3):127-35     [PubMed PMID: 971985]


[6]

Sharma B, Gupta R, Anand R, Ingle R. Ocular manifestations of head injury and incidence of post-traumatic ocular motor nerve involvement in cases of head injury: a clinical review. International ophthalmology. 2014 Aug:34(4):893-900. doi: 10.1007/s10792-014-9898-8. Epub 2014 Jan 28     [PubMed PMID: 24469117]

Level 3 (low-level) evidence

[7]

Engel JM. Treatment and diagnosis of congenital fourth nerve palsies: an update. Current opinion in ophthalmology. 2015 Jul:26(5):353-6. doi: 10.1097/ICU.0000000000000179. Epub     [PubMed PMID: 26247132]

Level 3 (low-level) evidence

[8]

Dhaliwal A, West AL, Trobe JD, Musch DC. Third, fourth, and sixth cranial nerve palsies following closed head injury. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2006 Mar:26(1):4-10     [PubMed PMID: 16518159]

Level 2 (mid-level) evidence

[9]

Khawam E, Scott AB, Jampolsky A. Acquired superior oblique palsy. Diagnosis and management. Archives of ophthalmology (Chicago, Ill. : 1960). 1967 Jun:77(6):761-8     [PubMed PMID: 6026184]


[10]

Heinze J. Cranial nerve avulsion and other neural injuries in road accidents. The Medical journal of Australia. 1969 Dec 20:2(25):1246-9     [PubMed PMID: 5373435]


[11]

Burgerman RS, Wolf AL, Kelman SE, Elsner H, Mirvis S, Sestokas AK. Traumatic trochlear nerve palsy diagnosed by magnetic resonance imaging: case report and review of the literature. Neurosurgery. 1989 Dec:25(6):978-81     [PubMed PMID: 2601831]

Level 3 (low-level) evidence

[12]

Burger LJ, Kalvin NH, Smith JL. Acquired lesions of the fourth cranial nerve. Brain : a journal of neurology. 1970:93(3):567-74     [PubMed PMID: 4319184]


[13]

Kung NH, Van Stavern GP. Isolated Ocular Motor Nerve Palsies. Seminars in neurology. 2015 Oct:35(5):539-48. doi: 10.1055/s-0035-1563568. Epub 2015 Oct 6     [PubMed PMID: 26444399]


[14]

Kushner BJ. Errors in the three-step test in the diagnosis of vertical strabismus. Ophthalmology. 1989 Jan:96(1):127-32     [PubMed PMID: 2919044]

Level 3 (low-level) evidence

[15]

Brazis PW. Isolated palsies of cranial nerves III, IV, and VI. Seminars in neurology. 2009 Feb:29(1):14-28. doi: 10.1055/s-0028-1124019. Epub 2009 Feb 12     [PubMed PMID: 19214929]


[16]

Knapp P. Classification and treatment of superior oblique palsy. The American orthoptic journal. 1974:24():18-22     [PubMed PMID: 4151473]


[17]

Tamhankar MA, Ying GS, Volpe NJ. Success of prisms in the management of diplopia due to fourth nerve palsy. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2011 Sep:31(3):206-9. doi: 10.1097/WNO.0b013e318211daa9. Epub     [PubMed PMID: 21378578]

Level 2 (mid-level) evidence

[18]

Talebnejad MR, Tahamtan M, Nowroozzadeh MH. Botulinum Toxin Injection for Treatment of Acute Traumatic Superior Oblique Muscle Palsy. Journal of ophthalmic & vision research. 2015 Jul-Sep:10(3):263-7. doi: 10.4103/2008-322X.170350. Epub     [PubMed PMID: 26730311]


[19]

Dwivedi R, Marsh IB. Superior oblique tuck: evaluation of surgical outcomes. Strabismus. 2019 Mar:27(1):24-29. doi: 10.1080/09273972.2018.1559204. Epub 2018 Dec 20     [PubMed PMID: 30620235]


[20]

Yumuşak E, Yolcu Ü, Küçükevcilioğlu M, Diner O, Mutlu FM. Outcomes of Unilateral Inferior Oblique Myectomy Surgery in Inferior Oblique Overaction Due to Superior Oblique Palsy. Turkish journal of ophthalmology. 2016 Jan:46(1):21-24     [PubMed PMID: 27800253]


[21]

Sanz PM, Escribano J, Gómez de Liaño P, Yela R. Surgical treatment of superior oblique palsy: Predictors of outcome. Indian journal of ophthalmology. 2017 Aug:65(8):723-728. doi: 10.4103/ijo.IJO_699_16. Epub     [PubMed PMID: 28820159]


[22]

Bradfield YS, Struck MC, Kushner BJ, Neely DE, Plager DA, Gangnon RE. Outcomes of Harada-Ito surgery for acquired torsional diplopia. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 2012 Oct:16(5):453-7. doi: 10.1016/j.jaapos.2012.06.007. Epub     [PubMed PMID: 23084384]

Level 2 (mid-level) evidence

[23]

Brodsky MC, Donahue SP, Vaphiades M, Brandt T. Skew deviation revisited. Survey of ophthalmology. 2006 Mar-Apr:51(2):105-28     [PubMed PMID: 16500212]


[24]

Wong AM. Understanding skew deviation and a new clinical test to differentiate it from trochlear nerve palsy. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 2010 Feb:14(1):61-7. doi: 10.1016/j.jaapos.2009.11.019. Epub     [PubMed PMID: 20227626]


[25]

Park UC, Kim SJ, Hwang JM, Yu YS. Clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy. Eye (London, England). 2008 May:22(5):691-6     [PubMed PMID: 17293794]

Level 2 (mid-level) evidence

[26]

Phuljhele S, Dhiman R, Sharma M, Kusiyait SK, Saxena R, Mahalingam K, Sharma P. Acquired Ocular Motor Palsy: Current Demographic and Etiological Profile. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). 2020 Jan-Feb:9(1):25-28. doi: 10.1097/01.APO.0000617940.70112.be. Epub     [PubMed PMID: 31990742]