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Enthesopathies

Editor: Timothy K. Tiu Updated: 6/5/2023 9:19:27 PM

Introduction

Entheses are boney insertion sites of tendons and ligaments. Enthesopathies are defined as the pathologies that affect the entheses.[1] Although somewhat controversial, there appear to be two main classifications of entheses: 1) fibrous and 2) fibrocartilaginous. The difference is that fibrous entheses insert directly onto the periosteum, whereas fibrocartilaginous enthesis lack periosteum.[2] 

Anatomically, the entheses are usually found outside the joint capsule with exceptions, including the sacroiliac, sternoclavicular, and distal interphalangeal joints.[3] Entheses have two main roles: stability of the joint, and to transduce mechanical forces.[4] A unique aspect of the entheses is also the relative lack of vascularity.[2] Enthesitis, a subset of enthesopathy, is the inflammation of the insertion sites for the tendons and ligaments on the bone.[1] It is associated with diffuse inflammatory disorders such as psoriatic arthritis (PsA) and spondyloarthropathies (SpA).[4]

Etiology

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Etiology

Enthesopathies can be separated into two broad categories 1) repetitive mechanical stress and 2) diffuse inflammatory response. Enthesopathies from repetitive mechanical stress can be seen in common sports-related injuries such as lateral and medial epicondylitis, and Achilles and shoulder enthesopathy. Diffuse inflammatory responses that lead to enthesopathies and enthesitis tend to affect multiple entheses. The repetitive local microtrauma allows innate immune cells to invade the local area and cause inflammation triggered by chemokines.[5] Chemokines involved in the local inflammatory response include CXCL1, CCL2, interleukin (IL)-17, tumor necrosis factor (TNF)-alpha, and prostaglandin E2 (PGE2).[3][5]

Epidemiology

The prevalence and incidence of enthesopathies from a diffuse inflammatory disease are difficult to assess and calculate given the varied nature, presentation, and etiology of the enthesopathies.[6] It has been reported the prevalence of enthesitis in patients with PsA is approximately 35%.[7] In patients with SpA, 10 to 60% of patients that are diagnosed with SpA have enthesitis.[6]

Pathophysiology

Enthesopathies can be due to a loss of fibrillar structure secondary to edema, mineralization, which leads to calcification and ossification, diffuse inflammatory disease, or altered structure of collagen fibers leading to a thickened enthesis.[1] Moreover, enthesopathies themselves can lead to other manifestations such as enthesophytes. Enthesophytes are due to new bone formation secondary to seronegative SpA, diabetes mellitus, local trauma, and calcium pyrophosphate deposition disease.[8] Oftentimes, mechanical stress is the inciting event that triggers the cascade and repetitive cycle of inflammation.[9] Common examples of mechanical stress enthesitis include lateral epicondylitis and medial epicondylitis of the elbow.

Enthesitis is a common finding in both PsA and SpA. The key difference between enthesitis from mechanical stress and that from a diffuse inflammatory process such as PsA and SpA is that the diffuse inflammatory processes tend to affect multiple entheses. Mechanical stress, albeit theorized to be at a lower threshold, seems to be an inciting event in both localized enthesitis from repetitive stress and diffuse enthesitis from an inflammatory disease.[10]

History and Physical

The history and physical of enthesopathies depends on the location of the affected entheses. The patient may complain of decreased range of motion of the affected area as well as localized pain. Inspection may reveal localized swelling or erythema. Pain may be elicited by palpating the affected area as well as ranging the affected joint. Range of motion should be assessed both actively and passively for mechanical deficits and pain limitations.

If a diffuse inflammatory disease is suspected, a more thorough physical exam should include the evaluation of commonly affected areas such as the sacroiliac joints, Achilles tendon, and distal interphalangeal joints. Moreover, asking a broad review of systems may reveal the underlying cause of enthesitis, such as weight loss, night sweats, chills, or any other constitutional symptoms.[4]

Evaluation

The evaluation includes a thorough history and physical exam, depending on the underlying etiology of the enthesopathy. For enthesopathies secondary to repetitive use with a low likelihood of underlying inflammatory disease, the evaluation is primarily through physical examination, with imaging as needed. X-rays can be used to evaluate for bony pathology and calcifications. Diagnostic ultrasound or magnetic resonance imaging can be used to visualize soft tissue, including the enthesis itself.[4]

Evaluation of enthesopathies secondary to a diffuse inflammatory response leading to enthesitis may include a complete blood count, HLA-B27 assessing for seronegative SpA, rheumatoid factor, anti-nuclear antibody, and other autoimmune factors that may reveal the underlying cause. Additionally, imaging studies may be ordered similar to those when evaluating enthesopathies from repetitive use.[3]

Treatment / Management

Treatment depends on the underlying etiology. For an overuse enthesopathy, the mainstay of treatment is ice, rest, and nonsteroidal anti-inflammatory drugs (NSAIDs) for 7-10 days. [11] However, NSAID use is somewhat controversial in the acute period, as they may inhibit healing by blunting the inflammatory response.[11][12] Adjunct therapies for enthesopathies also include skilled physical therapy, glucocorticoid injections, topical nitrate therapy, and platelet-rich plasma (PRP).(A1)

Skilled physical therapy has been shown to improve pain, increase function, and increase active range of motion in a broad range of pathologies, which include shoulder, hip, elbow, and Achilles enthesopathy.[11][13][14][15] From a biomechanics perspective, different joint position exercises may provide alternate stress on the tendon, which is theorized to stimulate healing after an injury.[16](A1)

Although routinely used in clinical practice, glucocorticoid injections are somewhat controversial. There is no clear evidence to support their use.[17] Moreover, glucocorticoids into the tendon are tenotoxic and may lead to further injury.[18](A1)

Topical nitrates are theorized to increase neovascularization, fibroblast activity, and promote collagen synthesis. Studies show promising results with topical glyceryl trinitrate (GTN) as being a good adjunct therapy for chronic tendinopathies such as wrist extensors, Achilles, patellar tendon, and rotator cuff. GTN comes in a patch form with dosages ranging from .72mg/day – 5mg/day for tendinopathies.[19](A1)

PRP is proposed to have its effect via directly introducing a concentrate of growth factors, as well as establishing a rich microenvironment that recruits additional cells and growth factors to promote healing. Although still being researched, promising studies have shown that PRP may help in multiple enthesopathies such as gluteal tendinopathy and elbow tendinopathies.[20][21]

For calcific enthesopathies, a technique called barbotage can be used. Under direct visualization via ultrasound or fluoroscopy, a calcific lesion is repeatedly injected and aspirated, typically with saline. This has been shown to be effective in lateral epicondylopathy and rotator cuff calcific tendonitis.[22][23](B3)

Enthesopathies caused by diffuse inflammatory diseases can be treated with disease-modifying antirheumatic drugs (DMARDs) such as methotrexate and hydroxychloroquine. Additionally, biologics such as rituximab, etanercept, and infliximab may be used to specifically act on inflammatory markers to help reduce the overall burden of disease.[24](B3)

Differential Diagnosis

The differential diagnosis of enthesopathies can include avulsions, fractures, ligament or tendon rupture, localized infection, contusions, muscle strains, and malignancy.

Prognosis

The prognosis of enthesopathies is generally favorable, given the underlying etiology. With adequate rest and rehabilitation, most cases of enthesopathies will resolve over 2-4 weeks.

Enthesopathies from diffuse inflammatory disease may result in prolonged recovery times and is relative to the severity and etiology of the underlying disease.

Complications

Tendon or ligament tear is a complication of both repetitive use and diffuse inflammatory disease enthesopathies.

Deterrence and Patient Education

Multiple subspecialties may be presented with the initial presentation of enthesopathies, and an astute clinician will need to discern where the patient may need to be referred. Education for localized enthesopathies from repetitive use can be safely done in the clinician’s office or with a skilled physical or occupational therapist. Educating on joint protective measures may also greatly benefit the patient with overuse enthesopathies. For patients with an underlying systemic inflammatory disease, a more thorough and comprehensive educational approach may be necessary. Discussions with subspecialists such as physiatrists, rheumatologists, internal medicine, and immunologists may all be needed to adequately educate and treat select patients.

Enhancing Healthcare Team Outcomes

An interprofessional team approach provides the best outcome for patients with enthesopathies. Teamwork and coordination are quintessential in patients with enthesopathies from inflammatory diseases. Multiple sub-specialties are involved in the coordination of care, which includes primary care clinicians, physiatrists, rheumatologists, physical therapists, and occupational therapists. Such an approach allowed for comprehensive evaluation and treatment, especially in those suffering from spondyloarthropathy. [Level 2][24][25]

References


[1]

Sudoł-Szopińska I, Kwiatkowska B, Prochorec-Sobieszek M, Maśliński W. Enthesopathies and enthesitis. Part 1. Etiopathogenesis. Journal of ultrasonography. 2015 Mar:15(60):72-84. doi: 10.15557/JoU.2015.0006. Epub 2015 Mar 30     [PubMed PMID: 26674568]


[2]

Benjamin M, Toumi H, Ralphs JR, Bydder G, Best TM, Milz S. Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load. Journal of anatomy. 2006 Apr:208(4):471-90     [PubMed PMID: 16637873]


[3]

Araujo EG, Schett G. Enthesitis in psoriatic arthritis (Part 1): pathophysiology. Rheumatology (Oxford, England). 2020 Mar 1:59(Suppl 1):i10-i14. doi: 10.1093/rheumatology/keaa039. Epub     [PubMed PMID: 32159793]


[4]

Schett G, Lories RJ, D'Agostino MA, Elewaut D, Kirkham B, Soriano ER, McGonagle D. Enthesitis: from pathophysiology to treatment. Nature reviews. Rheumatology. 2017 Nov 21:13(12):731-741. doi: 10.1038/nrrheum.2017.188. Epub     [PubMed PMID: 29158573]


[5]

Cambré I, Gaublomme D, Burssens A, Jacques P, Schryvers N, De Muynck A, Meuris L, Lambrecht S, Carter S, de Bleser P, Saeys Y, Van Hoorebeke L, Kollias G, Mack M, Simoens P, Lories R, Callewaert N, Schett G, Elewaut D. Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis. Nature communications. 2018 Nov 5:9(1):4613. doi: 10.1038/s41467-018-06933-4. Epub 2018 Nov 5     [PubMed PMID: 30397205]


[6]

Braun J, Khan MA, Sieper J. Enthesitis and ankylosis in spondyloarthropathy: what is the target of the immune response? Annals of the rheumatic diseases. 2000 Dec:59(12):985-94     [PubMed PMID: 11087703]


[7]

Polachek A, Li S, Chandran V, Gladman DD. Clinical Enthesitis in a Prospective Longitudinal Psoriatic Arthritis Cohort: Incidence, Prevalence, Characteristics, and Outcome. Arthritis care & research. 2017 Nov:69(11):1685-1691. doi: 10.1002/acr.23174. Epub 2017 Sep 21     [PubMed PMID: 27998023]


[8]

Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ, Edwards MH, Dennison EM, Cooper C, Williams M, Davey Smith G, Tobias JH. Osteophytes, enthesophytes, and high bone mass: a bone-forming triad with potential relevance in osteoarthritis. Arthritis & rheumatology (Hoboken, N.J.). 2014 Sep:66(9):2429-39. doi: 10.1002/art.38729. Epub     [PubMed PMID: 24910132]


[9]

Jacques P, Lambrecht S, Verheugen E, Pauwels E, Kollias G, Armaka M, Verhoye M, Van der Linden A, Achten R, Lories RJ, Elewaut D. Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Annals of the rheumatic diseases. 2014 Feb:73(2):437-45. doi: 10.1136/annrheumdis-2013-203643. Epub 2013 Aug 6     [PubMed PMID: 23921997]

Level 3 (low-level) evidence

[10]

Benjamin M, McGonagle D. The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. Journal of anatomy. 2001 Nov:199(Pt 5):503-26     [PubMed PMID: 11760883]

Level 3 (low-level) evidence

[11]

Steuri R, Sattelmayer M, Elsig S, Kolly C, Tal A, Taeymans J, Hilfiker R. Effectiveness of conservative interventions including exercise, manual therapy and medical management in adults with shoulder impingement: a systematic review and meta-analysis of RCTs. British journal of sports medicine. 2017 Sep:51(18):1340-1347. doi: 10.1136/bjsports-2016-096515. Epub 2017 Jun 19     [PubMed PMID: 28630217]

Level 1 (high-level) evidence

[12]

Rees JD, Wilson AM, Wolman RL. Current concepts in the management of tendon disorders. Rheumatology (Oxford, England). 2006 May:45(5):508-21     [PubMed PMID: 16490749]

Level 3 (low-level) evidence

[13]

Frizziero A, Vittadini F, Pignataro A, Gasparre G, Biz C, Ruggieri P, Masiero S. Conservative management of tendinopathies around hip. Muscles, ligaments and tendons journal. 2016 Jul-Sep:6(3):281-292. doi: 10.11138/mltj/2016.6.3.281. Epub 2016 Dec 21     [PubMed PMID: 28066732]


[14]

Smidt N, van der Windt DA, Assendelft WJ, Devillé WL, Korthals-de Bos IB, Bouter LM. Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomised controlled trial. Lancet (London, England). 2002 Feb 23:359(9307):657-62     [PubMed PMID: 11879861]

Level 1 (high-level) evidence

[15]

Sussmilch-Leitch SP, Collins NJ, Bialocerkowski AE, Warden SJ, Crossley KM. Physical therapies for Achilles tendinopathy: systematic review and meta-analysis. Journal of foot and ankle research. 2012 Jul 2:5(1):15. doi: 10.1186/1757-1146-5-15. Epub 2012 Jul 2     [PubMed PMID: 22747701]

Level 1 (high-level) evidence

[16]

Maganaris CN, Narici MV, Almekinders LC, Maffulli N. Biomechanics and pathophysiology of overuse tendon injuries: ideas on insertional tendinopathy. Sports medicine (Auckland, N.Z.). 2004:34(14):1005-17     [PubMed PMID: 15571430]


[17]

Speed CA. Fortnightly review: Corticosteroid injections in tendon lesions. BMJ (Clinical research ed.). 2001 Aug 18:323(7309):382-6     [PubMed PMID: 11509432]

Level 1 (high-level) evidence

[18]

Fredberg U. Local corticosteroid injection in sport: review of literature and guidelines for treatment. Scandinavian journal of medicine & science in sports. 1997 Jun:7(3):131-9     [PubMed PMID: 9200316]


[19]

Challoumas D, Kirwan PD, Borysov D, Clifford C, McLean M, Millar NL. Topical glyceryl trinitrate for the treatment of tendinopathies: a systematic review. British journal of sports medicine. 2019 Feb:53(4):251-262. doi: 10.1136/bjsports-2018-099552. Epub 2018 Oct 9     [PubMed PMID: 30301735]

Level 1 (high-level) evidence

[20]

Lee JJ, Harrison JR, Boachie-Adjei K, Vargas E, Moley PJ. Platelet-Rich Plasma Injections With Needle Tenotomy for Gluteus Medius Tendinopathy: A Registry Study With Prospective Follow-up. Orthopaedic journal of sports medicine. 2016 Nov:4(11):2325967116671692     [PubMed PMID: 27868077]


[21]

Kwapisz A, Prabhakar S, Compagnoni R, Sibilska A, Randelli P. Platelet-Rich Plasma for Elbow Pathologies: a Descriptive Review of Current Literature. Current reviews in musculoskeletal medicine. 2018 Dec:11(4):598-606. doi: 10.1007/s12178-018-9520-1. Epub     [PubMed PMID: 30255288]


[22]

Abate M, Salini V, Schiavone C. Ultrasound-guided Percutaneous Lavage in the Treatment of Calcific Tendinopathy of Elbow Extensor Tendons: A Case Report. Malaysian orthopaedic journal. 2016 Jul:10(2):53-55. doi: 10.5704/MOJ.1607.011. Epub     [PubMed PMID: 28435563]

Level 3 (low-level) evidence

[23]

Burke CJ, Adler RS. Ultrasound-Guided Percutaneous Tendon Treatments. AJR. American journal of roentgenology. 2016 Sep:207(3):495-506. doi: 10.2214/AJR.16.16089. Epub 2016 May 25     [PubMed PMID: 27224839]


[24]

Rizzello F, Olivieri I, Armuzzi A, Ayala F, Bettoli V, Bianchi L, Cimino L, Costanzo A, Cristaudo A, D'Angelo S, Daperno M, Fostini AC, Galeazzi M, Gilio M, Gionchetti P, Gisondi P, Lubrano E, Marchesoni A, Offidani A, Orlando A, Pugliese D, Salvarani C, Scarpa R, Vecchi M, Girolomoni G. Multidisciplinary Management of Spondyloarthritis-Related Immune-Mediated Inflammatory Disease. Advances in therapy. 2018 Apr:35(4):545-562. doi: 10.1007/s12325-018-0672-6. Epub 2018 Mar 7     [PubMed PMID: 29516409]

Level 3 (low-level) evidence

[25]

Armuzzi A, Felice C, Lubrano E, Cantini F, Castiglione F, Gionchetti P, Orlando A, Salvarani C, Scarpa R, Marchesoni A, Vecchi M, Olivieri I, Italian SpA-IBD Expert Panel Group. Multidisciplinary management of patients with coexisting inflammatory bowel disease and spondyloarthritis: A Delphi consensus among Italian experts. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2017 Dec:49(12):1298-1305. doi: 10.1016/j.dld.2017.06.004. Epub 2017 Jun 23     [PubMed PMID: 28822731]

Level 3 (low-level) evidence