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Night Eating Syndrome
Introduction
Night eating syndrome (NES) is a type of eating disorder related to eating after dinner and when awake at night. Wolff, Stunkard, and Grace discovered this condition in a group of patients seeking weight loss treatment.[1] The syndrome was identified when their patients reported consuming a caloric intake of 25% of daily calories or more at night.[1] Night eating syndrome is characterized by at least 3 of the following symptoms:
- A strong urge to eat between dinner and going to bed
- Anorexia in the morning and during the night
- Maintenance or sleep onset insomnia
- Depressed mood
- Evening mood worsening
- The belief that one cannot sleep without eating [2][3]
Etiology
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Etiology
The etiology of night eating syndrome has remained unknown. Recent research results have proposed a link between a psychological course and neurological and genetic processes. For example, results from a study by Lamerz and colleagues conducted on children in Germany showed that patients were more likely to develop night-eating syndrome if their mothers had night-eating behavior. These patients were compared to children of mothers who did not have night eating behavior.[4]
A recent study compared night eating behaviors in families with a person with the condition to those without one. The results showed that those with NES had first-degree relatives with the disorder more often than the control group, suggesting a heritability aspect to the disorder.[5] Stress can exacerbate the symptoms of the disorder, and symptoms can be alleviated by decreasing stress levels.[1] The initial onset and maintenance of the condition were shown by recent studies to be directly caused by stress and other psychiatric disorders like depression.[6]
Epidemiology
In the United States, the prevalence of night eating syndrome is 1.5%. NES prevalence is similar to other binge eating disorders like bulimia nervosa and anorexia nervosa.[7][8] This condition is more frequently seen in obese populations, although not all individuals with NES are, in fact, obese.[9][10] Results from a study in Sweden revealed a 2.5 times higher prevalence of NES in men with obesity along with a 2.8 times higher prevalence in women with obesity in comparison to nonobese of both genders.[11]
A NES prevalence between 6% and 64% was found among obese individuals looking for weight loss surgery in a review conducted by de Zwaan, Mitchell, Burgard, and Schenck. Antother study's results showed that up to 55% of individuals seeking bariatric surgery have reported some symptoms of NES.[12] NES typically appears in the late teens to late twenties. NES also appears to be long-lasting, with relapse and remission tethered to stressors.[13][14] A Swedish twin registry participant in an interview-based study had results that revealed more women than men meet all criteria for NES.[15] These findings could suggest that all sexes experience NES symptoms equally. However, women s are morenegatively affected.[15]
Those with NES are more likely to have another eating disorder than the non-NES population, with a 5 to 44% prevalence.[9] Overlapping symptoms between NES and binge eating disorder have been showns 15% to 20% of patients with NES. However, the conditions are differentiated by the quantity of food eaten per meal, the motivation for eating, and the concern about weight and shape.[16] Patients were recruited into a study by Lundgren from outpatient clinics using the NES screening questionnaire. They were asked about their evening food cravings, nocturnal ingestions, morning anorexia, and the sum of awakenings. The criteria for NES were met in 12.3% of the study participants, and it was found that those patients were also obese.[17][18]
Pathophysiology
Researchers believe that cognitions and a wide range of emotions might play a major role in developing NES; most symptoms occur at night due to the belief that the individual can not sleep without eating. Patients also feel a need to control the anxiety associated with that belief through eating.[19][20] Cortisol was examined during night eating as this hormone is released during stress associated with overeating.[21][22] Birketvedt and colleagues studied 33 participants, 12 with NES and 21 control subjects. The subjects were fed regular intervals of meals over 24 hours and given no food after 8:00 pm.[23] Blood tests were drawn every 2 hours over the 24 hours, with the results showing higher cortisol levels from 8:00 am to 2:00 am in night eaters compared to those in the control group.[23]
History and Physical
Some study results have determined criteria to include hyperphagia in the evening with 25% or more of daily caloric intake after dinner with not less than 2 nocturnal awakenings during the week to eat.[23][24][25] Additional criteria include the awareness of nocturnal eating habits and recall of the nocturnal eating habits.[2] A clinical picture is described by at least 3 of these criteria:
- Breakfast and morning eating are missed due to a lack of desire [26]
- The urge to eat between the evening meal and bedtime sleep [18][23]
- Difficulty initiating or maintaining sleep occurring for 4 or more nights per week [27]
- The belief that the individual must eat to return to sleep
- The mood that worsens at night or is frequently depressed [27][28][29]
Evaluation
In a randomized control trial done by the Look AHEAD (Action for Health in Diabetes) study, results showed that the diagnosis of NES was more related to patients with a depressed mood.[16][30][26][30][26] The study results also showed that diabetic individuals with obesity have higher body mass index and reported weight problems at much younger life than those without eating disorders.[31] In previous studies, a significant predictor of hemoglobin A1c of greater than 7 was discovered in individuals with type 1 and type 2 diabetes who reported evening hyperphagia along with 2 or more diabetes complications and obesity.[32]
Treatment / Management
Psychotherapy has been shown to decrease night-eating symptoms. Twenty-five patients were treated with cognitive behavioral therapy by Allison and colleagues within 12 weeks of diagnosis.[33] The interventional study included education, logging sleeping and eating habits, encouraging coping skills, regulating eating and sleep patterns, and weight management.[6][33] The study results showed reductions in weight gain, evening caloric intake, nocturnal ingestions, and recurrent awakenings at night. Treatment also showed improvements in mood enhancement and quality of life.(B3)
The serotonin system contributes to the regulation of eating, mood, and sleep. Therefore, it was assumed that reduced serotonin could lead to reduced satiety and circadian rhythm disturbances, leading to increased evening hyperphagia and nocturnal ingestions.[34] In a 12-week clinical trial study on 17 patients treated with sertraline and two additional studies that included randomized controlled trials, the results showed a massive reduction in night awakenings, evening hyperphagia, and calorie consumption after evening meals.[25][35](B3)
The rate for remission was 29%. However, the response rate was 67%.[35] Open-label trial testing escitalopram efficacy revealed a significant reduction in NES symptoms, caloric intake consumed after dinner, and nocturnal ingestions; however, no difference was noticed compared to placebo in a randomized controlled trial.[35][36][37] In a randomized study of 44 patients from both sexes divided into 3 groups: education, education plus progressive muscle relaxation (PMR), or PMR plus exercise. Vander Wal and colleagues concluded that the percentage of food eaten was significantly different between the 3 groups in the study, with the group doing PMR having the most significant reduction.[38] The increase of postsynaptic serotonin has been proven using phototherapy; two case studies used phototherapy to treat symptoms of NES and depression.[39] (A1)
Freidman and colleagues conducted a study using paroxetine and bright light therapy on a 51-year-old woman with depression and NES. The results showed that discontinuation of the phototherapy made her NES symptoms return.[40] The effect of promising light therapy was also studied on 15 patients with NES, and the results showed a tremendous reduction in NES symptoms along with mood and sleep disturbance after treatment.[41](B3)
Differential Diagnosis
Night eating syndrome is usually confused with sleep-related eating disorders. The main differential criterion between NES and sleep-related eating disorders is the nature and the component of nocturnal eating. While the NES is composed of both hyperphagia and nocturnal eating along with awareness, sleep-related eating disorders are mainly characterized by repeated involuntary eating habits during sleep.[2] A sleep-related eating disorder is considered parasomnia due to automatic and poorly recalled eating habits, along with nonfood items consumed, sharing similarities to sleepwalking.[2]
Night eating syndrome can be classified as an insomnia-related disorder as patients are awake, aware, and able to recall their eating habits. Generally, patients with NES do not report underlying sleep disorders. However, some patients might report both syndromes.[2][42] Sharing the behavior of evening hyperphagia between NES and binge eating disorder does not necessarily mean they share the exact etiology. Unlike binge eating disorder, evening hyperphagia in NES patients is mainly correlated to nocturnal anxiety.[20] In addition, the amount of food consumed in the evening in patients with NES is not as large as in patients with binge eating disorders.[23]
Prognosis
Patients treated for NES with pharmacological, cognitive therapy, and lifestyle changes have noticed a significant improvement in their symptoms.[43] For those who are untreated, many health issues and emotional challenges are related to being overweight or having obesity, such as high cholesterol, diabetes, and high blood pressure.[6]
Complications
Patients with NES commonly become overweight due to increased calorie intake before bedtime. The increased caloric intake results in complications such as diabetes, high blood pressure, cardiac disease, and obesity. Without psychotherapy, psychiatric disturbances can develop.[44] An association between NES and various psychopathologies, particularly depression, was found in most studies.[16][35] Many patients with NES were found to meet lifetime criteria for major depressive disorders, substance abuse, and anxiety disorder.[45][46]
Deterrence and Patient Education
NES is an eating disorder characterized by excessive night eating habits (after dinner) or awakening from sleep to eat (nocturnal ingestions).[6] Additionally, 3 or more symptoms occur: the urge to eat between dinner and sleep, morning anorexia, maintenance insomnia or sleep onset, depressed mood or worsened mood in the evening, and the belief that without eating, one can not get back to sleep.[2][3] The prevalence in the United States is 1.5%, about the same as binge eating disorder.[6] The symptoms are often in remission and relapse according to life stressors, starting early adulthood.[13][14] The treatment includes pharmacological and nonpharmacological therapy, such as cognitive behavioral therapy.[43]
Enhancing Healthcare Team Outcomes
Since most patients do not bring up issues with night eating either due to shame or guilt, it is recommended to use screening questions. The primary care clinician should refer the patient to a psychiatric specialist for appropriate treatment.[6] Patients with type 2 diabetes need to be screened for NES due to the high percentage of patients with pre-existing type 2 diabetes having clinical NES.[47] After diagnosis, treatment should be followed by an interprofessional healthcare team that includes psychiatry, internal medicine, and endocrinology, working with nurses, pharmacists, and other mental health professionals.
References
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