Lofgren Syndrome

Article Author:
Falon Brown
Article Editor:
Laura Tanner
10/27/2018 12:31:42 PM
PubMed Link:
Lofgren Syndrome


Lofgren syndrome is a clinically distinct phenotype of sarcoidosis, first described in 1946 by Swedish pulmonologist Sven Lofgren. Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that commonly involves the lungs with the second most commonly affected organ being the skin. Cutaneous manifestations of sarcoidosis are seen in up to 33% of patients and may be the first clinical sign of the disease. In contrast to the often-insidious onset, slow disease progression and chronic disease course typical of sarcoidosis, Lofgren syndrome presents acutely, in younger Caucasian patients with acute onset erythema nodosum, bilateral hilar lymphadenopathy, fever, and migratory polyarthritis, without granulomatous skin involvement. Lofgren syndrome portends a favorable prognosis.


Etiology and pathophysiology of cutaneous sarcoidosis are poorly understood and attributable to both genetic and environmental factors. Though acute sarcoidosis is not infectious, there is some thought that selected cases may be due to abnormal host reaction to exposure to one or more infective agents, such as Mycobacterium tuberculosis or Propionibacterium or environmental exposures, such as beryllium, dust, or other occupational agents.


Sarcoidosis affects patients of all ages and races. The incidence and clinical presentation of sarcoidosis differ depending on gender, ethnicity, geographic location, and genetic background. In the United States, women are affected more often than men with an overall African American predominance. Worldwide, the incidence of sarcoidosis is highest in Scandinavians (Sweden and the United Kingdon) and lowest in Spain and Japan.

Lofgren syndrome consistently appears to be more common in females. It occurs most commonly in European Caucasians, especially patients with Scandinavian descent. Young to middle age adults are more likely to present with this disease with a median age of 37 years old. Specific manifestations of the components of Lofgren syndrome differ based on gender, whereas erythema nodosum is found predominantly in women and arthropathy/arthritis is seen more commonly in men. It classically occurs in the spring months.


In general, sarcoidosis is thought to be a polygenic disorder. The impact of HLA alleles on the pathogenesis of sarcoidosis varies significantly, depending upon disease subtype and racial group. In the case of Lofgren syndrome, HLA-B8/DR3 has a strong association with the disease and also with overall disease resolution.

Despite intensive investigation, no cause or proven pathophysiologic mechanism has been unveiled. It has been hypothesized that hosts may have a genetic predisposition but still require exposure to a specific antigen whether it be exogenous or endogenous. This trigger then activates macrophages and ultimately leads to an exaggerated cellular immune response leading to granuloma formation. The pathogenesis is very complex and not yet well understood. At the core of the process, T cells play a dominant role in this immune reaction. Studies have shown that granulomas and bronchioloalveolar lavage samples from patients with pulmonary sarcoidosis shown prominent lymphocytic pleocytosis. The majority of lymphocytes within these granulomas are CD4+T helper 1 (Th1) lymphocytes, contributing to an overall elevated CD4/CD8 ratio. CD4+T cells secrete interleukin (IL)-2, IL-12, IL-18, and interferon (IFN)-gamma, which in combination with the release of tumor necrosis factor (TNF)-alpha by macrophages and some CD8+T cells, leads to persistent Th1 activity, persistent IFN-gamma elevation and macrophage accumulation within the tissue. Compartmentalization of granuloma-forming CD4+ T lymphocytes and monocytes/macrophages within peripheral tissues leads to systemic lymphopenia and decreased systemic CD4/CD8 ratio.


Lofgren syndrome typically does not require histologic diagnosis however similar to other forms of sarcoidosis is characterized by non-caseating epithelioid granulomas, usually with a sparse or absent surrounding lymphocytic inflammation, also known as “naked” granulomas, when a biopsy is performed.

History and Physical

Lofgren syndrome includes erythema nodosum, bilateral hilar lymphadenopathy, fever, and migratory polyarthritis and occasionally includes uveitis.

The arthritis of Lofgren syndrome occurs more often in men and periarticular inflammation involving soft tissue and tenosynovitis rather than true arthritis. It typically involves ankles symmetrically but can involve knees, wrists, and elbow.

Erythema nodosum presents as painful, bright red, subcutaneous nodules that are typically symmetric on the anterior shins, in contrast to macular/popular sarcoidosis which has a predilection for the site of repetitive trauma. These lesions along with the fever typically remit spontaneously within 6 weeks and may resolve with post-inflammatory hyperpigmentation but without scarring or atrophy. Resolution of lymphadenopathy may be delayed may take up to 1 year, but does resolve completely in 90% of cases.


The diagnosis of sarcoidosis is complex with no definitive test exists. It requires clinic radiographic correlation, exclusion of alternative disease that can induce granuloma formation, such as tuberculosis, and histologic detection of noncaseating granulomas. There are several specific clinical situations where a presumptive diagnosis can be made based on clinic radiographic findings alone, and biopsy is not considered necessary. Bilateral hilar lymphadenopathy, migratory polyarthralgia, erythema nodosum, and fevers of Lofgren syndrome is one such example.

Chest radiography is still necessary to make this diagnosis though may see a variety of alternative pathology other than classic bilateral hilar adenopathy, including unilateral hilar adenopathy or right paratracheal lymphadenopathy with or without pulmonary involvement.

Should disease deviate from a classic course or fail to resolve within expected time definitive histologic diagnosis should be pursued. Of note, erythema nodosum lesions will not show sarcoidal granulomas and are therefore not useful in establishing the diagnosis. The first step in this process should be to determine the most appropriate site for biopsy. A comprehensive physical examination should be performed with extra caution taken to throughout examine periorificial sites, including parotid glands, lacrimal glands, and conjunctiva, extremities, sites of previous trauma or tattoos, and comprehensive lymph node assessment. Without an easily accessible superficial biopsy sit, patients may require more invasive biopsy method. Alternatively, minimally invasive methods have emerged including flexible bronchoscopy with bronchoalveolar lavage (BAL), endobronchial biopsy, and transbronchial biopsy to assist in the diagnosis of sarcoidosis. Several studies have noted the increased amount of activated CD4+ Th1 cells, IgG-secreting plasma cells among others along with a reduction in CD8 T cells. These are notable elevated CD4/CD8 ratio which when greater than 3.5 has been shown in previous studies to have a specificity of 94% for the diagnosis of sarcoidosis.

Other lab tests are not typically required and remain quite non-specific however may find systemic lymphopenia, elevated levels of calcium, alkaline phosphatase, C-reactive protein (CRP), acetylcholinesterase (ACE), or gamma globulin (polyclonal). Tuberculin skin test or QuantiFERON gold should be performed in all patient to exclude the diagnosis of tuberculosis which can mimic both erythema nodosum and sarcoidosis.

Treatment / Management

Treatment of Lofgren syndrome is typically supportive with spontaneous resolution occurring over 1 to 2 years. Constitutional symptoms and arthralgias can be treated with non-steroidal anti-inflammatory drug or colchicine. In rare, severe cases may warrant corticosteroids use which can usually be tapered quickly over a few weeks to months.

Differential Diagnosis

The reaction pattern of fever, arthralgia, and lesions of erythema nodosum, though suggestive are not specific for sarcoidosis. Reactions may be idiopathic or caused by a number of other triggers including:

  • Medication-induced causes of penicillin, sulfa drugs, oral contraceptives, immunizations
  • Infections such as Streptococcus, enteric bacteria, Mycobacterium tuberculosis, coccidioidomycosis, histoplasmosis, blastomycosis
  • Other systemic inflammatory diseases like inflammatory bowel disease, lupus, Behcet's disease
  • Pregnancy

Approximately 10% to 22% of cases of erythema nodosum are attributed to sarcoidosis. A thorough medical history can help distinguish between many of the above causes of erythema nodosum. Tuberculosis should be ruled out with either Tuberculin skin test or QuantiFERON gold. Combination of classic radiographic pulmonary findings of bilateral hilar adenopathy can assist in confirming the diagnosis of Lofgren syndrome. As discussed above, if syndrome does not follow classic timeline alternative diagnosis should be considered, and histologic confirmation of disease should be pursued.


Lofgren syndrome portends an excellent prognosis is associated with a greater than 90% chance of spontaneous remissions within 2 years.

Pearls and Other Issues

Lofgren syndrome is a specific acute clinical presentation of systemic sarcoidosis, consisting of a classic triad of fever, erythema nodosum, and bilateral hilar adenopathy; however, this characteristic triad is not always present and has also been associated with migratory polyarthritis, especially involving ankles in men. Must have a chest radiograph to confirm hilar adenopathy. Otherwise, no specific confirmatory tests are necessary. There is significant overlap among other known etiologies of erythema nodosum which can also contribute to systemic granuloma formation. Should presentation deviate from classic findings listed above further workup and, histopathologic correlation is required. Ultimately, sarcoidosis remains a diagnosis of exclusion.


Sex-specific manifestations of Löfgren's syndrome., Grunewald J,Eklund A,, American journal of respiratory and critical care medicine, 2007 Jan 1     [PubMed PMID: 17023727]
Sarcoidosis., O'Regan A,Berman JS,, Annals of internal medicine, 2012 May 1     [PubMed PMID: 22547486]
Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients., Neville E,Walker AN,James DG,, The Quarterly journal of medicine, 1983 Autumn     [PubMed PMID: 6657915]
Genetics of sarcoidosis., Fischer A,Grunewald J,Spagnolo P,Nebel A,Schreiber S,Müller-Quernheim J,, Seminars in respiratory and critical care medicine, 2014 Jun     [PubMed PMID: 25007082]
Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999.,, American journal of respiratory and critical care medicine, 1999 Aug     [PubMed PMID: 10430755]
Genetic, Immunologic, and Environmental Basis of Sarcoidosis., Moller DR,Rybicki BA,Hamzeh NY,Montgomery CG,Chen ES,Drake W,Fontenot AP,, Annals of the American Thoracic Society, 2017 Dec     [PubMed PMID: 29073364]
Granuloma genes in sarcoidosis: what is new?, Fischer A,Rybicki BA,, Current opinion in pulmonary medicine, 2015 Sep     [PubMed PMID: 26164297]
Löfgren's syndrome: human leukocyte antigen strongly influences the disease course., Grunewald J,Eklund A,, American journal of respiratory and critical care medicine, 2009 Feb 15     [PubMed PMID: 18996998]
Diagnostic Performance of Bronchoalveolar Lavage Fluid CD4/CD8 Ratio for Sarcoidosis: A Meta-analysis., Shen Y,Pang C,Wu Y,Li D,Wan C,Liao Z,Yang T,Chen L,Wen F,, EBioMedicine, 2016 Jun     [PubMed PMID: 27428439]
Diagnosis of sarcoidosis., Costabel U,Ohshimo S,Guzman J,, Current opinion in pulmonary medicine, 2008 Sep     [PubMed PMID: 18664976]
Course and prognosis of sarcoidosis around the world., Siltzbach LE,James DG,Neville E,Turiaf J,Battesti JP,Sharma OP,Hosoda Y,Mikami R,Odaka M,, The American journal of medicine, 1974 Dec     [PubMed PMID: 4432869]
Acute sarcoid arthritis: occurrence, seasonal onset, clinical features and outcome., Glennås A,Kvien TK,Melby K,Refvem OK,Andrup O,Karstensen B,Thoen JE,, British journal of rheumatology, 1995 Jan     [PubMed PMID: 7881838]
Th17-lineage cells in pulmonary sarcoidosis and Löfgren's syndrome: Friend or foe?, Miedema JR,Kaiser Y,Broos CE,Wijsenbeek MS,Grunewald J,Kool M,, Journal of autoimmunity, 2018 Jan 5     [PubMed PMID: 29310925]
Immunologic response of sarcoidosis., Zissel G,Prasse A,Müller-Quernheim J,, Seminars in respiratory and critical care medicine, 2010 Aug     [PubMed PMID: 20665389]