Article Author:
Pratiksha Singh
Article Editor:
Jamie Terrell
1/11/2019 2:40:33 PM
PubMed Link:


Antacids are a group of drugs that have been on the market for several years. They were initially first-line defense against peptic ulcer disease; however, the discovery of proton pump inhibitors revolutionized the treatment of peptic ulcer disease. Currently, antacid use is restricted for the relief of mild intermittent gastroesophageal reflux disease (GERD) associated heartburn [1]. The estimated prevalence of heartburn at least once per week in North America ranges from 18% to 28%[2] with 25% adults reporting heartburn on a daily basis. [3],[4],[5]

Antacids are medications that do not require a prescription, in other words, they are self-prescribed. Antacids are a combination of various compounds with various salts of calcium, magnesium, and aluminum as the active ingredients. The antacids act by neutralizing the acid in the stomach and by inhibiting pepsin, which is a proteolytic enzyme. Each of these cationic salts have a characteristic pharmacological property that determines its clinical use. Antacids have been used for the following:

  • Heartburn symptoms in GERD
  • Duodenal and gastric ulcers
  • Stress gastritis
  • Pancreatic insufficiency
  • Non-ulcer dyspepsia
  • Diarrhea caused bile-acid
  • Biliary reflux
  • Constipation
  • Osteoporosis
  • Urinary alkalinization 
  • Phosphate binding in chronic renal failure [6]

Mechanism of Action

The antacids reduce the acid reaching the duodenum by neutralizing the acid present in the stomach. The main objectives are:

  • Alleviating pain
  • Relieving pylorospasms
  • Avoid digestion and corrosion by acid chyme

The salts' mechanism of neutralization of acid varies, and each salt has a different mechanism with the ultimate goal of acid neutralization.

Aluminum Hydroxide

The formulation of aluminum hydrochloride and water results in neutralization of the acid in the stomach. It is also known to inhibit pepsin activity.[7] Aluminum hydroxide is complexed with a sulfated polysaccharide sucrose octasulfate to form sucralfate. This complex does not have a significant buffering action against the acid or has no effect on the pepsin secretion and does not alter the gastric acid production in any way.[8],[9] Nevertheless, it is known to heal chronic ulcers and prevent acute mucosal damage induced chemically by reducing access to pepsin and acid. Sucralfate likes its aluminum hydroxide component is known to stimulate angiogenesis and granulation tissue formation.[8]

Aluminum hydroxide is also useful in hyperphosphatemia due to its ability to bind phosphate in the gastrointestinal (GI) tract and subsequently prevent absorption of phosphate [10].

Calcium Salts

They neutralize gastric acidity resulting in increased gastric and duodenal bulb pH; they additionally inhibit the proteolytic activity of pepsin if the pH is greater than 4 and increase lower esophageal sphincter tone. The calcium released from calcium carbonate is known to increase peristalsis in the esophagus pushing the acid into the stomach and provide relief from symptoms of heartburn. The calcium salts also form combined insoluble compounds with dietary phosphate and prevent the absorption of later.[11]

The acid neutralizing mechanism of the antacids is well understood as mentioned above. In addition to this, there are other mechanisms that add to the ulcer healing properties of this class of drugs. The exact mechanism is still unclear, but it is believed to be a combination of 

  • Ability to promote angiogenesis
  • Bind to bile acids
  • Inhibit peptic activity
  • Suppress Helicobacter pylori growth [12],[7]


The dose for antacids depends upon the age of the patient, the purpose of administration (neutralization of acid or off-label use) and presence of other comorbidities like renal or hepatic impairment. As all the forms of these medications are available as over the counter medication, the dosing recommendation varies by product/and or manufacturer. 

 Aluminum Hydroxide (Antacid) 

  • Oral: Usually taken daily after meals and at bedtime at a dose of  640 mg up to 5 to 6 times a day with a maximum dose of 3840 mg per 24 hours.
  • Suspension  The dose for suspension form is 320 mg/5 mL (473 mL). The suspension is to be shaken before use and is to be followed by water.


  • Oral:  The use is reserved for patients with serum phosphorus levels greater than 7 mg/dl. It is to be taken with meals at a dose of 300  to 600 mg 3 times a day, with use limited to a short period (4 weeks).[13]

Calcium Carbonate (Antacid)

It is used up to a maximum dose of 8000 mg per day up to 2 weeks with 1 to 4 tablets for symptomatic relief.


The total dose is not to exceed 2000 mg per day.[13]

Pregnancy and Breastfeeding

Antacids containing aluminum salts are safe to be used in pregnant women as well as for women during labor for aspiration prophylaxis.  The information regarding the use of aluminum-containing antacids in breastfeeding females has not been studied, but aluminum is known to be endogenous to breast milk.[14],[15] In case of calcium-containing antacids excessive use is to be avoided in pregnant women as calcium crosses the placenta. The amount of calcium reaching the fetus is dependent on the physiological changes in the mother. The maternal calcium intake also affects the amount of calcium excreted in the breast milk; it is believed that the use of calcium-containing antacids is safe during breastfeeding. [16]

Adverse Effects

The adverse effects are prominent in the infants and the elderly population. The chronic use of antacids in this population is not recommended due to safety concerns.

Aluminum Hydroxide:  

Aluminum use is associated with an increased risk of toxicity in individuals with renal failure and infants. It presents as:

  • Osteopenia
  • Microcytic anemia
  • Neurotoxicity
  • Osteomalacia
  • Constipation 
  • Fecal impaction
  • Nausea
  • Vomiting
  • Abdominal cramps
  • Hypomagnesemia
  • Hypophosphatemia [17],[18],[19],[20]

Calcium Carbonate

The adverse reactions often seen with this  group of antacids are:

  • Abdominal pain
  • Anorexia
  • Constipation
  • Acid rebound
  • Nausea
  • Vomiting
  • Flatulence
  • Xerostomia
  • Headache
  • Xerostomia
  • Hypercalcemia
  • Hypophosphatemia
  • Milk-alkali syndrome [20],[21]


The absolute contraindication is hypersensitivity to any component of the formulation. Also, the drug is to be used with caution in patients with:

  • Renal  failure
  • Heart failure
  • Edema 
  • Cirrhosis
  • Low-sodium diets
  • Uremia
  • GI hemorrhages
  • Hyperparathyroidism
  • Renal calculus
  • Achlorhydria


The average therapeutic dose of antacid is 10 to 15 mL (1 tablespoon or 1 package content) of liquid or 1 to 2 tablets 3 to 4 times a day. Periodic monitoring of calcium and phosphorus levels is suggested in patients on chronic therapy.


No information is available regarding toxicities caused by aluminum- and calcium-containing antacids. However, antacids are to be used cautiously in the high-risk population mentioned above.

Enhancing Healthcare Team Outcomes

Antacids are available as over the counter medications, meaning that patients do not require a prescription to obtain them. This results in the improper use of these medications with little to no relief of symptoms. There is a need to educate patients regarding the importance of a correct mode of administration, time of administration, and dosage for the prompt and prolonged relief of symptoms. These medications only provide symptomatic relief, which may mask an underlying disorder, but lack of awareness in this regard delays diagnosis in health conditions like GERD, peptic ulcer, gastric ulcer, and hiatal hernia. Although these medications do not cause toxicities in high doses, it is imperative to understand their interaction with other medications especially in patients on polypharmacy. The physicians, nurses, pharmacists, and the pharmaceutical companies have a combined responsibility to educate the patients regarding the safe use of these medications to improve outcomes.