Urinary incontinence is known as the leakage of any volume of urine, which is mostly involuntary. The three most well-known types of urinary incontinence are urgency/urge incontinence, stress incontinence, and overflow incontinence. Some patients have symptoms of many different types (mixed), and some can have functional symptoms. Patients with urge incontinence typically complain of a sudden compelling urge to void that is difficult to hold and that often results in involuntary leakage of urine.
Stress incontinence involves involuntary, often sudden, loss of urine due to increased intra-abdominal pressure. On the other hand, overflow incontinence mainly includes an overdistended bladder (either due to reduced detrusor contractility and/or bladder outlet obstruction), often leading to involuntary loss of urine. This article will be focusing on a brief review of urgency/urge urinary incontinence.
The etiologies of urge incontinence often involve the detrusor muscle of the urinary bladder, which is the specialized smooth muscle in the bladder wall. These include detrusor muscle overactivity, poor compliance of the detrusor, and bladder hypersensitivity.
The prevalence of urinary incontinence of any kind varies mainly with age and obesity. Other factors found to be associated with urinary incontinence of different subtypes include previous hysterectomy or pelvic surgery, parity, pulmonary disease, diabetes mellitus, dementia, or residing in a nursing home.
The data regarding the true prevalence of different types of urinary incontinences vary widely depending on the population studied, the social stigma and lack of interest to self-report (respondent bias in observational studies), and also on the case definitions in the questionnaires used. This is probably the reason why, in many epidemiological studies from earlier dates, there had been no differentiation between urge and stress urinary incontinence.
Accurate prevalence measurement for urinary incontinence via robust epidemiological studies and validated measures tend to exist more in the United States and some developed European /Asian countries rather than the developing world. Even then, the reported prevalence for any sub-type of urinary incontinence in adult women is of a broad range (5% to 72%), with an approximate convergence of 30% according to different studies).
Overall, the association of age and urinary incontinence is well established. When the whole population is considered as one, most studies pick either mixed or urge incontinence as less prevalent than stress incontinence. Observational data from four European countries, as well as median prevalence data from a review of epidemiological studies from around the world, have revealed similar trends. Unlike stress incontinence, which reaches a peak mostly around the fifth decade of a patient's life and then shows a decline, both urge, and mixed incontinence continues to increase in prevalence with increasing age. The association of age with incontinence also prevails in men, but severe incontinence in elderly males is often half the number of that in women.
When considering the prevalence of urge incontinence specifically among women and men, a slightly different picture is depicted. Studies have shown that stress incontinence is of high prevalence among postmenopausal women, whereas urge incontinence may have a somewhat lower prevalence. Even then, it is this second type of incontinence that is often extraordinarily bothersome and is more likely to require treatment. The prevalence of "any sub-type" of urinary incontinence" (3% to 11%) in all ages of men is considered much lower than that for women. Interestingly, urge incontinence is often the predominant subtype among 40% to 80% of those within the male population.
The care for any urinary incontinence almost always begins at a primary clinician’s office. The presentation of incontinence symptoms can often be late due to the unwillingness of the patient population to report it. Therefore, a thorough and empathetic history taking should be conducted by the primary clinician. History should include discussion about the patient’s typical voiding pattern, onset, and duration of incontinence symptoms, whether or not the patient is bothered by symptoms and any associated factors that can affect incontinence, i.e., amount and type of daily fluid intake and bladder irritants (caffeine, carbonated beverages, artificial sweeteners, alcohol, etc.). Most histories should also focus on triggering factors or events of urinary incontinence (e.g., feeling of urgency, cough, sneezing, feeling of running water, lifting, bending, sexual activity, movement, changes in position), constant or intermittent leakage of urine, coexisting medical condition (such as diabetes mellitus, diabetes insipidus, urogynecological cancer, cardiorespiratory diseases, chronic cough, dementia, delirium, presence of a urinary tract infection, obesity and sleep apnea).
Other factors requiring assessment should include urinary frequency (>7 micturition episodes in a day), urgency, pain with a full bladder, obstetric history (number and mode of deliveries), gynecological history (history of pelvic organ prolapse, anal incompetence, menopause, sexual dysfunction), any previous pelvic surgery (incontinence procedures, pelvic floor reconstruction, and hysterectomy), history of surgery of the central nervous system or spinal surgeries.
Clinicians should also do a thorough review of any current medicines that can exacerbate or lead to incontinence symptoms, e.g., alpha-adrenergic agonists and antagonists, angiotensin-converting enzyme (ACE) inhibitors, anticholinergic drugs, calcium channel blockers, cholinesterase inhibitors (increases bladder contractility and can cause urgency incontinence), diuretics, lithium, psychotropic medications, sedatives, hypnotics, selective serotonin reuptake inhibitors (the increased cholinergic activity can lead to urge incontinence) and lastly opioid analgesics.
It is well validated that sometimes symptom presentation is not enough to guide patient care for a specific type of urinary incontinence. A focused physical examination, therefore, should include pelvic/genitourinary examination as well as neurological, gait, mental status, and body mass index (BMI) assessment, all of which can be started in the primary care setting. An abdominal examination can reveal information regarding any costovertebral angle tenderness, pelvic masses, and palpable bladder. A positive Valsalva maneuver for >6 seconds might reveal evidence of pelvic organ prolapse. A digital examination of the pelvic floor will disclose information regarding the tone and strength of the pelvic floor. Additionally, a speculum exam might reveal vaginal atrophy, incontinence associated dermatitis, and extra-urethral urine loss/fistula.
Neurological examination should include details of mental status, perineal reflexes and sensation, patellar reflexes, gait, and a mobility assessment. A postvoid residual gives valuable insight to bladder emptying in patients with obstructive symptoms or neurological diseases but should only be done with ultrasonography for better accuracy and less invasiveness. Congestive heart failure should also be ruled out with a cardiovascular examination in case of any lower extremity edema.
While it is challenging to not have a single test to diagnose urge incontinence, other simple office-based examinations can aid in ruling out different types and pathophysiology of incontinence. A positive cough stress test (observation of immediate leakage of urine with cough when a bladder has at least 200 mL of urine) has excellent sensitivity and specificity for stress incontinence, especially in standing position. A cotton swab test can be used to evaluate urethral hypermobility. Here a cotton swab is inserted through a lubricated urethra up to the neck of the bladder, and the test is considered positive if the cotton swab angle changes >30 degrees from resting position with the Valsalva maneuver.
The evaluation for urge incontinence of urine can be done with the following sequential steps.
The treatment of urge urinary incontinence is designed to achieve a degree of decrease in bladder contractility. It also aims to acquire increased bladder capacity and decreased afferent input to the bladder. According to the American Urological Association guidelines, treatment options should be considered at three different levels.
The differential diagnoses for urge incontinence include all of the reversible causes discussed in the evaluation section. Then again, the classification and characterization of urinary incontinence are somewhat challenging. It is most often dependent on history and subjective complaints from the patient due to a lack of adherence to proper history and physical exam technics. Therefore urge incontinence symptoms can easily have a differential diagnosis of either stress or mixed type incontinence. Another more common differential diagnosis can be overactive bladder syndrome (OAB). While urge incontinence and OAB are often used interchangeably, most OAB cases do not have any incontinence symptoms. Other conditions, such as diabetes mellitus, recurrent UTI, and neurological diseases, can also be included in the differential diagnosis for the urge incontinence.
The prognosis of urge incontinence differs from person to person, and hence treatment plans should ideally be individualized after discussion with the patient. While behavioral therapy and medications have promising results in the younger patient population, the options of neuromodulation should be considered early in the algorithm for the elderly population. According to the American Urological Association, the efficacy of treatment guidelines and prognosis of urge urinary incontinence depends on many factors related to the patient's age and co-morbid conditions. Frailty, functional and cognitive impairment, family/caregiver support, co-morbid conditions play pivotal roles in a patient's participation in behavioral therapies. Comparatively, younger individuals have a higher success rate and increased quality of life with behavioral therapies alone or combined with medications.
The use of antimuscarinic agents in elderly patients with cognitive impairment and dementia might lead to further worsening of dementia/Alzheimers disease. Coexisting medications with anticholinergic properties such as medications for parkinsonism, donepezil, anti-nausea medications, and sedatives will lead to poor prognosis. Thus third-line treatment options such as PTNS might need to be included in treatment and prognosis discussion earlier in the disease process for the elderly/affected population. A baseline mini-mental status exam score can prove vital while assessing the quality of life improvement. Beer's criteria for risk assessment or antimuscarinic risk scale can be considered essential for the elderly population, whereas, in the younger community, side effect management can lead to better disease prognosis and treatment success.
Again, while considering the third-line treatment options, cognitive assessment is essential to predict the outcome. Despite all these considerations, when left untreated or unattended, the prognosis of urge urinary incontinence is abysmal. It is socially burdensome and leads to significant morbidity.
Complications of urge urinary incontinence can be related to the disease process itself and also to the medications and surgical procedures. Complications of chronic urinary incontinence include:
Complications of all the surgical or bladder neuromodulation procedures can be:
Despite the wide prevalence of urge incontinence, very few patients seek help, assuming that they just have to live with it. Specific questions for urinary symptoms of urge and stress incontinence should be included in the review of systems, as many patients are uncomfortable discussing this with the provider. When history and exam are suggestive of urge incontinence, lifestyle changes like cutting back on caffeine, alcohol, artificial sweeteners that increase urinary frequency and avoiding them close to bedtime can help many patients to reduce urgency and urine leaks. It is important to avoid constipation that could worsen urge incontinence by increasing fiber intake. Even though many patients have heard about pelvic floor exercises and bladder retraining, they often perform them incorrectly. Providers should take the opportunity during the initial evaluation to educate on the correct technique of the exercises or offer a referral to a physical therapist who has special training in these exercises.
Asking the patient to have scheduled bathroom breaks helps to retrain the bladder. To begin, the patient should be asked to hold their urine for at least an hour. If they feel the urge, ask them to try to wait until the whole hour is passed. After they get used to waiting 1 hour, the patient can try waiting longer between bathroom visits. The goal should be to train the bladder to hold urine for 3 to 4 hours between bathroom visits. During an urge, patients can try sitting down or standing still, taking a deep breath, and squeeze the pelvic floor muscles. This can help them relax and overcome the urge. When the urge passes, they can then walk slowly to the bathroom to urinate.
Providing printed handouts and going through self-management skills and outlining the available treatments to control and cope with the symptoms will improve patient confidence and cooperation with the treatment. Resourceful patient education is available on the American College of Obstetrics and Gynecology website.
Urge incontinence is a complicated condition, and patients often present late to their primary care providers. Therefore, primary care providers should be proactive in gathering a thorough history, physical examination, perform office-based investigations to rule out reversible causes, and decide when to refer to a specialist (urologist/urogynecologist). A culture of shared and informed decision making with the patient should be developed. In this process, patients and their family members or caregivers should also be included. A clear cut discussion on the treatment goal and different treatment options often leads to better patient compliance.
A thorough review of all possible reasons for the failure of treatment, side effects of various medications, and measures of improvement of quality of life should also be included. For example, not all patients will achieve complete incontinence free life. Still, many will see a significant reduction in bothersome symptoms that might lead to a considerable improvement in the quality of life. The ethical responsibility of the clinician is to always offer the least invasive treatment option depending on the patient's co-morbidities. An interprofessional team approach involving excellent communication among specialists, primary care providers, patients/families, nurses, and pharmacists often leads to improved treatment outcomes, patient-centered care, and better patient safety.
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