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Delusions


Delusions

Article Author:
Kamron Fariba
Article Editor:
Fatma Fawzy
Updated:
10/6/2020 3:21:59 PM
For CME on this topic:
Delusions CME
PubMed Link:
Delusions

Introduction

In his Critique of Pure Reason, Kant presents the existence of the noumenon (the thing-in-itself) and subsequent phenomenon - the "thing" as it appears to the observer. The veil preventing the unblemished mirroring of the noumenon by the phenomenon is the perceiver's subjective synthesis of the incoming stimuli. Kant further elaborates that the perceiver will, ultimately, never truly acknowledge the objective noumenal reality, as the act of perceiving implies the synthesis of incoming empiric sensation with a priori knowledge and intuition. As a more digestible encapsulation, all experience incorporates an incoming sensation (the noumenon) followed by an organizing concept (the phenomenon), thus engendering a distinctly individualized subjective reality.[1]

Applying this epistemological heuristic, individuals of a common ilk will experience similar phenomenological realities, as they share synchronous schemata. However, in the happenstance of deviant sensory processing, the afflicted individual would undoubtedly experience a drastically aberrant perception of reality. This distortion is the foundation for the nosologic distinction of "delusion."

Jaspers (1883-1969) was amongst the first to describe and classify delusions.[2] In his book General Psychopathology (1913), he suggests that a delusion is a "perverted view of reality, incorrigibly held." These perversions are enigmatically derived, held with extraordinary certainty, and absolutely unamenable. He further emphasized that these false beliefs exist along a continuum of thought disturbance, increasing in severity of distortion from normal thinking patterns to 'true' delusions. One hundred years later, Jaspers' postulation remains a leading candidate in the investigation of delusion morphology.[1] 

As per the diagnostic and statistical manual of psychiatric disorders, delusions are defined as firm and fixed beliefs based on inadequate grounds not amenable to the rational argument or evidence to the contrary, not in sync with regional, cultural, or educational background.[3]

Etiology

Despite over a century of interest in this phenomenon, no single unifying theory has been comforted; however, postulations suggesting psychological, neurobiological, cognitive, and emotional etiologies have been offered.

Psychodynamic Theory

No discussion of abstract psychological phenomena would be satisfactory without at least an allusion to Freud. Always in character, Freud suggests that delusions are manifestations of unresolved conflicts between an individual's psychological agencies - the superego, ego, and id. This imbroglio is none other than the repression of homosexual impulses emanating from the id. In an attempt to expiate unending denigration from the superego, the ego implements immature defenses, following the sequence of denial, reaction formation, and finally, projection. The phenomenology of this sequence precipitates as the patient, initially, denies his homosexual impulses, and instead emphasizes his disgust for homosexuals. His repressed impulses are then projected externally, as he accuses others of harboring lascivious intentions. Thus, the inchoate psychic conflict, ultimately, manifests in the delusion that other men are trying to engage in lewd acts with him, inciting paranoia and distress.[1]

Anthropological Theory

Roberts (1992) proposes a model with three stages.

  1. Pre-Psychotic: In this phase, much like the stress-diathesis model, a person with an innate vulnerability or predisposition to a psychotic type illness is exposed to a stressor, which serves as the antecedent.
  2. Acute phase: the person begins to experience unusual or idiosyncratic feelings, which become the seeds of delusions. If personal meaning is attributed to these ideas and sensations, 'simple delusions' are formed.
  3. Elaboration: 'simple delusions' - Further form is given to these ideas, which are expanded upon and elaborated. This personalized meaning and associated ideas become incorporated into current thinking, increasing the complexity and rigidity and further reinforcing any perceptual distortions and attribution of meaning.[1]

Neurobiological Theory

Experts suggest that elevated dopaminergic transmission can increase 'signal to noise' differences in the neural network. Consequently, this hyperactive dopamine activity manifests as the tendency to ascribe unrelated external events with personal significance.[4][5] The aberrant dopaminergic activity can impact attention, mood, motivation, and interpersonal interactions. Areas in the brain, including the substantia nigra, dorsolateral prefrontal cortex, ventral striatum, ventromedial prefrontal cortex, hippocampus, and mesolimbic pathways have been implicated in the experience of delusions.[6] Furthermore, the ability of dopamine antagonists to treat and reduce the intensity of delusions has been considered as evidence of the role dopamine excess plays in the neurobiology of delusions.[7]

Perceptual-Cognitive Theories

This includes the 'salience' theory in which delusions are the result of imbalanced attention, where more attention is paid to certain idiosyncratic aspects of a situation, to the exclusion of more relevant information. This leads to a skewed decision-making process.[8] The two-factor theory expounds on this concept, stating that both salience and faulty cognition are required for delusions to be sustained.[9][10]

These faulty perceptual-cognitive processes may also be associated with a 'jumping to conclusions' tendency. People with this tendency spend less time reviewing the information before making decisions, are more likely to miss or misinterpret details, and feel more certain of their choices. These ideas become fixed, and perception becomes influenced by the faulty logic, which supports the idiosyncratic meaning attached to people, places, and situations. This impacts the accuracy of the patient's overall perceptions and conclusions, which subsequently impacts information integration and understanding, increasing the likelihood of mistaken interpretations of stimuli.[11] These distorted perceptions become integrated into an overall schema and further distort perceptions as the delusions are now accepted unquestioningly.

Brain network theory proposes that disconnections between essential parts of the default mode and semantic networks lead to perceptual-cognitive-affective integration difficulties and ineffective application of cognitive resources.[12][13]

Biographical Theory

Trauma has been implicated as a risk factor for the development of psychosis and delusions, most particularly trauma involving violence of an interpersonal nature. Early childhood trauma has been linked with changes in the developing brain, including a shrinking of the hippocampus, hyperarousal of the amygdala, alterations in neurotransmitters e.g., dopamine, GABA, glutamate - and the subsequently increased diathesis towards delusional manifestations.[14][15]

Integrative Theory

Van Der Gaag (2006) proposed an integrative neuropsychiatric 4-factor model by synthesizing several theoretical perspectives, suggesting that the onset of a delusion is multifactorial.[5]

  1. A Biological Component - this leads to aberrant perceptions and salience of stimuli.
  2. A Cognitive Component - the aberrant perceptions are interpreted based on the person's history and integrated into their overall schemas.
  3. A Psychological Integrative Component - as perceptions become integrated into the person's overall worldview, they become reinforced by faulty logic, and further delusions precipitate.
  4. A Psychological Maintenance Component - as delusions become integrated into overall percepts, the delusions are maintained, further impacting perceptions.

Epidemiology

Delusions can precipitate in isolation or as psychiatric sequelae of underlying conditions. In isolation, as in delusional disorder, epidemiologists can feasibly produce estimates of prevalence. However, when manifesting as psychiatric sequelae, accurate estimates prove untenable. With this prefaced, the prevalence of the delusional disorder in the United States, as reported by the DSM-V, is estimated at 0.02%. The female-to-male ratio ranges between 1.18 and 3 to 1. Men are more prone to develop paranoid delusions. Women are more likely than men to develop delusions of erotomania. Socioeconomic factors associated with delusions include being married, employed, recently immigrated, financial stressors, celibacy, and widowhood.[16]

Pathophysiology

Klaus Conrad appropriated five stages involved in the progression of delusions, consisting of, in sequence, trema, apophany, anastrophe, consolidation, and residuumTrema represents the manifestation of a 'delusional mood', resulting in distorted perceptions. Next, the stage of apophany symbolizes the designation of new meanings for psychological events. This is subsequently followed by anastrophe, which is the heightening of the psychosis. The penultimate phase, consolidation, concludes in a new psychological reality or  'delusional state', ultimately leading to residuum, which is the new baseline 'autistic state'.[17]  

History and Physical

Delusions can manifest as primary psychiatric phenomena or secondary sequelae in the context of other mental or other medical conditions.[18][19][20] However, unlike the protean history preceding the presentation, the underlying archetypal content of the delusions prove to be relatively prosaic.

Some of the most clinically encountered types of delusions are:

  1. Erotomanic: A delusion that another person, more frequently someone of higher status, is in love with the individual[18] (Clerembault syndrome)
  2. Delusional jealousy: That one's sexual partner is unfaithful (Othello syndrome) [21]
  3. Grandiose: A conviction of great talent, discovery, inflated self-worth, power, knowledge, or relationship with someone famous or deity[22]
  4. Persecutory: The central theme is being conspired against, attacked, harassed, poisoned obstructed in the pursuit of long-term goals[23]
  5. Religious delusions: The belief that the affected person is a god or chosen to act as a god[24]
  6. Bizarre: A delusion involving a phenomenon that is impossible, not understandable, and unrelated to normal life[25]
  7. Somatic: Involve bodily functions and sensations (i.e., pseudocyesis, alien hand syndrome, Alice in Wonderland syndrome)[26]
  8. Control: the delusion that some external force is controlling one's feelings, impulses, and thoughts[27]
  9. Thought broadcasting: A delusion that one's thoughts are projected outwards and perceived by others[28][18]
  10. Thought insertion or withdrawal: A delusion that one's thought is not one's own but inserted into their mind by an external source or entity; or one's thoughts are being removed[28][18]
  11. Delusional Misidentification Disorder: a) Cotard Disorder[29], the belief that one is dead or does not exist, or one's organs are putrifying or have been removed b) Fregoli syndrome,[30] the delusional belief that different people are a single person who is in disguise.
  12. Delusions of infestation: also known as the delusions of parasitosis or Ekbom syndrome, is an infrequent psychotic disorder characterized by a firm and false belief that there is a parasitic infestation of the skin, with no medical evidence that could support this claim[31]
  13. Delusions of misidentification: The belief that a familiar person/place has been switched with a look-alike (Capgras disorder)[30]

Picardi (2018) noted that delusions of grandeur were commonly seen in bipolar disorder, whereas delusions of guilt were consistently associated with psychotic depression, both unipolar and bipolar. Although persecutory delusions are common across diagnostic groups, these were found more frequently in schizophrenia and delusional disorders rather than in mood disorders. Delusions of thought broadcasting, insertion, or withdrawal appear to be most frequently associated with chronic psychotic disorders.[32]

Young, Kim, and Park (2012) reviewed shifts in persecutory delusions between the differing generations. They noted a shift in delusional themes, temporally related to current political issues. In the earliest group reviewed, delusions were somatic in origin, primarily of having syphilis. With the onset of the second world war, delusions in American patients contained an increased number of references to Germans, and, during the Cold War, of communists.[33]

Evaluation

Evaluating delusional states can prove difficult, even for the seasoned clinician. Prior to a psychiatric evaluation, the physician should rule out delusional manifestation in the setting of a medical disease.

There is no specific diagnostic test to identify delusions; however, the following factors should be considered essential as part of any clinical evaluation.

1. Genetics/Family History as Risk Factor

Positive family history for mental disorders should be considered as a risk factor in symptom expression.[34]

2. Environment as Moderator

Smeets et al. in 2014 noted that there is evidence suggesting environmental implications on the manifestation and theme of delusions.[35]

3. Early Exposure to Trauma as a Specific Risk Factor

There is a significant body of research on the link between early/childhood exposure to trauma and the subsequent development and severity of delusions.[36] Some researchers have proposed that the type of trauma may impact the level of risk and the expression of the delusional material.[36][37]

4. Tenacity of Beliefs

Despite their encapsulation, these beliefs are impervious to reasoning, evidence, and argument; attempts to confront the delusions may precipitate resistance, early treatment termination, and alienation from the patient.[38]

5. Content and Culture

Delusions appear in many cultures. Persecutory delusions appear most frequently, followed by religious and grandiose delusions. However, recent research indicates that the delusional content and expression is partly reflective of the person's culture as well as the socio-economic and political events experienced by that person.[39][40][41]

Treatment / Management

Individuals experiencing delusions do not often seek medical attention voluntarily, as their delusions are ego-syntonic, leading to the externalization of psychic distress onto others. Often patients are prompted to seek help by concerned family members after noticing social and occupational dysfunction.[42]

In the event that an individual seeks treatment, creating therapeutic rapport is the quintessential aim for the clinician.[43] Direct attempts to confront delusions are unlikely to be successful and may lead to significant patient distress. A more fruitful focus for clinicians may be to suspend judgment and examine the impact and potential function of these beliefs in the patient's daily life. A focus on context, exploration, and further understanding of the patients' culture and history will likely prove more productive.

Bebbington and Freeman (2017) propose an integrated neuropsychiatric framework for understanding and treating delusions. The authors indicate that treatment requires amelioration of both biological and psychological aspects and that both processes need to occur in order to lead to remission. The remission of the biological aspect consists of the dampening of mesolimbic dopamine release with antipsychotic medication. This reduced dopaminergic activity decreases the uneven salience and attribution of personalized meaning to surrounding stimuli. With the decrease in intensity of salience, the person is able to reassess the stimuli and more accurately distribute attention, which in turn reduces the level of over personalized meaning, leading to a more realistic appraisal of the situation. As insight improves, the therapist can subsequently attempt to "shake" the once "unshakable" delusion.[44] 

Psychological remission consists of the reappraisal of primary psychotic experiences. Both forms of remission are partially independent, and shifts in both areas are required for the remission of symptoms.[45]

Differential Diagnosis

As previously mentioned, delusions can precipitate in the setting of psychotic spectrum disorders, manic depressive illness, and isolation. Some research indicates that as many as 20% of those who experience a severe mood disorder may experience delusions, most of which are persecutory or derisive. Delusions in affective disorders tend to have more of a mood component and may be slightly more organized than those seen in schizophrenia.[45]

Delusions also occur with some frequency in various dementia syndromes[46], including Alzheimer disease[47], vascular dementia, frontotemporal dementia[48], and Lewy body dementia[49]; delusional themes in dementia spectrum disease are primarily of theft.[45] It is estimated that 25 to 40% of patients diagnosed with Alzheimer experience delusions at some stage of their illness.

In a 2006 study, Scarmeas found that approximately 50% of patients with Lewy body dementia experienced delusions and noted these patients were prone to delusional misidentification syndromes such as Capgras or Fregoli syndrome.[30] Delusions can also be observed in Charles Bonnet syndrome, which is linked to sensory hearing loss.[50][51]

Treatment Planning

In the event the treatment teams decide to pursue pharmacologic management, the neuroleptic medication should be chosen based on the side effect profile, tolerability, coexisting comorbidities, age, and financial burden of the medications.[52][53][54]

Prognosis

Prognosis varies, depending on comorbid conditions. Patients with primary delusions appear to function better overall than those with primary psychotic disorders and worse than those with primary affective disorders.[55][56] Theoretically, delusions precipitating in the setting of an ongoing medical disease should terminate following the resolution of the underlying disease.

Complications

Complications are often related to associated or comorbid conditions. There have been reports of violence, stalking, and homicide associated with delusions, particularly related to jealousy in Othello syndrome, refusal to provide care or displaying aggression towards family members as seen in Capgras syndrome, and putting oneself in danger, such as in Fregoli syndrome.[57][58][59][58][57][30] In rare but dramatic responses to somatic delusions, patients may attempt to amputate limbs or even attempt enucleation.[60] Grandiose delusions may result in injury due to feelings of invincibility. And lastly, the elegiac, taunting delusions in paranoia may lead patients to kill themselves.[61]

Deterrence and Patient Education

Increased psychoeducation for patients, families, and the public can increase awareness of delusion symptomatology, prompting more rapid recognition, and ultimately resulting in more appropriate management.[62]

Enhancing Healthcare Team Outcomes

Interprofessional consultations play an integral role in the setting of delusions. Patients often present to non-psychiatric specialties due to a lack of insight. Instead, these patients may present to emergency departments and police stations with bizarre complaints of persecution and poisoning. These eccentric presentations should incite concern, and a subsequent consultation should be requested. Once in the appropriate setting, efficient healthcare teamwork is essential. Nursing staff are paramount to orient and address patient needs, while case management assists in the litigious aspects of the case. Psychiatric technicians provide security for patients and staff. Persons suffering from delusions can prove challenging to treat, but with cohesive teamwork, this daunting task becomes manageable.

"This research was supported (in whole or part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities."


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