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Pitavastatin


Pitavastatin

Article Author:
Harneet Bhatti
Article Editor:
Prasanna Tadi
Updated:
7/8/2020 8:48:26 AM
For CME on this topic:
Pitavastatin CME
PubMed Link:
Pitavastatin

Indications

Pitavastatin is currently FDA approved for the management of primary dyslipidemia and mixed dyslipidemia as adjunctive therapy to dietary changes to help lower total cholesterol, low-density lipoprotein cholesterol (LDL), apolipoprotein B (Apo B), triglycerides (TG) and to increase high-density lipoprotein cholesterol (HDL).[1][2][3] It is also FDA approved to treat heterozygous familial hypercholesterolemia (HeFH) in pediatric patients over 8 years of age.[4][5] Unlike other statins, pitavastatin has not been studied in any large randomized controlled study to determine whether its use is associated with decreased cardiovascular events.

Mechanism of Action

Pitavastatin competitively inhibits 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway. Inhibiting this enzyme decreases the production of mevalonic acid from HMG-CoA. This enzymatic inhibition, in turn, increases the number of LDL receptors expressed on hepatocytes to compensate for the loss of mevalonic acid and results in greater LDL catabolism.[6][7]

Pharmacokinetics: 

Absorption: 

Peak plasma concentrations of pitavastatin are reached within approximately 1 hour after oral administration. It has a bioavailability greater than 60%. It has some absorption in the colon; however, its absorption mainly occurs in the small intestine. In comparison to all other statins, pitavastatin reaches peak plasma concentrations the fastest and has the highest bioavailability.

Distribution: 

Pitavastatin is largely bound to protein (>99%), primarily to albumin and alpha-1 acid glycoprotein, with a mean volume of distribution of 148L. 

Metabolism: 

Pitavastatin is mainly metabolized in the liver by UGT1A3 and UGT2B7 and minimally by CYP2C9 and CYP2C8.

Excretion: 

The half-life of pitavastatin is approximately 12 hours. The majority of pitavastatin (79%) is excreted in the feces, whereas approximately 15% is excreted in the urine.[6]

Administration

Pitavastatin is available as 1 mg, 2 mg, and 4 mg tablets for oral administration. Patients may take the drug at any time of the day; however, the time of day should remain consistent. Patients can take it with or without food. 

Adult dosing: 

Pitavastatin is a moderate-intensity statin. The dose range for pitavastatin is between 1 mg to 4 mg once daily; 2 mg once daily is the recommended starting dosage, and the maximum dose is 4 mg once daily. The actual starting dosage and maintenance dosage should be individualized to the patient's characteristics and goals of therapy as per the American College of Cardiology/American Heart Association Guidelines.[1][8] Lipid levels should be assessed four weeks after starting therapy to determine whether the response is appropriate and whether the dosage is appropriate.  

Pediatric dosing: 

For children aged eight years and older, for management of HeFH, 2 mg once daily is the recommended starting dosage. Lipid levels should be re-assessed four weeks after initiating therapy and adjusted accordingly. The maximum recommended dosage is 4 mg once daily.[4][5]

Geriatric Dosing: 

Research has determined no significant difference in terms of safety and efficacy was determined between geriatric patients (age greater than 65) and younger patients.[7][9]

Renal impairment:

Patients with a glomerular filtration rate between 15 to 59 mL/min/1.73 m not requiring hemodialysis and patients with end-stage renal disease requiring hemodialysis should initiate pitavastatin at 1 mg once daily to a maximum dose of 2 mg once daily. 

Hepatic impairment:

Pitavastatin is contraindicated in the presence of active liver disease and patients with unexplained elevated liver enzymes.[9][10]

Drug Interactions: 

Pitavastatin is mainly metabolized by glucuronidation via liver UGTs, and there is comparably only minimal metabolism by cytochrome P450 enzymes.[6]

The following drugs may decrease the serum concentration of pitavastatin: darunavir/ritonavir, lopinavir/ritonavir, ezetimibe, digoxin, and itraconazole. 

The following drugs may increase the serum concentration of pitavastatin: cyclosporine, erythromycin, rifampin, atazanavir, gemfibrozil, fenofibrate, enalapril, and diltiazem.[7]

Adverse Effects

The most commonly reported adverse effects related to pitavastatin use include back pain, constipation, diarrhea, myalgia, and pain in extremities. Reports exist of rash, pruritus, and urticaria. There are also reports of myopathy and rhabdomyolysis, leading to acute renal failure. Pitavastatin use can also cause lab abnormalities, including elevated creatine phosphokinase, transaminases (aspartate aminotransferase [AST]/serum glutamic-oxaloacetic transaminase, or alanine aminotransferase [ALT]/serum glutamic-pyruvic transaminase), alkaline phosphatase, bilirubin, and glucose. High fasting serum glucose levels and high HgA1c levels have also occurred with pitavastatin use.[10][11][12]

Contraindications

Pitavastatin use is contraindicated in patients with known hypersensitivity, including rash, pruritus, urticaria, to any component of this drug. Its use is also contraindicated in patients with active liver disease or unexplained elevated levels of hepatic transaminases. Pregnant women or ones who may become pregnant should also avoid pitavastatin use. As pitavastatin is known to pass into breast milk, the recommendation is that nursing mothers also avoid pitavastatin use.[10][13]

Monitoring

Liver function tests and a lipid panel should be performed before starting pitavastatin to establish baseline levels. A repeat lipid panel should be obtained six weeks after initiation. Once stable, the monitoring of lipids can be yearly. Liver function tests are repeatable as clinically necessary.

Toxicity

A common side effect of pitavastatin toxicity is myalgia. In the setting of overdose, there is no known treatment. Patients should be provided with supportive measures and should receive treatment for any symptoms. Given the high protein binding ratio of pitavastatin, hemodialysis would not be beneficial.

Enhancing Healthcare Team Outcomes

The management of hyperlipidemia is an essential aspect of healthcare, given the risk of cardiovascular disease associated with it. Interprofessional communication and communication with the patient from all members of the patient’s health care team is vital to help decrease the risk of cardiovascular events. Physicians and pharmacists can work together to determine which medications will best help a patient in the setting of their known comorbidities. As a group, physicians, pharmacists, and nursing staff can relay information regarding the risks associated with hyperlipidemia and the importance of medication compliance. Medication compliance may improve if patients are aware of the long-term benefits of statin use. Pharmacists can also further provide information regarding side effects. Such information from a reliable source may help reduce the fear associated with statin use and further improve medication compliance. Follow up visits with a physician may increase medication compliance as well, given that it provides an opportunity for patients to learn more about hyperlipidemia and its management.[14] [Level III] One study determined that telephone calls to patients every six months may also help improve adherence to medications.[15] [Level 5] Also, nutritionists and dieticians can play an essential role in the management of hyperlipidemia as they help guide patients towards individualized lifestyle modifications. 


References

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[2] Chan P,Shao L,Tomlinson B,Zhang Y,Liu ZM, An evaluation of pitavastatin for the treatment of hypercholesterolemia. Expert opinion on pharmacotherapy. 2019 Jan;     [PubMed PMID: 30482061]
[3] Pirillo A,Catapano AL, Pitavastatin and HDL: Effects on plasma levels and function(s). Atherosclerosis. Supplements. 2017 Jul;     [PubMed PMID: 28716185]
[4] Benekos T,Kosmeri C,Vlahos A,Milionis H, Nine-year overview of dyslipidemia management in children with heterozygous familial hypercholesterolemia: a university hospital outpatient lipid clinic project in Northwestern Greece. Journal of pediatric endocrinology     [PubMed PMID: 32084003]
[5] Braamskamp MJ,Stefanutti C,Langslet G,Drogari E,Wiegman A,Hounslow N,Kastelein JJ, Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk. The Journal of pediatrics. 2015 Aug;     [PubMed PMID: 26059337]
[6] Mukhtar RY,Reid J,Reckless JP, Pitavastatin. International journal of clinical practice. 2005 Feb;     [PubMed PMID: 15854203]
[7] Kajinami K,Takekoshi N,Saito Y, Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor. Cardiovascular drug reviews. 2003 Fall;     [PubMed PMID: 12931254]
[8] Betteridge J, Pitavastatin - results from phase III     [PubMed PMID: 21193153]
[9] Chamberlin KW,Baker WL, Benefit-risk assessment of pitavastatin for the treatment of hypercholesterolemia in older patients. Clinical interventions in aging. 2015;     [PubMed PMID: 25931816]
[10] Pitavastatin 2012;     [PubMed PMID: 31643396]
[11] Flores NA, Pitavastatin Nissan/Kowa Yakuhin/Novartis/Sankyo. Current opinion in investigational drugs (London, England : 2000). 2002 Sep;     [PubMed PMID: 12498010]
[12] Teramoto T, Pitavastatin: clinical effects from the LIVES Study. Atherosclerosis. Supplements. 2011 Nov;     [PubMed PMID: 22152283]
[13] Eiland LS,Luttrell PK, Use of statins for dyslipidemia in the pediatric population. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 2010 Jul;     [PubMed PMID: 22477808]
[14] Brookhart MA,Patrick AR,Schneeweiss S,Avorn J,Dormuth C,Shrank W,van Wijk BL,Cadarette SM,Canning CF,Solomon DH, Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin use. Archives of internal medicine. 2007 Apr 23;     [PubMed PMID: 17452550]
[15] Jelinek M,Vale MJ,Liew D,Grigg L,Dart A,Hare DL,Best JD, The COACH program produces sustained improvements in cardiovascular risk factors and adherence to recommended medications-two years follow-up. Heart, lung     [PubMed PMID: 19648058]