Continuing Education Activity

Terazosin is a medication used in the management and treatment of benign prostatic hyperplasia and essential hypertension. Terazosin is a long-acting, selective alpha-1 adrenergic receptor antagonist. This activity reviews the indications, action, and contraindications for Terazosin as a valuable agent in managing benign prostatic hyperplasia, essential hypertension, and nephrolithiasis.

Objectives:

• Describe the pharmacokinetics and pharmacodynamics of terazosin with emphasis on the context of patient safety.
• Identify the indications for terazosin therapy.
• Review the mechanism of action of terazosin that leads to its therapeutic effect.
• Summarize interprofessional team strategies regarding the appropriate uses of terazosin to enhance patient safety and comfort while minimizing the risk of adverse events.

Indications

Terazosin was approved by the Food and Drug Administration (FDA) in 1987 initially as a treatment for hypertension.[1] Later in 1993, it was approved as a treatment for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia.[2] The role of pharmacologic therapy in distal urinary tract stones is currently a focus of research, with terazosin and other alpha-1 antagonists under consideration for potential therapeutic value in addition to its traditionally accepted symptomatic relief effects.[3] 

Off-label uses for terazosin currently being studied include the following:

• In more recent literature, terazosin, among other agents of its class been the subject of research as an off-label agent for the use of medical expulsive therapy (MET), a form of medical management for distal ureteral calculi.[4][5]
• Alleviation of nightmares associated with post-traumatic stress disorder (PTSD)[3]
• Antihidrotic in patients who have hyperhidrosis related to selective serotonin reuptake inhibitor (SSRI) use[6] 
• Chronic prostatitis/chronic pelvic pain syndrome[7]
• Urethritis associated with radiation therapy[8]
• Idiopathic oligozoospermia[9]

Mechanism of Action

Terazosin is a selective, quinazoline-derived post-synaptic alpha-1 antagonist.[10] Alpha-1 adrenergic receptors subdivide into alpha-1A, alpha-1B, and alpha-1D.[11] Due to their nature as adrenergic receptors, they are members of the G-protein coupled receptor category. Terazosin is a competitive antagonist at these receptors, similar to other selective alpha-1 antagonists such as prazosin and doxazosin, notably at alpha-1A, which comprises the majority of alpha receptors in the urothelium.[12] The alpha-1 receptors are commonly located diffusely in smooth muscle tissue, including vascular smooth muscle, sphincter smooth muscle, and urinary bladder smooth muscle.[13]

Alpha-1 adrenergic receptors are also present in many other organ systems, including the central nervous system, endocrine system, and gastrointestinal system. The primary anti-hypertensive action occurs by blocking vascular smooth muscle in the arterioles. The anti-obstructive urinary tract effects result from smooth muscle relaxation in the ureters, bladder, and urethral sphincter.[14] Terazosin's exertion of an anti-nightmare effect does not have a clearly elucidated mechanism. However, a possible explanation could be due to the presence of presynaptic alpha-adrenergic receptors in the central nervous system.

Administration

Terazosin is available in the US in oral capsule formulation in the form of a hydrochloride salt, available in 1 mg, 2 mg, 5 mg, and 10 mg formulations. For the FDA approved indications of hypertension and benign prostatic hyperplasia, the dosing route, frequency, and amount are as follows:

Hypertension

The initial dose is 1 mg to 10 mg orally daily, titrated upwards as needed to a maximum of 20 mg daily. Considered a second-line agent due to adverse effects, additional consideration as an agent if the patient also experiences lower urinary tract symptoms associated with benign prostatic hyperplasia.[15][16]

Benign Prostatic Hyperplasia

The initial dose is 1 mg to 10 mg orally at bedtime, titrated upwards as needed based upon patient response up to 20 mg daily in 1 or 2 divided doses.[17]

For Non-FDA approved indications, including medical expulsive therapy (MET), chronic prostatitis, hyperlipidemia, urethritis, hyperhidrosis, and oligospermia:

Medical Expulsive Therapy for Distal Ureteral Calculi

2 mg to 10 mg orally at bedtime. Most studies have indicated usage of 2 mg to 5 mg, and only rarely have 10 mg doses been cited. For MET, the typical duration of terazosin is for up to 2 weeks, and the patient may discontinue therapy following the expulsion of the stone.[4]

Chronic Prostatitis/Chronic Pelvic Pain Syndrome

1 mg to 5 mg orally daily for 14 weeks. Terazosin demonstrated effectiveness in a study comparing alpha-antagonist naïve patients with chronic prostatitis/chronic pelvic pain syndrome with a placebo.[7]

Hyperlipidemia/Hypercholesterolemia

5 mg, 10 mg, or 20 mg orally daily. Studies demonstrating the lipid-lowering effects were subject to confounding factors due to titration of drug dosing to diastolic blood pressure or meeting the maximum (20 mg) dosage for terazosin. Additionally, there have not been studies to demonstrate a mortality benefit, as seen for other lipid-lowering drugs.[18][19]

Idiopathic Oligozoospermia

2 mg orally daily. One clinical study by Gregoriou et al. demonstrated a statistically significant improvement in spermatozoa count and seminal fluid volume after treatment with six months of terazosin. However, the study noted no change in the mean percentage of abnormal spermatozoa and also did not detect any significant difference in pregnancy rates.[9]

Urethritis associated with Radiotherapy in Prostate Cancer

2 mg to 6 mg orally daily. One study from Zelefsky et al. suggests an improvement in urinary tract symptoms associated with radiotherapy for localized prostate cancer.[20]

Antidepressant-induced Excessive Sweating

1 mg to 6 mg orally daily. A recent clinical trial demonstrated a positive response to hyperhidrosis associated with selective serotonin reuptake inhibitor use.[3]

Adverse Effects

Terazosin is generally well-tolerated. Many adverse effects of terazosin are explainable due to its blockade of alpha-1 adrenergic receptors.[16][14]

• Statistically significant adverse effects associated with terazosin detected in placebo-controlled trials listed in the FDA database include dizziness, headache, weakness, postural hypotension, and nasal congestion.[21][22]
• First-dose syncope is rare and may be mitigated by bedtime use. Orthostatic hypotension is common and should merit strong consideration when prescribing terazosin.[23] 
• According to the FDA, post-marketing surveys also found priapism, atrial fibrillation, anaphylaxis, and intraoperative floppy iris syndrome associated with terazosin use, though instances of such occurrences were extremely rare.

Drug Interactions

Terazosin has been used in many patients on various concomitant medicines; while these interactions are not studied extensively, no interactions are observed.

Contraindications

The only absolute contraindication to the usage of terazosin is allergy or hypersensitivity to the medication. Relative contraindications include usage in geriatric populations due to the potential for patient harm associated with syncope and/or postural hypotension due to terazosin use, patients with heart failure, and general intolerance of the adverse effects associated with terazosin.[24] It is important to note that in geriatric patient populations, the occurrence of syncope or orthostatic hypotension can lead to falls, which are associated with increased mortality, morbidity, loss of functional capacity, and institutionalization for diagnostic workup/rehabilitation related to the syncope.[25]

While terazosin is not contraindicated for use in pediatric populations, caution is advised due to limited data available regarding the use of the drug in children. However, there are small studies of safe usage in children without adverse outcomes.[26][27]

Warnings

Prostatic Cancer

BPH and prostate carcinoma can cause many similar symptoms, and both diseases usually co-exist. Hence, patients thought to have benign prostatic hyperplasia should be tested before starting terazosin to exclude the carcinoma of the prostate.

Intraoperative Floppy Iris Syndrome (IFIS)

During cataract surgery, IFIS has been observed in some patients treated with alpha-1 blockers presently or in the past. Therefore, the ophthalmologist should consider possible modifications of surgical techniques, such as using iris dilator rings, iris hooks, or viscoelastic substances. There is no benefit of stopping terazosin before cataract surgery.

Monitoring

The use of terazosin does not require plasma/blood drug level monitoring. However, after the first dose, vital orthostatic signs should be obtained to exclude postural hypotension. If used for hypertension, orthostatic blood pressures may be checked regularly during the titration interval to confirm efficacy.[1] If used for lower urinary tract symptoms associated with benign prostatic hyperplasia, standard clinical assessment of patients may determine efficacy.[5]

Toxicity

Overdose of terazosin may lead to hypotension, and standard life-support protocols should be in place for instances of hemodynamic instability. There are no antidotes for terazosin toxicity specifically. Vasopressors may be used to support physiologic blood pressure parameters in the event of terazosin overdose. Terazosin is long-acting, with an elimination half-life of approximately 12 hours, and is highly protein-bound. Elimination is via renal excretion (40%) and via excretion of feces (60%).[28]

Enhancing Healthcare Team Outcomes

Medications are crucial components of the practice of medicine. In addition to procedural treatments, medications represent an essential aspect of therapy delivery. However, the process of delivering medication to a patient involves a complex interplay between interprofessional healthcare team members from several disciplines. 

• A qualified physician or mid-level practitioner (NP or PA) must prescribe the medication with appropriate knowledge and assessment of the medication's efficacy and safety profiles according to the patient's demographics, comorbidities, and clinical needs. 
• The pharmacist who receives the prescription must verify that the dosage prescribed is appropriate and is responsible for communicating with the provider should any mistake or unsafe prescription be discovered and check for potential drug-drug interactions. 
• The pharmacy technician assisting the pharmacist is encouraged to aid in this role and remain vigilant when physically placing the pills in a bottle and ensuring the label is clear and correct. 
• The nurse is responsible for administrating the medication to the patient requires vigilance and awareness of the potential hypotension associated with Terazosin and should be meticulous in their measurement of vital orthostatic signs after administration.
• A medical assistant may also assist in measuring vital signs and could be the first person to discover medication safety issues.
• The patient and/or their caregiver are the crucial final step in the process, verbalizing any questions or concerns they may have regarding the use of the prescribed medication and signs/symptoms for which they should be vigilant.

Though Terazosin is relatively contraindicated in geriatric populations, it may still prove to be a useful drug that treats multiple comorbidities at once to limit polypharmacy.[29] [Level 3] Terazosin is mainly prescribed for patients with hypertension and BPH.[30][31]  The patient and the rest of the healthcare team, including their physician/mid-level, pharmacy team, and the nursing team, should remain vigilant and aware of the possibility of hypotension or arrhythmia associated with terazosin use. With this type of interprofessional team approach, there can be a maximal therapeutic benefit with minimal adverse events. [Level 5]