Pronator teres syndrome (PTS), first described by Henrik Seyffarth in 1951, is caused by a compression of the median nerve (MN) by the pronator teres (PT) muscle in the forearm.  The PT muscle is named because of its action and shape; it is a rounded muscle that pronates the forearm. In the majority of cases (66%), it arises from unequal two heads: the larger humeral head from the upper part of the medial epicondyle and the smaller ulnar head from the coronoid process of the ulna.  They pass down to the forearm, form a common flexor tendon, and insert into the radial shaft. Before the two heads unite, the median nerve passes between them in 74% to 82% of the cases, innervating both heads from C6-7 roots.  The absence of the ulnar head is rare (14%) and may reduce the risk of median nerve entrapment.  Many individuals have additional fibrous brands within the two heads of the PT muscle.  The anterior interosseous nerve (AIN) then branches from the MN about 5 to 8 cm distal to the medial epicondyle.
Quick and repetitive grasping or pronation movements (prolonged hammering, ladling food, cleaning dishes, tennis) may cause PT muscle hypertrophy and entrapment of MN, especially in those individuals who have additional fibrous brands.  Pronator teres syndrome has been described after local trauma, compression with Schwanomma, and in patients undergoing anticoagulation therapy and renal dialysis.  Tight lacertus fibrosis (also known as the bicipital aponeurosis) may exacerbate the symptoms of pronator teres syndrome.
Pronator teres syndrome may manifest with pain in the volar forearm region, aggravated by resisted pronation of the forearm and flexion of the elbow, and a positive Tinel sign over the proximal edge of PT.  The patient may report significant weakness. Wasting of the median nerve innervated muscles is rare in pronator teres syndrome, but a mild weakness of flexor pollicis longus (FPL) and abductor pollicis brevis (APB) is not uncommon, with some involvement of flexor digitorum profundus (FDP) to digits 2 and 3 and opponens pollicis (OP). The PT itself is usually spared because it received innervation before the MN pierces it. Sensory loss is variable, involving the palm of the hand or mimic that of carpal tunnel syndrome including the thenar eminence, thumb, index, middle, and ring fingers. Positive Phalen test over the PT muscle can be present in 50% of cases. 
It is important that nerve conduction studies (NCS) are done in pronator teres syndrome to rule out other neuropathies, but they seldom show abnormalities.  Sensory and motor amplitudes are reduced more than conduction velocities, mostly in patients with severe and axonal symptoms.  Electromyography (EMG) abnormalities occur in FPL and FDP to digits 2 and 3, less often in the FDS and APB, and only rarely in PT because compression at the site most often occurs distal to its innervation. If any of the median muscles are abnormal, other muscles innervated by the same myotomes as the proximal median muscles but supplied by a different nerve should be tested to exclude more proximal lesion within the brachial plexus or cervical roots. Some authors report abnormal electrodiagnostic findings in 10% of pronator teres syndrome only. 
Pronator teres syndrome among other entrapments within the upper limb also can be diagnosed by ultrasound and magnetic resonance imaging, but ultrasound is advantageous due to its dynamic character and lower cost.  Several studies with an ultrasound evaluation of median nerve between the humeral and ulnar heads of PT concluded that cross-sectional area of MN positively correlates with severity, duration of symptoms, and nerve conduction failure. 
Conservative treatment includes rest, modification of activities that exacerbate the symptoms, physical and occupational therapy, nonsteroidal anti-inflammatory medications, and local injections with corticosteroids or local anesthetic.  Patients usually may continue to work unless they present with prominent motor or sensory deficits that limit work activities. Conservative treatment should be conducted for at least 6 weeks. If conservative treatment fails, surgery is considered.
Surgical treatment is indicated if a patient is symptomatic, has one or more objective findings in a physical examination of weakness or motor atrophy, and has abnormal electrodiagnostic studies.  Surgery usually includes exploration of MN in the forearm and release of PT muscle as well as all other compressive structures – ligament of Struthers, lacertus fibrosis, and/or fascia of flexor digitorum superficialis. Although MN is sometimes decompressed at multiple sites, this is considered a single procedure. 
An endoscopic release has advantages over open surgery because it does not compromise the nerve's blood supply, reduces scar formation, and has been reported to have excellent results.  In the case of recurrent symptoms, open surgery has been indicated. 
Pronator teres syndrome should also be distinguished from carpal tunnel syndrome (CTS), MN entrapment at the wrist, which is the most common MN entrapment syndrome, as well as from AIN syndrome, brachial plexus injury, or cervical radiculopathy.
Pronator teres syndrome has a sensory loss in the entire median nerve distribution versus CTS where sensation is spared over the thenar eminence because palmar cutaneous branch leaves the median nerve proximal to carpal tunnel but distal to PT muscle. In addition, pronation is spared in CTS, and nocturnal paresthesia symptoms are usually absent in pronator teres syndrome.  NCS and amplitude of the MN may decrease in the forearm, but the distal motor and sensory latencies are normal in pronator teres syndrome except when there is associated CTS. 
Because of overlapping symptoms, CTS is sometimes diagnosed, and more proximal pronator teres syndrome is missed when both are present in the same limb.  Thus in patients with CTS pronator teres syndrome should be ruled out especially when the patient is a candidate for surgery. 
To distinguish AIN from pronator teres syndrome, the pronation should be demonstrated with the elbow flexed (PQ function) to avoid contribution of the PT, which is the primary muscle to pronate with the arm extension.  Also, there is no sensory loss in AIN syndrome (as it carries only deep sensory fibers to the wrist), and in some cases, pronator teres syndrome may have only mild paresthesias in MN distribution. In both cases, FPL and FDP to digits 2 and 3 may be affected; but in AIN, the pronator quadratus (PQ) does not weaken the PT as AIN leaves MN distal to PT muscle. Clinically, in both cases, the patient presents with an inability to flex the distal phalanx of the thumb, index, and middle fingers and the weakness of pronation.
In the case of brachial plexus injury or cervical radiculopathy, the examination may reveal weakness in other muscles outside the median nerve territory. Neck pain that radiates to the arm is a common complaint, suggesting cervical radiculopathy.
One group of authors describe a neuralgic amyotrophy as a potential competing condition with pronator teres syndrome due to similar symptoms; but it usually involves multiple nerves, and pain is more commonly localized in the shoulder rather than in the forearm. Neuralgic amyotrophy is an idiopathic condition that usually improves spontaneously in 6 to 12 months. 
Pronator teres syndrome only requiring PT muscle release has a good recovery in most of the cases, and patients return to light duty in approximately 3 weeks and regular duty in 6 weeks. . Occupation therapy fastens recovery and is particularly important for patients who underwent tendon transfers or have a residual weakness. In these cases, patients may return to light duty work in approximately 6 to 8 weeks and regular duty in 10 to 12 weeks. 
Complications of surgical treatment are rare. In one study of 72 patients treated with pronator teres syndrome, no complications were recorded during the operations with an overall postoperative satisfaction rate (very satisfied and satisfied) of 59%.  Theoretical complications from surgery include:
When considering conservative treatment, patients should be advised on minimizing their engagement of activities that involve frequent forearm pronation. These activities include:
Pronator teres syndrome can be often misdiagnosed as it shares symptoms with more common carpal tunnel syndrome. The etiology may vary, and it may affect various people ranging from a patient with multiple comorbidities (e.g., hemodialysis) to healthy individuals who are involved in sports or other physical activities requiring repetitive pronation movements of the forearm as well as people with specific anatomic variations of the elbow region. Different specialists may encounter patients with pronator teres syndrome including urgent care medical professionals, primary care physicians, sports physicians, and others. The role of a physiatrist or a neurologist who specializes in neuromuscular conditions and performs NCV/EMG studies is crucial in diagnosis and treatment of this condition. The radiologist also plays a role in diagnosing pronator teres syndrome, but he/she will need proper guidance from the referring specialist. Physical and occupational therapists manage conservative treatment, but if it fails, the surgeon gets involved. Thus it takes an interprofessional group of specialists to manage patients with pronator teres syndrome. Existing evidence regarding pronator teres syndrome is inadequate. (Level V)
|||Lacey SH,Soldatis JJ, Bilateral pronator syndrome associated with anomalous heads of the pronator teres muscle: a case report. The Journal of hand surgery. 1993 Mar [PubMed PMID: 8463605]|
|||SEYFFARTH H, Primary myoses in the M. pronator teres as cause of lesion of the N. medianus (the pronator syndrome). Acta psychiatrica et neurologica Scandinavica. Supplementum. 1951 [PubMed PMID: 14902580]|
|||Olewnik Ł,Podgórski M,Polguj M,Wysiadecki G,Topol M, Anatomical variations of the pronator teres muscle in a Central European population and its clinical significance. Anatomical science international. 2018 Mar [PubMed PMID: 28849397]|
|||Vymazalová K,Vargová L,Joukal M, Variability of the pronator teres muscle and its clinical significance. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 2015 [PubMed PMID: 26662149]|
|||Nebot-Cegarra J,Perez-Berruezo J,Reina de la Torre F, Variations of the pronator teres muscle: predispositional role to median nerve entrapment. Archives d'anatomie, d'histologie et d'embryologie normales et experimentales. 1991-1992 [PubMed PMID: 1366347]|
|||Hsiao CW,Shih JT,Hung ST, Concurrent carpal tunnel syndrome and pronator syndrome: A retrospective study of 21 cases. Orthopaedics [PubMed PMID: 27894853]|
|||Hartz CR,Linscheid RL,Gramse RR,Daube JR, The pronator teres syndrome: compressive neuropathy of the median nerve. The Journal of bone and joint surgery. American volume. 1981 Jul [PubMed PMID: 7240329]|
|||Afshar A, Pronator Syndrome Due to Schwannoma. Journal of hand and microsurgery. 2015 Jun [PubMed PMID: 26078521]|
|||Farrell HF, Pain and the pronator teres syndrome. Bulletin of the Hospital for Joint Diseases. 1976 Apr [PubMed PMID: 974290]|
|||Asheghan M,Hollisaz MT,Aghdam AS,Khatibiaghda A, The Prevalence of Pronator Teres among Patients with Carpal Tunnel Syndrome: Cross-sectional Study. International journal of biomedical science : IJBS. 2016 Sep [PubMed PMID: 27829824]|
|||Bair MR,Gross MT,Cooke JR,Hill CH, Differential Diagnosis and Intervention of Proximal Median Nerve Entrapment: A Resident's Case Problem. The Journal of orthopaedic and sports physical therapy. 2016 Sep [PubMed PMID: 27494058]|
|||Olehnik WK,Manske PR,Szerzinski J, Median nerve compression in the proximal forearm. The Journal of hand surgery. 1994 Jan [PubMed PMID: 8169356]|
|||Kowalska B,Sudoł-Szopińska I, Ultrasound assessment on selected peripheral nerve pathologies. Part I: Entrapment neuropathies of the upper limb - excluding carpal tunnel syndrome. Journal of ultrasonography. 2012 Sep [PubMed PMID: 26674101]|
|||Carter GT,Weiss MD, Diagnosis and Treatment of Work-Related Proximal Median and Radial Nerve Entrapment. Physical medicine and rehabilitation clinics of North America. 2015 Aug [PubMed PMID: 26231964]|
|||Bridgeman C,Naidu S,Kothari MJ, Clinical and electrophysiological presentation of pronator syndrome. Electromyography and clinical neurophysiology. 2007 Mar-Apr [PubMed PMID: 17479724]|
|||Bilecenoglu B,Uz A,Karalezli N, Possible anatomic structures causing entrapment neuropathies of the median nerve: an anatomic study. Acta orthopaedica Belgica. 2005 Apr [PubMed PMID: 16152850]|
|||Ulrich D,Piatkowski A,Pallua N, Anterior interosseous nerve syndrome: retrospective analysis of 14 patients. Archives of orthopaedic and trauma surgery. 2011 Nov [PubMed PMID: 21611763]|
|||Keiner D,Tschabitscher M,Welschehold S,Oertel J, Anterior interosseous nerve compression syndrome: is there a role for endoscopy? Acta neurochirurgica. 2011 Nov [PubMed PMID: 21786008]|
|||Svernlöv B,Nylander G,Adolfsson L, Patient-reported outcome of surgical treatment of nerve entrapments in the proximal forearm. Advances in orthopedics. 2011 [PubMed PMID: 21991420]|