Maternal morbidity and mortality are global socioeconomic and healthcare burdens, and postpartum infections account for a significant, and often preventable, portion of that burden. The postpartum period is traditionally defined as the six weeks following delivery, and infections are relatively common, affecting an estimated 5 to 7% of women during this time. Puerperal sepsis is one of the top five causes of maternal deaths worldwide and accounts for 10 to 15% of deaths in the postpartum period. Infections are also the most common cause of death following spontaneous or induced abortions. The medical burden of these infections is compounded by the alarmingly rapid increase in bacterial resistance to commonly used antibiotics.
Postpartum infections also present a significant social burden: they increase maternal anxiety and the risk of postpartum depression, interfere with bonding, and negatively impact breastfeeding. Postpregnancy infections discussed in this review include infections that occur after live births, stillbirths, and spontaneous or induced abortion. Mastitis is not included in this discussion, as it does not directly result from pregnancy or delivery.
The majority of postpartum infections result from physiologic and iatrogenic trauma to the abdominal wall and reproductive, genital, and urinary tracts that occur during childbirth or abortion, which allows for the introduction of bacteria into these normally sterile environments.
In contrast to encouraging global trends, maternal mortality in the United States has been increasing in the past four decades, rising 140% between 1987 and 2013, and the United States has one of the highest pregnancy-related mortality rates of high-income countries. Unfortunately, this disturbing trend cannot be fully attributed to better record-keeping, and, notably, these figures exclude deaths that result following spontaneous and induced abortions as well as maternal deaths following stillbirths, all conditions which are associated with higher maternal morbidity and mortality than live births.
Studying rates of postpartum infections and their effects is difficult, as most of these infections occur following maternal hospital discharge, and decreasing hospital stay following childbirth further inhibits the detection of postpartum complications, including infection. Available data shows that postpartum infections account for 19% of maternal deaths following stillbirth and 34% of deaths following spontaneous or induced abortions.
The latest data from the Centers for Disease Control show that infections are the leading cause of pregnancy-related deaths in Hispanic women in the United States and disproportionately affect ethnic minorities. On the whole, postpartum infections are more common in women who underwent cesarean section as opposed to vaginal delivery, and the risk is further increased for women who underwent labor before the cesarean section.
The risk of postpartum infections is likewise increased in patients at the extremes of maternal age or with high body mass index, diabetes, hypertension, immune compromise, bacterial vaginosis, group-B streptococcus positive status, and sexually transmitted infections. Birth events associated with increased risk of infection include preterm or post-term labor, prolonged rupture of membranes or labor, multiple internal exams, thick meconium staining, internal fetal or uterine monitoring, operative vaginal delivery, manual removal of the placenta, retained products of conception, use of a foley catheter, and postpartum hemorrhage.
Postpartum infections can be roughly grouped into those caused by ascending vaginal microflora into the reproductive tract and those which result from iatrogenic trauma to the abdominal wall or perineum during delivery. Because of the complexity of the birthing process, it is important to remember that ascending vaginal flora plays a role in surgical site infections, and surgical intervention likewise plays a role in the ascension of vaginal microflora into the reproductive tract.
Infections resulting from ascending infection into the reproductive tract include endometritis and septic abortion. Endometritis is an infection of the endometrium and myometrium. Endometritis occurs most commonly in the postpartum period, as childbirth allows ascending vaginal bacterial flora to infect the upper reproductive tract. This infection is five to ten times more common following cesarean section compared to vaginal delivery. Other risk factors include rupture of membranes >18 hours, chorioamnionitis, bacterial vaginosis, use of internal fetal monitoring, repeated vaginal examination, and maternal colonization with group A or B streptococcus. The most common pathogens in endometritis are those normally associated with the reproductive and urinary tracts and include group B streptococci, enterococci, Escherichia coli, and Klebsiella pneumonia.
Chlamydia trachomatis should be suspected in endometritis presenting > 7 days postpartum and in high-risk populations, such as women under age 25. Septic abortion is an infection of the products of conception following spontaneous or induced abortion. Septic abortions result from the migration of vaginal flora through an open os following an incomplete or improperly performed abortion, resulting in infection of the products of conception. Infection may also spread to the uterus. Septic abortions are associated with a high risk of bacteremia, as the infection can enter the maternal blood supply through the intervillous space of the placenta. Mortality from septic abortion is directly correlated with gestational age at the time of pregnancy termination.
As the pregnancy progresses, the placenta enlarges, and there is more tissue to become infected; thus, mortality from septic abortion increases with increasing gestational age. Because they are both caused by ascending urogenital flora, the microbiological profiles of endometritis and septic abortions are similar. However, because of the devitalized tissue present in septic abortions, infections with anaerobic bacteria are more common in this setting.
Surgical site infections (SSI) are relatively common following birth, complicating 2-7% of cesarean deliveries. Episiotomy sites can also become infected. SSI can be broadly divided into deep organ infections and incisional infections, which can be further divided into superficial incisional (involving the skin or subcutaneous tissues) and deep incisional (involving the muscle or fascia) infections. Endometritis following surgical delivery is an example of a deep organ infection; other postpartum deep site infections include infected hematomas and pelvic abscesses. A history of prior cesarean section is correlated with an increased risk of recurrent site infection, likely secondary to baseline poor vascularization of the scar tissue from the prior surgery.
Incisional site infections present with erythema and purulent drainage at the site and can be associated with systemic symptoms such as fever and malaise. Like endometritis and septic abortion, SSI can be caused by contamination of the wound with microflora from the genitourinary tract; however, they can also be caused by commonly isolated skin flora. Infections occurring within the first two postoperative days are most commonly caused by group A or B streptococci. Other commonly isolated pathogens include Ureaplasma urealyticum, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Staphylococcal species.
More rarely, necrotizing fasciitis of the surgical site can develop, characterized by rapid necrosis of the fascia and subcutaneous tissue with relative sparing of the musculature. Postpartum patients who develop necrotizing fasciitis typically have underlying medical comorbidities, with diabetes being the most commonly reported. Type I necrotizing fasciitis results from polymicrobial infection with aerobic and anaerobic organisms; type II results from infection with group A streptococcus. Both types can occur in the postpartum period and can complicate cesarean deliveries as well as episiotomies.
In addition to the classic portions of the history of present illness, important details to elicit during history taking include:
Physical examination should include:
In endometritis, fever is often the first sign, with uterine tenderness, bleeding, and foul-smelling lochia as additional signs. Patients presenting with signs of severe systemic illness, shock, and/or abdominal pain out of proportion to examination findings should raise suspicion for infection with GAS, which can cause endometritis associated with toxic shock syndrome as well as necrotizing fasciitis.
Fever is common in septic abortion but may not be present. Usually, only mild abdominal pain is present, although generalized peritonitis can be seen in severe infection. In addition to GAS, septic abortion associated with sepsis or shock can also occur in the setting of infection with Clostridium species or toxin-producing strains of Escherichia coli.
Superficial incisional site infections typically present with erythema, warmth, and pain at the site; purulent drainage may also be present. These infections occur most commonly 4 to 7 days following surgery; as mentioned above, signs of infection in the first 48 hours should raise suspicion for group A or B streptococci.
Deep incisional infections may show minimal external examination findings, in fact, pain out of proportion to examination is a hallmark of necrotizing fasciitis. Unlike superficial site infections, deep incisional infections are more likely to be associated with fever and hemodynamic compromise. The examination may show skin necrosis or ecchymosis, crepitus, and bullae. Imaging studies may show gas in the soft tissues, but definitive diagnosis and management are surgical; surgery should not be delayed for diagnostic studies, as these infections are rapidly progressive and fatal if not managed promptly.
Septic pelvic thrombophlebitis (SPT) should be suspected in patients with persistent pain, leukocytosis, and fever despite adequate antibiotic therapy for the above conditions for more than 3 to 5 days. Deep organ infections such as an infected hematoma or pelvic abscess should likewise be considered if the patient is not responding to appropriate antibiotics.
As in all infectious conditions, evaluation should include blood and/or wound cultures prior to the initiation of antibiotics. Laboratory findings typical of infection include leukocytosis with neutrophilia and a left shift as well as lactic acidosis. Notably, no postpartum infection can be excluded based on lab work alone, and clinicians should not be falsely reassured if laboratory diagnostics are unremarkable. Endometritis is largely a clinical diagnosis. Findings suggestive of endometritis include fever, abdominal tenderness, and foul-smelling lochia. If septic abortion is suspected based on history, an ultrasound should be obtained to evaluate for retained products of conception.
If the infection has spread to the uterus, gas may be seen in the myometrium on plain film or computed tomography (CT). Surgical site infections are likewise a clinical diagnosis suggested by history and physical examination. If post-surgical deep organ infection is suspected, CT with intravenous contrast may help with diagnosis. Workup for pelvic thrombophlebitis should be initiated if the patient does not defervesce following 3-5 days of appropriately broad-spectrum antibiotics. Pelvic vein thrombosis is typically seen radiologically with CT or magnetic resonance imaging (MRI).
Knowledge of the microbiological profiles of different postpartum infections, local resistance patterns, and the severity of the patient’s illness should guide antibiotic choices. As a general rule, antibiotic regimens, particularly in very sick patients, should have a broad-spectrum of antimicrobial coverage at the beginning and should be narrowed as more clinical evidence from cultures or pathology specimens becomes available. Pharmacists can often help tailor initial antibiotic choices and aid in narrowing the spectrum as care progresses. Consideration should be given to whether the patient is breastfeeding, and all efforts should be made to use antibiotics that will allow the patient to continue breastfeeding safely.
While antibiotic regimens may differ for specific postpartum infections, the foundation of the treatment of most infectious conditions is the same. In patients with hemodynamic compromise, balanced crystalloid fluids should be given to a maximum of 30 ml/kg of ideal body weight. If mean arterial pressure is persistently below 65 mmHg despite adequate fluid resuscitation, a vasopressor should be started. Broad-spectrum antibiotics should be given as soon as possible, and blood cultures should be obtained before antibiotic administration if doing so does not significantly delay antibiotics. If the infection requires surgical intervention, prompt consultation of a surgical service is of utmost importance.
The treatment of endometritis varies with severity. Patients with mild, early endometritis may be able to receive outpatient treatment; shared decision-making between the provider and the patient should always precede the decision to treat on an outpatient basis. Intramuscular and oral regimens can also be used in low-resource settings where intravenous antibiotics may not be an option. In patients who are appropriate for outpatient treatment, potential 14-day regimens include clindamycin 600 mg orally every 6 hours plus gentamicin intramuscularly 4.5 mg/kg every 24 hours; amoxicillin-clavulanate 875 mg orally twice daily; cefotetan 2g intramuscularly every 8 hours; meropenem or imipenem-cilastatin 500 mg intramuscularly every 8 hours; or amoxicillin 500 mg and metronidazole 500 mg every 8 hours.
The listed regimens are safe for breastfeeding patients and resulted in a greater than 85% cure rate in early endometritis. As with all patients receiving outpatient treatment, strict return precautions for worsening symptoms should be given. In patients who will receive intravenous therapy for endometritis, the empiric combination of clindamycin (900 mg every 8 hours or 600 mg every 6 hours) and gentamicin (5 mg/kg daily or 1.5 mg/kg every 8 hours) is the most effective . Ampicillin (3g intravenously every 6 hours) can be added for better coverage of enterococcus and in patients who are GBS positive, as there is increasing resistance to clindamycin among GBS isolates. Parenteral therapy should continue until the patient defervesces and their pain improves. Improvement should be seen in 48 to 96 hours. If the patient does not improve, consider a pelvic abscess or infected hematoma, septic pelvic thrombophlebitis, or infection with enterococcus.
The mainstay of treatment for septic abortion is the removal of the infected products of conception. Broad-spectrum antibiotics should be initiated within an hour of making the diagnosis. In addition to the clindamycin and gentamicin with/or without ampicillin regimen mentioned above, other parenteral regimens include ampicillin (2g every 8 hours), gentamicin (5 mg/kg daily), and metronidazole (500 mg every 12 hours); levofloxacin (500 mg every 12 hours) and metronidazole (500 mg every 12 hours); imipenem (500 mg every 6 hours); piperacillin-tazobactam (4.5 g every 8 hours); or ticarcillin-clavulanate (3.1g every 4 hours). In cases not complicated by a pelvic abscess, intravenous antibiotics should be continued until 48 hours after the patient shows clinical improvement ).
For mild superficial surgical infections without systemic symptoms or purulence, an oral course of antibiotics is typically sufficient. A first-generation cephalosporin like cephalexin should be used when there is no associated purulence. If there is superficial purulence without evidence of an abscess, consider possible infection with methicillin-resistant Staphylococcus aureus and expand coverage accordingly. If the area of erythema and induration extends fewer than 5 centimeters from the incision, there are systemic signs of infection, or there is a concern for an underlying abscess, the wound should be opened, explored, cultured, then packed with moist gauze, which should be changed twice daily. Empiric coverage for genitourinary (as above) organisms should be started.
Necrotizing fasciitis is a surgical emergency that cannot be sufficiently treated with antibiotics. However, pending emergent surgical intervention, broad-spectrum antibiotics should be started. A common regimen is vancomycin and piperacillin-tazobactam with clindamycin, which is used for its anti-toxin activity.
Finally, treatment for SPT is intravenous ampicillin (2 g then 1 g every 4 hours), gentamicin (5 mg/kg daily), and clindamycin (900 mg every 8 hours). The use of heparin remains controversial, as there have been no studies to date that suggest it provides clinical benefit beyond appropriate antibiotic administration.
Postpartum fever is defined as an oral temperature ≥38.0°C (≥100.4°F) on any two of the first 10 days postpartum, excluding the first 24 hours. The first postpartum day is excluded because fevers are common in this period, not associated with increased maternal morbidity, and are typically self-limiting. High temperatures in the postpartum period can be caused by fever or by hyperthermia. Other than infections, deep vein thrombosis, and breast engorgement can also cause fever in the postpartum period. Breast engorgement can be associated with a slight increase in maternal temperature.
Unfortunately, there is no documented cut-off point for what temperature is too high just to be caused by breast engorgement. The presence of myalgias and breast erythema suggest mastitis rather than engorgement as the diagnosis. It is important to remember that postpartum patients can develop infections exclusive of their puerperal status; screening for common infections like urinary tract infections and pneumonia can be done by history and physical examination.
Causes of hyperthermia include serotonin syndrome, neuroleptic malignant syndrome, an overdose of sympathomimetic or anticholinergic agents, withdrawal from ethanol or benzodiazepines, aspirin toxicity, and thyroid storm. History and physical examination are the foundation of evaluation for these diagnoses. A review of the patient's medication list and inquiry regarding initiation of new serotonergic or neuroleptic agents, which may be used for postpartum depression or psychosis, can screen for serotonin syndrome and neuroleptic malignant syndrome.
The hallmark physical examination finding for serotonin syndrome is hyperreflexia and clonus, while for neuroleptic malignant syndrome, lead-pipe rigidity is characteristic. Aspirin toxicity is usually suggested by history; physical examination may show altered mental status, hyperpnea, and abdominal tenderness.
The overdose of sympathomimetic agents presents with tachycardia, hypertension, diaphoresis, and agitation. Withdrawal from benzodiazepines or ethanol can present with tremors, tachycardia, hypertension, and hyperthermia and progress to seizures. Anticholinergic toxicity is characterized by altered mental status, anhidrotic hyperthermia, mydriasis, flushing, and urinary retention. Finally, delivery can precipitate thyroid storm, which presents with hyperthermia, hyperreflexia, nausea, vomiting, and abdominal pain.
All postpartum infections can progress to sepsis, bacteremia, shock, and death if not treated appropriately. Necrotizing fasciitis is especially notable for its rapid progression to fulminant infection and death. A notable complication of endometritis and deep space infections of the pelvis is SPT. Endometritis affects the endometrium and myometrium but can progress beyond the uterus to include abscess, peritonitis, and pelvic thrombophlebitis. SPT results from intimal pelvic vein injury caused by adjacent uterine infection, bacteremia, or trauma from vaginal or surgical delivery. Infection can also involve the ovarian veins and the inferior vena cava. Risk factors include cesarean section and chorioamnionitis.
Poor access to healthcare is not only an important risk factor for developing postpartum infections but a direct factor in treatment delays and associated morbidity and mortality. New mothers may delay care secondary to concern that they will be hospitalized away from their baby. Patients with infection following elective abortion may avoid care due to stigma. Postpartum psychiatric conditions and an increase in domestic violence in the peripartum period may likewise inhibit care. Providers should seek to create a non-judgmental environment for these patients to discuss their concerns and share decision-making regarding the need for hospitalization and antibiotic choices.
While many patient economic and health risk factors cannot be modified in the peripartum period, healthcare providers can modify several factors to decrease the patient risk for infection. Care bundles of evidence-proven measures have been shown to reduce infection associated with cesarean delivery. Recommendations for such measures based on the phase of labor are discussed below and are best carried out by an interprofessional team.
Prior to delivery, interventions can be taken to reduce patient risk for infection. Shaving before delivery should be avoided, and patients should be counseled on this prior to their expected delivery date. In patients with planned surgical delivery, the CDC recommends preoperative showering. While there is no strong evidence for the use of chlorhexidine as the agent of choice, there is limited evidence suggesting its superiority in preventing surgical site infections when compared to soap. Peripartum glycemic control is important; while hypoglycemia should be avoided, evidence has shown that maintaining blood sugar <200 mg/dL is associated with a decrease in surgical site infections. Screening and treatment of bacterial vaginosis have likewise been shown to decrease the risk of postpartum endometritis and may decrease the risk of other surgical site infections. An alcohol-based agent should be used to prepare the skin at the anticipated incision site. For cesarean deliveries, preparation of the vagina with a 4% chlorhexidine solution has been shown to reduce the risk of endometritis. In patients with preterm prelabor rupture of membranes, antibiotics should be used until delivery.
During labor, limiting vaginal examinations during labor and avoiding internal fetal monitoring, if possible, can decrease the risk of postpartum infections. In surgical deliveries, a single dose of prophylactic antibiotics should be given one hour prior to the incision. Providers should pay special attention to dosing preoperative antibiotics according to the patient's weight, as many antibiotics require a dose increase in obese patients. While the American College of Obstetricians and Gynecologists (ACOG) does not specifically recommend redosing of preoperative antibiotics in cesarean section, providers should consider re-dosing prophylactic antibiotics if the surgical delivery is greater than 3-4 hours or complicated by hemorrhage. Manual extraction of the placenta should be avoided when possible. Meticulous hand washing, strict adherence to sterile techniques, and limiting operating room traffic can likewise decrease the patient risk for infection.
Finally, outbreaks of GAS infection in postpartum women have often been linked back to colonized or infected health care providers prompting the CDC to recommend health care worker screening when two or more episodes of postpartum GAS infection cases are identified over a six-month period.
|||Prestinaci F,Pezzotti P,Pantosti A, Antimicrobial resistance: a global multifaceted phenomenon. Pathogens and global health. 2015; [PubMed PMID: 26343252]|
|||Belfort MA,Clark SL,Saade GR,Kleja K,Dildy GA 3rd,Van Veen TR,Akhigbe E,Frye DR,Meyers JA,Kofford S, Hospital readmission after delivery: evidence for an increased incidence of nonurogenital infection in the immediate postpartum period. American journal of obstetrics and gynecology. 2010 Jan; [PubMed PMID: 19889389]|
|||Groer MW,Morgan K, Immune, health and endocrine characteristics of depressed postpartum mothers. Psychoneuroendocrinology. 2007 Feb; [PubMed PMID: 17207585]|
|||Creanga AA, Maternal Mortality in the United States: A Review of Contemporary Data and Their Limitations. Clinical obstetrics and gynecology. 2018 Jun; [PubMed PMID: 29561285]|
|||Tharpe N, Postpregnancy genital tract and wound infections. Journal of midwifery [PubMed PMID: 18455098]|
|||Yokoe DS,Christiansen CL,Johnson R,Sands KE,Livingston J,Shtatland ES,Platt R, Epidemiology of and surveillance for postpartum infections. Emerging infectious diseases. 2001 Sep-Oct; [PubMed PMID: 11747696]|
|||Chang J,Elam-Evans LD,Berg CJ,Herndon J,Flowers L,Seed KA,Syverson CJ, Pregnancy-related mortality surveillance--United States, 1991--1999. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002). 2003 Feb 21; [PubMed PMID: 12825542]|
|||Petersen EE,Davis NL,Goodman D,Cox S,Syverson C,Seed K,Shapiro-Mendoza C,Callaghan WM,Barfield W, Racial/Ethnic Disparities in Pregnancy-Related Deaths - United States, 2007-2016. MMWR. Morbidity and mortality weekly report. 2019 Sep 6; [PubMed PMID: 31487273]|
|||Allen VM,O'Connell CM,Liston RM,Baskett TF, Maternal morbidity associated with cesarean delivery without labor compared with spontaneous onset of labor at term. Obstetrics and gynecology. 2003 Sep; [PubMed PMID: 12962927]|
|||Newton ER,Prihoda TJ,Gibbs RS, A clinical and microbiologic analysis of risk factors for puerperal endometritis. Obstetrics and gynecology. 1990 Mar; [PubMed PMID: 2406660]|
|||Eschenbach DA, Treating spontaneous and induced septic abortions. Obstetrics and gynecology. 2015 May; [PubMed PMID: 25932831]|
|||Ahman E,Shah IH, New estimates and trends regarding unsafe abortion mortality. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2011 Nov; [PubMed PMID: 21885049]|
|||Olsen MA,Butler AM,Willers DM,Devkota P,Gross GA,Fraser VJ, Risk factors for surgical site infection after low transverse cesarean section. Infection control and hospital epidemiology. 2008 Jun; [PubMed PMID: 18510455]|
|||Allen-Bridson K,Gross C,Hebden JN,Morrell GC,Wright MO,Horan T, Healthcare-associated infections studies project: an American Journal of Infection Control and National Healthcare Safety Network data quality collaboration-Ventilator-associated event 1, 2013. American journal of infection control. 2013 Nov; [PubMed PMID: 23972519]|
|||Kawakita T,Landy HJ, Surgical site infections after cesarean delivery: epidemiology, prevention and treatment. Maternal health, neonatology and perinatology. 2017; [PubMed PMID: 28690864]|
|||Chaim W,Bashiri A,Bar-David J,Shoham-Vardi I,Mazor M, Prevalence and clinical significance of postpartum endometritis and wound infection. Infectious diseases in obstetrics and gynecology. 2000; [PubMed PMID: 10805361]|
|||Roberts S,Maccato M,Faro S,Pinell P, The microbiology of post-cesarean wound morbidity. Obstetrics and gynecology. 1993 Mar; [PubMed PMID: 8437791]|
|||Fontes RA Jr,Ogilvie CM,Miclau T, Necrotizing soft-tissue infections. The Journal of the American Academy of Orthopaedic Surgeons. 2000 May-Jun; [PubMed PMID: 10874222]|
|||Barant S,Radbata D,Oberweis D,Jacobs D,Marecaux G,Zielonka E,Maréchal M, [Abdominal necrotizing fasciitis after caesarean delivery]. Revue medicale de Bruxelles. 2016; [PubMed PMID: 28525192]|
|||Almarzouqi F,Grieb G,Klink C,Bauerschlag D,Fuchs PC,Alharbi Z,Vasku M,Pallua N, Fatal Necrotizing Fasciitis following Episiotomy. Case reports in surgery. 2015; [PubMed PMID: 26064762]|
|||ACOG Practice Bulletin No. 195: Prevention of Infection After Gynecologic Procedures. Obstetrics and gynecology. 2018 Jun; [PubMed PMID: 29794678]|
|||Dalton E,Castillo E, Post partum infections: A review for the non-OBGYN. Obstetric medicine. 2014 Sep; [PubMed PMID: 27512432]|
|||Singer M,Deutschman CS,Seymour CW,Shankar-Hari M,Annane D,Bauer M,Bellomo R,Bernard GR,Chiche JD,Coopersmith CM,Hotchkiss RS,Levy MM,Marshall JC,Martin GS,Opal SM,Rubenfeld GD,van der Poll T,Vincent JL,Angus DC, The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23; [PubMed PMID: 26903338]|
|||Meaney-Delman D,Bartlett LA,Gravett MG,Jamieson DJ, Oral and intramuscular treatment options for early postpartum endometritis in low-resource settings: a systematic review. Obstetrics and gynecology. 2015 Apr; [PubMed PMID: 25751198]|
|||Mackeen AD,Packard RE,Ota E,Speer L, Antibiotic regimens for postpartum endometritis. The Cochrane database of systematic reviews. 2015 Feb 2; [PubMed PMID: 25922861]|
|||Udoh A,Effa EE,Oduwole O,Okusanya BO,Okafo O, Antibiotics for treating septic abortion. The Cochrane database of systematic reviews. 2016 Jul 1; [PubMed PMID: 27364644]|
|||Savaris RF,de Moraes GS,Cristovam RA,Braun RD, Are antibiotics necessary after 48 hours of improvement in infected/septic abortions? A randomized controlled trial followed by a cohort study. American journal of obstetrics and gynecology. 2011 Apr; [PubMed PMID: 21195382]|
|||Fitzwater JL,Tita AT, Prevention and management of cesarean wound infection. Obstetrics and gynecology clinics of North America. 2014 Dec; [PubMed PMID: 25454997]|
|||Kamath RS,Sudhakar D,Gardner JG,Hemmige V,Safar H,Musher DM, Guidelines vs Actual Management of Skin and Soft Tissue Infections in the Emergency Department. Open forum infectious diseases. 2018 Jan; [PubMed PMID: 29354655]|
|||Stevens DL,Bisno AL,Chambers HF,Dellinger EP,Goldstein EJ,Gorbach SL,Hirschmann JV,Kaplan SL,Montoya JG,Wade JC, Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014 Jul 15; [PubMed PMID: 24947530]|
|||Haeri S,Baker AM, Estimating risk factors and causes for postpartum febrile morbidity in teenage mothers. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2013 Feb; [PubMed PMID: 23445136]|
|||Spencer JP, Management of mastitis in breastfeeding women. American family physician. 2008 Sep 15; [PubMed PMID: 18819238]|
|||Boushra MN,Miller SN,Koyfman A,Long B, Consideration of Occult Infection and Sepsis Mimics in the Sick Patient Without an Apparent Infectious Source. The Journal of emergency medicine. 2019 Jan; [PubMed PMID: 30396751]|
|||Simon LV,Hashmi MF,Callahan AL, Neuroleptic Malignant Syndrome 2020 Jan; [PubMed PMID: 29489248]|
|||Wolf C,Curry A,Nacht J,Simpson SA, Management of Alcohol Withdrawal in the Emergency Department: Current Perspectives. Open access emergency medicine : OAEM. 2020; [PubMed PMID: 32256131]|
|||Robinson D,Araklitis G, Anticholinergic therapy: A case-based approach. Case reports in women's health. 2020 Jan; [PubMed PMID: 31867226]|
|||Keyal NK,Pokharel N,Khanal S, Thyroid storm presenting as septic shock in the intensive care unit: A Case Series. JNMA; journal of the Nepal Medical Association. 2020 Jan; [PubMed PMID: 32335640]|
|||van Dillen J,Zwart J,Schutte J,van Roosmalen J, Maternal sepsis: epidemiology, etiology and outcome. Current opinion in infectious diseases. 2010 Jun; [PubMed PMID: 20375891]|
|||Burdick H,Pino E,Gabel-Comeau D,McCoy A,Gu C,Roberts J,Le S,Slote J,Pellegrini E,Green-Saxena A,Hoffman J,Das R, Effect of a sepsis prediction algorithm on patient mortality, length of stay and readmission: a prospective multicentre clinical outcomes evaluation of real-world patient data from US hospitals. BMJ health [PubMed PMID: 32354696]|
|||Faure K,Dessein R,Vanderstichele S,Subtil D, [Postpartum endometritis: CNGOF and SPILF Pelvic Inflammatory Diseases Guidelines]. Gynecologie, obstetrique, fertilite [PubMed PMID: 30890463]|
|||DeNoble AE,Heine RP,Dotters-Katz SK, Chorioamnionitis and Infectious Complications after Vaginal Delivery. American journal of perinatology. 2019 Dec; [PubMed PMID: 31238347]|
|||McKinley LP,Wen T,Gyamfi-Bannerman C,Wright JD,Goffman D,Sheen JJ,D'Alton ME,Friedman AM, Hospital Safety-Net Burden and Risk for Readmissions and Severe Maternal Morbidity. American journal of perinatology. 2020 May 5; [PubMed PMID: 32369860]|
|||Kawakita T,Umans JG, Does a Care Bundle Reduce Racial Disparities in Postcesarean Surgical Site Infections? American journal of perinatology. 2019 Nov; [PubMed PMID: 31087317]|
|||Shea SK,Soper DE, Prevention of Cesarean Delivery Surgical Site Infections. Obstetrical [PubMed PMID: 30756124]|
|||Berríos-Torres SI,Umscheid CA,Bratzler DW,Leas B,Stone EC,Kelz RR,Reinke CE,Morgan S,Solomkin JS,Mazuski JE,Dellinger EP,Itani KMF,Berbari EF,Segreti J,Parvizi J,Blanchard J,Allen G,Kluytmans JAJW,Donlan R,Schecter WP, Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA surgery. 2017 Aug 1; [PubMed PMID: 28467526]|
|||Al-Niaimi AN,Ahmed M,Burish N,Chackmakchy SA,Seo S,Rose S,Hartenbach E,Kushner DM,Safdar N,Rice L,Connor J, Intensive postoperative glucose control reduces the surgical site infection rates in gynecologic oncology patients. Gynecologic oncology. 2015 Jan; [PubMed PMID: 25263249]|
|||ACOG Practice Bulletin No. 199: Use of Prophylactic Antibiotics in Labor and Delivery. Obstetrics and gynecology. 2018 Sep; [PubMed PMID: 30134425]|
|||ACOG Practice Bulletin No. 74. Antibiotic prophylaxis for gynecologic procedures. Obstetrics and gynecology. 2006 Jul; [PubMed PMID: 16816087]|
|||ACOG Practice Bulletin No. 199 Summary: Use of Prophylactic Antibiotics in Labor and Delivery. Obstetrics and gynecology. 2018 Sep; [PubMed PMID: 30134418]|
|||Prevention of invasive group A streptococcal disease among household contacts of case patients and among postpartum and postsurgical patients: recommendations from the Centers for Disease Control and Prevention. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2002 Oct 15; [PubMed PMID: 12355382]|