Continuing Education Activity

Join us for an informative Continuing Medical Education (CME) event on de Quervain tenosynovitis, a condition named after the renowned Swiss surgeon Fritz de Quervain, who first described it in 1895. This engaging session will delve into the intricacies of this condition, which involves tendon entrapment within the first dorsal compartment of the wrist. De Quervain tenosynovitis manifests as a thickening and myxoid degeneration of the tendon sheaths, specifically affecting the abductor pollicis longus and extensor pollicis brevis tendons as they traverse through the fibro-osseous tunnel situated along the radial styloid at the distal wrist. Patients with this condition often experience exacerbated pain during thumb movement and radial or ulnar wrist deviation. Additionally, de Quervain tenosynovitis predominantly affects women, particularly those in the late stages of pregnancy or the postpartum period.

This comprehensive CME activity will encompass a thorough exploration of the etiology, clinical presentation, evaluation, and management of de Quervain tenosynovitis. Participants will gain valuable insights into both nonoperative and surgical treatment approaches. Nonoperative strategies typically include immobilization and corticosteroid injections in the first dorsal compartment, relieving most patients. For those cases where conservative treatments fall short, our experts will discuss the surgical release of the first dorsal compartment as a viable solution. Attendees will also have the opportunity to examine the crucial role of the interprofessional healthcare team in evaluating, diagnosing, and managing this condition.

Objectives:

• Identify the etiologies and pathophysiology of de Quervain tenosynovitis.

• Identify the examination procedures necessary to perform on a patient presenting with suspected de Quervain tenosynovitis.

• Determine the treatment and management of de Quervain tenosynovitis.

• Compare possible interprofessional team strategies for improving care coordination and communication to advance the evaluation and treatment of de Quervain tenosynovitis and improve outcomes.

Introduction

De Quervain tenosynovitis, named after Swiss surgeon Fritz de Quervain, is a condition that involves tendon entrapment affecting the first dorsal compartment of the wrist. With this condition, thickening and myxoid degeneration of the tendon sheaths around the abductor pollicis longus and extensor pollicis brevis develop where the tendons pass in through the fibro-osseous tunnel located along the radial styloid at the distal wrist.[1] Pain is exacerbated by thumb movement and radial and ulnar deviation of the wrist.[2][3] The condition typically affects women in the late pregnancy or the postpartum period.[4]

The management starts with nonoperative treatment in the form of immobilization and corticosteroid injection in the first dorsal compartment. The majority of the patients benefit from conservative treatment. In patients where nonoperative treatment doesn't provide pain relief, surgical release of the first dorsal compartment is indicated.[5]

Etiology

While the exact cause of de Quervain tenosynovitis is unclear, it has been attributed to myxoid degeneration with fibrous tissue deposits and increased vascularity rather than acute inflammation of the synovial lining. This deposition results in the thickening of the tendon sheath, painfully entrapping the abductor pollicis longus and extensor pollicis brevis tendons. It is associated with repetitive wrist movements, specifically requiring thumb radial abduction, simultaneous extension, and radial wrist deviation. The classic patient population is mothers of newborns who repeatedly lift a newborn with thumbs radially abducted and wrists going from ulnar to radial deviation.[6] Some possible etiologies for the disease include acute injury to the wrist, increased frictional forces to the wrist by forceful movements of the wrist and the thumb, pathogenic causes, inflammatory ailments, and anatomical variations in the first dorsal compartment.[7][8]

Epidemiology

One study estimated the prevalence of de Quervain tenosynovitis to be 0.5% in men and 1.3% in women, with peak prevalence among those in their forties and fifties.[9] Another study determined the prevalence to be 0.36% in women and 0.13% in men.[10] The condition may be seen more commonly in individuals with a history of medial or lateral epicondylitis. Bilateral involvement is often reported in new mothers or child care providers in whom spontaneous resolution typically occurs once lifting of the child is less frequent.[11][12] Pregnancy and manual labor are two significant risk factors for the disease.[13]

Pathophysiology

The extensor tendons of the wrist are divided into 6 extensor compartments by the extensor retinaculum.[5] The first dorsal compartment of the wrist contains the abductor pollicis longus and extensor pollicis brevis tendons lined by a synovial sheath that separates it from the five other dorsal wrist compartments. As these tendons pass through an approximately 2 cm long fibrous tunnel passing over the radial styloid and under the transverse fibers of the extensor retinaculum, they are at risk for entrapment, particularly in acute trauma or repetitive motion.[8][14] The first compartment gets shrunk due to the thickening of the tendon sheath, causing a "stenosing" tenosynovitis of the wrist.[4]

There is a formation of fibrocartilage in response to the increased stress over the tendon sheaths, leading to its thickening. There is neovascularization seen over the tendon sheaths. Myxoid degeneration is also seen in the tendons in this condition. A septum is often seen in the first dorsal compartment between the two tendons, which not only constricts the volume of the first compartment but also has important considerations in nonoperative as well as operative treatment.[15]

History and Physical

Patients present with radial-sided wrist pain typically worsened by thumb and wrist motion. The condition may be associated with pain or difficulty opening a jar lid. Tenderness overlying the radial styloid is usually present. If present, the swelling over the wrist is generally seen proximal to the radial styloid. The typical patient population is a pregnant woman in the third trimester or a breastfeeding mother who holds her child repeatedly.[16]

There are various provocative clinical tests described for de Quervain tenosynovitis. The Finkelstein test requires the patient to place the thumb in palmar flexion while the examiner does ulnar deviation of the wrist. A positive test is indicated by the induction of sharp pain along the radial wrist at the first dorsal compartment. The Eichhoff test involves asking the patient to clench the thumb with the other fingers while deviating the wrist towards the ulna, which elicits a sharp shooting pain over the radial aspect of the wrist if positive. The WHAT test (causing wrist hyperflexion and thumb abduction) is another provocative clinical test described for this condition.[1]

Evaluation

The diagnosis of de Quervain tenosynovitis is a clinical one based on the typical history and examination findings. While not helpful in confirming the diagnosis, plain radiographs may help differentiate other causes of radial wrist pain, such as thumb carpometacarpal joint osteoarthritis.[17][18] Ultrasonography of the wrist helps in the identification of the septum in the first dorsal compartment, the elucidation of which helps increase the success rates of corticosteroid injections. When opting for surgical management, preoperative identification of the septum through ultrasonography is helpful, as both the subcompartments need to be released to provide effective pain relief.[5]

Treatment / Management

De Quervain tenosynovitis can be self-limiting and may resolve without intervention. For those individuals with persistent symptoms, splinting, systemic anti-inflammatories, and corticosteroid injections are the most frequently utilized nonsurgical treatment options. Splinting with a thumb spica brace may offer patients temporary relief, but failure and recurrence are often high, and compliance is often low.[19][20][21] Splinting may be a temporary measure for patients who don't want to opt for any intervention. Immobilization of the wrist alone may only help relieve pain in patients with mild pain. Moreover, strict immobilization in a thumb spica cast or rigid splint may prove detrimental as it might increase the myxoid degeneration of the involved tendons. Therefore, immobilization in a removable semi-rigid splint may be more helpful.[1]

Corticosteroid injection has been reported to provide near complete relief with one or two injections in 52% to 90% of patients.[22] The injection is performed into the tendon sheath 1 cm proximal to the radial styloid, where the tendons are palpable. An attempt should be made to palpably infiltrate both the abductor pollicis longus and extensor pollicis brevis sheaths as deep as possible in the fibro-osseous tunnel to minimize the risk of subcutaneous atrophy and hypopigmentation. Ultrasound guidance during injection has been reported to allow visualization and adequate injection of the multiple septae and sheaths, which may be present in the first dorsal extensor compartment. The success rate of the corticosteroid injection increases when the procedure is performed under ultrasound guidance.[23] Symptomatic relief is reported by about 50% of patients with a single injection. A second injection may provide relief in another 40% to 45% of patients. Potential steroid injection complications include fat and dermal atrophy and hypopigmentation, typically associated with subcutaneous injection rather than in the tendon sheath. These may improve or resolve over time. Also, multiple injections within a short period may cause weakening of the tendons, causing their thinning and eventual rupture.

Various other nonoperative treatment modalities have also been described in the form of laser therapy, therapeutic ultrasound therapy, and acupuncture, but there is no consensus or high-quality evidence about the effectiveness of these therapies.[24]

If symptoms fail to improve or recur after two corticosteroid injections, operative management is an option. Surgery is usually performed in the outpatient setting. It can entail local, regional, or general anesthesia and typically involves a tourniquet to limit intraoperative bleeding and allow for the identification of critical anatomic structures. This is performed through an approximately 2 cm transverse skin incision over the first dorsal compartment. Using caution to avoid injury to the branches of the superficial radial sensory nerve, the ligament covering the first dorsal compartment is exposed through blunt dissection. The dorsal margin of the sheath is then sharply incised. Subsheaths are identified and incised if present. Once all subcompartments are released, the skin is closed, a bulky, soft dressing is applied, and early mobilization is performed. Multiple variations of surgical techniques have been reported in the literature, including endoscopic approaches and partial excision of the extensor retinaculum. Regardless of the method, high rates of symptomatic relief are reported with low rates of complications.[4]

Post-operative care is usually limited. A simple dressing or wrap is frequently utilized without complex wound care. Patients are advised to begin early use for activities of daily living and other light activities. Once sutures are removed, usually by two weeks, patients are typically released to resume normal activities. Patients may experience mild swelling and tenderness at the surgical site for a few months.

Surgical complications are infrequent but do occur. Local soft tissue infection and wound dehiscence are the most frequent but are typically managed with nonoperative interventions, including oral antibiotics and local wound care, respectively. The superficial radial nerve overlying the first dorsal compartment can be injured due to sharp transection, traction injury, or compression related to scarring. This can result in extreme sensitivity, pain, and paresthesias. While sometimes self-limited, this can rarely require surgical intervention for neurolysis or treatment of a neuroma. Following the release, patients may also experience subluxation of the first dorsal compartment tendons with wrist flexion and extension. This may be bothersome when the tendons rub or sublux over the radial styloid. This may be associated with excessive release of the tendon sheath at the time of surgery. Hypertrophic scarring is another complication seen with the operative management of this condition.[4][5][1]

Differential Diagnosis

The differential diagnoses that can mimic this condition include:

• Osteoarthritis of the first carpometacarpal joint
• Scaphoid fracture
• Radial styloid fracture
• Sensory branch of radial nerve neuritis (Wartenberg's syndrome)
• Intersection syndrome
• Trigger thumb

Prognosis

Most patients are treated successfully with nonoperative management. Corticosteroid injection, with or without immobilization, is effective in many patients. Even when the nonoperative command fails, releasing the first dorsal compartment relieves pain in almost all patients. Hence, the prognosis is usually good for these patients. Certain risk factors for failure of nonoperative treatment include the female sex, hypothyroidism, presence of septum in the first compartment, and psychiatric illness.

Complications

Complications related to surgery include:

• Injury to the superficial radial nerve
• Entrapment of the abductor pollicis longus and extensor pollicis brevis
• Subluxation of the tendons

Deterrence and Patient Education

The patients should be educated about the risk factors of the disease, its treatment options, and potential complications. When multiple steroid injections are required, they should be adequately spaced out by a few weeks to prevent the possible complications associated with the injections.[1]

Enhancing Healthcare Team Outcomes

De Quervain tenosynovitis is a relatively common disorder. The patient may present to several specialists, including a hand surgeon, orthopedic surgeon, primary care provider, or an emergency room physician. Nurses may encounter this disorder at workers' compensation clinics and rehabilitation centers. Finally, some patients may present to a pharmacist and ask for a pain reliever. The key is to make the diagnosis promptly and avoid the morbidity of the condition.

For patients who seek treatment, the outcomes are excellent. For patients who don't get treatment, the resulting pain often results in disability. Surgery has the best outcome but can cause complications. Cortisone injections do work, but recurrences are known to occur. In addition, with cortisone injections, the recovery may take 3 to 9 months. All patients should avoid repetitive actions to prevent the recurrence of symptoms. Some patients may need a job change, and others may need to enroll in long-term hand rehabilitation exercises.[3][25]