Continuing Education Activity

Laparoscopic surgery has gained increasing popularity in clinical practice. As part of laparoscopic surgeries, gas insufflation is usually adopted to increase operative space and visualization for surgeons. The abdomen is the most common location for these laparoscopic interventions, particularly in general and gynecologic surgeries. Carbon dioxide (CO₂) is the most commonly used gas for insufflation during laparoscopic surgery because it is colorless, inexpensive, nonflammable, and has higher blood solubility than air, which reduces the risk of complications if venous embolism occurs. The use of CO₂ gas for insufflation presents some risks. Among the most common complications associated with CO₂ insufflation is CO₂ embolism. Although CO₂ microembolism commonly occurs during laparoscopy, clinically significant emboli are rare and potentially fatal. The clinical sign of CO₂ embolism depends on embolized gas volume and range from asymptomatic to cardiovascular collapse or even death. This activity reviews the epidemiology, pathophysiology, clinical presentation, treatment, and prevention of CO₂ embolisms and the medical team's role in managing this condition.

Objectives:

• Determine the pathophysiology of carbon dioxide embolism.

• Apply the presentation of a patient with carbon dioxide embolism.

• Differentiate the treatment options for carbon dioxide embolism.

• Communicate the medical team's role in managing patients with a carbon dioxide embolism.

Introduction

Laparoscopic surgery has gained increasing popularity in clinical practice. As part of laparoscopic surgeries, gas insufflation is usually adopted to increase operative space and visualization for surgeons. The abdomen is the most common location for these laparoscopic interventions, particularly gastrointestinal and gynecologic surgeries. Carbon dioxide (CO₂) is the most commonly used gas for insufflation during laparoscopic surgery because it is colorless, inexpensive, non-flammable, and has higher blood solubility than air, which reduces the risk of complications if venous embolism occurs.[1]

The use of CO₂ gas for insufflation presents some risks. Among the most common complications associated with CO₂ insufflation is CO₂ embolism. Although CO₂ micro embolism commonly occurs during laparoscopy, clinically significant emboli are rare and potentially fatal. The clinical sign of CO2 embolism depends on the volume of embolized gas and range from asymptomatic to cardiovascular collapse or even death. This topic reviews the epidemiology, pathophysiology, clinical presentation, treatment, and prevention of CO₂ embolisms.

Etiology

CO₂ embolism may occur during insufflation of the abdomen for laparoscopic surgeries. This usually occurs due to the accidental placement of the Veress needle into an organ or large vessel.[2] After negative aspiration, the insertion of the Veress needle and subsequent CO₂ insufflation are both techniques performed without visual guidance. Later onset embolism may be associated with injured vessels that allow CO₂ to enter the circulation.[3]

Epidemiology

The incidence of CO₂ embolism is very rare. A recent meta-analysis reported 7 in 489335 laparoscopic surgeries (0.001%).[4]  However, when transesophageal echocardiography (TEE) was used during laparoscopic surgery to monitor for CO₂ embolism, the incidence of any grade of gas embolism during laparoscopic surgeries varied widely. The incidence of CO₂ embolism varied between 6.25% and 100%.[5][6] Despite these variations in incidence, clinically significant CO₂ embolism remains fatal, with mortality as high as 28%.[7]

Pathophysiology

Two possible mechanisms can explain the pathophysiology of CO₂ embolism:

1) CO₂ embolism can occur from the accidental intravascular injection of CO₂, which may arise from the inappropriate placement of the Veress needle within the intravascular space. A similar mechanism is possible with trocar insertion.

2) CO₂ embolism can also result from gas entering injured vessels, abdominal walls, or operative sites. This proposed mechanism results in less profound clinical change and may explain late-onset CO₂ embolism.

The volume of gas entrained affects clinical presentation. In a study on cardiopulmonary responses to experimental venous CO₂ embolism in pigs, researchers found a mortality of 60% at a continuous intravenous CO₂ infusion rate of 1.2 mL/kg/min.[8] When converted for a 60 kg person, this equates to a rate of 72 mL/min and represents approximately 5% of the volume of CO₂ that could be infused into a vein by a Veress needle in 1 minute at a low-flow rate.[8]

Gas in the venous circulation may obstruct pulmonary circulation and cause cardiac symptoms, including cardiovascular collapse and neurological sequelae.[2] It is associated with hypotension, increased central venous pressure (CVP), pulmonary arterial pressure (PAP), and hypoxemia.[9] In patients with patent foramen ovale, paradoxical arterial embolism may be possible and can result in transient or permanent neurological deficits.

History and Physical

CO₂ embolism may be small, asymptomatic, transient, and self-resolving. Signs of gas embolism include systemic hypotension, tachypnea, dyspnea, cyanosis, tachycardia or bradycardia, arrhythmia, asystole, or “mill-wheel” splashing auscultatory murmur.[6] Paradoxical embolism may be associated with altered mental status, focal neurological deficits, or loss of consciousness.

Evaluation

Transesophageal (TEE) is the most sensitive method for detecting subclinical intravenous CO₂ as small as 0.1mL/kg.[10] The TEE transgastric view has been shown to identify CO₂ embolism optimally.[11][12][13] The transesophageal Doppler is a highly sensitive but less expensive alternative to TEEs.[13] The precordial Doppler may also be used but has a high false-negative rate associated with the positioning of the probe.[6] Standard intraoperative noninvasive monitors can aid in detecting CO₂ embolism, albeit with less sensitivity. Five-lead ECG may show right ventricular strain as indicated by widened QRS complex, right bundle branch block, and right axis deviation. A sudden decrease or loss of end-tidal CO₂ suggests a drastic decrease in cardiac output due to gas embolism. Continuous pulmonary arterial pressure can be used to evaluate for gas embolism.[6]

Treatment / Management

Management of a suspected CO₂ embolism begins with desufflation of the abdomen.[14] Surgeons should be informed immediately and stop insufflation when there is clinical suspicion of CO₂ embolism. Note that hemorrhage is possible when the intraabdominal pressure is reduced since the embolism may have been due to a vascular injury. The Durant or Trendelenburg position directs the gas bubble into the right ventricle apex and away from the pulmonary artery.[2][15]

Ventilation with 100% oxygen could wash out CO₂, reduce ventilation-perfusion mismatch, and improve hypoxemia.[16] Hyperventilation is also used to help eliminate CO₂. While the placement of a multi-orifice central venous catheter may be a consideration in surgeries with a high risk of air embolism (eg, specific neurosurgical cases) to perform an aspiration, placement of a central venous catheter in an unanticipated case of CO₂ embolism would be more beneficial for potential vasopressor administration, although aspiration could be attempted.[2]

Also, hyperbaric oxygen may reduce bubble size in patients experiencing neurologic deficits. Supportive treatment with fluid, vasopressors, and cardiopulmonary bypass may be necessary for patients with severe cardiovascular collapse.[6]

Differential Diagnosis

The differential diagnoses for a carbon dioxide embolism includes the following:

• Air embolism
• Pulmonary embolism
• Pneumothorax
• Bronchospasm
• Pulmonary edema
• Hypovolemia
• Cardiogenic shock
• Myocardial infarction
• Septic shock
• Electromechanical dissociation
• Cerebral hypoperfusion
• Stroke
• Other embolisms (eg, amniotic fluid, fat)

Prognosis

The prognosis varies depending on the size of the embolism and the severity of clinical presentation.

Complications

The complications that can manifest with carbon dioxide embolisms are as follows:

• Cardiac arrest
• Neurological sequelae (eg motor deficits, cognitive deficits, seizures)
• Death

Deterrence and Patient Education

Prevention of CO₂ embolism targets potential methods of gas entry into circulation during laparoscopic surgery. Correct positioning of the Veress needle should be verified with a negative aspiration of blood before insufflation with a low flow rate and low-pressure setting, or alternative modes of entry and pneumoperitoneum creation should be utilized.[14] Low insufflation pressure during laparoscopic surgery may diminish the pathophysiological changes. After properly placing the trocars, patients should be placed in the Trendelenburg position.[2] Positive end-expiratory pressure (PEEP) of 5 cm H₂O may be used intraoperatively to decrease atelectasis caused by pneumoperitoneum.[17]

Enhancing Healthcare Team Outcomes

Minimally invasive laparoscopic procedures have increased in popularity and, in many cases, have superseded traditionally open surgical procedures. Patients should be assessed via preoperative medical evaluation to determine cardiopulmonary risks and anticipate possible complications. Additionally, it is important to foster a “speak up” culture where all interprofessional team members feel comfortable communicating potential concerns related to patient safety.[18]

An alternative to using the Veress needle technique is applying the Hasson technique to establish pneumoperitoneum.[4] In a systematic review, gas embolism was 0.001% (7/489000 cases) with the Veress needle, while no embolisms were reported in 12444 cases using the Hasson technique.[4]

Further, reducing the insufflation pressure can reduce the risk of CO₂ embolism. In a randomized trial of 498 patients undergoing endoscopic saphenous vein harvesting, the incidence of CO₂ embolisms was significantly higher in the high insufflation pressure group (15 mg Hg CO₂) than in the low insufflation group (12 mg Hg CO2).[11]

The healthcare team must coordinate to prevent CO₂ embolism by preventing gas entry into circulation during laparoscopic surgery. Correct positioning of the Veress needle should be verified with a negative aspiration of blood before insufflation with a low flow rate and low-pressure setting, or alternative modes of entry and pneumoperitoneum creation should be utilized. Operative specialty-trained nurses assisting in surgery can identify issues and call the surgeon's attention. Perioperative nurses monitor patients and provide feedback to the team.