Vertigo is the allusion of movement, a perception of motion though none exists. It is a sensation of swaying, tilting, spinning, or feeling unbalanced, which may be experienced as self-motion to some versus movement of the surrounding environment to others. Due to highly variable descriptions of the vertigo experience, it is often consolidated into the umbrella term “dizziness,” which is a very common complaint, accounting for over three million emergency department (ED) visits annually. Vertigo can be of vestibular or peripheral origin or be due to non-vestibular or central causes. With regards to peripheral vertigo, benign paroxysmal positional vertigo (BPPV) is the most common cause, accounting for over one-half of all cases. It is of great importance to identify BPPV versus other causes of vertigo as the differential diagnosis includes a spectrum of diseases processes ranging from benign to life-threatening.
Benign paroxysmal positional vertigo occurs due to the displacement of calcium-carbonate crystals or otoconia within the fluid-filled semicircular canals of the inner ear. These otoconia are essential to proper functioning of the utricle of the otolithic membrane by helping deflect the hair cells within endolymph, which relays positional changes of the head including tilting, turning, and linear acceleration.
Dizziness, including vertigo, affects 15% to 20% of adults yearly based on population studies. The lifetime prevalence of BPPV specifically was found to be 2.9%, and incidence increases with age due to age-related degeneration of the otolithic membrane. Additionally, BPPV is about two to three times more common in women versus men. 
With BPPV, otoconia (also known as “otoliths” or “canaliths”) dislodge and settle within the endolymph of the semicircular canals. When the head remains static, there is no stimulus causing the hair cells to fire. With motion, however, the displaced otoconia shift within the fluid, and the subsequent stimulus is unbalanced with respect to the opposite ear, inappropriately causing symptoms of dizziness, spinning, and/or swaying. Hence, symptoms of BPPV are profound with movement but classically lessen with rest.
A detailed history and physical are imperative to the evaluation of vertigo since differentiating vestibular versus central, potentially life-threatening, processes is of critical importance. Ask open-ended questions to obtain the best possible description of symptoms. Ask regarding the timing of symptoms and context, as well as exacerbating and alleviating factors. Inquire about recent viral infections due to association with labyrinthitis and about trauma, recent neurosurgery, and medications that may be ototoxic as this may suggest an alternate diagnosis. Relapses are common, so a history of recurrent vertiginous spells suggests BPPV. Due to age-related degeneration of the otolithic membrane, BPPV frequently occurs in the elderly population, though close consideration must be made for central causes of vertigo, which also correlate with increasing age and cerebrovascular disease.
Classically, the symptoms of BPPV are sudden in onset, provoked by movement, and decreased with rest. The Dix-Hallpike test is a diagnostic maneuver that can be performed quickly and easily to evaluate for BPPV. It is based on the anatomical properties of the inner ear, which predispose displaced otoconia to settle in the posterior semicircular canal. Theoretically, otoconia may settle in the superior or lateral semicircular canals, leading to a negative test, though with a sensitivity of 79% and specificity of 75%, this maneuver does have clinical utility. The Dix-Hallpike helps localize the affected ear by exacerbating both symptoms and clinical signs such as nystagmus. Subsequently, the Epley maneuver can be performed, coercing the crystals back into the utricle and removing the disturbance from the otolithic membrane. The Epley can promptly relieve symptoms, though relapses are common. Additionally, the Epley is often not tolerated by elderly patients as well as those with active nausea/vomiting and those with profound symptoms who cannot cooperate. The Epley is contraindicated in cervical spine injury/abnormality, such as possible atlantoaxial subluxation, as well as in patients with possible carotid or vertebral artery dissection. In addition to these special tests, it is imperative to perform a full neurological exam, including cranial nerves, coordination, and gait. The neurological exam is expectedly normal in BPPV with a few exceptions. Patients with BPPV can demonstrate nystagmus, which is typically horizontal and unidirectional as well as fatigable, meaning it peaks in intensity but subsequently tapers off. Vertical, torsional, or direction-changing nystagmus should raise concern for the central cause. With BPPV, there is a latency period of 30 seconds or less between provocative head movement and onset of nystagmus. Also, the otoconia in BPPV cause aberrant impulses to be fired from the semicircular canals via cranial nerve VIII, impairing the vestibular-ocular reflex. Patients with BPPV will have issues coordinating head movement with extra-ocular movement, leading to an abnormal head impulse test. The HiNTS exam, which includes nystagmus and head impulse testing, is a sequence of tests to help discern central versus peripheral causes of dizziness. It would be of value to perform in the physical exam of patients being evaluated for possible BPPV.
BPPV is largely a clinical diagnosis, and often the battery of laboratory and imaging tests ordered only help rule-out other possibilities. As above, obtaining a good history and performing a thorough neurological exam is imperative. Laboratory studies are not found to be helpful. Imaging of the head in BPPV is unremarkable. Head CT and MRI are useful to rule-out infarct, hemorrhage, masses/tumors, or other pathology that would suggest alternative causes of vertigo. The Dix-Hallpike, if it can be tolerated, should be performed as a provocative test to observe for expected changes in symptoms and to localize which inner ear is involved.
After using the Dix-Hallpike maneuver to localize which side is problematic, the Epley maneuver can be performed. This series of positional changes helps dislodge otoconia from the otolithic membrane and back into the utricle, removing the disturbance and symptomatology. As aforementioned, the Dix-Hallpike and Epley are not always tolerated by patients with BPPV, in which case treatment is symptomatic. Antihistamines address vertigo by suppressing labyrinth excitability and vestibular end-organ receptors. The antihistamine best-supported in the literature for vertigo is Meclizine, 25 mg to 100 mg daily. Vertigo associated with BPPV is typically abrupt in onset, very brief, and truly paroxysmal, just as the name suggests, and medications may not be particularly beneficial. Hence, routine medical management with Meclizine is not indicated unless the frequency of vertigo spells is high and disruptive to daily function. Nausea and vomiting is another common complaint with BPPV and can be treated with anti-emetics as needed: ondansetron, metoclopramide, or promethazine/prochlorperazine. Patients with recurrent BPPV should be provided with ENT referral for further evaluation as there are lateral and horizontal canal variants of BPPV that require specific re-positioning maneuvers different from the Epley.
Vestibular neuritis, labyrinthitis, brainstem or cerebellar infarction, brainstem or cerebellar hemorrhage, traumatic vestibulopathy, cerebellopontine angle neoplasm, vestibular migraine, medication ototoxicity, herpes zoster oticus, decompression sickness, brainstem encephalitis, vertebrobasilar insufficiency, vertebral artery dissection.
Persistent nausea and vomiting
BPPV is a very common presentation in primary care. It is estimated that at least 20% of patients will complain of vertigo during a clinic visit. Tragically, the condition is often misdiagnosed and patients are erroneously treated for some other disorder, leading to very high morbidity. Primary care physicians, nurse practitioners, urgent care providers and emergency department physicians must be aware of this disorder and know how to manage it. Once the diagnosis is made and treatment initiated, the prognosis is good. Most people develop symptom resolution in 4-6 weeks, although in some patients the symptoms persist. Despite optimal treatment, there is a recurrence rate of 5-25%. The risk of recurrence is higher in females, older patients and those with psychiatric comorbidities. (Level V)
|||Parker IG,Hartel G,Paratz J,Choy NL,Rahmann A, A Systematic Review of the Reported Proportions of Diagnoses for Dizziness and Vertigo. Otology [PubMed PMID: 30439765]|
|||Alimoğlu Y,Altın F,Açıkalın RM,Yaşar H, Two-Hour Follow-Up is Equivalent to One-Day Follow-Up of Posterior Canal Benign Paroxysmal Positional Vertigo. The journal of international advanced otology. 2018 Nov 9 [PubMed PMID: 30411707]|
|||Male AJ,Ramdharry GM,Grant R,Davies RA,Beith ID, A survey of current management of Benign Paroxysmal Positional Vertigo (BPPV) by physiotherapists' interested in vestibular rehabilitation in the UK. Physiotherapy. 2018 Sep 5 [PubMed PMID: 30389100]|
|||Zamergrad MV,Grachev SP,Gergova AA, [Acute vestibular disorder in the elderly: stroke or peripheral vestibulopathy]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018 [PubMed PMID: 30346433]|
|||Bruintjes TD,van der Zaag-Loonen HJ,Eggelmeijer F,van Leeuwen RB, The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2018 Dec [PubMed PMID: 30315360]|
|||Power L,Murray K,Szmulewicz D, Early experience with a multi-axial, whole body positioning system in the treatment of Benign Paroxysmal Positional Vertigo (BPPV). Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2018 Oct 27 [PubMed PMID: 30377044]|
|||Lloyd M,Mackintosh A,Grant C,McManus F,Kelly AM,Karunajeewa H,Tang CY, Evidence-based management of patients with vertigo, dizziness, and imbalance at an Australian metropolitan health service: an observational study of clinical practice. Physiotherapy theory and practice. 2018 Oct 17 [PubMed PMID: 30332324]|
|||Luryi AL,LaRouere M,Babu S,Bojrab DI,Zappia J,Sargent EW,Schutt CA, Traumatic versus Idiopathic Benign Positional Vertigo: Analysis of Disease, Treatment, and Outcome Characteristics. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2018 Oct 16 [PubMed PMID: 30324864]|
|||Pérez-Vázquez P,Franco-Gutiérrez V,Soto-Varela A,Amor-Dorado JC,Martín-Sanz E,Oliva-Domínguez M,Lopez-Escamez JA, Practice Guidelines for the Diagnosis and Management of Benign Paroxysmal Positional Vertigo Otoneurology Committee of Spanish Otorhinolaryngology and Head and Neck Surgery Consensus Document. Acta otorrinolaringologica espanola. 2018 Nov - Dec [PubMed PMID: 28826856]|
|||Britt CJ,Ward BK,Owusu Y,Friedland D,Russell JO,Weinreich HM, Assessment of a Statistical Algorithm for the Prediction of Benign Paroxysmal Positional Vertigo. JAMA otolaryngology-- head [PubMed PMID: 30178063]|
|||Luryi AL,Lawrence J,Bojrab D,LaRouere M,Babu S,Hong R,Zappia J,Sargent E,Chan E,Naumann IC,Schutt CA, Patient, disease, and outcome characteristics of benign paroxysmal positional vertigo with and without Meniere's disease. Acta oto-laryngologica. 2018 Jul 17 [PubMed PMID: 30016894]|