A 55-year-old male with diabetes mellitus is admitted with a severe infection of his face. The patient has a very high fever, is in septic shock, and the entire right face appears necrotic. What is the most likely organism?
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Mucormycosis is caused by Mucorales fungi, an opportunistic fungus. The fungi commonly infect persons with diabetes mellitus or individuals who are immunosuppressed.
Mucorales fungi have great potential to invade the local tissues and cause rapid fulminating of the surrounding tissue.
On microscopy, the fungus is broad-based and has a right-angle appearance. Most patients have a poor prognosis after acquiring mucormycosis.
Mucormycosis is characterized by hyphae growing around blood vessels and can be life-threatening in patients with diabetes mellitus or those who are severely immunocompromised. "Mucormycosis" and "zygomycosis" often are used interchangeably; however, Zygomycota has been identified as polyphyletic and is not included in fungal classification systems. While zygomycosis includes Entomophthorales, mucormycosis excludes this group.
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Pediatric Lab Normals
An Interesting Case of a 57-Year-Old Male with an Upper Gastrointestinal Bleeding and Obstructive Uropathy with Bilateral Hydronephrosis Diagnosed with Systemic Mucormycosis., Izaguirre-Anariba DE,Chee F,Thet Z,Lanza J,, Case reports in infectious diseases, 2018 [PubMed PMID: 30026991]
Successful treatment of pulmonary mucormycosis in two pediatric hematopoietic stem cell transplant patients., Elgarten CW,Levy EM,Mattei P,Fisher BT,Olson TS,Freedman JL,, Pediatric transplantation, 2018 Jul 16 [PubMed PMID: 30014584]
Orbitocerebral mucormycosis and intracranial haemorrhage: a role for caution with steroids in suspected giant cell arteritis., Bhatt H,Zilani G,Hayhurst C,, BMJ case reports, 2018 Jul 15 [PubMed PMID: 30012677]
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