Which of the following platelets should be used for transfusion to minimize human leukocyte (HLA) antibody formation?
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Platelets can be pooled from multiple random donors, or plateletpheresis can be used to obtain multiple units from a single donor.
Pooled platelets are less expensive and easier to collect and process, but they have increased contamination risks and expose the recipient to the antigens of multiple donors. Apheresed single donor platelets are more expensive but reduce the risk of transfusion-transmitted diseases and HLA antibody formation.
Prophylactic transfusions should be done when the platelet count is less than 10,000 per microliter. For routine use, a transfusion of four to six units is adequate for most patients and can increase the platelet count by 30,000.
ABO compatibility is preferred but not required. ABO compatible platelets are more effective at increasing the patient's platelet count.