What is the one major difference between Crohn disease and ulcerative colitis?
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The main difference between Crohn disease and ulcerative colitis is the location and nature of the inflammatory reaction.
Crohn disease can occur anywhere in the gastrointestinal tract with skip lesions, whereas ulcerative colitis is limited to the colon.
Microscopically, ulcerative colitis is localized to the mucosa, whereas Crohn disease is transmural.
Both disorders produce extraintestinal manifestations including arthritis, skin lesions, and eye problems.
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