A 55-year-old homeless male presents with gynecomastia, spider angiomata, and testicular atrophy. What is the typical pattern of liver enzymes in the suspected condition?
Select Your Answer:
The diagnosis of liver disease secondary to alcohol use can be challenging. Often patients are not forthcoming about intake. Certain physical and laboratory findings can be helpful. Dependence on alcohol is not found in all those with alcoholic liver disease. Aspartate aminotransferase (AST) is double alanine aminotransferase (ALT) in more than 80% of patients with alcoholic liver disease.
Gamma-glutamyltransferase is the best indicator of recent alcohol intake but the enzyme is also found in organs other than the liver and can be increased secondary to other causes.
Elevated alkaline phosphatase is seen in diseases of liver and bone. It is not specific to alcohol injury.
Elevated bilirubin also is found in many liver diseases. It is not specific to alcohol injury.
*eMedicine, Google Scholar, UpToDate, WheelessOnline, and DermNet are not affiliated with StatPearls. We do not control their content or advertising.
Adult Lab Normals
Pediatric Lab Normals
Future Trends in the Treatment of Non-Alcoholic Steatohepatitis., Fiorucci S,Biagioli M,Distrutti E,, Pharmacological research, 2018 Jul 15 [PubMed PMID: 30021122]
Does Nox2 over-activate in children with non-alcoholic fatty liver disease?, Loffredo L,Zicari AM,Perri L,Carnevale R,Nocella C,Angelico F,Del Ben M,Mosca A,Zaffina S,Panera N,Alisi A,Duse M,Violi F,Nobili V,, Antioxidants & redox signaling, 2018 Jul 18 [PubMed PMID: 30019598]
Non-heavy drinking and worsening of non-invasive fibrosis markers in nonalcoholic fatty liver disease: A cohort study., Chang Y,Cho YK,Kim Y,Sung E,Ahn J,Jung HS,Yun KE,Shin H,Ryu S,, Hepatology (Baltimore, Md.), 2018 Jul 17 [PubMed PMID: 30019340]
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation., Tang Y,Cao G,Min X,Wang T,Sun S,Du X,Zhang W,, Journal of physiology and biochemistry, 2018 Jul 17 [PubMed PMID: 30019185]
Activation of the CXCL16/CXCR6 pathway promotes lipid deposition in fatty livers of apolipoprotein E knockout mice and HepG2 cells., Ma KL,Wu Y,Zhang Y,Wang GH,Hu ZB,Ruan XZ,, American journal of translational research, 2018 [PubMed PMID: 30018721]