A patient is placed on therapy with an antipsychotic drug. Four weeks later, he presents with fever, catatonia, stupor, and Parkinsonian features suggestive of neuroleptic malignant syndrome. Which of the following medications is most appropriate?
Select Your Answer:
Dantrolene is a muscle relaxant. It acts on the ryanodine receptor.
Dantrolene is used to treat malignant hyperthermia that is triggered by general anesthesia.
Dantrolene also is used to treat malignant neuroleptic syndrome, muscle spasticity, cerebral palsy, and MPTP intoxication.
Dantrolene cannot be used in individuals with liver dysfunction, compromised lung, and heart impairment.
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Managing Manic Delirium in Bipolar Disorder With Features of Mania, Catatonia, and Neuroleptic Malignant Syndrome., Singh G,Akinyemi E,, The primary care companion for CNS disorders, 2017 Dec 21 [PubMed PMID: 29272572]
[Neuroleptic malignant syndrome]., Knorr R,Schöllkopf J,Haen E,, Der Nervenarzt, 2017 Dec 5 [PubMed PMID: 29209753]
Neuroleptic Malignant Syndrome After Early Administration of Risperidone Long-Acting Injection., Mitchell BG,McMahon BC,Mitchell CW,, The primary care companion for CNS disorders, 2017 Nov 30 [PubMed PMID: 29195036]
Neuroleptic malignant syndrome (NMS) associated with amisulpride and sertraline use: A case report and discussion., Uvais NA,Gangadhar P,Sreeraj VS,Rafeeque PA,, Asian journal of psychiatry, 2017 Nov 7 [PubMed PMID: 29174670]
Neuroleptic malignant syndrome: a review for neurohospitalists., Berman BD,, The Neurohospitalist, 2011 Jan [PubMed PMID: 23983836]
Mortality from neuroleptic malignant syndrome., Shalev A,Hermesh H,Munitz H,, The Journal of clinical psychiatry, 1989 Jan [PubMed PMID: 2562951]
Haloperidol in neuroleptic malignant syndrome., Shalev A,Ursano RJ,, The American journal of psychiatry, 1988 May [PubMed PMID: 3358478]
The role of external heat load in triggering the neuroleptic malignant syndrome., Shalev A,Hermesh H,Munitz H,, The American journal of psychiatry, 1988 Jan [PubMed PMID: 2892428]
Neuroleptic Malignant Syndrome: Complications, Outcomes, and Mortality., Modi S,Dharaiya D,Schultz L,Varelas P,, Neurocritical care, 2016 Feb [PubMed PMID: 26223336]
Neuroleptic malignant syndrome., Strawn JR,Keck PE Jr,Caroff SN,, The American journal of psychiatry, 2007 Jun [PubMed PMID: 17541044]
Residual catatonic state following neuroleptic malignant syndrome., Caroff SN,Mann SC,Keck PE Jr,Francis A,, Journal of clinical psychopharmacology, 2000 Apr [PubMed PMID: 10770467]
Clinical and pharmacologic risk factors for neuroleptic malignant syndrome: a case-control study., Berardi D,Amore M,Keck PE Jr,Troia M,Dell'Atti M,, Biological psychiatry, 1998 Oct 15 [PubMed PMID: 9798079]