This content is provided by StatPearls
Build quizzes with our comprehensive database in your specialty and track your progress. See your score history and get additional learning resources.Signup For Free Access!
A 69-year-old radiologist develops an acute intense headache combined with slurring of the speech and confusion. In the emergency department, he is found to have a Glasgow coma scale of 7. An emergent CT scan of the brain reveals a well-demarcated site with bleeding in the left frontal lobe. The bleeding appears to be centered in the cortex. The patient has no other pertinent history and does not take any medications. Which of the following is most likely responsible for his findings?
Select Your Answer:
Teaching Points
- Cerebral amyloid angiopathy (CAA) is secondary to deposition of beta amyloid in the arterioles and small arteries of the brain and leptomeninges. It also is seen in Alzheimer disease.
- In cerebral amyloid angiopathy, there is intracerebral bleeding in the neocortex in a specific lobe.
- The hematoma is centered in the cerebral cortex and seen on CT scan.
- The majority of patients are over 60 years, and there is rarely blood in the cerebrospinal fluid. Patients suffering from CAA-related bleeding may not have Alzheimer disease.
StatPearls Review Article:
Click here to become an author
*eMedicine, Google Scholar, UpToDate, WheelessOnline, and DermNet are not affiliated with StatPearls. We do not control their content or advertising.
Adult Lab Normals
Pediatric Lab Normals
Calculator
PubMed References
| Journal Club: Florbetapir imaging in cerebral amyloid angiopathy-related hemorrhages., Charidimou A,Giese AK,Pasi M,van Veluw SJ,Xiong L,Fotiadis P,Marini S,Schirmer MD,Viswanathan A,, Neurology, 2018 Sep 18 [PubMed PMID: 30224502] | |
| The Clinical Dilemma of Anticoagulation Use in Patients with Cerebral Amyloid Angiopathy and Atrial Fibrillation., Cannistraro RJ,Meschia JF,, Current cardiology reports, 2018 Sep 12 [PubMed PMID: 30209626] | |
| Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer's Disease with or without Acute 3D6 Immunotherapy., Gustafsson S,Gustavsson T,Roshanbin S,Hultqvist G,Hammarlund-Udenaes M,Sehlin D,Syvänen S,, Neuropharmacology, 2018 Sep 7 [PubMed PMID: 30201212] | |
| Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke., Howe MD,Atadja LA,Furr JW,Maniskas ME,Zhu L,McCullough LD,Urayama A,, Neurobiology of aging, 2018 Aug 9 [PubMed PMID: 30172921] | |
| Assessment of pathological features in Alzheimer's disease brain tissue with a large field-of-view visible-light optical coherence microscope., Lichtenegger A,Muck M,Eugui P,Harper DJ,Augustin M,Leskovar K,Hitzenberger CK,Woehrer A,Baumann B,, Neurophotonics, 2018 Jul [PubMed PMID: 30137880] |
