A 55-year-old rancher has both basal cell and squamous cell skin cancers, as well as Mees lines in the fingernails. What water contaminant has he most likely been drinking for a long time?
Select Your Answer:
Skin cancers in areas normally unexposed to sunlight warrant a consideration of arsenic intake.
Mees lines represent arsenic deposits in the nails.
In the United States, the maximum concentration in drinking and bottled water is 10 ppb. The IDLH (immediately dangerous to life and health) value for arsenic metal and inorganic arsenic compounds are 5 mg/m3.
Based on non-carcinogenic effects, the United States Food and Drug Administration set the "level of concern" for inorganic arsenic in apple and pear juices at 23 ppb. In consideration of apple juice consumption by children, exposure, and carcinogenic effect, the FDA established 10 ppb for apple juice, the same level as the drinking water standard. Internationally, there has been a concern about arsenic in rice. Children should not eat more than 1.5 servings per week of rice and should not drink rice milk as part of their daily diet before age 5.
*eMedicine, Google Scholar, UpToDate, WheelessOnline, and DermNet are not affiliated with StatPearls. We do not control their content or advertising.
Adult Lab Normals
Pediatric Lab Normals
Arsine toxicity is induced by inhalation but not by percutaneous exposure in hairless mice., Kato K,Yamanaka K,Shimoda Y,Yamano Y,Nagano K,Hata A,Endo Y,Tachikawa M,Endo G,, The Journal of toxicological sciences, 2014 Apr [PubMed]
Speciation without chromatography using selective hydride generation: inorganic arsenic in rice and samples of marine origin., Musil S,Pétursdóttir ÁH,Raab A,Gunnlaugsdóttir H,Krupp E,Feldmann J,, Analytical chemistry, 2014 Jan 21 [PubMed]
Levels and chemical speciation of arsenic in representative biota and sediments of a tropical mangrove wetland, India., Fattorini D,Sarkar SK,Regoli F,Bhattacharya BD,Rakshit D,Satpathy KK,Chatterjee M,, Environmental science. Processes & impacts, 2013 Apr [PubMed]
Oxygen versus sulfur: Structure and reactivity of substituted arsine oxides and arsine sulfides., Orthaber A,Sax AF,Francesconi KA,, Journal of computational chemistry, 2012 Jan 5 [PubMed]
[Arsine: an unknown industrial chemical toxic]., Plantamura J,Dorandeu F,Burnat P,Renard C,, Annales pharmaceutiques francaises, 2011 Jul [PubMed]