Which of the following statements about neuromuscular blocking agents is false?
Select Your Answer:
The actions of nondepolarizing blocking agents are readily reversed by increasing the concentration of normal transmitters at the receptors.
Reversal of nondepolarizing drugs is best accomplished by administering choline esterase inhibitors such as neostigmine.
In contrast, the paralysis produced by depolarizing blockers is increased by cholinesterase inhibitors.
The drugs block neuromuscular transmission at the neuromuscular junction causing paralysis of the skeletal muscles. This is accomplished either by acting presynaptically via the inhibition of acetylcholine synthesis or release or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate. In clinical use, neuromuscular blockade is used adjunctively to anesthesia to paralyze the vocal cords and permit intubation of the trachea as well as to optimize the surgical field by inhibiting spontaneous ventilation to cause relaxation of skeletal muscles. Because the appropriate dose of neuromuscular-blocking drug may paralyze the muscles of the diaphragm, mechanical ventilation should be available. Patients are still aware of pain; hence, general anesthetics or analgesics must also be given.
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Adult Lab Normals
Pediatric Lab Normals
Impact of high- versus low-dose neuromuscular blocking agent administration on unplanned 30-day readmission rates in retroperitoneal laparoscopic surgery., Boon M,Martini C,Yang HK,Sen SS,Bevers R,Warlé M,Aarts L,Niesters M,Dahan A,, PloS one, 2018 [PubMed]
Influence of tetanic stimulation on the staircase phenomenon and the acceleromyographic time-course of neuromuscular block: a randomized controlled trial., Mazzinari G,Errando CL,Díaz-Cambronero O,Martin-Flores M,, Journal of clinical monitoring and computing, 2018 May 18 [PubMed]
Neuromuscular Block and Blocking Agents in 2018., Unterbuchner C,, Turkish journal of anaesthesiology and reanimation, 2018 Apr [PubMed]
Effect of Atropine With Propofol vs Atropine With Atracurium and Sufentanil on Oxygen Desaturation in Neonates Requiring Nonemergency Intubation: A Randomized Clinical Trial., Durrmeyer X,Breinig S,Claris O,Tourneux P,Alexandre C,Saliba E,Beuchée A,Jung C,Levy C,Marchand-Martin L,Marcoux MO,Dechartres A,Danan C,, JAMA, 2018 May 1 [PubMed]