Allopurinol should be avoided in a patient receiving which of the following drugs?
Select Your Answer:
Allopurinol inhibits xanthine oxidase, the enzyme that breaks down mercaptopurine.
Thus, people who take allopurinol should either get a reduced dose of 6-mercaptopurine (6-MP) or discontinue allopurinol.
6-MP is used to treat acute lymphocytic leukemia and acute myelogenous leukemia.
It is used off-label for chronic myelogenous leukemia, Crohn disease, ulcerative colitis, and histiocytosis X.
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