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Extrapyramidal side effects are most common with which neuroleptic?
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Teaching Points
- Extrapyramidal side effects are most common after haloperidol, perhaps because haloperidol is frequently prescribed in hospitals.
- Extrapyramidal side effects look Parkinson-like with akathisia and dystonia.
- The higher the dose of haloperidol, the more severe the dystonias. These symptoms can be reduced by decreasing dosage or using benztropine.
- However, in many cases, dystonias persist after the antipsychotic drug is stopped.
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PubMed References
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| Lorazepam Added to Haloperidol Effective for Agitated Delirium in End-of-Life Cancer Patients., Shrikant Kulkarni N,, American family physician, 2018 Feb 15 [PubMed PMID: 29671522] | |
| Haloperidol-induced parkinsonism is attenuated by varenicline in mice., Sharma AK,Gupta S,Patel RK,Wardhan N,, Journal of basic and clinical physiology and pharmacology, 2018 Apr 10 [PubMed PMID: 29634484] | |
| Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study., Park Y,Bateman BT,Kim DH,Hernandez-Diaz S,Patorno E,Glynn RJ,Mogun H,Huybrechts KF,, BMJ (Clinical research ed.), 2018 Mar 28 [PubMed PMID: 29592958] | |
| Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine., Takaki M,Kodama M,Mizuki Y,Kawai H,Yoshimura B,Kishimoto M,Sakamoto S,Okahisa Y,Yamada N,, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018 May [PubMed PMID: 29571966] | |
| Long-Acting Injectable Second-Generation Antipsychotics: An Update and Comparison Between Agents., Jann MW,Penzak SR,, CNS drugs, 2018 Mar [PubMed PMID: 29569082] |
