Pearls Sample Question
Physiological Adaptation (Care Ill Patients)
11/8/2018 9:09:37 PM
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What is the mechanism of action of digoxin?
Select Your Answer:
1. Inhibiting calcium pump
2. Inhibiting sodium pump
3. Inhibiting phosphodiesterase
4. Stimulating potassium secretion into renal tubules
Digoxin is a glycoside, which acts as an inotropic agent. It is often used to treat atrial arrhythmias. It is sometimes used for congestive heart failure.
Digoxin acts by inhibiting Na/K-ATPase and increases levels of sodium and calcium ions in the cells.
Digoxin also decreases heart rate by slowing impulses at the atrioventricular node, chiefly by increasing vagal activity.
Quinidine, verapamil, and amiodarone all increase plasma levels of digoxin by displacing it from tissues.
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Adult Lab Normals
Pediatric Lab Normals
Management of digoxin toxicity., Pincus M,, Australian prescriber, 2016 Feb
[PubMed PMID: 27041802]
Digoxin Toxicity and Use of Digoxin Immune Fab: Insights From a National Hospital Database., Hauptman PJ,Blume SW,Lewis EF,Ward S,, JACC. Heart failure, 2016 Mar 25
[PubMed PMID: 27039127]
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