The single most important risk factor for post-transplant lymphoma is a lack of previous exposure to Epstein-Barr virus (EBV).
The greatest risk is with EBV-positive donor organs being transplanted to EBV-negative recipients.
A more important risk factor for post-transplant lymphoproliferative disease (PTLD) is the dose of anti-thymocyte immunoglobulin (thyroglobulin) utilized for the treatment of rejection. PTLD has the highest incidence in small intestinal transplants in which thyroglobulin is administered to both donors (to prevent graft vs host) and recipients.
Studies indicate that seronegativity to EBV increases post-transplant lymphomas.
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Adult Lab Normals
Pediatric Lab Normals
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