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Pediatric-Hematology-Oncology

Pediatric-Hematology-Oncology

Stay up to date on the latest medical knowledge with this Pediatric-Hematology-Oncology activity. In this online self-assessment activity, you'll read our reference articles and test your knowledge with 267 activities in Pediatric-Hematology-Oncology for 247.5 total CME hours.


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Featured Article Activities

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Acrodermatitis Enteropathica

Acrodermatitis enteropathica is a rare skin disorder associated with zinc deficiency that is most often seen in infants. ...
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Rating: 5.00
Hours: 1

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Splenic Sequestration Crisis

Young children with sickle cell anemia are at risk for acute splenic sequestration crises. These occur when an excessive ...
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Hours: 0.75

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Antibody Deficiency Disorder

Antibody deficiency disorders may present soon after birth with recurrent infections. Normal individuals have 5 classes ...
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Hours: 0.75

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Agammaglobulinemia

Agammaglobulinemia or hypogammaglobulinemia is a rare inherited immunodeficiency disorder, characterized by low or absen ...
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Hours: 1

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Hepatoblastoma

Hepatoblastomas are the most common primary malignant liver tumor in pediatric patients, and most often occur within the ...
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Hours: 0.75

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Vitamin K Deficiency

Vitamin K refers to a group of fat-soluble compounds involved in coagulation, bone development, and cardiovascular healt ...
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Hours: 1.25

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Pediatric-Hematology-Oncology Activities

Title Description Hours Questions
Abetalipoproteinemia Abetalipoproteinemia is a rare autosomal recessive disorder marked by low or absent levels of plasma cholesterol, low-density lipoproteins and very-lo ... Read the Article 1 8 Activity MD/PA Activity DO
Acitretin Acitretin belongs to a group of drugs known as retinoids. Retinoids include natural and synthetic compounds that have similar activity to vitamin A. V ... Read the Article 1 7 Activity MD/PA Activity DO
Acquired Hemophilia Acquired hemophilia is an uncommon but severe bleeding disorder. It is caused by the development of autoantibodies directed against one of the antihem ... Read the Article 0.75 5 Activity MD/PA Activity DO
Acrodermatitis Enteropathica Acrodermatitis enteropathica is a rare skin disorder associated with zinc deficiency that is most often seen in infants. Zinc is a very important micr ... Read the Article 1 7 Activity MD/PA Activity DO
Acute Chest Syndrome Acute chest syndrome occurs due to vaso-occlusion within the pulmonary vasculature of patients with sickle cell disease. This results in deoxygenation ... Read the Article 1 10 Activity MD/PA Activity DO
Acute Intermittent Porphyria Acute intermittent porphyria is a rare autosomal dominant disease, characterized by a deficiency of hydroxymethylbilane synthase (HMBS). It presents w ... Read the Article 1 8 Activity MD/PA Activity DO
Acute Kidney Injury Acute kidney injury, previously known as acute renal failure, denotes a sudden and often reversible reduction in the kidney function, as measured by ... Read the Article 1.5 20 Activity MD/PA Activity DO
Acute Lymphocytic Leukemia Acute lymphocytic leukemia (ALL) is a malignancy of B or T lymphoblasts characterized by uncontrolled proliferation of abnormal, immature lymphocytes ... Read the Article 1 10 Activity MD/PA Activity DO
Acute Myeloid Leukemia Acute myeloid leukemia (AML) is the most common leukemia among the adult population and accounts for about 80% of all cases. It is characterized by cl ... Read the Article 1 9 Activity MD/PA Activity DO
Acute Porphyria Acute porphyrias are a group of rare disorders characterized by an enzymatic defect in the heme biosynthetic pathway. Patients present with acute, deb ... Read the Article 0.75 6 Activity MD/PA Activity DO
Acute Stroke Acute strokes, also known as cerebrovascular accidents, are broadly classified as either ischemic or hemorrhagic. Acute strokes result in loss of bloo ... Read the Article 1.75 26 Activity MD/PA Activity DO
Agammaglobulinemia Agammaglobulinemia or hypogammaglobulinemia is a rare inherited immunodeficiency disorder, characterized by low or absent B cells with absent immunogl ... Read the Article 1 8 Activity MD/PA Activity DO
Ala Dehydratase Deficiency Porphyria ALA dehydratase porphyria is an extremely rare type of acute porphyria that follows a chronic course punctuated by acute attacks. To avoid multiple re ... Read the Article 0.75 6 Activity MD/PA Activity DO
ALK Negative Anaplastic Large Cell Lymphoma ALK-negative anaplastic large cell lymphoma (ALK(-) ALCL) is an uncommon CD30-positive T-cell lymphoma that presents a major diagnostic challenge. It ... Read the Article 1 6 Activity MD/PA Activity DO
Alpha Thalassemia Hemoglobin H disease (alpha-thalassemia) can be found in patients that live in areas with a high incidence of malaria. Symptoms at presentation, such ... Read the Article 1 7 Activity MD/PA Activity DO
Ameloblastoma Ameloblastomas are rare, odontogenic tumors derived from odontogenic ectoderm. Ameloblastomas represent about 1% of all jaw tumors, but they are the s ... Read the Article 1 6 Activity MD/PA Activity DO
Aneurysmal Bone Cysts Aneurysmal bone cysts are non-malignant, tumor-like, vascular lesions that can grow aggressively, be locally destructive, and weaken bones to the poin ... Read the Article 1 6 Activity MD/PA Activity DO
Aniridia Aniridia is defined as a partial or complete absence of the iris. It may be associated with various systemic disorders and multiple ocular morbidities ... Read the Article 1 6 Activity MD/PA Activity DO
Antalgic Gait In Children Antalgic gait is common in pediatric patients. The differential diagnosis is broad and includes both benign and more serious etiologies. A careful his ... Read the Article 1 6 Activity MD/PA Activity DO
Anthracyclines Anthracyclines are drugs extracted from Streptomyces spp and used in the treatment of various types of cancers. These agents are among the most effect ... Read the Article 0.75 6 Activity MD/PA Activity DO
Antibody Deficiency Disorder Antibody deficiency disorders may present soon after birth with recurrent infections. Normal individuals have 5 classes of immunoglobulins and several ... Read the Article 0.75 5 Activity MD/PA Activity DO
Antiemetic Medications Nausea is a commonly encountered symptom in healthcare, one that is difficult for any patient. Causes may be as simple as the body's defense against a ... Read the Article 0.75 6 Activity MD/PA Activity DO
Aplastic Anemia Aplastic anemia refers to the syndrome of chronic primary hematopoietic failure from injury leading to diminished or absent hematopoietic precursors i ... Read the Article 1 11 Activity MD/PA Activity DO
Aprepitant Aprepitant is a medication used in the management and treatment of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiti ... Read the Article 0.75 6 Activity MD/PA Activity DO
Asplenia Asplenia means the absence of a spleen. Asplenia can occur in a variety of clinical settings, and it can refer to an anatomic absence of the spleen or ... Read the Article 0.75 5 Activity MD/PA Activity DO
Astrocytoma Astrocytoma originates in astrocytes, which are a kind of glial cells in the cerebrum which are star-shaped. It is the most common glioma, usually aff ... Read the Article 1 8 Activity MD/PA Activity DO
Ataxia Telangiectasia Ataxia telangiectasia (Louis-Bar Syndrome) is a rare autosomal recessive condition characterized by cutaneous telangiectasias, cerebellar atrophy with ... Read the Article 1.25 13 Activity MD/PA Activity DO
Autotransfusion Autotransfusion has not always been a safe procedure. The first known documented procedure of autotransfusion was performed in 1818 by Dr. James Blund ... Read the Article 0.75 5 Activity MD/PA Activity DO
Beckwith Wiedemann Syndrome Beckwith-Wiedemann Syndrome is the most common overgrowth syndrome. It is a genetic imprinting disorder, and it can present as a wide and varied clini ... Read the Article 1 6 Activity MD/PA Activity DO
Bernard Soulier Syndrome Bernard-Soulier syndrome is a rare inherited blood clotting disorder that is characterized by unusually giant platelet cells, thrombocytopenia, and pr ... Read the Article 1 7 Activity MD/PA Activity DO
Beta Thalassemia Thalassemias are a common cause of microcytic anemia and are due to impaired synthesis of the globin protein component of hemoglobin. Beta-thalassemia ... Read the Article 1 7 Activity MD/PA Activity DO
Blood Donation Blood donation is a vital part of worldwide healthcare. It allows for blood transfusion as a life-sustaining and life-saving procedure. Over one hundr ... Read the Article 1 7 Activity MD/PA Activity DO
Blue Nevus Blue nevi are melanotic dermal lesions that commonly presents as a blue nodule on the scalp, extremities, sacrococcygeal region, or buttocks. Its char ... Read the Article 1 7 Activity MD/PA Activity DO
Bone Marrow Failure Bone marrow failure (BMF) refers to the decreased production of one or more major hematopoietic lineages which leads to diminished or absent hematopoi ... Read the Article 1 8 Activity MD/PA Activity DO
Bone Marrow Transplantation In Sickle Cell Disease Since the Sickle Cell Anemia Act, there has been progress in the screening and treatment of sickle cell disease. For instance, in most parts of the Un ... Read the Article 0.75 4 Activity MD/PA Activity DO
Bronchogenic Cyst Bronchogenic cysts are foregut-derived cystic malformations of the respiratory tract. They are usually located within the mediastinum at an early stag ... Read the Article 0.75 6 Activity MD/PA Activity DO
Bruton Agammaglobulinemia Bruton agammaglobulinemia, also known as X-linked agammaglobulinemia (XLA) or Bruton's agammaglobulinemia, is an inherited immunodeficiency disorder. ... Read the Article 0.75 5 Activity MD/PA Activity DO
Burkitt Lymphoma Burkitt lymphoma (BL) is an aggressive non-Hodgkin B-cell lymphoma. The disease is associated with Epstein Barr virus (EBV), human immunodeficiency vi ... Read the Article 1 10 Activity MD/PA Activity DO
Busulfan Busulfan is a medication used in the management and treatment of allogeneic hematopoietic progenitor cell transplantation specifically for patients wi ... Read the Article 1 8 Activity MD/PA Activity DO
Capillary Infantile Hemangiomas Capillary hemangiomas (infantile hemangiomas, juvenile hemangiomas, hemangioblastomas or strawberry nevi of infancy), are common benign orbital neopla ... Read the Article 0.75 4 Activity MD/PA Activity DO
Cardiac Rhabdomyoma Cardiac rhabdomyoma is a rare tumor. It arises from the striated muscles. It is a type of hamartoma seen in the pediatric age group. Although mostly a ... Read the Article 0.75 5 Activity MD/PA Activity DO
Cardiac Tamponade Cardiac tamponade is a medical emergency that takes place when abnormal amounts of fluid accumulate in the pericardial sac compressing the heart and l ... Read the Article 1.25 16 Activity MD/PA Activity DO
Carnitine Deficiency Carnitine deficiency is a condition characterized by low carnitine levels in the body. Carnitine deficiency could be primary (due to defect in carniti ... Read the Article 0.75 5 Activity MD/PA Activity DO
Cavernous Hepatic Hemangiomas Hepatic hemangiomas are benign, hypervascular, venous malformations that occur in the liver. They are the most common benign mesenchymal tumors of the ... Read the Article 0.75 4 Activity MD/PA Activity DO
Celiac Disease Celiac disease, also known as gluten-sensitive enteropathy, is an autoimmune disease of the small intestine. Celiac disease is a condition in which th ... Read the Article 1.5 24 Activity MD/PA Activity DO
Cervical Clear Cell Carcinoma The management of clear cell carcinoma of the cervix is complex, and new approaches have been recently introduced. To achieve optimal outcomes, the ba ... Read the Article 0.75 6 Activity MD/PA Activity DO
Chediak Higashi Syndrome Chediak Higashi syndrome (CHS) is an autosomal recessive disorder that is characterized by easy bruising, oculocutaneous albinism and recurrent pyogen ... Read the Article 0.75 5 Activity MD/PA Activity DO
Child Intussusception Intussusception is a condition in which part of the intestine folds into the section next to it. Intussusception usually involves the small bowel and ... Read the Article 1.25 14 Activity MD/PA Activity DO
Childhood Brain Tumors Pediatric brain tumors are the most common type of solid childhood cancer and only second to leukemia as a cause of pediatric malignancies. They are c ... Read the Article 1 9 Activity MD/PA Activity DO
Chimeric Antigen Receptor T-Cell Therapy Chimeric antigen receptors (CARs) are recombinant receptors for antigens which redirect the specificity and function of T lymphocytes and/or other imm ... Read the Article 1 12 Activity MD/PA Activity DO
Chondroblastoma Chondroblastoma is a benign, chondroid-producing neoplasm composed of chondroblasts. It accounts for less than 1% of all bone tumors and usually arise ... Read the Article 1 10 Activity MD/PA Activity DO
Chordoma A chordoma is a low-grade, slow-growing but locally invasive and locally aggressive tumor that is a type of sarcoma. Chordomas arise from remnants of ... Read the Article 1 10 Activity MD/PA Activity DO
Choroid Plexus Papilloma Choroid plexus papillomas (CPPs) are rare central nervous system tumors. They may be seen at any age, but are more common in infants. Their site of oc ... Read the Article 0.75 5 Activity MD/PA Activity DO
Chromosome Instability Syndromes Chromosomal instability syndromes are a group of inherited disorders associated with chromosomal instability and breakage either spontaneously or in r ... Read the Article 0.75 5 Activity MD/PA Activity DO
Chronic Granulomatous Disease Chronic granulomatous diseases (CGD) are a group of recurrent life-threatening infections due to a hereditary defect in forming reactive oxygen specie ... Read the Article 1.25 16 Activity MD/PA Activity DO
Chronic Myelogenous Leukemia Chronic myeloid leukemia (CML), BCR-ABL1-positive, is classified as a myeloproliferative neoplasm predominantly composed of proliferating granulocytes ... Read the Article 1 9 Activity MD/PA Activity DO
Cinchonism Cinchonism is a collection of symptoms described as hearing loss, tinnitus, dizziness, flushing, and blurry vision stemming from the ingestion of quin ... Read the Article 0.75 5 Activity MD/PA Activity DO
Cisplatin Cisplatin is a medication used in the management and treatment of solid tumors and hematologic malignancies. It is in the alkylating agent class of cy ... Read the Article 1 7 Activity MD/PA Activity DO
Common Variable Hypogammaglobulinemia Common variable immunodeficiency (CVID) is the most common primary immunodeficiency which can present in a variety of clinical manifestations. It req ... Read the Article 0.75 5 Activity MD/PA Activity DO
Congenital Pulmonary Airway Malformation Congenital pulmonary airway malformation is a congenital lung disease that can present from the prenatal period to childhood. Though rare overall, it ... Read the Article 0.75 6 Activity MD/PA Activity DO
Congenital Smooth Muscle Hamartoma Congenital smooth muscle hamartoma is a benign proliferation of smooth muscle cells, organized in haphazardly-oriented bundles among the reticular der ... Read the Article 0.75 6 Activity MD/PA Activity DO
Cooley Anemia Thalassemia major or Cooley anemia is one of the common monogenic hereditary hemoglobin disorders. It results from the absence of a beta-globin chain ... Read the Article 1 6 Activity MD/PA Activity DO
Craniopharyngioma Craniopharyngioma is a rare, virtually benign tumor of the central nervous system (CNS). It is a partly cystic embryonic malformation that can occur i ... Read the Article 0.75 6 Activity MD/PA Activity DO
Crohn Disease Crohn disease (CD) and ulcerative colitis (UC) are two conditions commonly referred to as inflammatory bowel disease (IBD). They are immunologically m ... Read the Article 2 34 Activity MD/PA Activity DO
Cryptorchidism Cryptorchidism is the absence of at least one testicle from the scrotum. It is the most common birth defect involving the male genitalia. About 3% of ... Read the Article 1.25 13 Activity MD/PA Activity DO
Cyclic Neutropenia Cyclic neutropenia is a very rare hematological condition characterized by regular fluctuations in blood neutrophil counts, leading to periodic neutro ... Read the Article 0.75 5 Activity MD/PA Activity DO
Cystic Hygroma Cystic hygromas are the most common subtype of lymphangiomas, presenting at birth and in early infancy. Enlargement of cystic hygromas is common, and ... Read the Article 1 7 Activity MD/PA Activity DO
Dapsone Dapsone is indicated for a variety of conditions, both dermatologic and non-dermatologic. The FDA-approved indications are leprosy and dermatitis herp ... Read the Article 1 10 Activity MD/PA Activity DO
Death and Dying Death is a part of natural life; however, society is notorious for being uncomfortable with death and dying as a topic on the whole. Many caregivers e ... Read the Article 0.75 3 Activity MD/PA Activity DO
Dermal Melanocytosis This activity outlines the evaluation & management of congenital dermal melanocytosis (Mongolian spot). It explains the role of the interprofessional ... Read the Article 0.75 6 Activity MD/PA Activity DO
Diamond Blackfan Anemia Diamond Blackfan anemia (DBA) is a congenital type of anemia with pure red cell aplasia causing congenital bone abnormalities and most commonly presen ... Read the Article 0.75 5 Activity MD/PA Activity DO
Diffuse Intrinsic Pontine Glioma Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of childhood cancer that forms in the brainstem. They are very rare and almost always oc ... Read the Article 0.75 5 Activity MD/PA Activity DO
Dyskeratosis Congenita Dyskeratosis congenita, also known as Zinsser-Engman-Cole syndrome, is an uncommon genodermatosis classically associated with the triad of oral leukop ... Read the Article 1 7 Activity MD/PA Activity DO
Ecthyma Gangrenosum Ecthyma gangrenosum (EG) is a cutaneous infection that most commonly occurs in immunocompromised individuals with fulminant bacteremia. EG was first d ... Read the Article 0.75 4 Activity MD/PA Activity DO
Ehlers Danlos Syndrome Ehlers-Danlos syndrome (EDS) is a genetic disorder affecting collagen formation and function. It affects virtually every organ system, which can resul ... Read the Article 1 9 Activity MD/PA Activity DO
Emicizumab Emicizumab is a medication used in the management and treatment of hemophilia A. It belongs to the bispecific monoclonal antibody class of medications ... Read the Article 1 9 Activity MD/PA Activity DO
Endovascular Papillary Angioendothelioma Endovascular papillary angioendothelioma (EPA), also known as Dabska tumor (DT) and papillary intralymphatic angioendothelioma (PILA), represents a bo ... Read the Article 1 10 Activity MD/PA Activity DO
Enterohemorrhagic Escherichia Coli Enterohemorrhagic Escherichia coli (EHEC) is a bacterial infection resulting in bloody dysentery and an increased risk of hemolytic uremic syndrome (H ... Read the Article 1 7 Activity MD/PA Activity DO
Eosinophilic Granuloma Eosinophilic granuloma (EG) is a rare and mildest form of Langerhans cell histiocytosis. The presentation of EG can be monostotic, polyostotic, or can ... Read the Article 0.75 5 Activity MD/PA Activity DO
Epithelioid Sarcoma Epithelioid sarcoma is a rare soft tissue sarcoma of young adults that presents as a painless, slow growing mass. Complete surgical resection can be c ... Read the Article 0.75 5 Activity MD/PA Activity DO
Erythema Infectiosum Erythema infectiosum, also known as fifth disease, is a common viral exanthem caused by parvovirus B19. It is commonly seen in children between five a ... Read the Article 1.25 14 Activity MD/PA Activity DO
Erythropoietic Protoporphyria Erythropoietic protoporphyria (EPP) is an inherited porphyria resulting in the accumulation of protoporphyrins in red blood cells that causes acute, p ... Read the Article 0.75 5 Activity MD/PA Activity DO
Ewing Sarcoma Ewing sarcoma is the second most common primary malignant bone tumor, mostly affecting adolescents in the second decade of their life, and it is a hig ... Read the Article 1 10 Activity MD/PA Activity DO
Exchange Transfusion Therapeutic plasma exchange (TPE) is a procedure employed to "cleanse" the blood of various pathologic entities including antibodies, immune complexes ... Read the Article 0.75 5 Activity MD/PA Activity DO
Exophthalmos Exophthalmos is the protrusion of one or both eyes anteriorly out of the orbit due to an increase in orbital contents within the rigid bony orbit. It ... Read the Article 0.75 5 Activity MD/PA Activity DO
Factor XIII Deficiency Factor XIII deficiency is a rare bleeding disorder that is challenging to recognize clinically. The lab tests such as the prothrombin time, INR, and a ... Read the Article 0.75 5 Activity MD/PA Activity DO
Familial Adenomatous Polyposis Familial adenomatous polyposis (FAP) or familial polyposis coli (FPC) is an autosomal dominant polyposis syndrome with varying degrees of penetrance. ... Read the Article 1.25 13 Activity MD/PA Activity DO
Fanconi Anemia Fanconi anemia is a rare genetic disorder, involving all three blood cell lines. It is the most common cause of inherited bone marrow failure characte ... Read the Article 1 8 Activity MD/PA Activity DO
Febrile Neutropenia Neutropenic fever is defined as a single oral temperature of greater than or equal to 101 F, or a temperature greater than or equal to 100.4 F for at ... Read the Article 0.75 6 Activity MD/PA Activity DO
Femoral Head Avascular Necrosis Avascular necrosis of the femoral head is a type of osteonecrosis due to disruption of blood supply to the proximal femur. There are approximately 100 ... Read the Article 1 8 Activity MD/PA Activity DO
Fever of Unknown Origin Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961. FUO was defined as a temperature of 101 F (38.3 C) or high ... Read the Article 0.75 5 Activity MD/PA Activity DO
Fibrinogen Fibrinogen is a 340kDa hexameric plasma glycoprotein synthesized by the liver and is the major structural component of a clot. The type of fibrinogen ... Read the Article 0.75 5 Activity MD/PA Activity DO
Gardner Syndrome Gardner syndrome is a phenotypic variant of familial adenomatous polyposis. It is an autosomal dominant disease characterized by numerous adenomatous ... Read the Article 1 8 Activity MD/PA Activity DO
Gaucher Disease Gaucher disease is an autosomal recessive inborn error of metabolism due to the toxic accumulation of glucocerebroside lipids in various organs. It re ... Read the Article 1.25 14 Activity MD/PA Activity DO
Germ Cell Seminoma Germinoma is an uncommon pediatric brain tumor that is morphologically identical to its gonadal counterpart: testicular seminoma and ovarian dysgermin ... Read the Article 1 7 Activity MD/PA Activity DO
Glanzmann Thrombasthenia Glanzmann thrombasthenia is a congenital bleeding disorder caused by a deficiency of the platelet integrin alpha IIb beta3. This integrin is the plate ... Read the Article 0.75 4 Activity MD/PA Activity DO
Gliomas Glioma is the most common form of central nervous system (CNS) neoplasm that originates from glial cells. In the United States, there are six cases of ... Read the Article 1 8 Activity MD/PA Activity DO
Glomus Cancer Glomangioma or glomuvenous malformation is a rare cutaneous venous malformation that shows glomus cells (undifferentiated smooth muscle cells which ar ... Read the Article 0.75 6 Activity MD/PA Activity DO
Glucose 6 Phosphate Dehydrogenase Deficiency Glucose-6-phosphate dehydrogenase is an enzyme found in the cytoplasm of all cells in the body. It is a housekeeping enzyme that plays a vital role in ... Read the Article 0.75 5 Activity MD/PA Activity DO
Gorlin Syndrome Gorlin syndrome, also called Gorlin-Goltz syndrome, basal cell nevus syndrome (BCNS), or nevoid basal cell carcinoma syndrome, is an autosomal dominan ... Read the Article 0.75 5 Activity MD/PA Activity DO
Graft Versus Host Disease Graft-versus-host disease (GVHD) occurs due to the presence of immunocompetent T lymphocytes in the graft attacking the immunodeficient recipient tiss ... Read the Article 0.75 5 Activity MD/PA Activity DO
Granular Cell Tumor Granular cell tumors are rare neoplasms derived from Schwann cells with characteristic pathologic findings. They can exhibit either benign or malignan ... Read the Article 1 6 Activity MD/PA Activity DO
Hemarthrosis Hemarthrosis is a condition of articular bleeding, that is into the joint cavity. This can occur after an injury or, more commonly, in bleeding disord ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hematopoietic Stem Cell Transplantation Bone marrow transplant, also known as hematopoietic stem cell transplant (HPSCT) involves the administration of healthy hematopoietic stem cells to pa ... Read the Article 1 7 Activity MD/PA Activity DO
Hemoglobin C Disease Hemoglobin C is a common hemoglobin variant that has a single amino acid substitution (lysine substituted for the glutamate) in the sixth position of ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hemolytic Anemia Hemolytic anemia is a class of anemia that is caused by the destruction of red blood cells, increased hemoglobin catabolism, decreased levels of hemog ... Read the Article 1 9 Activity MD/PA Activity DO
Hemolytic Diseases Of The Newborn Hemolytic disease of the fetus and newborn is a red blood cell mismatch between mothers and their fetus that can cause significant morbidity and morta ... Read the Article 1 6 Activity MD/PA Activity DO
Hemolytic Transfusion Reaction Hemolytic transfusion reactions are one possible complication from transfusions. Hemolysis is the rupture of red blood cells, and can occur intravascu ... Read the Article 0.75 4 Activity MD/PA Activity DO
Hemolytic Uremic Syndrome Hemolytic uremic syndrome (HUS) is thrombotic microangiopathy characterized by the presence of the triad of symptoms: thrombocytopenia, acute renal im ... Read the Article 1 9 Activity MD/PA Activity DO
Hemophilia Hemophilia A and B are the most common severe hereditary hemorrhagic disorders. Hemophilia A and B result from factor VIII and factor IX protein defic ... Read the Article 1.25 10 Activity MD/PA Activity DO
Hemophilia A Hemophilia encompasses a group of inherited disorders that alter blood coagulation. Classical hemophilia, also known as hemophilia A, is a hereditary ... Read the Article 1 10 Activity MD/PA Activity DO
Hemorrhagic Disease Of Newborn Hemorrhagic disease of the newborn is a life-threatening condition that is caused due to insufficient vitamin K levels in the newborns as a result of ... Read the Article 1 9 Activity MD/PA Activity DO
Henoch Schonlein Purpura Henoch-Schonlein purpura is an IgA-mediated immune vasculitis involving the small vessels of the joints, kidneys, gastrointestinal (GI) tract, skin, a ... Read the Article 0.75 6 Activity MD/PA Activity DO
Hepatic Hemangioma Hemangiomas are benign vascular tumors that may involve either the skin or viscera. Infantile hemangioma (IH) grows rapidly after birth then involutes ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hepatitis C Hepatitis C virus (HCV) is a major public health problem affecting 185 million people worldwide. The percentage of people who are seropositive for ant ... Read the Article 1.5 24 Activity MD/PA Activity DO
Hepatoblastoma Hepatoblastomas are the most common primary malignant liver tumor in pediatric patients, and most often occur within the first 2 years of life. The hi ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hereditary Angioedema Hereditary angioedema (HAE) is an autosomal dominant disease caused by either a lack of C1-inhibitor protein or by dysfunctional C1-inhibitor protein. ... Read the Article 1 11 Activity MD/PA Activity DO
Hereditary Elliptocytosis Hereditary elliptocytosis is a group of inherited heterogenous red blood cell (RBC) membrane disorders characterized by elliptical-shaped RBCs. The pr ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hereditary Spherocytosis Hereditary spherocytosis, a type of congenital hemolytic anemia, is the most prevalent cause of hemolytic anemia due to an abnormal red cell membrane. ... Read the Article 1.5 20 Activity MD/PA Activity DO
Hodgkin Lymphoma Hodgkin lymphoma (HL) is a rare monoclonal lymphoid neoplasm characterized by the following four features: HL usually presents in young adults, common ... Read the Article 1 8 Activity MD/PA Activity DO
Horseshoe Kidney Horseshoe kidneys are the most common fusion defect of the kidneys occurring in approximately 1:500 individuals. They are characterized by abnormaliti ... Read the Article 1 8 Activity MD/PA Activity DO
Human Metapneumovirus Human metapneumovirus is an important pathogen that causes upper and/or lower respiratory tract infections. It does require the clinician to be knowle ... Read the Article 0.75 6 Activity MD/PA Activity DO
Hydroa Vacciniforme Hydroa vacciniforme is a rare photosensitivity disorder of childhood. Hydroa vacciniforme-like lymphoma is a more aggressive and fatal variant of hydr ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hyperbaric Treatment Of Brain Radiation Necrosis Delayed effects of radiation therapy can include radiation necrosis of the brain, which generally occurs in the area of the brain where the tumor was ... Read the Article 0.75 4 Activity MD/PA Activity DO
Hyperkalemia Hyperkalemia is defined as a serum or plasma potassium level above the upper limits of normal, usually greater than 5.0 mEq/L to 5.5 mEq/L. While mild ... Read the Article 1.25 14 Activity MD/PA Activity DO
Hyperuricemia Hyperuricemia is a common disorder that affects patients of all ages and genders. The most common manifestation of hyperuricemia is gout, which can be ... Read the Article 0.75 5 Activity MD/PA Activity DO
Hypogammaglobulinemia Hypogammaglobulinemia is a disorder caused by low serum immunoglobulin or antibody levels. Immunoglobulins are the main components of the humoral immu ... Read the Article 1 9 Activity MD/PA Activity DO
Ifosfamide Ifosfamide is a cytotoxic medication used in the management and treatment of various cancers such as lymphomas, sarcomas, and lung cancers. It is in t ... Read the Article 0.75 5 Activity MD/PA Activity DO
IgA Deficiency Immunoglobulin A (IgA) deficiency is a common primary immunodeficiency characterized by undetectable serum IgA, a concomitant lack of secretory IgA, a ... Read the Article 1 11 Activity MD/PA Activity DO
Immune Thrombocytopenic Purpura Immune thrombocytopenia purpura (ITP) is defined as a low platelet count, usually, less than 100,000 in the presence of a generalized petechial rash, ... Read the Article 1 6 Activity MD/PA Activity DO
Immunodeficiency Immunodeficiency results from a failure or absence of elements of the immune system, including lymphocytes, phagocytes, and complement system. Immunod ... Read the Article 1 8 Activity MD/PA Activity DO
Immunotherapy Immunotherapy is used to upregulate or downregulate the immune system to achieve a therapeutic effect in immunological mediated disorders including im ... Read the Article 1 7 Activity MD/PA Activity DO
Intestinal Carcinoid Cancer Carcinoid tumor refers to a well-differentiated neuroendocrine tumor (NET) that originate commonly in the gastrointestinal tract (about 55%) or in oth ... Read the Article 1 9 Activity MD/PA Activity DO
Intravenous Immunoglobulin (IVIG) Intravenous Immunoglobulin (IVIG) is a pooled antibody and a biological agent used in the management of various immunodeficiency states and a plethora ... Read the Article 1 10 Activity MD/PA Activity DO
Inverted Urothelial Papilloma Inverted urothelial papilloma is a rare non-invasive endophytic urothelial tumor of the urinary bladder accounting for less than 1% of urothelial neop ... Read the Article 0.75 5 Activity MD/PA Activity DO
ITP-Immune Thrombocytopenic Purpura Immune thrombocytopenic purpura (ITP) is an autoimmune pathology characterized by a low platelet count, purpura and hemorrhagic episodes caused by ant ... Read the Article 1.25 13 Activity MD/PA Activity DO
Job Syndrome Job Syndrome (Hyper-IgE syndrome) is a rare, primary immunodeficiency distinguished by the clinical triad of atopic dermatitis, recurrent skin staphyl ... Read the Article 0.75 5 Activity MD/PA Activity DO
Juvenile Xanthogranuloma Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis and is fairly common, often affecting infants and young children. Cutaneous lesi ... Read the Article 0.75 5 Activity MD/PA Activity DO
Kasabach Merritt Syndrome Kasabach-Merritt phenomenon (KMP), first described in 1940, is a rare but life-threatening coagulopathy of infancy which presents with thrombocytopeni ... Read the Article 0.75 5 Activity MD/PA Activity DO
Kawasaki Disease Kawasaki disease (KD) is an acute, self-limited medium vessel vasculitis that has a predilection for the coronary arteries. This activity reviews the ... Read the Article 1.5 17 Activity MD/PA Activity DO
Klinefelter Syndrome Klinefelter syndrome (KS) is the result of 2 or more X chromosomes in a phenotypic male. The clinical phenotype of KS was first described in males wit ... Read the Article 1.25 16 Activity MD/PA Activity DO
Klippel Trenaunay Weber Syndrome Klippel Trenaunay syndrome is cutaneous vascular malformation syndrome involving a triad of capillary and venous malformation and limb hypertrophy. Th ... Read the Article 0.75 5 Activity MD/PA Activity DO
Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is an idiopathic condition characterized by proliferation of abnormal Langerhans (antigen-presenting) cells. The d ... Read the Article 0.75 5 Activity MD/PA Activity DO
Laryngeal Papillomas Laryngeal papilloma is a benign lesion caused by a viral infection of epithelial cells leading to an overgrowth in one or different segments of the re ... Read the Article 0.75 5 Activity MD/PA Activity DO
Lead Toxicity Lead became a common occupational toxin with the birth of the Industrial Revolution, by the end of the 19-century childhood lead poisoning secondary t ... Read the Article 1.25 15 Activity MD/PA Activity DO
Leucovorin Leucovorin is a medication used in the treatment of methotrexate toxicity and chemotherapy regimens. Leucovorin is a folate analog. This activity revi ... Read the Article 0.75 5 Activity MD/PA Activity DO
Leukocyte Adhesion Deficiency Leukocyte adhesion deficiency (LAD) is an immunodeficiency disorder involving both B and T cells and is characterized by an inability of leukocytes to ... Read the Article 0.75 5 Activity MD/PA Activity DO
Leukocytoclastic Vasculitis Leukocytoclastic vasculitis is a cutaneous, small-vessel vasculitis of the dermal capillaries and venules. This condition can be idiopathic or can be ... Read the Article 0.75 5 Activity MD/PA Activity DO
Leukocytosis Leukocytosis has a variety of etiologies with which clinicians of all backgrounds should be familiar. This activity outlines the evaluation of leukocy ... Read the Article 1 7 Activity MD/PA Activity DO
Littoral Cell Splenic Angioma Littoral cell angioma (LCA) is a rare splenic tumor. Both benign and malignant cases have been reported. This activity reviews the clinical presentati ... Read the Article 0.75 5 Activity MD/PA Activity DO
Low Grade Gliomas Low-grade gliomas are benign tumors and are grade 1 and grade 2 tumors according to WHO classification. They can be due to some genetic mutations or e ... Read the Article 0.75 5 Activity MD/PA Activity DO
Lymphangioma Lymphangiomas are uncommon, benign malformations of the lymphatic system that can occur anywhere on the skin and mucous membranes. Lymphangiomas can b ... Read the Article 0.75 4 Activity MD/PA Activity DO
Lymphoblastic Lymphoma Acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL) is a clonal hematopoietic stem cell disorder of B or T cell origin. The World Health O ... Read the Article 0.75 4 Activity MD/PA Activity DO
Lymphocyte Depleted Hodgkin Lymphoma Lymphocyte-depleted classic Hodgkin lymphoma is the rarest subtype of classic Hodgkin lymphoma, accounting for 1% to 1.5% of classic Hodgkin lymphoma ... Read the Article 0.75 6 Activity MD/PA Activity DO
Lymphohistiocytosis Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyper-inflammatory disorder affecting both newborns and adults alike. The disease is c ... Read the Article 0.75 5 Activity MD/PA Activity DO
Lymphomatoid Papulosis Lymphomatoid papulosis is a non-aggressive T-cell lymphoma characterized by recurrent, spontaneously-regressive papulonodular and sometimes, necrotic ... Read the Article 0.75 4 Activity MD/PA Activity DO
Lymphoproliferative Disorders Lymphoproliferative disorders (LPD) comprise a heterogeneous group of diseases characterized by uncontrolled production of lymphocytes that cause mono ... Read the Article 0.75 6 Activity MD/PA Activity DO
Lysosomal Storage Disease Lysosomal storage diseases (LSDs) are inborn errors of metabolism characterized by the accumulation of substrates in excess in various organs' cells d ... Read the Article 1 5 Activity MD/PA Activity DO
Lytic Bone Lesions Bone tumors are mostly benign. Most important determinants in imaging of bone tumors are morphology on plain radiograph (well defined lytic, ill-defin ... Read the Article 0.75 5 Activity MD/PA Activity DO
Malignant Salivary Gland Tumors Salivary gland tumors are a rare group of complex, heterogenous histologies that are located in the parotid gland, submandibular gland, sublingual gla ... Read the Article 1.25 14 Activity MD/PA Activity DO
Mastocytoma A mastocytoma is a tumor of mast cells, which are derived from myeloid stem cells and located in connective tissues, predominantly in the skin and muc ... Read the Article 0.75 5 Activity MD/PA Activity DO
May Hegglin Anomaly May-Hegglin anomaly (MHA) is a rare autosomal dominant disease characterized by neutrophils with abnormal cytoplasmic inclusions, large platelets, and ... Read the Article 0.75 6 Activity MD/PA Activity DO
Medium-Chain Acyl-COA Dehydrogenase Deficiency Medium-chain acyl-COA dehydrogenase (MCAD) deficiency is one of the most common fatty acid ß-oxidation disorders. It is an autosomal recessive disorde ... Read the Article 0.75 6 Activity MD/PA Activity DO
Medullary Thyroid Cancer Medullary thyroid cancer (MTC) is a tumor arising from the parafollicular cells, or C cells, of the thyroid gland. Medullary thyroid cancer produces c ... Read the Article 1 10 Activity MD/PA Activity DO
Medulloblastoma While leukemias are the most common type of malignancy affecting the pediatric population, brain tumors are the most common solid tumors in this popul ... Read the Article 1.25 14 Activity MD/PA Activity DO
Megaloblastic Anemia Megaloblastic anemia (MA) encompasses a heterogeneous group of anemias characterized by the presence in the bone marrow of large red blood cell precur ... Read the Article 0.75 4 Activity MD/PA Activity DO
Melanotic Neuroectodermal Tumor Of Infancy Melanotic neuroectodermal tumor of infancy (MNTI) is a rapidly growing benign tumor arising from the neural crest cells. It typically affects infants ... Read the Article 0.75 5 Activity MD/PA Activity DO
Menkes Kinky Hair Disease Menkes kinky hair disease is a rare X-linked recessive progressive multisystemic disease of copper metabolism. Patients usually exhibit a severe clini ... Read the Article 1 6 Activity MD/PA Activity DO
Mercaptopurine Mercaptopurine is a medication used in the management and treatment of acute lymphoblastic leukemia. It is in the class of medications known as purine ... Read the Article 0.75 6 Activity MD/PA Activity DO
Meromelia Meromelia is defined as a partial absence of a free limb. Limb deficiencies have been known to be caused by chromosomal abnormalities, genetic disorde ... Read the Article 0.75 5 Activity MD/PA Activity DO
Methemoglobinemia Methemoglobinemia is a condition with life-threatening potential in which diminution of the oxygen-carrying capacity of circulating hemoglobin occurs ... Read the Article 0.75 4 Activity MD/PA Activity DO
Mitomycin Mitomycin is a medication used in the treatment of anal carcinoma, bladder carcinoma, breast carcinoma, head and neck malignancies, and some other gas ... Read the Article 0.75 6 Activity MD/PA Activity DO
Multiple Endocrine Neoplasia Type 1 Multiple endocrine neoplasia Type 1 (MEN1), also known as Wermer syndrome, is a rare hereditary endocrine tumor syndrome. The most common tumors seen ... Read the Article 1 7 Activity MD/PA Activity DO
Multiple Endocrine Neoplasias Type 2 Multiple endocrine neoplasia type 2 (MEN 2) is a hereditary cancer syndrome associated primarily with tumors of the adrenal gland, thyroid and parathy ... Read the Article 1 9 Activity MD/PA Activity DO
Myeloperoxidase Deficiency Myeloperoxidase (MPO) is a hemoprotein expressed in azurophilic granules of neutrophils and in the lysosomes of monocytes. The enzyme has strong antib ... Read the Article 0.75 5 Activity MD/PA Activity DO
Nasopharyngeal Angiofibroma Nasopharyngeal angiofibroma is a rare highly vascular tumor within the posterior nasal cavity found almost exclusively in adolescent boys. This activi ... Read the Article 1 10 Activity MD/PA Activity DO
Neonatal Jaundice Neonatal jaundice is yellowish discoloration of the skin, conjunctiva, and sclera due to elevated serum or plasma bilirubin in the newborn period. Neo ... Read the Article 1 8 Activity MD/PA Activity DO
Neuroacanthocytosis Neuroacanthocytosis refers to a group of inherited genetic disorders resulting in a combination of misshapen red blood cells (acanthocytes) and progre ... Read the Article 0.75 6 Activity MD/PA Activity DO
Neuroblastoma Neuroblastoma (NB) is the most frequently-occurring extracranial childhood tumor. It is classified as an embryonal neuroendocrine tumor, originating f ... Read the Article 1 12 Activity MD/PA Activity DO
Neurocutaneous Syndromes As the name implies, neurocutaneous syndromes are disorders involving the nervous system and the skin. Two of the most common neurocutaneous syndrome ... Read the Article 0.75 4 Activity MD/PA Activity DO
Neurofibroma Neurofibromas are the most common peripheral nerve sheath tumor and are often found either by patients or during routine skin exams. These lesions app ... Read the Article 1 8 Activity MD/PA Activity DO
Neurofibromatosis Neurofibromatosis is a neurocutaneous disorder characterized by tumors in the nervous system and skin. The most common types of neurofibromatosis are ... Read the Article 1 11 Activity MD/PA Activity DO
Neurofibromatosis Type 1 Neurofibromatosis-1 (NF-1) or Von Recklinghausen's disease is one of the inheritable neurocutaneous disorders manifested by developmental changes in t ... Read the Article 0.75 6 Activity MD/PA Activity DO
Neurofibromatosis Type 2 Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors involving the central nervous sys ... Read the Article 0.75 6 Activity MD/PA Activity DO
Neutropenia Neutrophils play an essential role in immune defenses because they ingest, kill, and digest invading microorganisms, including fungi and bacteria. Fai ... Read the Article 1 10 Activity MD/PA Activity DO
Nevus Flammeus Nevus flammeus or port-wine stain is a capillary malformation usually presenting as a unilateral pink or red patch anywhere on the body of a newborn. ... Read the Article 1 7 Activity MD/PA Activity DO
Nevus Of Ota And Ito Ocular dermal melanosis, also known as nevus of Ota or oculodermal melanocyte, is benign melanosis that involves the distribution of the trigeminal ne ... Read the Article 1 12 Activity MD/PA Activity DO
Nevus Sebaceous Nevus sebaceus of Jadassohn, also referred to as organoid nevus, is a congenital malformation involving hamartomas of the pilosebaceous follicular uni ... Read the Article 1 7 Activity MD/PA Activity DO
Niemann-Pick Disease The management of Niemann-Pick disease and new approaches have been recently introduced. To achieve optimal outcomes, the basic and clinical aspects ... Read the Article 1 8 Activity MD/PA Activity DO
Nocturnal Enuresis Enuresis refers to the involuntary loss of urine during sleep that occurs at least twice a week in children older than 5 years of age (or the developm ... Read the Article 1 7 Activity MD/PA Activity DO
Non-Hodgkin Lymphoma Non-Hodgkin lymphoma is a group of malignant neoplasms originating from the lymphoid tissues, mainly the lymph nodes. These tumors may result due to c ... Read the Article 1.25 10 Activity MD/PA Activity DO
Optic Nerve Glioma Optic pathway gliomas are benign CNS tumors that primarily affect children. Although typically slow growing, the location of these tumors makes resect ... Read the Article 0.75 5 Activity MD/PA Activity DO
Oral Hemangiomas Oral hemangiomas are benign tumors that develop in and around the oral cavity due to endothelial cell proliferation. The majority of oral hemangiomas ... Read the Article 0.75 5 Activity MD/PA Activity DO
Osteoblastoma Osteoblastoma is an uncommon benign bone-forming neoplasm that accounts for about 1% of all primary bone tumors. It commonly arises in the posterior e ... Read the Article 1 6 Activity MD/PA Activity DO
Osteochondroma Osteochondromas are common benign osseous surface lesions generally arising from the metaphysis of long bones. The lesions are most commonly asymptoma ... Read the Article 0.75 5 Activity MD/PA Activity DO
Osteoclastoma A giant cell tumor of bone (GCTB) is an aggressive osteolytic neoplasm that primarily affects skeletally mature young adults. This tumor can have seve ... Read the Article 0.75 5 Activity MD/PA Activity DO
Osteogenic Sarcoma Osteogenic sarcoma is the most common primary malignant bone tumor with an annual incidence of 900 cases in the United States. This activity reviews t ... Read the Article 1.25 12 Activity MD/PA Activity DO
Osteoid Osteoma An osteoid osteoma is a benign bone-forming tumor that has no potential to become malignant. It classically causes severe pain at night and is relieve ... Read the Article 0.75 5 Activity MD/PA Activity DO
Osteosarcoma Osteosarcoma is a malignant osseous neoplasm. It is the most common primary bone cancer of childhood. Less frequently, it occurs in adults where it re ... Read the Article 1.25 10 Activity MD/PA Activity DO
Paroxysmal Nocturnal Hemoglobinuria Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease that presents clinically with a variety of nonspecific symptoms. It causes complications m ... Read the Article 1 8 Activity MD/PA Activity DO
Parvoviruses Parvovirus B19 is a virus that only infects humans. It is known to cause Fifth Disease, also known as erythema infectiosum or slapped cheek syndrome, ... Read the Article 0.75 5 Activity MD/PA Activity DO
Patient Controlled Analgesia Patient-controlled analgesia is used to treat acute, chronic, postoperative, and labor pain. A variety of medications can be used for patient-controll ... Read the Article 1 11 Activity MD/PA Activity DO
Pediatric Craniopharyngioma Pediatric craniopharyngioma could be considered one of the most complex neurosurgical pathologies in the pediatric population. The tumor's proximity t ... Read the Article 0.75 5 Activity MD/PA Activity DO
Pediatric Malignant Pleural Effusion The pleural cavity is a thin layer of the sac that is lined with a serous membrane that encloses the lungs and separates it from the thoracic cage. Th ... Read the Article 0.75 4 Activity MD/PA Activity DO
Pediatric Preoperative Management The preoperative management of anesthesia in children differs from that in adults. These differences include employing cognitive and age-appropriate l ... Read the Article 1 9 Activity MD/PA Activity DO
Pegfilgrastim Pegfilgrastim is a pegylated granulocyte colony-stimulating factor that is FDA-approved to decrease the risk of patients developing febrile neutropeni ... Read the Article 0.75 5 Activity MD/PA Activity DO
Peutz-Jeghers Syndrome Peutz-Jeghers syndrome (PJS) is a hereditary syndrome characterized by gastrointestinal (GI) polyposis, mucocutaneous pigmented macules, and predispos ... Read the Article 1 12 Activity MD/PA Activity DO
Pilocytic Astrocytoma Pilocytic astrocytoma is the most common childhood brain tumor and most often found in the posterior fossa. Complete resection usually cures the patie ... Read the Article 0.75 5 Activity MD/PA Activity DO
Plasmapheresis Plasmapheresis is a therapeutic intervention that involves extracorporeal removal, return, or exchange of blood plasma or components. The underlying m ... Read the Article 0.75 5 Activity MD/PA Activity DO
Platelet Transfusion Platelet transfusion is a lifesaving procedure that is carried out to prevent bleeding or stop ongoing bleeding in patients with low platelet count or ... Read the Article 0.75 5 Activity MD/PA Activity DO
Pleuropulmonary Blastoma Pleuropulmonary blastomas are rare, malignant mesenchymal tumors that typically present with non-specific symptoms. Radiologic features may increase t ... Read the Article 0.75 4 Activity MD/PA Activity DO
Pneumonia In An Immunocompromised Patient Pneumonia is a common clinical condition. It results from an infectious inflammatory process that involves the lung parenchyma and results in impairme ... Read the Article 1 6 Activity MD/PA Activity DO
Poikiloderma Congenitale Congenital poikiloderma, also known as Rothmund-Thomson syndrome (RTS), is a rare genodermatosis with autosomal recessive inheritance. It is character ... Read the Article 0.75 2 Activity MD/PA Activity DO
Posterior Reversible Encephalopathy Syndrome Posterior reversible encephalopathy syndrome (PRES) is a neurologic disorder in which a person presents with visual disturbance, seizure, headaches, a ... Read the Article 0.75 5 Activity MD/PA Activity DO
Pott Puffy Tumor Pott puffy tumor is a subperiosteal abscess due to associated frontal skull osteomyelitis. This usually occurs as a rare complication of frontal sinus ... Read the Article 0.75 4 Activity MD/PA Activity DO
Primary Bone Cancer Primary bone cancers are rare malignant tumors originating in bone and derived from primitive mesenchymal cells. They are frequently aggressive tumors ... Read the Article 1.25 13 Activity MD/PA Activity DO
Primitive Neuroectodermal Tumor In 2016, the World Health Organization published a revised classification of central nervous system tumors using molecular parameters. In this classif ... Read the Article 0.75 5 Activity MD/PA Activity DO
Protein C Deficiency Protein C deficiency is a rare but serious condition that can be congenital or acquired. Patients with this condition have a higher propensity to deve ... Read the Article 0.75 5 Activity MD/PA Activity DO
Protein S Deficiency Protein S deficiency is a rare but serious condition that can be congenital or acquired. Patients with this condition have higher propensity to develo ... Read the Article 0.75 5 Activity MD/PA Activity DO
Pure Red Cell Aplasia Pure red cell aplasia (PRCA) is a rare disorder which designates anemia secondary to failure of erythropoiesis. It is characterized by normocytic, nor ... Read the Article 1 5 Activity MD/PA Activity DO
Pyruvate Kinase Deficiency Pyruvate kinase deficiency (PKD) is the most common enzyme-related glycolytic defect that results in red cell hemolysis. Invariably, PKD results in he ... Read the Article 1 9 Activity MD/PA Activity DO
Radial Dysplasia Radial club hand encompasses a spectrum of complex congenital malformations of the radial side of the forearm. These are uncommon and can range from a ... Read the Article 0.75 6 Activity MD/PA Activity DO
Radiation Induced Coronary Artery Disease Radiation-induced coronary artery disease (RICAD) is the second most common cause of morbidity and mortality in mainly oncology patients treated with ... Read the Article 0.75 5 Activity MD/PA Activity DO
Refractory Anemia With Ring Sideroblasts Refractory anemia with ring sideroblasts (RARS) is a type of myelodysplastic syndrome (MDS) that is characterized by anemia and the presence of at lea ... Read the Article 0.75 5 Activity MD/PA Activity DO
Renal Calculi Renal calculi are a common cause of blood in the urine (hematuria) and pain in the abdomen, flank, or groin. They occur in one in 11 people at some ti ... Read the Article 1 6 Activity MD/PA Activity DO
Retinoblastoma Retinoblastoma is the most common primary intraocular malignancy of childhood. Patients management is best in consultation with an experienced ophthal ... Read the Article 1 7 Activity MD/PA Activity DO
Rhabdomyosarcoma Rhabdomyosarcoma (RMS) is a primitive pediatric malignant soft tissue sarcoma of skeletal muscle phenotype that originates from a primitive mesenchyma ... Read the Article 0.75 6 Activity MD/PA Activity DO
Roseola Infantum Roseola infantum is a common disease of childhood that is seen globally and is caused by infection with human herpesvirus 6 (HHV-6), or, less frequent ... Read the Article 1.25 16 Activity MD/PA Activity DO
Schwannoma Schwannomas (also known as neuromas, neurinomas "of Verocay" and neurilemmomas) are benign, well-encapsulated, slow-growing nerve sheath tumors that a ... Read the Article 1 8 Activity MD/PA Activity DO
Septic Shock Sepsis syndromes span a clinical continuum with variable prognosis. Septic shock, the most severe complication of sepsis, carries a high mortality. Se ... Read the Article 1.25 16 Activity MD/PA Activity DO
Serum Sickness Serum sickness is a rare but important cause of fever, arthritis, and rash in both children and adults. This activity reviews the differences between ... Read the Article 0.75 5 Activity MD/PA Activity DO
Severe Combined Immunodeficiency Severe combined immunodeficiency disease (SCID) is an inherited primary immunodeficiency disorder that presents by six months of age with opportunisti ... Read the Article 0.75 6 Activity MD/PA Activity DO
Shock Resuscitation At its most basic definition, the term “shock” means that there is a lack of adequate tissue oxygenation throughout the body. Typically, this lack of ... Read the Article 0.75 5 Activity MD/PA Activity DO
Shwachman-Diamond Syndrome Schwachman-Diamond syndrome (SDS) is an autosomal recessive disorder that is the second most common cause of exocrine pancreatic insufficiency after c ... Read the Article 0.75 4 Activity MD/PA Activity DO
Sickle Cell Anemia Sickle cell anemia is an inherited disorder of erythrocytes caused by an abnormality in hemoglobin. Hemoglobin in most healthy individuals is present ... Read the Article 1.5 19 Activity MD/PA Activity DO
Sickle Cell Disease Sickle cell disease (SCD) is a multisystem disorder and the most common genetic disease in the United States, affecting 1 in 500 African Americans. Ab ... Read the Article 1 9 Activity MD/PA Activity DO
Sickle Cell Trait Sickle cell trait (SCT) is a benign condition in which the affected individual has only one abnormal hemoglobin beta gene allele. This is in contrast ... Read the Article 0.75 6 Activity MD/PA Activity DO
Splenic Infarcts Splenic infarction occurs when the blood supply to the spleen is compromised resulting in tissue ischemia and eventual necrosis. It may be the result ... Read the Article 1 7 Activity MD/PA Activity DO
Splenic Rupture The spleen is an encapsulated hematopoietic organ that lies within the posterior aspect of the left upper quadrant in the peritoneal cavity. It has pr ... Read the Article 0.75 3 Activity MD/PA Activity DO
Splenic Sequestration Crisis Young children with sickle cell anemia are at risk for acute splenic sequestration crises. These occur when an excessive amount of blood becomes trapp ... Read the Article 0.75 6 Activity MD/PA Activity DO
Subclavian Vein Thrombosis Subclavian vein thrombosis occurs due to either a primary etiology or a secondary etiology. It requires a thorough history and physical exam for diagn ... Read the Article 1 9 Activity MD/PA Activity DO
Systemic Mastocytosis Systemic mastocytosis is an aggressive disorder characterized by the release of numerous vasoactive cell mediators due to excessive activity of mast c ... Read the Article 0.75 5 Activity MD/PA Activity DO
Telangiectatic Osteosarcoma Telangiectatic osteosarcoma is a rare high-grade malignant neoplasm, accounting for less than 4 percent of all cases of osteosarcoma. It is a rare var ... Read the Article 0.75 5 Activity MD/PA Activity DO
Testicle Cancer Testicular cancer is one of the most common malignancies in men aged 15 to 45 years. Etiology is multifactorial, comprising various genetic and enviro ... Read the Article 1 7 Activity MD/PA Activity DO
Testicular Seminoma Testicular seminomas are cancers that can usually be managed with surgical resection, although radiation is added for advanced stage disease. Stage 1 ... Read the Article 0.75 4 Activity MD/PA Activity DO
Thalassemia Thalassemia is a heterogeneous group of blood disorders affecting the hemoglobin genes and resulting in ineffective erythropoiesis. The decreased prod ... Read the Article 1 9 Activity MD/PA Activity DO
Thoracentesis Thoracentesis is a procedure that is performed to remove fluid from the thoracic cavity. This can be done for both diagnostic and therapeutic purposes ... Read the Article 1 10 Activity MD/PA Activity DO
Thrombin Thrombin is a topical hemostatic agent used to control and minimize blood loss during surgical procedures, is utilized in conjunction or as an alterna ... Read the Article 1 7 Activity MD/PA Activity DO
Thrombocytopenia Thrombocytopenia is a platelet count below the lower limit of normal, i.e., 150000/microliter (for adults). This activity reviews the etiology, evalua ... Read the Article 1.25 15 Activity MD/PA Activity DO
Thyroid Adenoma Thyroid adenoma is a benign lesion of the thyroid gland. There are two types of thyroid adenomas, follicular and papillary. Thyroid adenoma usually pr ... Read the Article 1 10 Activity MD/PA Activity DO
Transfusion Iron Overload Transfusion iron overload is associated with numerous blood transfusions. Excess iron from multiple blood transfusions deposit in different organs thr ... Read the Article 1 7 Activity MD/PA Activity DO
Transfusion Reactions Transfusion reactions are adverse events associated with the transfusion of whole blood or one of its components. They range in severity from minor to ... Read the Article 1.25 13 Activity MD/PA Activity DO
Transient Hypogammaglobulinemia of Infancy Transient hypogammaglobulinemia of infancy (THI) is a type of antibody deficiency that affects infant and children typically below the age of 6 years. ... Read the Article 0.75 5 Activity MD/PA Activity DO
Tuberous Sclerosis Tuberous sclerosis complex (TSC) is a genetic disorder that affects multiple systems. It is inherited in an autosomal dominant fashion and is characte ... Read the Article 2 34 Activity MD/PA Activity DO
Tumor Lysis Syndrome Tumor lysis syndrome is the most common oncologic emergency. This condition is prevalent in both adult and pediatric oncology patients undergoing chem ... Read the Article 1 10 Activity MD/PA Activity DO
Turcot Syndrome Turcot syndrome is the association of primary brain tumors with colorectal cancer. Hereditary non-polyposis colorectal cancer (HNPCC) and familial ade ... Read the Article 1 7 Activity MD/PA Activity DO
Vinca Alkaloid Toxicity Vinca alkaloids, which belong to a class of cell cycle phase M specific anti-tubulin agents are one of the first plant alkaloids to be developed for u ... Read the Article 1 6 Activity MD/PA Activity DO
Vitamin K Deficiency Vitamin K refers to a group of fat-soluble compounds involved in coagulation, bone development, and cardiovascular health. Vitamin K deficiency can co ... Read the Article 1.25 14 Activity MD/PA Activity DO
Von Hippel Lindau Syndrome Von Hippel-Lindau (VHL) syndrome is an autosomal dominant disease affecting several organ systems. The disease is characterized by the growth of cysts ... Read the Article 1 7 Activity MD/PA Activity DO
Von Willebrand Disease Von Willebrand disease is a bleeding disorder caused by the qualitative or quantitative deficiency of the pro-von Willebrand factor. Affected people m ... Read the Article 0.75 5 Activity MD/PA Activity DO
Waterhouse-Friderichsen Syndrome Waterhouse Friderichsen syndrome is a rare but life-threatening disorder associated with bilateral adrenal hemorrhage. In many cases, it is caused by ... Read the Article 0.75 5 Activity MD/PA Activity DO
Wilms Tumor Wilms tumor, or nephroblastoma, is the most common pediatric renal cancer, the most common pediatric abdominal cancer, and the fourth most common pedi ... Read the Article 1.25 15 Activity MD/PA Activity DO
Wiskott-Aldrich Syndrome Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder which classically includes the characteristic triad of immunodeficiency, thrombocytopenia, ... Read the Article 1.25 13 Activity MD/PA Activity DO
Wyburn-Mason Syndrome Wyburn-Mason syndrome is a rare nonhereditary congenital phakomatoses which presents with multiple arteriovenous malformations that tend to be large a ... Read the Article 1 7 Activity MD/PA Activity DO
X-linked Agammaglobulinemia X-linked agammaglobulinemia or XLA is a primary immunodeficiency disorder that prevents affected individuals from making antibodies and requires them ... Read the Article 0.75 5 Activity MD/PA Activity DO
X-Linked Immunodeficiency Primary immunodeficiencies (PID) are a heterogeneous group of diseases, mostly inherited, caused by more than 400 intrinsic disorders of the immune sy ... Read the Article 1 7 Activity MD/PA Activity DO
Yolk Sac Tumors Yolk sac tumors (also known as endodermal sinus tumors) are malignant primitive germ cell tumors; they are histologically similar to the mesenchyma of ... Read the Article 1 8 Activity MD/PA Activity DO

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