Lambert-Eaton Myasthenic Syndrome

Overview

4.6 out of 5 (27 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Sep 2023

Last Review Date

23 Oct 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular junction disorder affecting communication between nerves and muscles. This intricate disorder can manifest due to a paraneoplastic syndrome or a primary autoimmune disorder. The majority of cases are associated with small-cell lung cancer. This activity primarily focuses on analyzing the prominent clinical symptom of muscle weakness, which is driven by the development of antibodies that target voltage-gated calcium channels on presynaptic nerve terminals. As a result, the release of the acetylcholine neurotransmitter is reduced. This activity helps gain valuable insights into the intricate pathogenesis, practical diagnostic approaches, and tailored treatment strategies for LEMS. This activity also highlights the crucial role of the interprofessional healthcare team in coordinating the comprehensive management of this intricate syndrome.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify early clinical indicators of Lambert-Eaton myasthenic syndrome, such as proximal muscle weakness and autonomic dysfunction.

  • Implement individualized symptomatic management strategies tailored to LEMS severity to optimize acetylcholine levels and neuromuscular transmission.

  • Select the most suitable treatment options for LEMS patients based on the severity of weakness and malignancy association.

  • Communicate effectively with LEMS patients and their families, explaining the diagnosis, treatment options, prognosis, and potential adverse effects and outcomes of the treatment.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Otolaryngology–Head and Neck Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn their required annual part II self-assessment credit in the American Board of Otolaryngology–Head and Neck Surgery’s Continuing Certification program (formerly known as MOC). It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of recognizing participation.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Micheal M. on 12/7/2021

Dr Jagveer S. on 1/4/2023

Aseeb R. on 4/17/2023

Svetlana T. on 5/8/2023

Bernadette M. on 5/17/2023

Gaston D. on 6/11/2023

Mark L. on 6/24/2023

ASEEDU K. on 6/29/2023

asi y. on 9/8/2023

debbie s. on 10/14/2023

Marcus T. on 11/10/2023

ISLAM A. on 11/11/2023

Augusto L. on 11/13/2023

visa on 11/14/2023

Pamela P. on 11/24/2023

JAMES N. on 11/29/2023

Manish S. on 12/4/2023

Julia W. on 12/4/2023

Shreekant P. on 12/9/2023

Mohamed E. on 12/16/2023

Great review.

Richard P. on 12/17/2023

Juan M. on 12/18/2023

Richard S. on 12/21/2023

Gregorio J. on 12/29/2023

Karl O. on 2/2/2024

Bozena B. on 3/3/2024

Excellent questions and explanations

joerg r. on 3/18/2024

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