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|Alpha 1 Antitrypsin Mutation|
Credits: 1.00 Post-Assessment Questions: 5
Release Date: 5 Oct 2020
Expiration Date: 15 Jul 2021
Last Reviewed: 15 Jul 2020
Estimated Time To Finish: 60 Minutes
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Alpha-1 antitrypsin is a protease inhibitor produced primarily in the liver. It inhibits the neutrophil elastase activity in the lung and hence can protect it from proteolytic damage. It is responsible for approximately 90% of the protection against elastolytic activity in the lower airways caused by elastase released from neutrophils. If the neutrophils' elastases are not opposed, panacinar lung tissue is damaged and increases the risk of developing chronic obstructive pulmonary disease (COPD). On the other hand, the retention and accumulation of mutated polymers in the endoplasmic reticulum of hepatocytes renders the individuals with this disease at risk of "a gain of toxic function" leading to liver disease. This activity reviews the evaluation and management of alpha-1 antitrypsin mutation and highlights the role of interprofessional team members in collaborating to provide well-coordinated care and enhance patient outcomes in the care of patients with this rare condition.
This activity has been designed to meet the educational needs of physicians.
At the conclusion of this activity, the learner will be better able to:
The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.
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Authors: Ali Abdulkarim
Editors: Timothy Craig
Editors-In-Chief: Alsadiq Al-Hillan Savio JohnHela Kchir
Chief Medical Reviewer: Donna Aileen Trovela
Nurse Planner/Reviewer/Editor: Lisa Haddad
Pharmacy Planner/Reviewer/Editor: Mark Pellegrini
Physician Planner/Reviewer/Editor: Scott Dulebohn
The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.
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StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.
The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.
This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.
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