Anatomy, Thoracotomy and the Collateral Intercostal Neurovascular Bundle

Article Author:
Noel Boaz
Article Author (Archived):
Raymond Bernor
Article Editor:
Forshing Lui
Updated:
7/14/2019 8:39:16 PM
PubMed Link:
Anatomy, Thoracotomy and the Collateral Intercostal Neurovascular Bundle

Introduction

The neurovascular anatomy of the thoracic wall is clinically significant because clinicians must traverse it in such procedures as thoracentesis, thoracostomy, and thoracotomy.   

Structure and Function

The thoracic body wall is composed of a bony framework of the bodies and transverse processes of thoracic vertebrae articulating with ribs, the superior ten which form a bony ribcage around the thorax joining with the sternum and its costal cartilages anteriorly. Ribs 11 and 12, the “floating ribs,” form the posteroinferior most bony body wall of the thorax but terminate within the abdominal wall musculature anteriorly.[1] Ribs 1 through 7 articulate with the axial skeleton via costovertebral, costotransverse, and sternocostal joints. Ribs 8 through 10 articulate anteriorly via costochondral joints.

The musculofascial components of the thoracic wall form a three-layered intercostal membrane between the ribs consisting of external intercostal, internal intercostal, and innermost intercostal muscles which have a primary respiratory function.[2] The external intercostal muscles act to raise the ribs in a “bucket handle” fashion, thereby increasing thoracic volume, while the internal intercostals largely depress the ribs, decreasing thoracic volume, and aiding in exhalation.

Homology in muscle fiber orientation of the three muscle layers in both the thorax and abdominal body walls suggests that there is a primitive chordate bauplan that provides “plywood-like” integrity to the body wall. 

Neurovascular structures travel in the interval between innermost and inner intercostal muscles within the intercostal space, piercing as lateral cutaneous branches near the mid-axillary line and as anterior cutaneous branches parasternally.

Embryology

A three-layered body wall develops from somatopleuric mesoderm by the ninth week of gestation. The three intercostal muscle layers differentiate from hypaxial myotomes innervated by ventral primary rami of spinal nerves T1 to T11, the intercostal nerves.[3] Twelve ribs develop from segmental sclerotomes to interrupt the muscular wall and form the 11 intercostal spaces. The muscles of each intercostal space receive innervation by segmentally arranged spinal nerves denominated by the corresponding superjacent rib. Sensory innervation of the thoracic wall follows the embryonically derived pattern of overlapping dermomyotomes. The ventral primary ramus of T12 is serially homologous to an intercostal nerve but is named the subcostal nerve since it is not bounded inferiorly by a rib. This nerve, as well as the anterior branches of T7 to T11 continuing into the abdomen, are correctly termed thoracoabdominal nerves,[4] even though they are frequently referred to in the clinical literature as intercostal nerves. The three anterolateral muscle layers of the abdominal wall, as well as the rectus abdominis muscle, which they innervate, share their embryological origin and fiber directionality with the muscles of the intercostal space.

Vertebrae develop intersegmentally by embryonic fusion of the caudal half of the superjacent somitic sclerotome with the cranial half of the subjacent sclerotome. Ribs, myotomal derivatives, and segmental neurovasculature maintain their segmental embryonic patterning. The rib head in most ribs (2 to 9) thus articulates with two vertebrae at the costovertebral joint, but by convention, rib denomination is by reference to their subjacent vertebra. Rib 1 only articulates with the first thoracic vertebra, and ribs 10 through 12 also have only one facet at the costovertebral joint at which they articulate with the lower thoracic vertebrae.

The lining of the coelomic cavity develops as a mesothelium which invests organs as visceral pleura and the internal surface of the thoracic wall as parietal pleura. The space between visceral and parietal layers comprises the pleural cavity, which normally contains only serous fluid. The lungs inhabit the two halves of the thoracic cavity, not the pleural cavity.

Blood Supply and Lymphatics

While the intercostal space receives its innervation exclusively from the posterior side, its pattern of vascularization is both posterior and anterior.[1][2] Blood supply derives from the subclavian artery via the costocervical trunks (highest or supreme intercostal arteries) and the descending aorta posteriorly, and the internal thoracic (formerly internal mammary) arteries and their branches, the musculophrenic arteries, anteriorly. The two most superior intercostal spaces receive their posterior intercostal arteries from the highest intercostals. Nine posterior intercostal arteries (3 to 11) branch off bilaterally from the descending thoracic aorta, the right posterior intercostal arteries being longer because they must cross over the vertebral bodies to reach the right intercostal spaces. Six anterior intercostal arteries (1 through 6), which are of equal length on the right and left sides, branch off the bilaterally symmetrical internal thoracic arteries, in turn, branches of the subclavian arteries. The musculophrenic artery supplies the anterior intercostal arteries of spaces 7 to 9 after it branches off the internal thoracic. The anterior and posterior intercostal arteries anastomose within the intercostal spaces, except for the most inferior anterior intercostal arteries (10 and 11) which are rudimentary, if present at all.

Anterior and posterior intercostal veins draining the intercostal spaces also anastomose within the space and follow a similar pattern to the arteries. The most superior two to four intercostal spaces are drained by the variable highest (or superior) intercostal veins which drain into the subclavian veins which converge to empty into the superior vena cava. The remaining posterior intercostal veins (5 to 11) drain into the azygos venous system.  The left posterior intercostal veins are longer than the right because it is they which must cross the midline to reach the caval system. The anterior intercostal veins drain superiorly into the internal thoracic veins, which in turn follow into the brachiocephalic veins to the superior vena cava.

Lymphatic drainage of the left thoracic wall, as well as the right thoracic wall below the level of entry of the azygos vein into the superior vena cava, i.e., vertebral level T4-5, is into the thoracic duct.[5] The thoracic duct lies immediately posterior to the intercostal spaces on the bodies of the thoracic vertebrae and drains superiorly into the supraclavicular nodes at the left venous angle and thence into the left subclavian vein. The right superior thoracic wall is drained by the right lymphatic duct which empties into the right subclavian vein and is surrounded at that point by the right supraclavicular lymph nodes.

Nerves

Somatic afferent fibers grow out from developing intercostal nerves to innervate the underlying parietal pleura, which is sensitive to pain.[6] Neural crest cells that migrate from thoracic spinal levels develop into sympathetic chain ganglia on the posterior thoracic wall and connect to the spinal nerves via rami communicantes.[6] Sympathetic nerves that do not synapse in the chain ganglia form thoracic splanchnic nerves on the posterior thoracic wall. These fibers synapse in the cardiac or thoracic aortic plexuses and then distribute through the hilum of the lung to the visceral pleura.  Visceral afferent fibers accompanying sympathetics comingle with developing vagal nerve afferents accompanying parasympathetic nerves to supply the visceral pleura.

Surgical Considerations

Thoracotomy is the surgical entry into the chest cavity through the thoracic wall. Thoracentesis is a procedure required for aspiration of a pleural effusion. Other surgeries that involve thoracotomy include sympathectomy for hyperhidrosis [7], insertion of chest drains,[8] surgical preparation of an intercostal musculopleural flap [9], and resection of the lung.[10]

The location of thoracotomy on the thoracic wall is selected based on avoiding injury to underlying viscera, nerves, and vessels. The largest portion of the pleural cavity not filled with lung, thus making it accessible for surgical entry, is the costodiaphragmatic recess, which forms along the rim of the thoracic attachment of the diaphragm. The recess is bound inferiorly and peripherally by diaphragmatic and costal parietal pleura and superiorly and internally by visceral pleura covering the surface of the lung. The circumferential costal and dome-shaped diaphragmatic surfaces of the recess converge inferiorly leaving very little space between them at ribs 10 through 12. Here an inserted needle would risk puncturing the diaphragm and injuring subdiaphragmatic viscera – the liver on the right side and the spleen, transverse colon, or stomach on the left side.  The preferred location for thoracostomy for pleural effusion is in intercostal space nine up to intercostal space seven in the mid-axillary line posteriorly to the paravertebral line.[11]

Thoracostomy is forming an opening in the thoracic wall to evacuate air secondary to pneumothorax or pleural fluid secondary to pleural effusion. In this case, the lung is collapsed and gathered around the hilum, thus considerably enlarging the pleural cavity and minimizing the chances of piercing and injuring the lung during surgical entry into the thoracic cavity. The most typical location of thoracostomy is intercostal space 5 in the mid-axillary line.[4]

The site of thoracotomy within the intercostal space is also crucial because of the necessity of avoiding neurovascular structures which traverse the space.  The intercostal nerves enter the intercostal spaces posteriorly at the intervertebral foramen, cross into the space inferiorly, and pass superiorly to lie in the costal groove.[11] (Fig. 1)

Clinical Significance

Most standard medical treatments of the procedure of thoracentesis correctly draw attention to the location of the intercostal nerve as the most inferior of the neurovascular structures in the costal groove on the inferior aspect of the ribs (“V-A-N” from superior to inferior), with the caution that punctures immediately inferior to the rib will likely injure the intercostal nerve. However, most of these sources fail to note the presence of the collateral branch of the intercostal nerve coursing along the superior aspect of the rib below (Fig. 1), and thus inadvisedly recommend surgical entry at this point into the intercostal space. Injury to the collateral intercostal nerve can cause the patient unnecessary pain both during the procedure and post-operatively.

Placement of intercostal catheter for thoracocentesis or chest tube placement: this is usually and most safely performed within the "triangle of safety." The triangle of safety is defined with the arm abducted. The apex of the triangle is the axilla. The anterior border is the lateral edge of the pectoralis major muscle and the posterior border forms from the lateral margin of the latissimus dorsi. The base of the triangle is the fifth intercostal space. Chest tube placement should be near the base of this triangle in the midaxillary line. The site of entry is classically taught to be just above the superior border of the lower rib. This location can certainly reduce the risk of venous puncture. However, it may injure the collateral intercostal nerve resulting in post-op pain. The better site should be around 25% of the distance above the superior border of the lower rib or better still to use an ultrasound guide.

Intercostal nerve block requires an understanding of the course of ventral primary rami of spinal nerves, their relationship to the sympathetic trunk, and the variable branching pattern of the intercostal nerves.[1][6][12][13] The relationship of deep branches of the intercostal nerves to the parietal pleura allows intrapleural approaches to analgesia.[14]



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      Dissection by K. Meshida, R. Bernor, and N.T. Boaz. Contributed by Noel T. Boaz, Ph.D., M.D.

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