[1]
Schumann G, Bonora R, Ceriotti F, Clerc-Renaud P, Ferrero CA, Férard G, Franck PF, Gella FJ, Hoelzel W, Jørgensen PJ, Kanno T, Kessner A, Klauke R, Kristiansen N, Lessinger JM, Linsinger TP, Misaki H, Panteghini M, Pauwels J, Schimmel HG, Vialle A, Weidemann G, Siekmann L. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. Part 3. Reference procedure for the measurement of catalytic concentration of lactate dehydrogenase. Clinical chemistry and laboratory medicine. 2002 Jun:40(6):643-8
[PubMed PMID: 12211663]
[2]
Holmes RS, Goldberg E. Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs. Computational biology and chemistry. 2009 Oct:33(5):379-85. doi: 10.1016/j.compbiolchem.2009.07.006. Epub 2009 Jul 19
[PubMed PMID: 19679512]
[3]
Drent M, Cobben NA, Henderson RF, Wouters EF, van Dieijen-Visser M. Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation. The European respiratory journal. 1996 Aug:9(8):1736-42
[PubMed PMID: 8866602]
[4]
Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins. 2001 May 1:43(2):175-85
[PubMed PMID: 11276087]
[5]
Khan AA, Allemailem KS, Alhumaydhi FA, Gowder SJT, Rahmani AH. The Biochemical and Clinical Perspectives of Lactate Dehydrogenase: An Enzyme of Active Metabolism. Endocrine, metabolic & immune disorders drug targets. 2020:20(6):855-868. doi: 10.2174/1871530320666191230141110. Epub
[PubMed PMID: 31886754]
Level 3 (low-level) evidence
[6]
Passarella S, Schurr A. l-Lactate Transport and Metabolism in Mitochondria of Hep G2 Cells-The Cori Cycle Revisited. Frontiers in oncology. 2018:8():120. doi: 10.3389/fonc.2018.00120. Epub 2018 Apr 23
[PubMed PMID: 29740537]
[7]
Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z. Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. The Journal of biological chemistry. 2016 Dec 2:291(49):25306-25318
[PubMed PMID: 27738103]
[8]
de Bari L, Atlante A. Including the mitochondrial metabolism of L-lactate in cancer metabolic reprogramming. Cellular and molecular life sciences : CMLS. 2018 Aug:75(15):2763-2776. doi: 10.1007/s00018-018-2831-y. Epub 2018 May 4
[PubMed PMID: 29728715]
[9]
Laughton JD, Charnay Y, Belloir B, Pellerin L, Magistretti PJ, Bouras C. Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain. Neuroscience. 2000:96(3):619-25
[PubMed PMID: 10717443]
[10]
Markert CL, Shaklee JB, Whitt GS. Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation. Science (New York, N.Y.). 1975 Jul 11:189(4197):102-14
[PubMed PMID: 1138367]
[11]
Schueren F, Lingner T, George R, Hofhuis J, Dickel C, Gärtner J, Thoms S. Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals. eLife. 2014 Sep 23:3():e03640. doi: 10.7554/eLife.03640. Epub 2014 Sep 23
[PubMed PMID: 25247702]
[12]
Auerbach G, Ostendorp R, Prade L, Korndörfer I, Dams T, Huber R, Jaenicke R. Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. Structure (London, England : 1993). 1998 Jun 15:6(6):769-81
[PubMed PMID: 9655830]
[13]
Eventoff W, Rossmann MG, Taylor SS, Torff HJ, Meyer H, Keil W, Kiltz HH. Structural adaptations of lactate dehydrogenase isozymes. Proceedings of the National Academy of Sciences of the United States of America. 1977 Jul:74(7):2677-81
[PubMed PMID: 197516]
[14]
Adeva-Andany M, López-Ojén M, Funcasta-Calderón R, Ameneiros-Rodríguez E, Donapetry-García C, Vila-Altesor M, Rodríguez-Seijas J. Comprehensive review on lactate metabolism in human health. Mitochondrion. 2014 Jul:17():76-100. doi: 10.1016/j.mito.2014.05.007. Epub 2014 Jun 12
[PubMed PMID: 24929216]
[15]
Overgaard M, Rasmussen P, Bohm AM, Seifert T, Brassard P, Zaar M, Homann P, Evans KA, Nielsen HB, Secher NH. Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Jul:26(7):3012-20. doi: 10.1096/fj.11-191999. Epub 2012 Mar 21
[PubMed PMID: 22441982]
[16]
Liberti MV, Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? Trends in biochemical sciences. 2016 Mar:41(3):211-218. doi: 10.1016/j.tibs.2015.12.001. Epub 2016 Jan 5
[PubMed PMID: 26778478]
[17]
Al Bawab AQ, Zihlif M, Jarrar Y, Sharab A. Continuous Hypoxia and Glucose Metabolism: The Effects on Gene Expression in Mcf7 Breast Cancer Cell Line. Endocrine, metabolic & immune disorders drug targets. 2021:21(3):511-519. doi: 10.2174/1871530320666200506082020. Epub
[PubMed PMID: 32370732]
[18]
Shi Y, Pinto BM. Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation. PloS one. 2014:9(1):e86365. doi: 10.1371/journal.pone.0086365. Epub 2014 Jan 17
[PubMed PMID: 24466056]
[19]
Spriet LL, Howlett RA, Heigenhauser GJ. An enzymatic approach to lactate production in human skeletal muscle during exercise. Medicine and science in sports and exercise. 2000 Apr:32(4):756-63
[PubMed PMID: 10776894]
[20]
Valvona CJ, Fillmore HL, Nunn PB, Pilkington GJ. The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor. Brain pathology (Zurich, Switzerland). 2016 Jan:26(1):3-17. doi: 10.1111/bpa.12299. Epub 2015 Sep 17
[PubMed PMID: 26269128]
[21]
Tokinoya K, Ishikura K, Yoshida Y, Ra SG, Sugasawa T, Aoyagi A, Nabekura Y, Takekoshi K, Ohmori H. LDH isoenzyme 5 is an index of early onset muscle soreness during prolonged running. The Journal of sports medicine and physical fitness. 2020 Jul:60(7):1020-1026. doi: 10.23736/S0022-4707.20.10278-0. Epub 2020 Apr 6
[PubMed PMID: 32253893]
[22]
Feng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y. Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer medicine. 2018 Dec:7(12):6124-6136. doi: 10.1002/cam4.1820. Epub 2018 Nov 6
[PubMed PMID: 30403008]
Level 2 (mid-level) evidence
[23]
Mercer RM, Corcoran JP, Porcel JM, Rahman NM, Psallidas I. Interpreting pleural fluid results . Clinical medicine (London, England). 2019 May:19(3):213-217. doi: 10.7861/clinmedicine.19-3-213. Epub
[PubMed PMID: 31092513]
[24]
Jurisic V, Radenkovic S, Konjevic G. The Actual Role of LDH as Tumor Marker, Biochemical and Clinical Aspects. Advances in experimental medicine and biology. 2015:867():115-24. doi: 10.1007/978-94-017-7215-0_8. Epub
[PubMed PMID: 26530363]
Level 3 (low-level) evidence
[25]
Mishra D, Banerjee D. Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment. Cancers. 2019 May 29:11(6):. doi: 10.3390/cancers11060750. Epub 2019 May 29
[PubMed PMID: 31146503]
[26]
Gallo M, Sapio L, Spina A, Naviglio D, Calogero A, Naviglio S. Lactic dehydrogenase and cancer: an overview. Frontiers in bioscience (Landmark edition). 2015 Jun 1:20(8):1234-49
[PubMed PMID: 25961554]
Level 3 (low-level) evidence
[27]
Liu J, Chen G, Liu Z, Liu S, Cai Z, You P, Ke Y, Lai L, Huang Y, Gao H, Zhao L, Pelicano H, Huang P, McKeehan WL, Wu CL, Wang C, Zhong W, Wang F. Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer. Cancer research. 2018 Aug 15:78(16):4459-4470. doi: 10.1158/0008-5472.CAN-17-3226. Epub 2018 Jun 11
[PubMed PMID: 29891507]
[28]
Granchi C, Bertini S, Macchia M, Minutolo F. Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials. Current medicinal chemistry. 2010:17(7):672-97
[PubMed PMID: 20088761]
[29]
Di Bussolo V, Calvaresi EC, Granchi C, Del Bino L, Frau I, Lang MC, Tuccinardi T, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents. RSC advances. 2015:5(26):19944-19954
[PubMed PMID: 26167277]
Level 3 (low-level) evidence
[30]
Urbańska K, Orzechowski A. Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells. International journal of molecular sciences. 2019 Apr 27:20(9):. doi: 10.3390/ijms20092085. Epub 2019 Apr 27
[PubMed PMID: 31035592]
[31]
Augoff K, Hryniewicz-Jankowska A, Tabola R. Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer. Cancer letters. 2015 Mar 1:358(1):1-7. doi: 10.1016/j.canlet.2014.12.035. Epub 2014 Dec 17
[PubMed PMID: 25528630]
Level 3 (low-level) evidence
[32]
Martens A, Wistuba-Hamprecht K, Geukes Foppen M, Yuan J, Postow MA, Wong P, Romano E, Khammari A, Dreno B, Capone M, Ascierto PA, Di Giacomo AM, Maio M, Schilling B, Sucker A, Schadendorf D, Hassel JC, Eigentler TK, Martus P, Wolchok JD, Blank C, Pawelec G, Garbe C, Weide B. Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Jun 15:22(12):2908-18. doi: 10.1158/1078-0432.CCR-15-2412. Epub 2016 Jan 19
[PubMed PMID: 26787752]
Level 2 (mid-level) evidence
[33]
Weide B, Martens A, Hassel JC, Berking C, Postow MA, Bisschop K, Simeone E, Mangana J, Schilling B, Di Giacomo AM, Brenner N, Kähler K, Heinzerling L, Gutzmer R, Bender A, Gebhardt C, Romano E, Meier F, Martus P, Maio M, Blank C, Schadendorf D, Dummer R, Ascierto PA, Hospers G, Garbe C, Wolchok JD. Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Nov 15:22(22):5487-5496. doi: 10.1158/1078-0432.CCR-16-0127. Epub 2016 May 16
[PubMed PMID: 27185375]
[34]
Bedikian AY, Millward M, Pehamberger H, Conry R, Gore M, Trefzer U, Pavlick AC, DeConti R, Hersh EM, Hersey P, Kirkwood JM, Haluska FG, Oblimersen Melanoma Study Group. Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2006 Oct 10:24(29):4738-45
[PubMed PMID: 16966688]
[35]
Smylie MG. Use of immuno-oncology in melanoma. Current oncology (Toronto, Ont.). 2020 Apr:27(Suppl 2):S51-S58. doi: 10.3747/co.27.5135. Epub 2020 Apr 1
[PubMed PMID: 32368174]
[36]
Yao Y, Wang H, Li B. LDH5 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014 Jul:35(7):6973-81. doi: 10.1007/s13277-014-1903-3. Epub 2014 Apr 18
[PubMed PMID: 24744144]
Level 1 (high-level) evidence
[37]
Monroe GR, van Eerde AM, Tessadori F, Duran KJ, Savelberg SMC, van Alfen JC, Terhal PA, van der Crabben SN, Lichtenbelt KD, Fuchs SA, Gerrits J, van Roosmalen MJ, van Gassen KL, van Aalderen M, Koot BG, Oostendorp M, Duran M, Visser G, de Koning TJ, Calì F, Bosco P, Geleijns K, de Sain-van der Velden MGM, Knoers NV, Bakkers J, Verhoeven-Duif NM, van Haaften G, Jans JJ. Identification of human D lactate dehydrogenase deficiency. Nature communications. 2019 Apr 1:10(1):1477. doi: 10.1038/s41467-019-09458-6. Epub 2019 Apr 1
[PubMed PMID: 30931947]
[38]
Lee BJ, Zand L, Manek NJ, Hsiao LL, Babovic-Vuksanovic D, Wylam ME, Qian Q. Physical therapy-induced rhabdomyolysis and acute kidney injury associated with reduced activity of muscle lactate dehydrogenase A. Arthritis care & research. 2011 Dec:63(12):1782-6. doi: 10.1002/acr.20584. Epub
[PubMed PMID: 22127970]
Level 2 (mid-level) evidence
[39]
Lund AM, Christensen E, Skovby F. [Diagnosis and acute treatment of inborn metabolic diseases in infants]. Ugeskrift for laeger. 2002 Nov 25:164(48):5613-9
[PubMed PMID: 12523004]
[40]
Walenta S, Mueller-Klieser WF. Lactate: mirror and motor of tumor malignancy. Seminars in radiation oncology. 2004 Jul:14(3):267-74
[PubMed PMID: 15254870]