Idiopathic Guttate Hypomelanosis

Article Author:
Falon Brown
Article Editor:
Jonathan Crane
10/27/2018 12:31:39 PM
PubMed Link:
Idiopathic Guttate Hypomelanosis


Idiopathic guttate hypomelanosis (IGH) is a benign, typically asymptomatic, leukodermic dermatosis of unclear etiology that is classically seen in elderly, fair-skinned individuals, and often goes unrecognized or undiagnosed. Occasionally, IGH is aesthetically displeasing. However, it is not a dangerous process. Once present, lesions do not remit. Treatment is aimed at improving the cosmesis of lesions.


The etiology of IGH remains unknown. Several hypotheses exist, including the notion that this is a manifestation of the skin's normal aging process, occurs secondary to cumulative chronic sun exposure, or occurs as a result of repeated microtrauma to the skin. None of these hypotheses have been verified.


IGH occurs in all races and skin types. It is thought to occur more frequently in fair-skinned individuals. However, it can occur in darker skin types and is more noticeable in these patients. Despite the previous conception that it occurs more commonly in females, recent studies show equal male and female prevalence. One possibility for this discrepancy is a heightened perception of cosmetic problems by women versus men. Regardless of gender, the prevalence and incidence increase with age. Up to 80% of people over the age of 70 years are noted to have IGH. However, a recent study noted up to 87% patients aged 40 and older had at least one lesion. In addition, IGH may present in young adults in 20s and 30s.


The pathogenesis of IGH seems to be complex and multifactorial and likely involving both genetic and environmental factors, given the extremely high overall incidence.

Many studies have advocated the central role of sun exposure, although a definite causal relationship has not been statistically proven. Interestingly, lesions are uncommon on face and neck (which are typical sites for other actinic processes), suggesting multifactorial pathophysiology.

Small studies have noted a higher prevalence of these lesions in the family of patients with IGH compared with controls, implying at least partial hereditary component to pathogenesis. A recent study helped confirm this theory, which noted that within a subset of renal transplant patients, there was there is a statistically significant increase in the incidence of IGH with the HLA-DQ3 haplotype, and a negative association in patients with the HLA-DR8 haplotype.

Histopathologic correlation to elucidate possible underlying mechanisms of disease has also been inconsistent as well. Some studies note the reduction in the total number of melanocytes as the underlying driving factor, while others suggest structural abnormalities, such as fewer melanosomes, decreased dendrites, decreased tyrosinase activity, or even defective keratinocyte uptake rather than a melanocytic process.


As the diagnosis can usually be made on history and physical exam alone, lesions of IGH typically do not need to be examined with histopathology. If a biopsy is requested or necessarily sampled, pathology lesions classically present with a decrease in the total number of DOPA-positive epidermal melanocytes within the basal layer of the epidermis, although not completely absent as in vitiligo. Furthermore, there is an overall decrease melanin pigmentation. This is best noted when compared with adjacent "normal" epidermis, as isolated lesions without neighboring normal tissue for comparison may be difficult to distinguish. Additional features include flattening of rete ridges with or without atrophy of the epidermis. Epidermal atrophy is more frequently found in non-sun-exposed areas. There may be orthokeratosis ("basket-weave" hyperkeratosis) or compact orthokeratosis of the overlying stratum corneum.

On electron microscopy, melanocytes appear to undergo a degenerative process in that a dilated endoplasmic reticulum and swelling of mitochondria have been noted. Additionally, a decrease in number or melanosomes and of dendrites (in contrast to vitiligo, which notes increase number of dendrites) have been noted.

History and Physical

IGH presents with multiple small, scattered, discrete, round or oval-shaped achromic or hypochromic macules which are classically 2 to 6 mm in size and develop slowly over the years. Occasionally, there is an admixture of larger lesions up to 2.5 cm. Lesions are typically smooth, though scaly and even hyperkeratotic variants have been reported. Lesions do not assume regular pattern or grouping and do not change in size or regress once present. Adnexal structures such as hair follicles do not seem to be affected; hairs within the lesions usually retain their pigment. These lesions occur most commonly on sun-exposed areas, such as the dorsal upper and lower extremities, and they favor distal sites over proximal sites. However, sun-protected areas including the trunk, and rarely the face, can also be affected.


Given the benign course of IGH, no laboratory, radiographic, or other tests are typically necessary to investigate these patients.

Dermoscopy can be a valuable tool in the evaluation of lesions of IGH. Dermoscopy findings. Listed in order of incidence, IGH can assume varying morphologies:  

  • Amoeboid: pseudopod-like extensions
  • Feathery: irregularly pigmented with feathery margins and whitish central area
  • Petaloid: polycyclic margins, resembling petals of a flower
  • Nebuloid: indistinct, smudged borders

The nebulous pattern is noted more often in early lesions compared with ameboid, feathery, and petaloid patterns which are noted in older lesions.

Treatment / Management

Patients should be reassured that lesions of IGH are benign, and no treatment necessary. There are no universally accepted efficacious treatments for this condition.

In general, as sunlight is most likely a contributing or potentially even precipitating factor, the use of sunscreens and physical barriers should be recommended for all patients.

In addition to photoprotection, treatment for cosmetic purposes are available and have shown variable promise alone or in combination. These include cryotherapy, superficial abrasion, topical steroids, topical retinoids, topical calcineurin inhibitors, dermabrasion, topical 88% phenol, fractional carbon dioxide lasers, non-ablative fractional photothermolysis via fractional 1550-nm ytterbium/erbium fiber laser, and excimer light treatment. Patients should be counseled on the risk of worsening leukoderma with cryotherapy and of long-standing (although, not permanent) erythema and postinflammatory hyperpigmentation with treatments such as fractional carbon dioxide lasers. Promising studies have postulated that combination fractional photothermolysis and topical use of calcineurin inhibitors may improve outcomes. More recently, studies have noted an increase in melanocytes with combination microneedling with microinfusion of 5-fluorouracil via tattoo machine which may be a promising treatment option.

Differential Diagnosis

Differential diagnosis of guttate leukoderma is broad. Similar lesions may be seen in the setting of various generalized dyschromatoses. It is crucial to distinguish IGH lesions from vitiligo early in the disease course because, in contrast to vitiligo, lesions of IGH do not progress. Other common dermatologic conditions in the differential diagnosis include pityriasis versicolor, pityriasis alba, cafe au lait macules, lichen sclerosis, guttate morphea, and simple post inflammatory hypopigmentation. Each of which has a distinct typical distribution and associated findings which are fairly characteristic. Some of the less commonly thought of lesions which are important to distinguish include achromic verruca plana, pityriasis lichenoides chronica, disseminated hypopigmented keratoses that follow psoralen and ultraviolet A (PUVA) therapy, clear cell papulosis, and atrophie blanche.

Achromic verruca plana lesions will be more susceptible to koebnerization and histologically would expect to see koilocytes. Clinically, lesions of pityriasis lichenoides chronica are more widespread with overlying scale. Disseminated hypopigmented keratoses occur following PUVA therapy with well-demarcated, small, hypopigmented, flat-topped papules occurring on the trunk and extremities in a uniform distribution. Histologically note variable acanthosis, hyperorthokeratosis or parakeratosis, and papillomatosis, and a normal amount of melanin and melanocytes. Clear cell papulosis is a rare condition which occurs in young children more typically on face and trunk, at times noted to occur along "milk lines." Lesions present as multiple hypopigmented, barely elevated, small flat-topped papules and macules. Histologically, these lesions are characterized by large clear cells in the basal layer that have a pattern of immunohistochemical staining similar to Toker's clear cells of the nipple and extramammary Paget disease. Both IGH and atrophie blanch favor the distal dorsal extremities, such as dorsal shins. However, lesions of atrophie blanche tend to occur in the site of a previous ulcer with more angulated margins and tend to be more porcelain white, depressed atrophic scars with a surrounding rim of telangiectasia.


IGH is a benign condition with an excellent prognosis; however, once present, lesions do not remit without treatment. As such, they primarily represent a cosmetic concern. IGH may be an indication of cumulative sun exposure. However, no direct correlation has been made to date.


Activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: Preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial., Arbache S,Roth D,Steiner D,Breunig J,Michalany NS,Arbache ST,de Souza LG,Hirata SH,, Journal of the American Academy of Dermatology, 2018 Jan     [PubMed PMID: 29241792]
Therapeutic pearl: 5-fluorouracil tattoo for idiopathic guttate hypomelanosis., Wambier CG,Wambier SPF,Pereira Soares MT,Breunig J,Cappel MA,Landau M,, Journal of the American Academy of Dermatology, 2017 Nov 1     [PubMed PMID: 29102493]
Comprehensive understanding of idiopathic guttate hypomelanosis: clinical and histopathological correlation., Kim SK,Kim EH,Kang HY,Lee ES,Sohn S,Kim YC,, International journal of dermatology, 2010 Feb     [PubMed PMID: 20465639]
Clinical features of idiopathic guttate hypomelanosis in 646 subjects and association with other aspects of photoaging., Shin MK,Jeong KH,Oh IH,Choe BK,Lee MH,, International journal of dermatology, 2011 Jul     [PubMed PMID: 21699514]
On the pathogenesis of idiopathic guttate hypomelanosis., Falabella R,Escobar C,Giraldo N,Rovetto P,Gil J,Barona MI,Acosta F,Alzate A,, Journal of the American Academy of Dermatology, 1987 Jan     [PubMed PMID: 3805391]
HLA-DQ3 is associated with idiopathic guttate hypomelanosis, whereas HLA-DR8 is not, in a group of renal transplant patients., Arrunategui A,Trujillo RA,Marulanda MP,Sandoval F,Wagner A,Alzate A,Falabella R,, International journal of dermatology, 2002 Nov     [PubMed PMID: 12452995]
On the nature of idiopathic guttate hypomelanosis., Wilson PD,Lavker RM,Kligman AM,, Acta dermato-venereologica, 1982     [PubMed PMID: 6183861]
Idiopathic guttate hypomelanosis. Ultrastructural study., Ortonne JP,Perrot H,, Archives of dermatology, 1980 Jun     [PubMed PMID: 7377803]
Dermoscopic evaluation of idiopathic guttate hypomelanosis: A preliminary observation., Ankad BS,Beergouder SL,, Indian dermatology online journal, 2015 May-Jun     [PubMed PMID: 26009709]
Idiopathic guttate hypomelanosis., Whitehead WJ,Moyer DG,Vander Ploeg DE,, Archives of dermatology, 1966 Sep     [PubMed PMID: 4951808]
Idiopathic guttate hypomelanosis., Falabella R,, Dermatologic clinics, 1988 Apr     [PubMed PMID: 3288384]
Idiopathic guttate hypomelanosis., Cummings KI,Cottel WI,, Archives of dermatology, 1966 Feb     [PubMed PMID: 5904027]
Hypopigmented keratosis: is it a hyperkeratotic variant of idiopathic guttate hypomelanosis?, Kim SK,Park JY,Hann SK,Kim YC,Lee ES,Kang HY,, Clinical and experimental dermatology, 2013 Jul     [PubMed PMID: 23600406]
Pimecrolimus for idiopathic guttate hypomelanosis., Asawanonda P,Sutthipong T,Prejawai N,, Journal of drugs in dermatology : JDD, 2010 Mar     [PubMed PMID: 20232585]
Topical tacrolimus significantly promotes repigmentation in idiopathic guttate hypomelanosis: a double-blind, randomized, placebo-controlled study., Rerknimitr P,Disphanurat W,Achariyakul M,, Journal of the European Academy of Dermatology and Venereology : JEADV, 2013 Apr     [PubMed PMID: 22324720]
Combination of non-ablative fractional photothermolysis and 0.1% tacrolimus ointment is efficacious for treating idiopathic guttate hypomelanosis., Chitvanich S,Rerknimitr P,Panchaprateep R,Pongprutthipan M,Asawanonda P,, The Journal of dermatological treatment, 2016 Oct     [PubMed PMID: 26864301]
Therapeutic wounding - 88% phenol in idiopathic guttate hypomelanosis., Ravikiran SP,Sacchidanand S,Leelavathy B,, Indian dermatology online journal, 2014 Jan     [PubMed PMID: 24616848]
The effect of fractional carbon dioxide lasers on idiopathic guttate hypomelanosis: a preliminary study., Shin J,Kim M,Park SH,Oh SH,, Journal of the European Academy of Dermatology and Venereology : JEADV, 2013 Feb     [PubMed PMID: 22646755]
Non-ablative fractional photothermolysis in treatment of idiopathic guttate hypomelanosis., Rerknimitr P,Chitvanich S,Pongprutthipan M,Panchaprateep R,Asawanonda P,, Journal of the European Academy of Dermatology and Venereology : JEADV, 2015 Nov     [PubMed PMID: 25303024]
Excimer Light Treatment for Idiopathic Guttate Hypomelanosis: A Pilot Study., Gordon JR,Reed KE,Sebastian KR,Ahmed AM,, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017 Apr     [PubMed PMID: 27930376]
Hypopigmented macules of photodamaged skin and their treatment with topical tretinoin., Pagnoni A,Kligman AM,Sadiq I,Stoudemayer T,, Acta dermato-venereologica, 1999 Jul     [PubMed PMID: 10429990]