Hidradenitis suppurativa (HS), also called acne inversus, is a chronic inflammatory skin condition with lesions including deep-seated nodules and abscesses, draining tracts, and fibrotic scars. These lesions most commonly occur in intertriginous areas and areas rich in apocrine glands. Among the most common are axillary, groin, perianal, perineal, and inframammary locations. Treatment varies based on severity and can include topical and systemic antibiotics, hormone therapy, immune modulators, and surgery. Because of the associated pain, sensitive locations, drainage, odor and scarring, this condition may have a negative psychosocial impact.
The definitive etiology of HS remains unestablished but appears to have genetic, environmental, and behavioral influences.
Thirty-three percent to 40% of individuals with HS report an affected first-degree relative, showing a hereditary component with an autosomal dominant transmission pattern. In a small subset of affected families and in spontaneous cases, they have identified a mutation of the gamma-secretase Notch signaling pathway.
Environmental and behavioral factors also contribute. Individuals with HS are more commonly over-weight or obese. This is likely because of a multiplicity of factors. Obesity leads to a greater intertriginous surface area and skin friction, increased sweat production and retention, and hormonal changes leading to relative androgen excess. Metabolic syndrome is more common in obese individuals and thus also seen more commonly in HS.
Smoking is also prevalent among those diagnosed with HS. Causation is unclear; however, nicotine may cause increased follicular plugging. As with obesity; disease progression and severity are worse in those who smoke.
The primary occurrence evidences hormonal influence during years from puberty to menopause, the prevalence of HS in females over males, and fluctuations with menstrual cycles and exogenous hormones.
Estimated prevalence ranges from under 1% to 4%. These numbers are likely underestimated because of under-reporting and misdiagnosis. The onset of the condition is between puberty and age 40, with the most common onset between ages 21 and 29. Women are more commonly affected than men in an approximate ratio of 3 to 1. There is a lack of evidence to show a pattern of racial or ethnic predilection.
The pathologic process of HS begins when a defective hair follicle becomes occluded and ruptures, spilling its contents, including keratin and bacteria, into the surrounding dermis. A chemotactic inflammatory response by surrounding neutrophils and lymphocytes can then lead to abscess formation and subsequent destruction of the pilosebaceous unit and other adjacent structures. Other possible contributors to pathology include abnormal antimicrobial peptides, abnormal secretion of apocrine glands, and abnormal invaginations of the epidermis leading to tract formation, and deficient numbers of sebaceous glands.
They have noted the observance of immunological abnormalities. It has detected elevated levels of inflammatory cytokines including tumor necrosis factor alpha and various interleukins in the lesions of HS and provide possible targets for emerging treatments. Bacteria do not appear to be causative. Aspirate from an unruptured lesion typically yields a sterile culture. However, bacterial infection and colonization that occur during the process can secondarily worsen HS.
Because the early stages of HS are often mistaken for other conditions, the average delay in the correct diagnosis is 7 years. Clinical diagnosis requires recognition of the morphology (deep, inflamed, painful nodules, sinus tracts, scars), the location (intertriginous areas, apocrine gland containing areas), and the chronicity of the disease process (prolonged course with periods of activity and remission).
Up to half of the individuals will report a prodromal syndrome involving burning, stinging, pain, pruritus, warmth, or hyperhidrosis in the area 12 to 48 hours before the appearance of a lesion. Triggers can include menstruation, weight gain, stress, hormonal changes, excessive heat, and perspiration. On presentation, individuals are typically well appearing and afebrile, unless secondary infection or advanced disease is present.
Characteristic primary lesions are deep-seated nodules, usually 0.5 to 2 cm that last from days to months. They are often mistaken for furuncles or “boils.” However, while a furuncle will respond rapidly to drainage or antibiotics, the nodules of HS are deep and can rupture and track subcutaneously. Multiple recurrent nodules in the same area may lead to the formation of intercommunicating sinus tracts that can ulcerate or drain. Drainage may be purulent and malodorous. Other lesions include open comedones (described as a “tombstone” comedones), often double or multi-headed. In advanced stages, thick fibrotic scars and plaques can develop leading to architectural distortion of the area.
The axilla is the most common location for HS lesions. Other common areas are inguinal, inner thighs, perianal and perineal, inframammary, buttocks, pubic area, scrotum, vulva, trunk, and less commonly the scalp and retro-auricular areas.
Pertinent history includes onset from puberty into young adulthood and a history of recurrent lesions with intermittent improvement or resolution. HS is a chronic condition. Identifying a family history of a similar condition is also helpful in establishing the proper diagnosis.
Once the history and complete physical exam is complete, us can use the Hurley staging system to classify the case.
They consider HS part of the follicular occlusion tetrad which also includes acne conglobate, dissecting cellulitis of the scalp, and pilonidal sinus. Diagnosis of HS in an individual warrants evaluation for these coexisting diagnoses. There is also an association with metabolic syndrome, inflammatory bowel disease, and spondyloarthropathy; therefore, the physician should keep these in mind during the history and physical.
There are no biological or pathological tests of diagnosis. It does not need a biopsy for diagnosis. However, a biopsy is beneficial to rule out squamous cell carcinoma in the presence of severe HS if the diagnosis is uncertain. Bacterial cultures are not beneficial unless secondary infection or an alternative diagnosis. Imaging is not typically helpful; however, ultrasound may be a useful tool pre-operatively to identify the extent of sinus tracts. Lesions may warrant further imaging including MRI in severe perianal disease.
Overall goals include treating existing lesions to minimize pain and drainage, decreasing the frequency of recurrence, and prevention of disease progression.
They base most treatment algorithms on expert opinion, and consensus as limited studies exist comparing treatment regimens.
In early uncomplicated disease, they considers topical antibiotics the first line. Topical clindamycin has been the most effective.  Intralesional corticosteroids can reduce local inflammation, and partial de-roofing (punch debridement) of individual lesions can facilitate healing.
They show the recommended treatment for Hurley Stage II and resistant Hurley Stage I is oral antibiotics. Antibiotics in the tetracycline family have been the most effective.  If treatment failure persists, combination therapy with oral clindamycin plus rifampin is recommended.  Anti-androgenic hormonal therapy shich includes Cyproterone acetate, oral contraceptives, spironolactone, and finasteride. They have used oral retinoids with mixed responsiveness. While isotretinoin is most effective in acne, acitretin appears to be more effective in HS.  Systemic steroids are effective with some individuals.
For Hurley stage III and resistant other stages, tumor necrosis factor-alpha inhibitors are indicated. Adalimumab is the only FDA-approved medication to treat HS.
Surgery showed at this stage may involve wide excision to include the lesions, tracts, and scars of an entire affected area. A combination of medical treatment besides a surgical excision is often the preferred approach. Other anecdotal therapeutic options may include localized laser and pulsed light therapy which help to disrupt the inflammatory process.
Pain management is also critical. The pain of HS is both inflammatory and non-inflammatory. Sources of pain can include scarring and fibrous areas (causing tensile pain), keloids, abscesses, open ulcerations, sinus tracts, frictional pain, lymphedema, anal fissures, and arthritis. Depending on disease severity and type of pain, topical agents (lidocaine, topical anti-inflammatories), systemic nonsteroidal anti-inflammatories, acetaminophen, atypical anticonvulsants including gabapentin or pregabalin, and serotonin-norepinephrine reuptake inhibitors may be beneficial. Duloxetine is helpful if there is comorbid depression.
Regardless of the stage of disease, treatment should include management of comorbidities that contribute to the development of or worsening of the disease process. Individuals are above ideal weight or who smoke have more severe disease progression, so counseling and help with weight loss and smoking cessation are important components of treatment.
Treatment also involves avoidance of skin trauma. Eliminating tight and synthetic clothing, avoiding harsh products or cleaning tools (loofahs, washcloths, brushes) and avoiding adhesive dressings can be beneficial. They can use soft dressings with clear petroleum jelly or non-occlusive dressings to avoid further irritation to draining lesions.
A critically important but often overlooked aspect of treatment involves the psychosocial aspect of the disease. Quality of life is diminished in individuals with this condition because of the associated pain, drainage, odor, and sensitive affected areas. Patients may become socially isolated, may have employment difficulties because of missed days of work when flares occur and may have increased sexual or relationship dysfunction. Assurance is given that this condition is not contagious and is not the result of poor hygiene. Counseling and support groups are often helpful additions to treatment plans.
Prognosis is variable. There is no cure for this condition. With delays in diagnosis and treatment during the early stages of the disease the prognosis worsens. Not addressing the comorbid conditions of smoking and obesity by also lead to delays with healing.
Complications include both physical and psychological conditions. Physically, recurrence of lesions leading to abscesses, tracts, and scarring can cause chronic pain, limb contractures, and impaired mobility. Lymphatic obstruction can lead to peripheral lymphedema. Long-term effects of chronic inflammation can also occur, including anemia, hyperproteinemia, and amyloidosis and axial and peripheral arthropathy. In rare cases, a superimposed infection can lead to systemic illness ranging in severity. Squamous cell carcinoma can occur in the setting of HS, sometimes occurring up to 30 years after diagnosis. There is an associated increase in buccal and hepatocellular cancer based on observational data. I could postulate a causal relationship between HS and these cancers as they are also more common in smokers, and there is a high prevalence of smoking among individuals with HS.
Psychologically, chronic pain besides drainage, odor, and deformity of skin appearance can lead to depression, social isolation, decreased relationship satisfaction, sexual dysfunction, decreased work productivity, and even suicide in extreme cases.
Patient education involves reassurance that the condition is not infectious or caused by poor hygiene. Patients should report lesions as soon as they occur so that proper treatment started for immediate relief and avoidance of chronic worsening of the condition. They should also know lifestyle modifications including maintenance of healthy weight, smoking cessation, and avoiding skin trauma by wearing looser fitting clothing, avoiding abrasive cleansing and adhesive bandages. The risks and benefits of various treatments is essential to explain to patients, including topical and oral medications and surgery; and offered the most effective treatment available for their state of disease. Psychosocial education and treatment is instrumental with patients.
HS is a complex condition with numerous comorbidities. An interprofessional approach is most effective in the management of this disease.
Although, HS is considered a dermatologic condition, individuals do not always present to the dermatology office with symptoms. Often family and internal medicine physicians, pediatricians, and obstetricians/gynecologists are their first contact within the health care system. It is critical for primary care providers to recognize HS based on the morphology, location, and chronicity of lesions and begin the correct treatment early in the disease process. Depending on the severity of the disease and the training of the primary providers, they may treat independently or refer to specialists including dermatologists, surgeons, wound care, and pain management. Since there is a significant psychosocial impact associated with HS, the treatment team should also include providers of mental health support. If not provided at the primary care level, they should give options to consult with psychiatrists, psychologists, or counselors as needed.