Fitz-Hugh-Curtis syndrome (FHCS), or perihepatitis, is a chronic manifestation of pelvic inflammatory disease (PID). It is described as an inflammation of the liver capsule, without the involvement of the liver parenchyma, with adhesion formation accompanied by right upper quadrant pain. A final diagnosis can be made through laparoscopy or laparotomy via direct visualization of violin string-like adhesions or through hepatic capsular biopsy and culture.
The syndrome was first illustrated by Stajano in 1920 in a non-English publication. In 1930 Curtis described adhesions between the anterior surface of the liver and the abdominal wall found during laparotomies in patients with atypical gallbladder attacks. He noted that while no other upper abdominal pathology was found, residual gonococcal tubal changes were frequently observed in the subjects.
In 1934, Fitz-Hugh, Jr. described similar cases which had presented with right upper quadrant abdominal pain. Laparotomy showed unusual, localized, peritonitis involving the anterior surface and edge of the liver and adjacent peritoneal surface of the diaphragm. After drainage, tube insertion smears from drained fluid showed gram-negative, intracellular, biscuit-shaped diplococci. It is now known, however, that the syndrome is not exclusive to gonococcal infection and has been reported in both sexes.
Fitz-Hugh-Curtis syndrome is a complication of PID. Microorganisms associated with PID are thought to spread through one of three ways:
PID is an ascending microbial infection involving the genital tract that affects sexually active women between 15 to 30 years of age. The United States experiences 750,000 cases of PID each year. FHCS is an uncommon manifestation of PID involving around 4% of adolescents. While many organisms are associated with FHCS, Chlamydia trachomatis is the most common pathogen involved.
As described in the etiology section, FHCS is a complication of PID. Microorganisms associated with PID are thought to spread in one of three ways:
Typically, patients with FHCS are women of childbearing age who visit a hospital with complaints of acute pain or chronic tenderness in the right upper abdomen. A thorough history and a high index of suspicion are necessary to reach an appropriate diagnosis. Right upper quadrant abdominal pain is a symptom of myriad pathologies including, but not exclusive to, cholecystitis, pleurisy, right pyelonephritis, subphrenic abscess, or herpes zoster infection, making an assessment for FHCS particularly difficult. 
The evaluating physician who suspects FHCS should focus on high-risk behaviors and symptoms in the appropriate patient population. Risk factors to consider are an age less than 25 years, age at first sexual encounter less than 15 years, history of PID, use of IUD or oral contraceptives, recent IUD insertions, and vaginal douching. Investigating a patient’s exposure to new, multiple, or symptomatic sex partners is also of paramount importance. Obtaining a complete past medical and past surgical history also may help narrow the differential further.
Right upper quadrant abdominal pain is caused by perihepatic inflammation and adhesion formation between the anterior surface of the liver and the abdominal wall. The pain is usually worse with movement and breathing, thereby mimicking other acute abdominal pathologies. Patients also may complain of lower abdominal, pelvic, or back pain with varying degrees of severity. Other symptoms may include fevers, chills, nausea, vomiting, vaginal discharge, dyspareunia, dysuria, cramping, and postcoital bleeding.
Physical exam findings may reveal the following:
The following are helpful in the evaluation of FHCS and PID.
Treatment of HFCS coincides with the management of PID. Goals of treatment are to relieve symptoms, eradicate the infection, and minimize risks of long-term sequelae (infertility or ectopic pregnancy). As the diagnosis of PID may be challenging and the potential for serious complications is great, the CDC advises that physicians maintain a low threshold for aggressive treatment. Antibiotics are successful in up to 75% of cases and most patients with PID can be managed as outpatients. Antibiotic therapy should be geared at covering the most common organisms, C. trachomatis, and N. gonorrhea, as well as gram-negative organisms, anaerobes, and streptococci.
Depending on the degree of suspicion, antibiotics regimens can be tailored for each patient. Most commonly, ceftriaxone and azithromycin are adequate for the control of gonococcal and chlamydial infections. Current recommendations for complicated pelvic inflammatory disease include ceftriaxone, doxycycline, and metronidazole.
Hospitalization should be considered for patients with the following conditions:
Patients with persistent symptoms of fever, chills, or cervical motion tenderness after 72 hours of treatment should be reevaluated for possible surgical intervention. Diagnostic laparoscopy is warranted in the setting of HFCS for symptomatic adhesiolysis and PID with goals of conserving reproductive potential with abscess drainage or unilateral adnexectomy if necessary. Laparotomy is usually reserved for patients experiencing surgical emergencies (ruptured abscesses) and for patients who are not candidates for laparoscopic intervention.
Fitz-Hugh-Curtis Syndrome may mimic a number of other diseases. These include:
There is insufficient data documenting the prognosis of FHCS as it usually responds to antibiotics very well. In one trial of triple therapy (penicillin-gentamicin-metronidazole) versus augmentin for non-chlamydial salpingitis, only one patient in each treatment group had treatment failure.
The diagnosis and management of HFCS are not easy and require a multidisciplinary team that ideally includes a gynecologist, radiologist, emergency department physician, specialty nurse, infectious disease expert and laboratory professionals. Treatment of HFCS coincides with the management of PID. Goals of treatment are to relieve symptoms, eradicate the infection, and minimize risks of long-term sequelae (infertility or ectopic pregnancy). As the diagnosis of PID may be challenging and the potential for serious complications is great, the CDC advises that physicians maintain a low threshold for aggressive treatment. Antibiotics are successful in up to 75% of cases and most patients with PID can be managed as outpatients. Antibiotic therapy should be geared at covering the most common organisms; C. trachomatis, and N. gonorrhea, as well as gram-negative organisms, anaerobes, and streptococci.
It is important for the primary care provider and nurse practitioner to treat the partner and educate the patient on safe sex practices. It is important to follow these patients until all symptoms have subsided and the cultures are negative.
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