Biotin

Article Author:
Karlyle Bistas
Article Editor:
Prasanna Tadi
Updated:
3/1/2020 1:17:37 PM
PubMed Link:
Biotin

Indications

Biotin (B7 or vitamin H) is a water-soluble vitamin, which has received publicity for promoting the growth of hair and nails. There are limited studies, which confirm the exact indications of biotin.[1] Biotinidase deficiency is uncommon but has been documented. Frank deficiency of biotinidase may present as conjunctivitis, ataxia, seizure, skin infections, and developmental delay in children.[2] Biotin may have benefits in those suffering from pathologic brittle hair syndrome or uncombable hair syndrome.[3][4] Otherwise, indications for supplementation remain unnecessary in healthy individuals.[1] Biotin deficiencies would require inborn errors of metabolism. Documentation on supplementation in healthy individuals remains unclear. To date, there have been no trials supporting claims of biotin supplementation being used to improve hair quality or quantity or nail growth.[5] The U.S. Food and Drug Administration does not recommend daily biotin usage, although patients who are breastfeeding or pregnant are recommended take from 5 mcg/ to 35 mcg/day. Pregnancy and smoking increase the metabolism of biotin and would require increased intake, although controversial.[6][7] There is limited evidence to suggest biotin can provide a benefit with hair and nail growth. 

Mechanism of Action

Biotin also acts as a coenzyme for multiple carboxylases in humans, and it changes the irreversible carboxylation of acetyl-CoA to malonyl-CoA.[2] These enzymes are vital in numerous metabolic processes. Recently, the new roles of biotin have been acknowledged, in particular, the roles in cell signaling and epigenetic regulation.[8] Biotins mechanism of action occurs by attaching to specific lysine residues.[9] The side effects of ingesting too much biotin could include an upset stomach, although it remains a vitamin with very low side effects. Biotin uptake by human colonic epithelial is a carrier-mediated process.[10] Vitamin B7 is a cofactor for three significant carboxylation reactions, which include the conversion of pyruvate to oxalacetate, acetyl-CoA to malonyl-CoA, and propionyl-CoA to methylmalonyl-CoA. A carboxylase reaction includes the transfer of carbon with the assistance of biotin. Essentially these conversions assisted by biotin break down food into glucose, the primary carbohydrate source for the brain and body. 

Administration

Biotin appears to be widely protein-bound.[4] Recommendations for biotin intake range from 5 ug/ to 35 ug/day depending on circumstances. For example, there is no daily recommendation, but biotin use may be appropriate and warranted for a breastfeeding mother due to increased demand for nutrients. Biotin is also required for the normal development of the fetus when the mother is pregnant. When needed, the most common route of administration for biotin is orally, but biotin administration can also be in an IV form. Therefore, there is no indication for daily use by the U.S. Food and Drug Administration, but when indicated, its administration is usually via the oral route. The IV form is for cases where biotin deficiency is apparent and symptomatic. It can also be useful when treating trichothiodystrophy (TDD), a rare autosomal recessive disorder, which appears to benefit from biotin intake. The tablet form of biotin usually comes in forms of 10, 50, or 100 mcg. 

Adverse Effects

Biotin consumption for beneficial means remains unclear, but it has been considered a very difficult drug to overdose on or cause injury to the body. When taking anticonvulsants such as carbamazepine or phenobarbital, the requirements for biotin increase due to these medications inhibiting uptake into the brush borders of membrane vesicles.[4] Smoking also metabolizes biotin quickly, therefore increased doses may be warranted when indicated if the patient is a smoker. Information on other drug interactions is minimal. There have been no reported injuries for taking too much biotin, but there are documented cases of biotin deficiency. 

Contraindications

Research supporting claims for the use of biotin for nails and hair remains ambiguous, but there has been well-documented research on the interactions of biotin and other drugs. There are no evident contraindications to taking this vitamin. Biotin is a safe and nontoxic vitamin that the body excretes when in excess. There are no known herbal interactions with biotin. Although not a contraindication, it is important to note if a person is taking biotin and smoking, they may require increased doses due to increased metabolism of biotin. 

Monitoring

Dermatologic manifestations appear to be the first sign of biotin deficiency. Biotin plasma concentration levels range from 400 to 1200 ng/L.[1] The daily recommendation for biotin if and when indicated has undergone research, although there appears to be no specific therapeutic index. In circumstances where biotin deficiency is a concern, the urinary biotin concentrations are testable. Although rare, if deficient, a patient may present with dermatitis, enteritis, or alopecia. Antibiotic use or extreme, excessive intake of raw egg whites may induce a state of deficiency, which is very rare. 

Toxicity

There is no specific antidote for overdosing on biotin. Excess in the body is rare, and since biotin is a water-soluble vitamin, it is excreted in the urine when in excess. Signs and symptoms of biotin overdose may include and are not limited to insomnia, excessive thirst, and urination. Since biotin has documentation in playing a role in postprandial glucose control, it bears mention that excess would cause signs and symptoms of a person experiencing hyperglycemia (e.g., increased thirst).[11] Diabetic patients should, therefore, be cautious before taking biotin. Although not impossible, it would be very difficult to overdose on biotin. Anaphylaxis is always a common concern with any medication but would present with systemic signs and symptoms. In rare cases, eosinophilic pleuropericardial effusion, a life-threatening condition may occur.[12] Poison control should always be contacted with a suspected overdose. 

Enhancing Healthcare Team Outcomes

As physicians, we must educate our patients when confronted with the matter that regular biotin use is not indicated and also not well-documented. Biotin marketing often claims it is "a magic pill for hair and nails," but the benefits remain unclear. Without the research to support regular usage, heavily marketed claims by the beauty and supplementation industry need to be challenged to examine the efficacy and safety of this drug, which they advertise for regular use. With the epidemic of type 2 diabetes in the United States, further exploration regarding biotins role in glucose control requires investigation, since studies have concluded it may be beneficial for obese patients and those with type 2 diabetes.[11]


References

[1] Patel DP,Swink SM,Castelo-Soccio L, A Review of the Use of Biotin for Hair Loss. Skin appendage disorders. 2017 Aug;     [PubMed PMID: 28879195]
[2] Zempleni J,Wijeratne SS,Hassan YI, Biotin. BioFactors (Oxford, England). 2009 Jan-Feb;     [PubMed PMID: 19319844]
[3] Al-Eitan LN,Alqa'qa' K,Amayreh W,Khasawneh R,Aljamal H,Al-Abed M,Haddad Y,Rawashdeh T,Jaradat Z,Haddad H, Identification and Characterization of BTD Gene Mutations in Jordanian Children with Biotinidase Deficiency. Journal of personalized medicine. 2020 Jan 21;     [PubMed PMID: 31973013]
[4] Zempleni J,Mock DM, Biotin biochemistry and human requirements. The Journal of nutritional biochemistry. 1999 Mar;     [PubMed PMID: 15539280]
[5] Soleymani T,Lo Sicco K,Shapiro J, The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity. Journal of drugs in dermatology : JDD. 2017 May 1;     [PubMed PMID: 28628687]
[6] Sealey WM,Teague AM,Stratton SL,Mock DM, Smoking accelerates biotin catabolism in women. The American journal of clinical nutrition. 2004 Oct;     [PubMed PMID: 15447901]
[7] Zempleni J,Mock DM, Bioavailability of biotin given orally to humans in pharmacologic doses. The American journal of clinical nutrition. 1999 Mar;     [PubMed PMID: 10075337]
[8] Zempleni J, Uptake, localization, and noncarboxylase roles of biotin. Annual review of nutrition. 2005;     [PubMed PMID: 16011464]
[9] Lamhonwah AM,Quan F,Gravel RA, Sequence homology around the biotin-binding site of human propionyl-CoA carboxylase and pyruvate carboxylase. Archives of biochemistry and biophysics. 1987 May 1;     [PubMed PMID: 3555348]
[10] Said HM,Ortiz A,McCloud E,Dyer D,Moyer MP,Rubin S, Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid. The American journal of physiology. 1998 Nov;     [PubMed PMID: 9814986]
[11] Xiang X,Liu Y,Zhang X,Zhang W,Wang Z, [Effects of biotin on blood glucose regulation in type 2 diabetes rat model]. Wei sheng yan jiu = Journal of hygiene research. 2015 Mar;     [PubMed PMID: 25997216]
[12] Debourdeau PM,Djezzar S,Estival JL,Zammit CM,Richard RC,Castot AC, Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. The Annals of pharmacotherapy. 2001 Apr;     [PubMed PMID: 11302404]