Acne vulgaris is an inflammatory disorder of pilosebaceous unit, which runs a chronic course and it is self-limiting. Acne vulgaris is triggered by Propionibacterium acnes in adolescence, under the influence of normal circulating dehydroepiandrosterone (DHEA). It is a very common skin disorder which can present with inflammatory and non-inflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back.
Acne occurs by hypersensitivity of the sebaceous glands to a normal circulating level of androgens, which are aggravated by P. acnes and inflammation. Causes of acne include the following:
Acne may appear in adolescence, and it persists through the early thirties. Acne is more common in males than in females. Urban populations are more affected than rural populations. About 20% of the affected individuals develop severe acne which results in scarring. Some races appear to be more affected than others. Asians and Africans tend to develop severe acne, but mild acne is more common in the white population. In general, populations with darker skin also tend to develop hyperpigmentation. Acne can also develop in neonates but in most cases resolves spontaneously.
During puberty, under the influence of androgens, sebum secretion is increased as 5-alpha reductase converts testosterone to more potent DHT, which binds to specific receptors in the sebaceous glands increasing sebum production. This leads to an increased hyperproliferation of follicular epidermis, so there is retention of sebum. Distended follicles rupture and release proinflammatory chemicals into the dermis, stimulating inflammation. P. acnes, Staphylococcus epidermis, and Malassezia furfur induce inflammation and induce follicular epidermal proliferation.
Factors aggravating acne include:
The acne lesion will usually show a dilated follicle with a plug of keratin. In advanced cases, one may see a dilated follicle which results in an open comedone. When the thin follicle wall ruptures, bacteria and signs of inflammation may be evident. Large acne lesions which are traumatized can develop fibrosis and scarring.
Acne occurs on centrofacial areas of the back, upper trunk, and deltoid region. Acne presents as polymorphic lesions starting with comedones.
Acne can leave various scars after healing which may present as depressed scars or hypertrophic and keloidal scars. Depressed scars may be gentle contour (boxcar scars) or ice pick scars which are deep pits. Acne is associated with seborrhoea and in the case of hyperandrogenism associated with hirsutism, acanthosis nigricans, irregular menstrual period, and weight gain.
Acne vulgaris is diagnosed clinically. However, in women of childbearing age, one should ask for a history of hirsutism or dysmenorrhea. If positive, then levels of testosterone, LH, FSH, and DHEA should be ordered.
Acne may not be life-threatening but it has lifelong psychosocial effects. People with acne and acne scars often develop anxiety and depression. the acne scars are almost impossible to correct. A study from Sweden suggests that acne in teenager boys may be a risk factor for prostate cancer development late in life.
The overall prognosis of acne is good with treatment.
Change in the diet has been suggested to avoid recurrence of acne. some experts recommend avoiding chocolate, spicy foods, junk foods and cola beverages.
One study found that a high protein- low glycemic diet lowered the risk of acne lesions.
If the patient is treated with spironolactone, levels of electrolytes should be measured regularly.
Acne is unavoidable but can be controlled by regular washing of the face by a pH balancing wash which is available as benzoyl peroxide and salicylic acid face wash. Avoidance of high glycemic index and/or dairy-based food plays a role. Management of stress and early detection and treatment of underlying causes like PCOD helps to control acne and preventing disfigurement.
Even though retinoids are excellent agents for acne, their use in women of childbearing age is limited because the agents are teratogenic. There is a registry for all individuals who are prescribed or dispensed retinoids like isotretinoin.
The American Academy of Dermatology has evidence-based guidelines on the management of acne.  (level V) Hence all healthcare workers including the primary care provider and nurse who manage acne must know these guidelines and how to stratify treatment. If the healthcare worker decides to use an oral contraceptive to manage acne, then they should follow the guidelines established by the WHO. Finally, determining the type of bacteria causing acne is only of academic importance and should not alter the treatment of acne.
If the acne is severe, then a consult with a dermatologist is highly recommended. The pharmacist should be fully aware of the adverse effects of isotretinoin and its potential teratogenic effects. The pharmacist should never dispense retinoids to a female of childbearing age without first speaking to the dermatologist. The pharmacist should educate the patient on the potential teratogenic effects of retinoids and adhere to the iPLEDGE risk management program.  (Level V)
For the most part, most patients have a good outcome after treatment. But in many patients, acne does leave residual scars. These can be avoided by educating the patient on not manipulating the lesions and seeking timely care. Once established, the treatment of acne scars is not optimal. (Level V)
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