Trigger Point Injection

Article Author:
Claudia Hammi
Article Author (Archived):
Jeremy Schroeder
Article Editor:
Brent Yeung
10/2/2019 8:37:36 PM
PubMed Link:
Trigger Point Injection


Myofascial trigger points are focal "knots" located in a taut band of skeletal muscle. These points are usually palpable and produce a characteristic referred pain upon palpation, along with pain locally and occasionally a local twitch response, they can sometimes be associated with chronic disorders of the musculoskeletal system.[1] Trigger points may be formed after acute trauma or by repeated micro-trauma, leading to stress on muscle fibers.[2] Pathogenesis of trigger points is thought to be related to abnormal motor end-plates within a muscle where the motor and nociceptive nerves co-exist, with a component of enhanced central sensitization in the spinal cord.[3][4] EMG studies have shown that trigger points exhibit spontaneous electrical activity, which suggests aberrant action potential generation.[5] This concept is supported by histological evidence through muscle biopsies showing evidence of muscle hyper-contracture consistent with continuous sarcoplasmic reticulum calcium release secondary to neural activation and action potential generation.[5][6] Patients may experience localized pain which can result in muscle tension and decreased range of motion in affected tissue. Muscles of the neck, shoulder, and pelvic girdle are commonly affected. Patients may experience tension headaches, temporomandibular joint pain, back pain, decreased shoulder range of motion, and stiffness as manifestations of their trigger points. Patients can have one or several trigger points throughout their musculoskeletal system. There are several approaches to the treatment of trigger points including ultrasonography, physical manipulation therapy, Spray and Stretch technique, and injections.[2]  


The most common muscle groups treated using trigger point injections include the masseter, levator scapulae, gluteus medius, quadratus lumborum, trapezius, sternocleidomastoid, and temporalis muscles.[7] Trigger points affecting the trapezius muscle may clinically manifest as tension headaches, pain in the neck, shoulders, and proximal arms.[8] The Iliopsoas muscle is the primary muscle responsible for trigger points causing groin pain.[9] 


Trigger point injections are a therapeutic modality to treat myofascial trigger points, especially in symptomatic patients, and have been demonstrated effectiveness to inactivate trigger points. Indications for trigger point injections include the presence of symptoms of active trigger points upon physical exam such as chronic or episodic headaches,[7] temporomandibular joint pain, back pain, decreased range of motion secondary to trigger points, and groin pain.


Contraindications to trigger point injections include the following[7]:

  • Patient refusal
  • Active infection over the site of trigger point
  • Local open skull defect
  • Practice caution in patients taking anticoagulation, pregnant patient, and in patients where anatomical landmarks are indistinguishable.
  • Avoid local anesthetics in those with known allergies


Materials for trigger point injections include the following:

  • 27- to 30-gauge 1.5-inch needle
  • A 5- to 10-mL syringe
  • Gloves
  • Anesthetic agent (optional): Lidocaine or bupivacaine without epinephrine
  • Topical anesthetic spray (optional)
  • Consider steroids such as triamcinolone or dexamethasone to possibly add to the local anesthetic mixture (optional)
  • Skin cleaning agents such as alcohol pads or chlorhexidine 2% 
  • Pulse oximeter and blood pressure monitor


Trained and skilled medical providers including physicians, physician assistants, and nurse practitioners can perform trigger point injections. A nurse must be available for preparation before the procedure.


The patient should be informed about the risks and benefits of trigger point injections. Obtain written consent by the patient or guardian decision maker before the start of the procedure. Equipment should be ready at the bedside, and a nurse should be available for time-out prior to starting the procedure. Depending on the trigger point location, the patient may be sitting or laying down. Cleanse the area with alcohol pads or chlorhexidine 2%, allowing it to dry. Some providers prefer to mark each trigger point with a skin marker as a guide prior to starting the procedure. If using a topical anesthetic spray, make sure to anesthetize the trigger points before starting the procedure.


Once a trigger point has been identified and the overlying skin cleansed, the clinician should use their non-dominant index finger and thumb to pinch the point between their fingers and stabilize the tissue. Once stabilized, using the dominant hand, the clinician will insert the needle attached to the 5 or 10mL syringe at a 30-degree angle into the trigger point and rhythmically continue needling the area by repeatedly inserting and retracting the needle without completely withdrawing the needle from the muscle. The clinician should continue this motion in multiple directions until muscle twitching has subsided, or until the muscle feels adequately relaxed. A "crunching" or "pulling" may be felt as the clinician inserts and retracts the needle within the tense muscle; this will likely decrease throughout the treatment. If dry-needling is the method, then treatment of that point is completed once the trigger point is relaxed. If an injection is the planned intervention, then the clinician should then aspirate and then inject 0.2 to 1mL of solution (local anesthetic +/- steroid) into the point, making sure to avoid intravascular injection. If treating multiple points then repeat the above steps. There are comparable results between dry needling and injection of local lidocaine; however, it has been shown that less post-needling soreness is associated with the injection of local anesthetic.[10] The mechanism behind trigger point injections is thought to be the outcome of physically disrupting aberrant muscle tissue through needling, which results in relaxation and lengthening of the muscle fiber, along with an increase in blood flow.[4][11]


Complications of trigger point injections include the following[12][7][13][14]:

  • Pain
  • Bleeding
  • Infection
  • Allergic reaction to the anesthetic agent
  • Systemic anesthetic toxicity 
  • Formation of a hematoma
  • Vascular injury
  • Although rare, there are some reports of complications such as pneumothorax, especially when treating trigger points in the cervicothoracic region using a needling technique
  • Severe hypokalemic paralysis has also been reported in one case report
  • Adverse effects connected to dry-needling technique include soreness after treatment, vasovagal and syncopal response, hemorrhages at the site of treatment, and acute cervical epidural hematoma

Clinical Significance

Musculoskeletal pain is a common complaint that many primary-care and pain providers diagnose and treat regularly. Treating pain with a multimodal approach is paramount in providing safe and effective results for patients. Trigger point injections can be wonderful adjunctive or primary therapy, alongside muscle relaxants and other medications aimed at decreasing pain in the musculoskeletal system. By targeting specific points of myofascial pain, clinicians can directly treat pathologic tissue and provide almost instantaneous relief with little to no side effects. Patients can have significant improvement in range of motion and overall functionality, without the need for taking pain medications. Meaningful results can be provided with trigger point injections and should merit consideration as a treatment modality in the appropriate setting.

Enhancing Healthcare Team Outcomes

Patient safety is of the utmost importance. Trigger point injections can be a valuable adjunct to treating chronic pain conditions involving the musculoskeletal system. Detailed history and musculoskeletal physical exam are suffering in preventing adverse outcomes.

A team-based, interprofessional approach should be implemented to ensure patient safety and the appropriateness of the procedure. This team should include the physician or mid-level practitioner, as well as a nurse to prepare the patient and assist during the procedure. If being performed as an inpatient procedure, the pharmacist may also be involved in preparing the injection. The nurse should monitor the patient during the procedure, assist with patient education, and report untoward changes in vital signs if the occur.

Communication with the patient throughout the procedure is essential to make sure the treatment is addressing an active trigger point. Practitioners, including nurses, should always take caution when handling sharps as accidental needle sticks may occur. Universal precaution guidelines should be followed, and hazardous materials should be disposed of appropriately. Documentation post procedure should include the location of trigger points treated; muscles injected, amount of local anesthetic used (if any), patient position during treatment, and post-procedure plan.

An interprofessional approach involving the clinicians, nurses, and pharmacists will result in the best patient outcomes. [Level 5]


[1] Lavelle ED,Lavelle W,Smith HS, Myofascial trigger points. The Medical clinics of North America. 2007 Mar;     [PubMed PMID: 17321283]
[2] Alvarez DJ,Rockwell PG, Trigger points: diagnosis and management. American family physician. 2002 Feb 15;     [PubMed PMID: 11871683]
[3] Hong CZ,Simons DG, Pathophysiologic and electrophysiologic mechanisms of myofascial trigger points. Archives of physical medicine and rehabilitation. 1998 Jul;     [PubMed PMID: 9685106]
[4] Wong CS,Wong SH, A new look at trigger point injections. Anesthesiology research and practice. 2012;     [PubMed PMID: 21969825]
[5] Jafri MS, Mechanisms of Myofascial Pain. International scholarly research notices. 2014;     [PubMed PMID: 25574501]
[6] Simons DG,Stolov WC, Microscopic features and transient contraction of palpable bands in canine muscle. American journal of physical medicine. 1976 Apr;     [PubMed PMID: 1266956]
[7] Robbins MS,Kuruvilla D,Blumenfeld A,Charleston L 4th,Sorrell M,Robertson CE,Grosberg BM,Bender SD,Napchan U,Ashkenazi A, Trigger point injections for headache disorders: expert consensus methodology and narrative review. Headache. 2014 Oct;     [PubMed PMID: 25168295]
[8] Akamatsu FE,Ayres BR,Saleh SO,Hojaij F,Andrade M,Hsing WT,Jacomo AL, Trigger points: an anatomical substratum. BioMed research international. 2015;     [PubMed PMID: 25811029]
[9] Kim DS,Jeong TY,Kim YK,Chang WH,Yoon JG,Lee SC, Usefulness of a myofascial trigger point injection for groin pain in patients with chronic prostatitis/chronic pelvic pain syndrome: a pilot study. Archives of physical medicine and rehabilitation. 2013 May;     [PubMed PMID: 23262156]
[10] Hong CZ, Lidocaine injection versus dry needling to myofascial trigger point. The importance of the local twitch response. American journal of physical medicine     [PubMed PMID: 8043247]
[11] Cagnie B,Barbe T,De Ridder E,Van Oosterwijck J,Cools A,Danneels L, The influence of dry needling of the trapezius muscle on muscle blood flow and oxygenation. Journal of manipulative and physiological therapeutics. 2012 Nov-Dec;     [PubMed PMID: 23206963]
[12] Ahiskalioglu EO,Alici HA,Dostbil A,Celik M,Ahiskalioglu A,Aksoy M, Pneumothorax after trigger point injection: A case report and review of literature. Journal of back and musculoskeletal rehabilitation. 2016 Nov 21;     [PubMed PMID: 26922846]
[13] Soriano PK,Bhattarai M,Vogler CN,Hudali TH, A Case of Trigger-Point Injection-Induced Hypokalemic Paralysis. The American journal of case reports. 2017 Apr 26;     [PubMed PMID: 28442701]
[14] Vulfsons S,Ratmansky M,Kalichman L, Trigger point needling: techniques and outcome. Current pain and headache reports. 2012 Oct;     [PubMed PMID: 22610507]