Trichinella Spiralis (Trichnellosis)

Article Author:
Prashanth Rawla
Article Editor:
Sandeep Sharma
6/26/2019 12:21:05 PM
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Trichinella Spiralis (Trichnellosis)


Trichinellosis also called trichinosis results from roundworms (nematodes) from the genus Trichinella. It is a parasitic infection. It is caused by consuming undercooked or raw meat (usually pork). Trichinella spiralis species is the common cause of human disease by eating raw or undercooked pork. Although, other mammals like wild carnivores and horses can be reservoirs of infection. It can cause symptoms varying from generalized fever, abdominal pain, diarrhea, nausea, vomiting’s, myalgia to more severe like myocarditis and encephalitis.


Trichinella spiralis is a nematode (roundworm) parasite.[1] It possesses the capability of infecting a wide range of mammals including pigs, horses, reptiles, and birds but it causes disease only in humans. By eating improperly cooked or raw pork, horse, or other domestic animal meat and wild game meat like bear meat, humans acquire the infection. Some reports have mentioned an occasional acquisition of the disease by ingestion of reptile meat, including lizards and turtles.[2] There are no reports of human to human transmission.


Trichinellosis occurs worldwide, and estimates are that about 10000 cases occur each year.[3] Cases usually tend to occur in clusters among groups of people who have consumed infected meat from a common animal.[4] There are nine species of Trichinella, and thus far reports exist of twelve genotypes trichinella.[5] The most common species of trichinella which can cause human disease is Trichinella spiralis, although other species of Trichinella implicated in human disease are: T. nativa, T. nelson, T. britovi, T. pseudospiralis, T. murelli, T. papuae.[5][6] Per the Centers for Disease Control and Prevention around 400 cases of trichinellosis were reported every year in the 1940s, but now the number of reported cases has dropped significantly and has been around 20 cases every year from 2008 to 2010.

Life cycle[3]:

  • The life cycle of trichinellosis divides into two stages: 1) domestic cycle and 2) sylvatic cycle
    • Domestic cycle: affects domestic animals, particularly swine, rodents, horses
    • Sylvatic cycle: affects wildlife like bear, wild boar, moose


Ingestion of undercooked or raw meat from domestic or sylvatic animal containing encysted larvae of Trichinella species can lead to Trichinellosis. T. spiralis results from the consumption of inadequately cooked or raw pork from domestic pigs.[7]

Enteric or gastrointestinal phase: After ingestion of infected meat by humans, the enzymes pepsin and hydrochloric acid act in the stomach and cause the release of the 1st stage of the larvae. These larvae invade the small intestine. Invasion can be asymptomatic or sometimes associated with abdominal pain, diarrhea, nausea, vomitings. Larvae then turn into adults and mate. Female trichinella worms produce larvae, which completes the gastrointestinal or enteric phase.

Systemic (parenteral) phase: Larvae enter the lymphatic circulation and then into the blood, reaching skeletal muscles, myocardium, and brain which are high in oxygen content. This phase leads to systemic symptoms like fevers, myositis, myalgias, periorbital edema and can even cause myocarditis and encephalitis.

History and Physical

Infection results from the consumption of raw or undercooked meat (especially pork). The incubation period is 1 to 6 weeks. In humans, the severity of infection severity of infection is related to the number of larvae ingested.[8]

Gastrointestinal symptoms are the first symptoms of trichinellosis. They usually occur in 2 to 7 days after consumption of raw or undercooked meat. Symptoms include abdominal pain, diarrhea, nausea, and vomiting.

Classic trichinellosis symptoms usually occur in 2 weeks after consumption of raw or undercooked meat and can last up to 8 weeks. Symptoms include fevers, chills, myalgias, periorbital or facial edema, weakness, and fatigue. Reports also exist of prolonged diarrhea.[9]. Other common symptoms are conjunctivitis and subconjunctival hemorrhages seen in about 50% of patients.[10] Splinter hemorrhages on nailbeds (subungual) and retinal hemorrhages can also occur.

Other less common manifestations include a headache, cough, rash, headache, dyspnea, and dysphagia. Hepatomegaly can also occur occasionally.[11] 

Severe complications include myocarditis, life-threatening arrhythmias, meningitis, encephalitis, respiratory myositis, secondary bacterial pneumonia, hematuria, and renal failure.[12][13][14][15]


Diagnosis is initially made usually based on clinical signs and symptoms. Diagnostic confirmation is by serology, or occasionally muscle biopsy may be needed.

A complete blood count can show leukocytosis and eosinophilia, which correlates with the number of worms causing infections.[3] Creatine kinase, lactate dehydrogenase, aldolase, and aminotransferases elevate due to the invasion of skeletal muscle by parasites causing muscle destruction.  Patients can also have hypokalemia, hypoalbuminemia, and increased serum IgE levels. All these tests are non-specific as can be seen in other parasitic disease and autoimmune diseases.[16]

Serological tests which are available are ELISA (enzyme-linked immunosorbent assay), indirect IF (immunofluorescence), and latex agglutination test. Serologic tests confirmation can be via western blot.[17] Sometimes serology is not reliable mainly during the early course of the disease(during the first 3 weeks or more). Infection with other organisms like nematodes or other helminths and autoimmune diseases can cause a false positive serologic reaction.

Definitive diagnosis method is a muscle biopsy.[10] Sensitivity is high if the biopsy is performed 4 weeks after infection. If performed early in the disease course it may be negative.

Treatment / Management

The clinical course of trichinellosis is self-limited in most cases, and it is uncomplicated.

Mild infections are treated symptomatically with antipyretics and anti-inflammatory agents.

Trichinella infection with systemic complications is treated with antiparasitic agents and corticosteroids.[18]

Albendazole 500mg twice daily given orally for 10 to 14 days (or) Mebendazole 200 to 400 mg thrice daily for 3 days, then 400 to 500 mg three times daily for 10 days.

Severe cases may require coadministration with prednisone at a dose of 30 to 60mg daily for a total of 10 to 14 days.

Albendazole and mebendazole are not considered safe in pregnant women and children less than or equal to 2 years of age. Specialist consultation is necessary in these cases and risk, and weighing the benefits vs. risks is necessary before administering the drug. The World Health Organization recommendations are that pregnant women can get antihelminthic medications (mebendazole, albendazole, pyrantel or levamisole) after their first trimester.[19]

Differential Diagnosis

  • Gastroenteritis - viral or bacterial
  • Polymyositis and dermatomyositis (autoimmune)
  • Periorbital cellulitis
  • Eosinophilia-myalgia syndrome

Eosinophilia can be present other helminthic infections like fasciola, schistosomiasis, toxocariasis, cysticercosis, visceral larva migrans, and sarcocystosis


Trichinellosis usually has a benign course and is self-limiting. Full recovery of patients within 2 months to 6 months of infection is the expectation. However, some cases might be severe, and even death is a possibility. Prognosis of the disease proportionately correlates with the parasitic burden.


  • Myocarditis
  • Pneumonitis
  • Secondary bacterial pneumonia
  • Nephritis
  • Chronic diarrhea
  • Neurotrichinellosis


  • Infectious disease
  • Cardiology if complications like myocarditis or arrhythmias arise
  • Surgical consultation might be necessary for a muscle biopsy

Deterrence and Patient Education

Trichinellosis is caused by consuming raw or undercooked meat of infected animals. Patients should receive education about the risk of transmission when consuming undercooked or raw meat. There are no reports of human to human transmission. Cases can occur in clusters among groups of people from the same community or family who have consumed infected meat from a common animal. Patients should be educated to heat the meat for at least 77 degrees Celsius which kills Trichinella larvae. Patients should also receive counseling regarding proper food safety practices.

Pearls and Other Issues

Postexposure prophylaxis with mebendazole if given within 6 days of exposure may be effective.[20]

Enhancing Healthcare Team Outcomes

Treatment and prevention of trichinellosis require a multidisciplinary team effort. Collaboration and effective communication between the healthcare team is crucial to ensure excellent patient service. Infectious disease consultations should be sought when necessary to provide the best treatment options for the patient. Nurses should educate patients on risks of transmission when consuming undercooked or raw meat. Pharmacists, nurses, and physicians should be aware of the potential side effects of antihelminthic medications used in the treatment of trichinellosis and should explain the associated side effects to the patients.

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