Halobetasol Cream

Article Author:
Nardin Awad
Article Editor:
Charles Preuss
Updated:
7/1/2019 10:01:07 AM
PubMed Link:
Halobetasol Cream

Indications

As an ultra-high potency steroid, halobetasol cream is indicated, and FDA approved for use in the treatment of many inflammatory and pruritic dermatological conditions. It is typically used for the treatment of plaque psoriasis but also has indications for use in several other conditions. A few common conditions include atopic dermatitis, alopecia areata, cutaneous lichen planus, lichen simplex chronicus, and granuloma annularae.[1]

Mechanism of Action

Although additional studies regarding the mechanism of action of topical corticosteroids are still necessary, topical corticosteroids, including halobetasol cream, generally have the same mechanism of action to exert their anti-inflammatory, immunosuppressive and anti-mitogenic effects. Corticosteroids alter the behavior of epidermal cells, dermal cells, and leukocytes that take part in skin diseases that are proliferative and inflammatory in nature.[2]

Corticosteroids bind to glucocorticoid receptor proteins in the cytoplasm of a cell to form a steroid-receptor complex. In the unbound state the receptor is cytoplasmic, but in the bound state, the complex moves into the cell nucleus and binds to DNA, changing the transcription of mRNA. Through this modification, corticosteroids can either increase or decrease the synthesis of proteins involved in inflammation cascade and the immune response. Corticosteroids increase the synthesis of lipocortin, which acts to reduce the activity of phospholipase A2, which releases arachidonic acid from phospholipids and thus decreases the synthesis of prostaglandins. Corticosteroids also suppress mRNA responsible for interleukin-1 formation. Together, these actions produce anti-inflammatory, immunosuppressive, and anti-mitogenic effects.[2][3]

Administration

Halobetasol cream is administered topically to the skin. As a cream, it is not occlusive like ointments, which makes it useful in intertriginous areas where ointments are inappropriate. Creams also vanish into the skin easily, making them cosmetically appealing to patients.[1] However, halobetasol propionate comes in a variety of different vehicles, including foams, lotions, and ointments. Foams are the least occlusive and spread rapidly, particularly in hairy areas, but they are generally expensive, whereas the occlusive nature of ointments make them better suited for thicker, hairless skin.[1]

Halobetasol cream is standardly used once to twice daily for two weeks.[4] The patient can calculate the amount of steroid that they should administer to an area through the use of the fingertip unit method. A fingertip unit is represented by the amount that will cover from the tip of the finger to the finger's first crease. For example, one hand-sized area of skin calls for 0.5 fingertip units, which are equivalent to 0.25 grams of medication.[1]

Adverse Effects

Common adverse effects of halobetasol cream include striae, purpura, rosacea, and acne,[5] with the most common adverse effect being atrophy.[1] Less common effects include hypertrichosis, alteration in pigmentation, delayed wound healing, and exacerbation of skin infections.[5] The application of very potent steroids can also induce deep-tissue tinea (fungal) infection known as a Majocchi granuloma.[1]

Systemic adverse effects are also possible, although they are far less prevalent than local adverse effects.[5] Possible systemic effects include hyperglycemia, adrenal insufficiency, Cushing syndrome, suppression of the hypothalamic-pituitary-adrenal axis, and even glaucoma if applied close to the eyes.[5] Children are at increased risk of systemic adverse effects due to their larger skin surface area about body weight. Systemic adverse effects usually result from misuse, such as when applying topical corticosteroids to extensive areas, especially under occlusion or for a prolonged period of time.[6]

Contraindications

The treatment of primary bacterial infections, such as impetigo, furuncles, carbuncles, ecthyma, and cellulitis by topical corticosteroids is an absolute contraindication.[7] The steroid may mask the infection and make it much more difficult to accurately diagnose and treat.[7] Relative contraindications for topical steroid use include candida and dermatophytes.[7] Topical steroids may be used as secondary treatments to decrease inflammation and pruritis in these conditions when appropriate.[7]

Monitoring

Halobetasol cream is typically used once or twice daily for two weeks in patients with plaque psoriasis.[8][4] As an ultra-high potency steroid, patients should not use halobetasol cream for more than three weeks continuously.[1] Its high potency makes it more likely for adverse effects to occur with prolonged use, including, but not limited to, atrophy, striae, bruising, hypertrichosis, Cushing syndrome, and suppression of the hypothalamic-pituitary-adrenal axis.[1] Ultra-high-potency steroids like halobetasol cream should not be used on the face, groin, axilla, or under occlusion,[1] as these areas have thinner skin and the intertriginous regions are more likely to develop such adverse effects. Patients should be monitored at follow-up visits every two to three weeks to reassess the condition being treated and modify the use of the corticosteroid cream, if necessary.[9]

Enhancing Healthcare Team Outcomes

Topical corticosteroids, including halobetasol cream, are commonly prescribed by dermatologists for the treatment and management of many inflammatory and pruritic conditions of the skin. They provide rapid relief to patients for a plethora of conditions, and therefore, prescritions for these agents are very common. However, proper counseling by the physician and/or pharmacist is not always adequately provided to the patient. Misuse of steroids can lead to clinically serious systemic and/or local effects.[9]

It is crucial to give patients the correct dosage form when prescribing topical corticosteroids. Solutions, foams, gels, lotions, creams, and ointments all have appropriate clinical applications. The proper frequency, amount, and duration of treatment should also be emphasized to patients to avoid overtreating an area, leading to adverse effects, or undertreating an area, leading to poor therapeutic outcomes.[9] Intertriginous regions should not have treatment with ointments, for example, and very rarely should a topical steroid be applied to a particular area more than twice a day.[5]

Additionally, glucocorticoid potency is an essential pharmacologic factor to take into account. Sometimes it is better to prescribe a more potent steroid to provide rapid control of the disease and stop treatment quickly, rather than use a less potent steroid for an extended period, especially in cases of self-limited conditions such as acute irritant dermatitis, panderous dermatitis, etc.[9] However, in other conditions, using a less potent formulation (such as halobetasol 0.01% lotion) can offer the same results as a more potent formulation (halobetasol 0.05% cream),[10] in which case the less potent option should be the choice in order to decrease the possibility of overtreatment and adverse drug effects. Generally, the least potent steroid should be used for the shortest time while still maintaining therapeutic effectiveness.[1]

Additionally, patients may have concerns about prescribed topical steroids that lead to nonadherence due to fear of harming themselves. This factor leads to a significant proportion of patients that do not receive adequate treatment. Patient education is, therefore, also important to dispel fears and false notions and ensure the safe use of topical corticosteroids.[5]

Therapy with halobetasol requires an interprofessional team approach, including physicians, specialty-trained nurses, and pharmacists, all collaborating across disciplines to achieve optimal patient results. [Level V]


References

[1] Ference JD,Last AR, Choosing topical corticosteroids. American family physician. 2009 Jan 15;     [PubMed PMID: 19178066]
[2] Kragballe K, Topical corticosteroids: mechanisms of action. Acta dermato-venereologica. Supplementum. 1989;     [PubMed PMID: 2533778]
[3] Mehta AB,Nadkarni NJ,Patil SP,Godse KV,Gautam M,Agarwal S, Topical corticosteroids in dermatology. Indian journal of dermatology, venereology and leprology. 2016 Jul-Aug;     [PubMed PMID: 27279294]
[4] A double-blind, vehicle-controlled paired comparison of halobetasol propionate cream on patients with plaque psoriasis., Katz HI,Gross E,Buxman M,Prawer SE,Schwartzel EH,Gibson JR,, Journal of the American Academy of Dermatology, 1991 Dec     [PubMed PMID: 1757613]
[5] Hengge UR,Ruzicka T,Schwartz RA,Cork MJ, Adverse effects of topical glucocorticosteroids. Journal of the American Academy of Dermatology. 2006 Jan;     [PubMed PMID: 16384751]
[6] Halobetasol propionate cream by day and halobetasol propionate ointment at night for the treatment of pediatric patients with chronic, localized plaque psoriasis and atopic dermatitis., Herz G,Blum G,Yawalkar S,, Journal of the American Academy of Dermatology, 1991 Dec     [PubMed PMID: 1757611]
[7] Cornell RC, Contraindications for using topical steroids. The Western journal of medicine. 1987 Oct;     [PubMed PMID: 18750337]
[8] Green LJ,Kerdel FA,Cook-Bolden FE,Bagel J,Lin T,Martin G,Pillai R,Israel R,Ramakrishna T, Safety and Efficacy of a Once-Daily Halobetasol Propionate 0.01% Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis: Results of Two Phase 3 Randomized Controlled Trials. Journal of drugs in dermatology : JDD. 2018 Oct 1;     [PubMed PMID: 30365586]
[9] Saraswat A, Ethical use of topical corticosteroids. Indian journal of dermatology. 2014 Sep;     [PubMed PMID: 25284852]
[10] A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle-Controlled Clinical Study to Compare the Safety and Efficacy of a Halobetasol Propionate 0.01% lotion and Halobetasol Propionate 0.05% cream in the Treatment of Plaque Psoriasis., Kerdel FA,Draelos ZD,Tyring SK,Lin T,Pillai R,, The Journal of dermatological treatment, 2018 Sep 12     [PubMed PMID: 30207807]