Wernicke-Korsakoff syndrome is a common complication of a thiamine deficiency that is primarily seen with alcoholics. This syndrome was classically described as a clinical triad consisting of altered mental status (i.e., confusion or dementia), nystagmus (or ophthalmoplegia), and ataxia. However, less than a third of patients present with this complete triad.
Wernicke-Korsakoff syndrome is a term that encompasses two different syndromes, Wernicke encephalopathy and Korsakoff syndrome. Wernicke encephalopathy is characterized by an acute confusional state with clinical features that are often reversible. While Korsakoff syndrome is characterized by confabulation, memory loss, and gait abnormalities that are often irreversible and results if Wernicke encephalopathy is not treated adequately.
The cause of Wernicke-Korsakoff syndrome is a deficiency of thiamine or vitamin B1. Individuals with poor nutrition for any reason are at risk for this disorder. The most common social factor associated with Wernicke-Korsakoff syndrome is chronic alcohol abuse, leading to decreased absorption and utilization of thiamine. However, it is important to note that there are nonalcoholic causes of thiamine deficiency, which can also produce Wernicke-Korsakoff syndrome.  These include individuals with malnutrition, starvation, schizophrenia, anorexia nervosa, prisoners of war, and terminal malignancies. In the past, baby formula, which was deficient in thiamine, also led to Wernicke-Korsakoff syndrome. Wernicke-Korsakoff syndrome also can develop during the first trimester of pregnancy in women who develop hyperemesis gravidarum. Another common cause is bariatric surgery and malignancies of the gastrointestinal (GI) tract.
Other common causes of Wernicke Korsakoff syndrome include:
The prevalence is between 0 and 2% worldwide. Specific subpopulations have higher prevalence rates, including people who are homeless, older individuals living alone or in isolation, and psychiatric inpatients. Interestingly, prevalence is not connected to alcohol consumption per capita. For example, in France, a country that is well known for its consumption of wine, the prevalence is approximately 0.4%, while Australia has a prevalence of approximately 3%.
Brain atrophy associated with Wernicke-Korsakoff Syndrome occurs most predominantly at the mammillary bodies, though it can also occur in other places, including the dorsomedial thalami, the periaqueductal gray, the walls of the third ventricle, and the tectal plate. This is best visualized by increased signal intensity on T2/FLAIR on MRI. In addition to the damage seen in these areas, there may be damage to the cortex, although this may be due to the direct toxic effects of alcohol as opposed to thiamine deficiency.
The amnesia associated with Wernicke-Korsakoff syndrome is a result of atrophy of the structures of the diencephalon (thalamus, hypothalamus, and mammillary bodies) and is similar to amnesia that is present as a result of damage to the medial temporal lobe. It has been argued that the memory impairment can occur as a result of damage along any part of the mammillothalamic tract, which may explain how Wernicke-Korsakoff Syndrome can develop in patients with damage exclusively to either the thalamus or the mammillary bodies.
The ocular motor lesions are due to damage to the abducens nuclei and eye movement centers in the midbrain/pons. Ataxia is due to damage in the superior vermis.
An individual with Wernicke-Korsakoff syndrome classically presents with (1) ocular disturbances which may include diplopia, painless vision loss, or strabismus, (2) gait abnormalities that include a wide-based, short-stepped gait and an inability to stand or ambulate without assistance, and (3) mental status changes that include apathy, a paucity of speech, and indifference to the environment. However, patients commonly do not present with this full triad. As the disorder progresses, other symptoms that may develop include agitation, anger, hallucinations, and confabulations.
The diagnosis of Wernicke-Korsakoff syndrome is made primarily by the history and clinical findings supplemented by labs and imaging. One should maintain a high level of suspicion because of the severe morbidity and mortality that results if treatment is delayed. Prophylactic thiamine administration is relatively safe and should be started even if the diagnosis has not been confirmed. Importantly, thiamine should be administered before glucose to avoid precipitating or exacerbating Wernicke-Korsakoff syndrome.
Unfortunately, it is rare for the individual with Wernicke-Korsakoff syndrome to recover fully even with aggressive treatment. After thiamine treatment, the symptoms of encephalopathy will improve in 5 to 12 days. The patient should be offered oral thiamine and consulted for the rehabilitation and treatment of other comorbid conditions. Most patients with Wernicke-Korsakoff syndrome need long-term care in a chronic care facility. Their prognosis is guarded.
The differential diagnosis includes the following:
Approximately 25% of patients with Wernicke-Korsakoff syndrome require long-term institutionalization. The patients that depend on long-term care often have one or more comorbidities (somatic and psychiatric).
Mental Status Complications
Global confusion often resolves gradually after treatment.
One in five patients who demonstrate signs of the amnestic state after initiating treatment will have a complete recovery. The remaining patients will have varying degrees of persistent learning and memory impairments.
Maximum recovery may take years and is dependent on abstinence from alcohol.
Approximately half of the patients with ataxic symptoms will recover completely. The other half will have an incomplete recovery, with a residual slow, shuffling, wide-based gait, and the inability to tandem walk.
Vestibular dysfunction improves in about half of all patients.
After starting treatment, patients typically recover from Wernicke-Korsakoff syndrome in a predictable pattern. Improvement of ocular abnormalities is the most dramatic, usually occurring within hours after thiamine administration.
If the ocular abnormality does not improve after administrating thiamine, the diagnosis of Wernicke-Korsakoff syndrome should be reevaluated.
Vertical nystagmus may persist for months while the fine horizontal nystagmus can persist indefinitely.
Sixth nerve palsies, ptosis, and vertical-gaze palsies all typically recover completely.
Mortality usually occurs secondary to infections and hepatic failure, but some deaths are attributable to defects of prolonged thiamine deficiency.
The mortality rate is 10% to 15% in severe cases.
Prognosis depends on the stage of disease at presentation and time of treatment.
Korsakoff syndrome often follows or accompanies Wernicke encephalopathy.
To reduce the risk of Wernicke-Korsakoff syndrome, limit the intake of alcohol, and ensure that proper nutrition needs are met.
Wernicke Korsakoff syndrome is often encountered by the primary care physician, nurse practitioner, or internist. While the diagnosis is relatively simple, the management is unsatisfactory. The disorder is progressive and carries very high morbidity and mortality. The condition is best managed by an interprofessional team that includes a neurologist, mental health nurse, psychiatrist, gastroenterologist, ophthalmologist, and an intensivist. The nurse should assist the clinician in inpatient and family education as the need for education is significant and requires reinforcement. Despite optimal treatment, full recovery does not occur. the majority of patients end up in a long term care facility and have a guarded prognosis.
This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare of any of its affiliated entities.
|||Gerridzen IJ,Joling KJ,Depla MF,Veenhuizen RB,Verschuur EML,Twisk JWR,Hertogh CMPM, Awareness and its relationships with neuropsychiatric symptoms in people with Korsakoff syndrome or other alcohol-related cognitive disorders living in specialized nursing homes. International journal of geriatric psychiatry. 2019 Mar 10; [PubMed PMID: 30854733]|
|||Yoon C,Gedzior J,DePry D, Wernicke-Korsakoff syndrome: Focus on low-threshold diagnosis and prompt treatment in the primary care setting. International journal of psychiatry in medicine. 2019 Mar 1; [PubMed PMID: 30823858]|
|||van Dongen LCM,Wingbermühle E,van der Veld WM,Vermeulen K,Bos-Roubos AG,Ockeloen CW,Kleefstra T,Egger JIM, Exploring the behavioral and cognitive phenotype of KBG syndrome. Genes, brain, and behavior. 2019 Feb 21; [PubMed PMID: 30786142]|
|||Polegato BF,Pereira AG,Azevedo PS,Costa NA,Zornoff LAM,Paiva SAR,Minicucci MF, Role of Thiamin in Health and Disease. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 2019 Jan 15; [PubMed PMID: 30644592]|
|||Doğan İG,Altiokka GU,Türker F,Saka B,Bilgiç B,Orhan EK, Wernicke's Encephalopathy due to Non-Alcoholic Gastrointestinal Tract Disease. Noro psikiyatri arsivi. 2018 Dec; [PubMed PMID: 30622385]|
|||Heirene R,John B,Roderique-Davies G, Identification and Evaluation of Neuropsychological Tools Used in the Assessment of Alcohol-Related Cognitive Impairment: A Systematic Review. Frontiers in psychology. 2018; [PubMed PMID: 30619013]|
|||McGlacken-Byrne D,Wallace E, Vitamin Deficiency and Systemic Failure: The Case For Greater Focus On Wernicke-Korsakoff Syndrome Irish medical journal. 2018 Dec 6; [PubMed PMID: 30560643]|
|||Arts NJ,Walvoort SJ,Kessels RP, Korsakoff's syndrome: a critical review. Neuropsychiatric disease and treatment. 2017; [PubMed PMID: 29225466]|
|||Nakamura ZM,Tatreau JR,Rosenstein DL,Park EM, Clinical Characteristics and Outcomes Associated With High-Dose Intravenous Thiamine Administration in Patients With Encephalopathy. Psychosomatics. 2018 Jul - Aug; [PubMed PMID: 29482863]|
|||Junghanns K,Wetterling T, [Alcohol withdrawal and its major complications]. Fortschritte der Neurologie-Psychiatrie. 2017 Mar; [PubMed PMID: 28320026]|
|||Latt N,Dore G, Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. Internal medicine journal. 2014 Sep; [PubMed PMID: 25201422]|
|||Isenberg-Grzeda E,Chabon B,Nicolson SE, Prescribing thiamine to inpatients with alcohol use disorders: how well are we doing? Journal of addiction medicine. 2014 Jan-Feb; [PubMed PMID: 24343128]|
|||Feeney GF,Connor JP, Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency. Drug and alcohol review. 2008 Jul; [PubMed PMID: 18584388]|
|||Harper C, The neurotoxicity of alcohol. Human [PubMed PMID: 17439928]|
|||Day E,Bentham P,Callaghan R,Kuruvilla T,George S, Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse. The Cochrane database of systematic reviews. 2004; [PubMed PMID: 14974055]|
|||Sanvisens A,Zuluaga P,Fuster D,Rivas I,Tor J,Marcos M,Chamorro AJ,Muga R, Long-Term Mortality of Patients with an Alcohol-Related Wernicke-Korsakoff Syndrome. Alcohol and alcoholism (Oxford, Oxfordshire). 2017 Jul 1; [PubMed PMID: 28340112]|